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Article ; Online: Developing a Cloud-Based Air Quality Monitoring Platform Using Low-Cost Sensors.

Samad, Abdul / Kieser, Joschka / Chourdakis, Ioannis / Vogt, Ulrich

2024 Volume 24, Issue 3

Abstract: Conventional air quality monitoring has been traditionally carried out in a few fixed places with expensive measuring equipment. This results in sparse spatial air quality data, which do not represent the real air quality of an entire area, e.g., when ... ...

Abstract	Conventional air quality monitoring has been traditionally carried out in a few fixed places with expensive measuring equipment. This results in sparse spatial air quality data, which do not represent the real air quality of an entire area, e.g., when hot spots are missing. To obtain air quality data with higher spatial and temporal resolution, this research focused on developing a low-cost network of cloud-based air quality measurement platforms. These platforms should be able to measure air quality parameters including particulate matter (PM10, PM2.5, PM1) as well as gases like NO, NO
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24030945
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Article ; Online: Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals:

Ansari, Mohd Nazam / Rehman, Najeeb Ur / Samad, Abdul / Ahmad, Wasim

Frontiers in bioscience (Landmark edition)

2024 Volume 29, Issue 1, Page(s) 43

Abstract: Background: Medicinal herbs are frequently used for the management of gastrointestinal disorders because they contain various compounds that can potentially amplify the intended therapeutic effects. Cuminaldehyde is a plant-based constituent found in ... ...

Abstract	Background: Medicinal herbs are frequently used for the management of gastrointestinal disorders because they contain various compounds that can potentially amplify the intended therapeutic effects. Cuminaldehyde is a plant-based constituent found in oils derived from botanicals such as cumin, eucalyptus, myrrh, and cassia and is responsible for its health benefits. Despite the utilization of cuminaldehyde for several medicinal properties, there is currently insufficient scientific evidence to support its effectiveness in treating diarrhea. Hence, the present investigation was carried out to evaluate the antidiarrheal and antispasmodic efficacy of cuminaldehyde, with detailed pharmacodynamics explored. Methods: An Results: Cuminaldehyde, at 10 and 20 mg/kg, exhibited 60 and 80% protection in mice from episodic diarrhea compared to the saline control group, whereas this inhibitory effect was significantly reversed in the pretreated mice with glibenclamide, similar to cromakalim, an ATP-dependent K+ channel opener. In the Conclusions: Present findings support the antidiarrheal and antispasmodic potential of cuminaldehyde, possibly by the predominant activation of ATP-dependent K+ channels followed by voltage-gated Ca++ inhibition. However, further in-depth assays are recommended to know the precise mechanism and to elucidate additional unexplored mechanism(s) if involved.
MeSH term(s)	Rats ; Mice ; Animals ; Antidiarrheals/adverse effects ; Parasympatholytics/adverse effects ; Cromakalim/adverse effects ; Glyburide/adverse effects ; Plant Extracts/pharmacology ; Jejunum ; Diarrhea/chemically induced ; Diarrhea/drug therapy ; Verapamil/adverse effects ; Adenosine Triphosphate ; Cymenes ; Benzaldehydes
Chemical Substances	Antidiarrheals ; Parasympatholytics ; cuminaldehyde (O0893NC35F) ; Cromakalim (0G4X367WA3) ; Glyburide (SX6K58TVWC) ; Plant Extracts ; Verapamil (CJ0O37KU29) ; Adenosine Triphosphate (8L70Q75FXE) ; Cymenes ; Benzaldehydes
Language	English
Publishing date	2024-02-10
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2901043
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Article: Acceptance, hesitancy and refusal towards COVID-19 vaccination.

Raut, Asavari / Samad, Abdul / Verma, Jay / Kshirsagar, Pranad

Clinical epidemiology and global health

2023 Volume 21, Page(s) 101283

Abstract: Problem: The determinants of COVID-19 vaccine acceptance, hesitancy, and refusal remain poorly understood. We assessed the general population of Pune after visiting tertiary care hospital for their willingness to accept the vaccine and the reason for ... ...

