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Article ; Online: Maintenance avelumab in metastatic bladder cancer as a step towards sequencing immunotherapy.

Samaha, Hady / Samaha, Ramy / Sarkis, Julien / Kattan, Joseph

2021 Volume 13, Issue 4, Page(s) 271–275

MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy ; Maintenance Chemotherapy ; Progression-Free Survival ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/mortality ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Antibodies, Monoclonal, Humanized ; Immune Checkpoint Inhibitors ; avelumab (KXG2PJ551I)
Language	English
Publishing date	2021-01-05
Publishing country	England
Document type	Editorial
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2020-0261
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Article ; Online: Calcification of the ascending aorta, left heart valves and coronaries: associated diseases and a new classification.

Samaha, Hady / Chalhoub, Najib / Tabet, Margherita / Smayra, Tarek / Sleilaty, Ghassan

Future cardiology

2022 Volume 18, Issue 9, Page(s) 687–695

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Aorta ; Aorta, Thoracic ; Calcinosis/diagnostic imaging ; Heart Valves ; Humans ; Tomography, X-Ray Computed ; Vascular Calcification/complications ; Vascular Calcification/diagnostic imaging
Language	English
Publishing date	2022-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2274267-0
ISSN	1744-8298 ; 1479-6678
ISSN (online)	1744-8298
ISSN	1479-6678
DOI	10.2217/fca-2022-0016
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Zs.A 6836: Show issues

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Article ; Online: Right posterior insular epidural stimulation in rats with neuropathic pain induces a frequency-dependent and opioid system-mediated reduction of pain and its comorbid anxiety and depression.

Mehsein, Zeinab / Kobaïter-Maarrawi, Sandra / Samaha, Hady / El Shami, Mohamad / Albeaini, Sylvana / Maarrawi, Joseph

Progress in neuro-psychopharmacology & biological psychiatry

2023 Volume 128, Page(s) 110845

Abstract: Neuropathic pain (NP) is a sensory, emotional, and persistent disturbing experience caused by a lesion or disease of the somatosensory system which can lead when chronic to comorbidities such as anxiety and depression. Available treatments ( ... ...

Abstract	Neuropathic pain (NP) is a sensory, emotional, and persistent disturbing experience caused by a lesion or disease of the somatosensory system which can lead when chronic to comorbidities such as anxiety and depression. Available treatments (pharmacotherapy, neurostimulation) have partial and unpredictable response; therefore, it seems necessary to find a new therapeutical approach that could alleviate most related symptoms and improve patients 'emotional state'. Posterior Insula seems to be a potential target of neurostimulation for pain relief. However, its effects on pain-related anxiety and depression remain unknown. Using rats with spared nerve injury (SNI), this study aims to elucidate the correlation between NP and anxio-depressive disorders, evaluate potential analgesic, anxiolytic, and antidepressant effects of right posterior insula stimulation (IS) using low (LF-IS, 50 Hz) or high (HF-IS, 150 Hz) frequency and assess endogenous opioid involvement in these effects. Results showed positive correlation between NP, anxiety, and depression. LF-IS reversed anhedonia and despair-like behavior through pain alleviation, whereas HF-IS only reduced anhedonia, all effects involving endogenous opioids. These findings support the link between NP and anxio-depressive disorders. Moreover, IS appears to have analgesic, anxiolytic and antidepressant effects mediated by the endogenous opioid system, making it a promising target for neurostimulation.
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2023.110845
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Article: Efficacy and Durability of Immune Response after Receipt of HPV Vaccines in People Living with HIV.

Losada, Cecilia / Samaha, Hady / Scherer, Erin M / Kazzi, Bahaa / Khalil, Lana / Ofotokun, Ighovwerha / Rouphael, Nadine

Vaccines

2023 Volume 11, Issue 6

Abstract: People living with HIV (PLH) experience higher rates of HPV infection as well as an increased risk of HPV-related disease, including malignancies. Although they are considered a high-priority group for HPV vaccination, there are limited data regarding ... ...

