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  1. Article: A 7-Step Guideline for Qualitative Synthesis and Meta-Analysis of Observational Studies in Health Sciences.

    Glisic, Marija / Raguindin, Peter Francis / Gemperli, Armin / Taneri, Petek Eylul / Salvador, Dante Jr / Voortman, Trudy / Marques Vidal, Pedro / Papatheodorou, Stefania I / Kunutsor, Setor K / Bano, Arjola / Ioannidis, John P A / Muka, Taulant

    Public health reviews

    2023  Volume 44, Page(s) 1605454

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 217531-9
    ISSN 2107-6952 ; 0301-0422
    ISSN (online) 2107-6952
    ISSN 0301-0422
    DOI 10.3389/phrs.2023.1605454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A 7-Step Guideline for Qualitative Synthesis and Meta-Analysis of Observational Studies in Health Sciences

    Glisic, Marija / Raguindin, Peter Francis / Gemperli, Armin / Taneri, Petek Eylul / Salvador, Dante Jr / Voortman, Trudy / Marques Vidal, Pedro / Papatheodorou, Stefania I. / Kunutsor, Setor K. / Bano, Arjola / Ioannidis, John P.A. / Muka, Taulant

    Public Health Reviews

    2023  Volume 44

    Abstract: Objectives: To provide a step-by-step, easy-to-understand, practical guide for systematic review and meta-analysis of observational studies. Methods: A multidisciplinary team of researchers with extensive experience in observational studies and ... ...

    Abstract Objectives: To provide a step-by-step, easy-to-understand, practical guide for systematic review and meta-analysis of observational studies. Methods: A multidisciplinary team of researchers with extensive experience in observational studies and systematic review and meta-analysis was established. Previous guidelines in evidence synthesis were considered. Results: There is inherent variability in observational study design, population, and analysis, making evidence synthesis challenging. We provided a framework and discussed basic meta-analysis concepts to assist reviewers in making informed decisions. We also explained several statistical tools for dealing with heterogeneity, probing for bias, and interpreting findings. Finally, we briefly discussed issues and caveats for translating results into clinical and public health recommendations. Our guideline complements “A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research” and addresses peculiarities for observational studies previously unexplored. Conclusion: We provided 7 steps to synthesize evidence from observational studies. We encourage medical and public health practitioners who answer important questions to systematically integrate evidence from observational studies and contribute evidence-based decision-making in health sciences.
    Keywords cohort studies ; cross-sectional studies ; evidence-based approach ; observational study ; systematic review and meta-analysis
    Subject code 306
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 217531-9
    ISSN 2107-6952 ; 0301-0422
    ISSN (online) 2107-6952
    ISSN 0301-0422
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Anemia and iron metabolism in COVID-19

    Taneri, Petek Eylul / Gómez-Ochoa, Sergio Alejandro / Llanaj, Erand / Raguindin, Peter Francis / Rojas, Lyda Z / Roa-Díaz, Zayne Milena / Salvador, Dante Jr / Groothof, Dion / Minder, Beatrice / Kopp, Doris / Hautz, Wolf E. / Eisenga, Michele F / Franco, Oscar H. / Glisic, Marija / Muka, Taulant

    Taneri, Petek Eylul; Gómez-Ochoa, Sergio Alejandro; Llanaj, Erand; Raguindin, Peter Francis; Rojas, Lyda Z; Roa-Díaz, Zayne Milena; Salvador, Dante Jr; Groothof, Dion; Minder, Beatrice; Kopp, Doris; Hautz, Wolf E.; Eisenga, Michele F; Franco, Oscar H.; Glisic, Marija; Muka, Taulant (2020). Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis. European journal of epidemiology, 35(8), pp. 763-773. Springer 10.1007/s10654-020-00678-5

    a systematic review and meta-analysis.

    2020  

    Abstract: Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ... ...

    Abstract Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), - 4.08 g/L (95% CI - 5.12; - 3.05)] and red blood cell count [WMD, - 0.16 × 1012 /L (95% CI - 0.31; - 0.014)], and higher ferritin [WMD, - 473.25 ng/mL (95% CI 382.52; 563.98)] and red cell distribution width [WMD, 1.82% (95% CI 0.10; 3.55)]. A significant difference in mean ferritin levels of 606.37 ng/mL (95% CI 461.86; 750.88) was found between survivors and non-survivors, but not in hemoglobin levels. Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19.
    Keywords 020 Library & information sciences ; 610 Medicine & health ; 360 Social problems & social services ; covid19
    Subject code 616
    Language English
    Publisher Springer
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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