Abstract	Problem: The determinants of COVID-19 vaccine acceptance, hesitancy, and refusal remain poorly understood. We assessed the general population of Pune after visiting tertiary care hospital for their willingness to accept the vaccine and the reason for their hesitancy and refusal. Methodology: A six-month descriptive cross-sectional study with 386 community members over the age of 18 who visited the Tertiary Hospital OPD was conducted. The vaccine acceptance and hesitancy was assessed using a self designed detailed questionnaire with a one-time face-to-face interview. Results: Acceptance for vaccine was observed in 235 (60.8%) participants, while 151 (39.2%) hesitated and refused. Participants with lower education (P < 0.00001), no employment did not readily accept the vaccine (P < 0.00001). Pregnant, breast-feeding women (21.8%) hesitated vaccine because of lack of evidence regarding vaccine safety. Participants (73.6%) were readily accepting (third dose) booster dose of vaccine when available. The reason for vaccine hesitance was the concern about side effects (58.2%) and reason for acceptance was to get immunity against COVID-19 (76.1%). Vaccine information source appears to be an influential aspect, as participants who obtained vaccination information from healthcare providers had no concerns regarding vaccination. Conclusion: The study has found a link between average education level, unemployment and vaccine acceptance and hesitancy. Factors influencing vaccine hesitancy include lack of vaccine information, vaccine side effects, and misinformation spread via social media. Clinical pharmacists can play an important role in boosting up vaccine acceptance by providing appropriate information in community.
Language	English
Publishing date	2023-04-04
Publishing country	India
Document type	Journal Article
ISSN	2452-0918
ISSN	2452-0918
DOI	10.1016/j.cegh.2023.101283
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Article: Characterization and evolutionary analysis of Cucumber mosaic virus isolate infecting

Sinha, Soumya / Samad, Abdul

3 Biotech

2021 Volume 11, Issue 11, Page(s) 468

Abstract: Cucumber mosaic virus (CMV) is one of the most widespread viruses that infects a large number of cultivated crops worldwide and causes severe losses. Besides vegetables and ornamental crops, it is also spreading on medicinal and aromatic plants (MAPs) at ...

Abstract	Cucumber mosaic virus (CMV) is one of the most widespread viruses that infects a large number of cultivated crops worldwide and causes severe losses. Besides vegetables and ornamental crops, it is also spreading on medicinal and aromatic plants (MAPs) at an alarming rate. Natural occurrence of green mosaic, leaf curling, necrosis, and distortion were observed on the leaves of
Language	English
Publishing date	2021-10-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-021-03023-z
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Article: Characterization and evolutionary analysis of Cucumber mosaic virus isolate infecting Salvia sclarea in India

Sinha, Soumya / Samad, Abdul

3 Biotech. 2021 Nov., v. 11, no. 11

2021

Abstract	Cucumber mosaic virus (CMV) is one of the most widespread viruses that infects a large number of cultivated crops worldwide and causes severe losses. Besides vegetables and ornamental crops, it is also spreading on medicinal and aromatic plants (MAPs) at an alarming rate. Natural occurrence of green mosaic, leaf curling, necrosis, and distortion were observed on the leaves of Salvia sclarea in the experimental field of CSIR-CIMAP, Lucknow, India. Mechanical transmission assay, morphological features, CP gene, and RNA3-based genomic characterization revealed the association of a new CMV isolate with the present disease. Virus is mechanically sap transmissible to the test plants. Transmission electron microscopy showed the presence of isodiametric particles of ~ 28 nm in diameter. Phylogenetic studies revealed that RNA3 (~ 2.2 kb) belongs to the subgroup IA of CMV. Multiple sequence alignment of amino acid sequences showed that MP possesses two unique changes in the RNA-binding domain and CP was found to be the conserved one with one change only. To the best of our knowledge, this is the first report of a CMV isolate infecting S. sclarea.
Keywords	Cucumber mosaic virus ; RNA ; Salvia sclarea ; genes ; genomics ; leaves ; necrosis ; phylogeny ; sequence alignment ; transmission electron microscopy ; viruses ; India
Language	English
Dates of publication	2021-11
Size	p. 468.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-021-03023-z
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Article: Genetic variant in TNF-α gene and its plasma level in relation to obstructive sleep apnoea in the Pakistani population.

Qamar, Ambreen / Hanif, Muhammad / Haque, Zeba / Zehra, Sitwat / Baig, Saifullah / Samad, Abdul

JPMA. The Journal of the Pakistan Medical Association

2024 Volume 74, Issue 1 (Supple-2), Page(s) S8–S13

Abstract: Objective: To assess the link between tumour necrosis factor-alpha -308 guanine/adenine polymorphism and tumour necrosis factor-alpha plasma levels in relation to obstructive sleep apnoea.: Methods: The cross-sectional study was conducted from ... ...