Abstract	People living with HIV (PLH) experience higher rates of HPV infection as well as an increased risk of HPV-related disease, including malignancies. Although they are considered a high-priority group for HPV vaccination, there are limited data regarding the long-term immunogenicity and efficacy of HPV vaccines in this population. Seroconversion rates and geometric mean titers elicited by vaccination are lower in PLH compared to immunocompetent participants, especially in individuals with CD4 counts below 200 cells/mm
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11061067
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Article ; Online: Perioperative chemotherapy with modified FOLFIRINOX for nonmetastatic pancreatic cancer: a new standard of care?

Radi, Imad / Samaha, Ramy / El Hajj, Joanna / Samaha, Hady / Kourie, Hampig Raphael

Future oncology (London, England)

2020 Volume 17, Issue 3, Page(s) 229–233

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Chemotherapy, Adjuvant ; Humans ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Perioperative Period ; Standard of Care ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor
Language	English
Publishing date	2020-12-11
Publishing country	England
Document type	Editorial
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2020-0836
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Article ; Online: AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans.

Science immunology

2024 Volume 9, Issue 94, Page(s) eadi8039

Abstract: Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is due to the generation of antigen-specific B cell clones with distinct specificities or the maturation of memory B cell clones that produce broadly cross-reactive ... ...

Abstract	Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is due to the generation of antigen-specific B cell clones with distinct specificities or the maturation of memory B cell clones that produce broadly cross-reactive antibodies is unknown. Here, we longitudinally analyzed immune responses in healthy adults after two-dose vaccination with either a virus-like particle COVID-19 vaccine (CoVLP), CoVLP adjuvanted with AS03 (CoVLP+AS03), or a messenger RNA vaccination (mRNA-1273). CoVLP+AS03 enhanced the magnitude and durability of circulating antibodies and antigen-specific CD4
MeSH term(s)	Adult ; Humans ; Influenza Vaccines ; Memory B Cells ; COVID-19 Vaccines ; Influenza, Human ; Antibodies, Viral ; COVID-19/prevention & control ; Drug Combinations ; Polysorbates ; Squalene ; alpha-Tocopherol
Chemical Substances	AS03 adjuvant (A7YT618XBV) ; Influenza Vaccines ; COVID-19 Vaccines ; Antibodies, Viral ; Drug Combinations ; Polysorbates ; Squalene (7QWM220FJH) ; alpha-Tocopherol (H4N855PNZ1)
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.adi8039
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Article ; Online: Heterologous versus homologous boosting elicits qualitatively distinct, BA.5-cross-reactive T cells in transplant recipients.

Thompson, Elizabeth A / Ngecu, Wabathi / Stoddart, Laila / Johnston, Trevor S / Chang, Amy / Cascino, Katherine / Alejo, Jennifer L / Abedon, Aura T / Samaha, Hady / Rouphael, Nadine / Tobian, Aaron Ar / Segev, Dorry L / Werbel, William A / Karaba, Andrew H / Blankson, Joel N / Cox, Andrea L

JCI insight

2023 Volume 8, Issue 10

Abstract: BackgroundThe SARS-CoV-2 Omicron BA.5 subvariant escapes vaccination-induced neutralizing antibodies because of mutations in the spike (S) protein. Solid organ transplant recipients (SOTRs) develop high COVID-19 morbidity and poor Omicron variant ... ...

