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  1. Article ; Online: The Pathogenesis of Systemic Sclerosis

    Junsuk Ko / Maria Noviani / Vasuki Ranjani Chellamuthu / Salvatore Albani / Andrea Hsiu Ling Low

    International Journal of Molecular Sciences, Vol 24, Iss 14287, p

    The Origin of Fibrosis and Interlink with Vasculopathy and Autoimmunity

    2023  Volume 14287

    Abstract: Systemic sclerosis (SSc) is an autoimmune disease associated with increased mortality and poor morbidity, impairing the quality of life in patients. Whilst we know that SSc affects multiple organs via vasculopathy, inflammation, and fibrosis, its exact ... ...

    Abstract Systemic sclerosis (SSc) is an autoimmune disease associated with increased mortality and poor morbidity, impairing the quality of life in patients. Whilst we know that SSc affects multiple organs via vasculopathy, inflammation, and fibrosis, its exact pathophysiology remains elusive. Microvascular injury and vasculopathy are the initial pathological features of the disease. Clinically, the vasculopathy in SSc is manifested as Raynaud’s phenomenon (reversible vasospasm in reaction to the cold or emotional stress) and digital ulcers due to ischemic injury. There are several reports that medications for vasculopathy, such as bosentan and soluble guanylate cyclase (sGC) modulators, improve not only vasculopathy but also dermal fibrosis, suggesting that vasculopathy is important in SSc. Although vasculopathy is an important initial step of the pathogenesis for SSc, it is still unclear how vasculopathy is related to inflammation and fibrosis. In this review, we focused on the clinical evidence for vasculopathy, the major cellular players for the pathogenesis, including pericytes, adipocytes, endothelial cells (ECs), and myofibroblasts, and their signaling pathway to elucidate the relationship among vasculopathy, inflammation, and fibrosis in SSc.
    Keywords scleroderma ; Raynaud ; systemic sclerosis ; vasculopathy ; inflammation ; fibrosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Toward Molecular Stratification and Precision Medicine in Systemic Sclerosis

    Maria Noviani / Vasuki Ranjani Chellamuthu / Salvatore Albani / Andrea Hsiu Ling Low

    Frontiers in Medicine, Vol

    2022  Volume 9

    Abstract: Systemic sclerosis (SSc), a complex multi-systemic disease characterized by immune dysregulation, vasculopathy and fibrosis, is associated with high mortality. Its pathogenesis is only partially understood. The heterogenous pathological processes that ... ...

    Abstract Systemic sclerosis (SSc), a complex multi-systemic disease characterized by immune dysregulation, vasculopathy and fibrosis, is associated with high mortality. Its pathogenesis is only partially understood. The heterogenous pathological processes that define SSc and its stages present a challenge to targeting appropriate treatment, with differing treatment outcomes of SSc patients despite similar initial clinical presentations. Timing of the appropriate treatments targeted at the underlying disease process is critical. For example, immunomodulatory treatments may be used for patients in a predominantly inflammatory phase, anti-fibrotic treatments for those in the fibrotic phase, or combination therapies for those in the fibro-inflammatory phase. In advancing personalized care through precision medicine, groups of patients with similar disease characteristics and shared pathological processes may be identified through molecular stratification. This would improve current clinical sub-setting systems and guide personalization of therapies. In this review, we will provide updates in SSc clinical and molecular stratification in relation to patient outcomes and treatment responses. Promises of molecular stratification through advances in high-dimensional tools, including omic-based stratification (transcriptomics, genomics, epigenomics, proteomics, cytomics, microbiomics) and machine learning will be discussed. Innovative and more granular stratification systems that integrate molecular characteristics to clinical phenotypes would potentially improve therapeutic approaches through personalized medicine and lead to better patient outcomes.
    Keywords systemic sclerosis ; stratification ; precision medicine ; molecular ; multi-omic analyses ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Editorial

    Manuela Battaglia / Salvatore Albani / Berent Prakken / Norman D. Rosenblum

    Frontiers in Medicine, Vol

    The Silent Cry: How to Turn Translational Medicine Towards Patients and Unmet Medical Needs

    2020  Volume 7

    Keywords translational research ; translational medicine (TM) ; unmet medical needs ; patient engagement in healthcare ; interdisciplinary ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Juvenile Spondyloarthritis

    Shi Huan Tay / Joo Guan Yeo / Jing Yao Leong / Salvatore Albani / Thaschawee Arkachaisri

    Frontiers in Medicine, Vol

    What More Do We Know About HLA-B27, Enthesitis, and New Bone Formation?