Abstract	Objective: To assess the link between tumour necrosis factor-alpha -308 guanine/adenine polymorphism and tumour necrosis factor-alpha plasma levels in relation to obstructive sleep apnoea. Methods: The cross-sectional study was conducted from December 2018 to March 2021 at the sleep clinic of Dow University Hospital, Karachi, on obstructive sleep apnoea patients and healthy controls. Epworth Sleep Scale score was used to determine daytime sleepiness, while full-night polysomnography was carried out for obstructive sleep apnoea confirmation and categorisation according to severity. Blood sample collection was followed by deoxyribonucleic acid extraction and plasma tumour necrosis factor-alpha measurement using enzyme-linked immunosorbent assay. Genotype distribution and allelic frequency were assessed. Data was analysed using SPSS 20. Results: Out of the 225 subjects, with a mean age of 47.68±9.88 years, 132 (58.7%) were males, and 93 (41.3%) were females. Among them, 150 (66.7%) were patients, and 75 (33.3%) were controls. Heterozygous tumour necrosis factor-alpha -308 guanine/adenine genotypes were significantly higher among the patients (p<0.05). Minor allele - 308 adenine showed an association with obstructive sleep apnoea, its severity, higher tumour necrosis factor-alpha levels, neck circumference, excessive daytime sleepiness and the presence of hypertension (p<0.05). Conclusions: Tumour necrosis factor-alpha -308 adenine allele and higher tumour necrosis factor-alpha levels were found to be linked with obstructive sleep apnoea. The polymorphism also showed an association with hypertension in obstructive sleep apnoea patients.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Adenine ; Cross-Sectional Studies ; Disorders of Excessive Somnolence/complications ; Guanine ; Hypertension/complications ; Pakistan/epidemiology ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/genetics ; Sleep Apnea, Obstructive/complications ; Tumor Necrosis Factor-alpha/genetics
Chemical Substances	Adenine (JAC85A2161) ; Guanine (5Z93L87A1R) ; Tumor Necrosis Factor-alpha ; TNF protein, human
Language	English
Publishing date	2024-02-22
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA-DUHS-S03
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Article: Out of site, out of mind: Changes in feather moss phyllosphere microbiota in mine offsite boreal landscapes.

Yin, Xiangbo / Martineau, Christine / Samad, Abdul / Fenton, Nicole J

Frontiers in microbiology

2023 Volume 14, Page(s) 1148157

Abstract: Plant-microbe interactions play a crucial role in maintaining biodiversity and ecological services in boreal forest biomes. Mining for minerals, and especially the emission of heavy metal-enriched dust from mine sites, is a potential threat to ... ...

Abstract	Plant-microbe interactions play a crucial role in maintaining biodiversity and ecological services in boreal forest biomes. Mining for minerals, and especially the emission of heavy metal-enriched dust from mine sites, is a potential threat to biodiversity in offsite landscapes. Understanding the impacts of mining on surrounding phyllosphere microbiota is especially lacking. To investigate this, we characterized bacterial and fungal communities in the phyllosphere of feather moss
Language	English
Publishing date	2023-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1148157
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Article ; Online: Innovative approaches in transforming microRNAs into therapeutic tools.

Samad, Abdul Fatah A / Kamaroddin, Mohd Farizal

Wiley interdisciplinary reviews. RNA

2022 Volume 14, Issue 1, Page(s) e1768

Abstract: MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine-tune an entire biological pathway by targeting multiple target genes. This characteristic makes miRNAs promising therapeutic tools to reinstate cell functions that are ... ...