    2021  Volume 8

    Abstract: Juvenile spondyloarthritis (JSpA) refers to a diverse spectrum of immune-mediated inflammatory arthritides whose onset occurs in late childhood and adolescence. Like its adult counterpart, JSpA is typified by a strong association with human leukocyte ... ...

    Abstract Juvenile spondyloarthritis (JSpA) refers to a diverse spectrum of immune-mediated inflammatory arthritides whose onset occurs in late childhood and adolescence. Like its adult counterpart, JSpA is typified by a strong association with human leukocyte antigen-B27 (HLA-B27) and potential axial involvement, while lacking rheumatoid factor (RF) and distinguishing autoantibodies. A characteristic manifestation of JSpA is enthesitis (inflammation of insertion sites of tendons, ligaments, joint capsules or fascia to bone), which is commonly accompanied by bone resorption and new bone formation at affected sites. In this Review, advances in the role of HLA-B27, enthesitis and its associated osteoproliferation in JSpA pathophysiology and treatment options will be discussed. A deeper appreciation of how these elements contribute to the JSpA disease mechanism will better inform diagnosis, prognosis and therapy, which in turn translates to an improved quality of life for patients.
    Keywords juvenile arthritis ; spondyloarthritis ; enthesitis related arthritis ; HLA-B27 ; osteogenesis ; enthesitis ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

    Gerdien Mijnheer / Nila Hendrika Servaas / Jing Yao Leong / Arjan Boltjes / Eric Spierings / Phyllis Chen / Liyun Lai / Alessandra Petrelli / Sebastiaan Vastert / Rob J de Boer / Salvatore Albani / Aridaman Pandit / Femke van Wijk

    eLife, Vol

    2023  Volume 12

    Abstract: Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-specific T cells. Although this inflammation is often limited to specific target tissues, it remains yet to be explored whether distinct affected sites are ... ...

    Abstract Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-specific T cells. Although this inflammation is often limited to specific target tissues, it remains yet to be explored whether distinct affected sites are infiltrated with the same, persistent T cell clones. Here, we performed CyTOF analysis and T cell receptor (TCR) sequencing to study immune cell composition and (hyper-)expansion of circulating and joint-derived Tregs and non-Tregs in juvenile idiopathic arthritis (JIA). We studied different joints affected at the same time, as well as over the course of relapsing-remitting disease. We found that the composition and functional characteristics of immune infiltrates are strikingly similar between joints within one patient, and observed a strong overlap between dominant T cell clones, especially Treg, of which some could also be detected in circulation and persisted over the course of relapsing-remitting disease. Moreover, these T cell clones were characterized by a high degree of sequence similarity, indicating the presence of TCR clusters responding to the same antigens. These data suggest that in localized autoimmune disease, there is autoantigen-driven expansion of both Teffector and Treg clones that are highly persistent and are (re)circulating. These dominant clones might represent interesting therapeutic targets.
    Keywords juvenile idiopathic arthritis ; regulatory T cell ; t cell receptor ; CyTOF ; tissue inflammation ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: When Parallel Roads Meet

    Uri Tabori / Joseph Ferenbok / Emmanuel Thomas / Joost Frans Swart Thomas / Salvatore Albani / Vicki Seyfert-Margolis / Emilie Sauvage

    Frontiers in Medicine, Vol

    Orchestrating Collaborations Between Regulatory, Ethical, and Business Partners in Translational Medicine

    2019  Volume 6

    Keywords translational medicine ; regulators ; innovators ; business ; patients ; Medicine (General) ; R5-920
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Immunomics in Pediatric Rheumatic Diseases

    Shi Huan Tay / Katherine Nay Yaung / Jing Yao Leong / Joo Guan Yeo / Thaschawee Arkachaisri / Salvatore Albani

    Frontiers in Medicine, Vol

    2019  Volume 6

    Abstract: The inherent complexity in the immune landscape of pediatric rheumatic disease necessitates a holistic system approach. Uncertainty in the mechanistic workings and etiological driving forces presents difficulty in personalized treatments. The development ...

    Abstract The inherent complexity in the immune landscape of pediatric rheumatic disease necessitates a holistic system approach. Uncertainty in the mechanistic workings and etiological driving forces presents difficulty in personalized treatments. The development and progression of immunomics are well suited to deal with this complexity. Immunomics encompasses a spectrum of biological processes that entail genomics, transcriptomics, epigenomics, proteomics, and cytomics. In this review, we will discuss how various high dimensional technologies in immunomics have helped to grow a wealth of data that provide salient clues and biological insights into the pathogenesis of autoimmunity. Interfaced with critical unresolved clinical questions and unmet medical needs, these platforms have helped to identify candidate immune targets, refine patient stratification, and understand treatment response or resistance. Yet the unprecedented growth in data has presented both opportunities and challenges. Researchers are now facing huge heterogeneous data sets from different origins that need to be integrated and exploited for further data mining. We believe that the utilization and integration of these platforms will help unravel the complexities and expedite both discovery and validation of clinical targets.
    Keywords immunomics ; rheumatology ; genomics ; transcriptomics ; proteomics ; cytomics ; Medicine (General) ; R5-920
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A phase I study of an adenoviral vector delivering a MUC1/CD40-ligand fusion protein in patients with advanced adenocarcinoma

    Tira J. Tan / W. X. Gladys Ang / Who-Whong Wang / Hui-Shan Chong / Sze Huey Tan / Rachael Cheong / John Whay-Kuang Chia / Nicholas L. Syn / Wai Ho Shuen / Rebecca Ba / Nivashini Kaliaperumal / Bijin Au / Richard Hopkins / Xinhua Li / Aaron C. Tan / Amanda O. L. Seet / John E. Connolly / Thaschawee Arkachaisri / Valerie Chew /
    Ahmad bin Mohamed Lajam / Dianyan Guo / Marvin Z. W. Chew / Martin Wasser / Pavanish Kumar / Salvatore Albani / Han Chong Toh

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 11

    Abstract: Ad-sig-hMUC1/ecdCD40L is a recombinant adenovirus vaccine comprising human MUC1 antigen fused to the extracellular domain of the CD40 ligand. Here the authors report the result of a phase I clinical trial of Ad-sig-hMUC1/ecdCD40L in patients with ... ...

    Abstract Ad-sig-hMUC1/ecdCD40L is a recombinant adenovirus vaccine comprising human MUC1 antigen fused to the extracellular domain of the CD40 ligand. Here the authors report the result of a phase I clinical trial of Ad-sig-hMUC1/ecdCD40L in patients with advanced adenocarcinoma.
    Keywords Science ; Q
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Author Correction

    Phuong H. D. Nguyen / Siming Ma / Cheryl Z. J. Phua / Neslihan A. Kaya / Hannah L. H. Lai / Chun Jye Lim / Jia Qi Lim / Martin Wasser / Liyun Lai / Wai Leong Tam / Tony K. H. Lim / Wei Keat Wan / Tracy Loh / Wei Qiang Leow / Yin Huei Pang / Chung Yip Chan / Ser Yee Lee / Peng Chung Cheow / Han Chong Toh /
    Florent Ginhoux / Shridhar Iyer / Alfred W. C. Kow / Yock Young Dan / Alexander Chung / Glen K. Bonney / Brian K. P. Goh / Salvatore Albani / Pierce K. H. Chow / Weiwei Zhai / Valerie Chew

    Nature Communications, Vol 12, Iss 1, Pp 1-

    Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

    2021  Volume 1

    Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21556-y. ...

    Abstract A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21556-y.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

    Phuong H. D. Nguyen / Siming Ma / Cheryl Z. J. Phua / Neslihan A. Kaya / Hannah L. H. Lai / Chun Jye Lim / Jia Qi Lim / Martin Wasser / Liyun Lai / Wai Leong Tam / Tony K. H. Lim / Wei Keat Wan / Tracy Loh / Wei Qiang Leow / Yin Huei Pang / Chung Yip Chan / Ser Yee Lee / Peng Chung Cheow / Han Chong Toh /
    Florent Ginhoux / Shridhar Iyer / Alfred W. C. Kow / Yock Young Dan / Alexander Chung / Brian K. P. Goh / Salvatore Albani / Pierce K. H. Chow / Weiwei Zhai / Valerie Chew

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 13

    Abstract: Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune ... ...

    Abstract Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppressive microenvironment, which was associated with tumour evolution and a poor prognosis.
    Keywords Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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