Abstract	MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine-tune an entire biological pathway by targeting multiple target genes. This characteristic makes miRNAs promising therapeutic tools to reinstate cell functions that are disrupted as a consequence of diseases. Currently, miRNA replacement by miRNA mimics and miRNA inhibition by anti-miRNA oligonucleotides are the main approaches to utilizing miRNA molecules for therapeutic purposes. Nevertheless, miRNA-based therapeutics are hampered by major issues such as off-target effects, immunogenicity, and uncertain delivery platforms. Over the past few decades, several innovative approaches have been established to minimize off-target effects, reduce immunostimulation, and provide efficient transfer to the target cells in which these molecules exert their function. Recent achievements have led to the testing of miRNA-based drugs in clinical trials, and these molecules may become next-generation therapeutics for medical intervention. Despite the achievement of exciting milestones, the dosage of miRNA administration remains unclear, and ways to address this issue are proposed. Elucidating the current status of the main factors of therapeutic miRNA would allow further developments and innovations to achieve safe therapeutic tools. This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action.
MeSH term(s)	MicroRNAs/genetics ; MicroRNAs/therapeutic use
Chemical Substances	MicroRNAs
Language	English
Publishing date	2022-11-27
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2634714-3
ISSN	1757-7012 ; 1757-7004
ISSN (online)	1757-7012
ISSN	1757-7004
DOI	10.1002/wrna.1768
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Article ; Online: Thermodynamic analysis of cumene production plant for identification of energy recovery potentials

Samad, Abdul / Saghir, Husnain / Ahmad, Iftikhar / Ahmad, Farooq / Caliskan, Hakan

Energy. 20232023 May 06, Feb. 06, v. 270 p.126840-

2023

Abstract: In this work, exergy analysis of cumene production plant is carried out in an integrated environment of Aspen Plus and MATLAB. Physical exergy is calculated in Aspen Plus V.10, while an interface of MATLAB and Aspen Plus is used to calculate chemical ... ...

Abstract	In this work, exergy analysis of cumene production plant is carried out in an integrated environment of Aspen Plus and MATLAB. Physical exergy is calculated in Aspen Plus V.10, while an interface of MATLAB and Aspen Plus is used to calculate chemical exergy of the process. For systematic analysis and comparison, the cumene plant is divided into three sections: preheating section, reaction section and separation section. Then, exergy efficiency, irreversibilities and exergetic improvement potential are calculated. The overall plant exergy efficiency, irreversibility and improvement potential are found as 84.93%, 95960.52 kW and 15102.5 kW, respectively. The reaction section has the highest exergy efficiency of 87.44%, while the separation section has the lowest exergy efficiency of 58.95%. The analyses performed in this study can provide a basis for optimization of design and operation of the plants.
Keywords	energy recovery ; exergy ; plant identification ; planting ; potential energy ; processing chemistry ; Cumene ; Diisopropylbenzene (DIPB) ; Friedel–crafts alkylation ; Exergy destruction ; Exergy efficiency
Language	English
Dates of publication	2023-0206
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2023.126840
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Article ; Online: Land-Use Change Impacts from Sustainable Hydropower Production in EU28 Region

Mohd Alsaleh / Muhammad Mansur Abdulwakil / Abdul Samad Abdul-Rahim

Sustainability, Vol 13, Iss 4599, p

An Empirical Analysis

2021 Volume 4599

Abstract: Under the current European Union (EU) constitution approved in May 2018, EU countries ought to guarantee that estimated greenhouse-gas releases from land use, land-use change, or forestry are entirely compensated by an equivalent accounted removal of ... ...

Abstract	Under the current European Union (EU) constitution approved in May 2018, EU countries ought to guarantee that estimated greenhouse-gas releases from land use, land-use change, or forestry are entirely compensated by an equivalent accounted removal of carbon dioxide (CO 2 ) from the air during the period between 2021 and 2030. This study investigates the effect of sustainable hydropower production on land-use change in the European Union (EU28) region countries during 1990–2018, using the fully modified ordinary least squares (FMOLS). The results revealed that land-use change incline with an increase in hydropower energy production. In addition, economic growth, carbon dioxide emissions, and population density are found to be increasing land-use changes, while institutional quality is found to be decreasing land-use change significantly. The finding implies that land-use change in EU28 region countries can be significantly increased by mounting the amount of hydropower energy production to achieve Energy Union aims by 2030. This will finally be spread to combat climate change and environmental pollution. The findings are considered robust as they were checked with DOLS and pooled OLS. The research suggests that the EU28 countries pay attention to the share of hydropower in their renewable energy combination to minimize carbon releases. Politicians and investors in the EU28 region ought to invest further in the efficiency and sustainability of hydropower generation to increase its production and accessibility without further degradation of forest and agricultural conditions. The authorities of the EU28 region should emphasize on efficiency and sustainability of hydropower energy with land-use management to achieve the international commitments for climate, biodiversity, and sustainable development, reduce dependence on fossil fuel, and energy insecurity.
Keywords	hydropower production ; land-use change ; sustainability ; EU28 region ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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