Abstract	BackgroundThe SARS-CoV-2 Omicron BA.5 subvariant escapes vaccination-induced neutralizing antibodies because of mutations in the spike (S) protein. Solid organ transplant recipients (SOTRs) develop high COVID-19 morbidity and poor Omicron variant recognition after COVID-19 vaccination. T cell responses may provide a second line of defense. Therefore, understanding which vaccine regimens induce robust, conserved T cell responses is critical.MethodsWe evaluated anti-S IgG titers, subvariant pseudo-neutralization, and S-specific CD4+ and CD8+ T cell responses from SOTRs in a national, prospective, observational trial (n = 75). Participants were selected if they received 3 doses of mRNA (homologous boosting) or 2 doses of mRNA followed by Ad26.COV2.S (heterologous boosting).ResultsHomologous boosting with 3 mRNA doses induced the highest anti-S IgG titers. However, antibodies induced by both vaccine regimens demonstrated lower pseudo-neutralization against BA.5 compared with the ancestral strain. In contrast, vaccine-induced S-specific T cells maintained cross-reactivity against BA.5 compared with ancestral recognition. Homologous boosting induced higher frequencies of activated polyfunctional CD4+ T cell responses, with polyfunctional IL-21+ peripheral T follicular helper cells increased in mRNA-1273 compared with BNT162b2. IL-21+ cells correlated with antibody titers. Heterologous boosting with Ad26.COV2.S did not increase CD8+ responses compared to homologous boosting.ConclusionBoosting with the ancestral strain can induce cross-reactive T cell responses against emerging variants in SOTRs, but alternative vaccine strategies are required to induce robust CD8+ T cell responses.FundingBen-Dov Family; NIH National Institute of Allergy and Infectious Diseases (NIAID) K24AI144954, NIAID K08AI156021, NIAID K23AI157893, NIAID U01AI138897, National Institute of Diabetes and Digestive and Kidney Diseases T32DK007713, and National Cancer Institute 1U54CA260492; Johns Hopkins Vice Dean of Research Support for COVID-19 Research in Immunopathogenesis; and Emory COVID-19 research repository.
MeSH term(s)	Humans ; Transplant Recipients ; Ad26COVS1 ; BNT162 Vaccine ; COVID-19 Vaccines ; Prospective Studies ; COVID-19/prevention & control ; SARS-CoV-2 ; Antibodies, Neutralizing ; Immunoglobulin G
Chemical Substances	Ad26COVS1 (JT2NS6183B) ; BNT162 Vaccine ; COVID-19 Vaccines ; Antibodies, Neutralizing ; Immunoglobulin G
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.168470
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Article ; Online: Durability of immune responses to mRNA booster vaccination against COVID-19.

The Journal of clinical investigation

2023 Volume 133, Issue 10

Abstract: BackgroundMaintaining durable immunity following vaccination represents a major challenge, but whether mRNA booster vaccination improves durability is unknown.MethodsWe measured antibody responses in 55 healthy adults, who received a booster dose of the ... ...

Abstract	BackgroundMaintaining durable immunity following vaccination represents a major challenge, but whether mRNA booster vaccination improves durability is unknown.MethodsWe measured antibody responses in 55 healthy adults, who received a booster dose of the Pfizer-BioNTech or Moderna vaccine against SARS-CoV-2 and calculated the half-life of the antibody titers. We also measured memory B and T cell responses in a subset of 28 participants. In 13 volunteers who received a second booster vaccine, we measured serum antibody titers and memory B and T cell responses.ResultsThe booster (third immunization) dose at 6 to 10 months increased the half-life of the serum-neutralizing antibody (nAb) titers to 76 days from 56 to 66 days after the primary 2-dose vaccination. A second booster dose (fourth immunization) a year after the primary vaccination further increased the half-life to 88 days. However, despite this modestly improved durability in nAb responses against the ancestral (WA.1) strain, there was a loss of neutralization capacity against the Omicron subvariants BA.2.75.2, BQ.1.1, and XBB.1.5 (48-, 71-, and 66-fold drop in titers, respectively, relative to the WA.1 strain). Although only 45% to 65% of participants demonstrated a detectable nAb titer against the newer variants after the booster (third dose), the response declined to below the detection limit in almost all individuals by 6 months. In contrast, booster vaccination induced antigen-specific memory B and T cells that persisted for at least 6 months.ConclusionThe durability of serum antibody responses improves only marginally following booster immunizations with the Pfizer-BioNTech or Moderna mRNA vaccines.
MeSH term(s)	Adult ; Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines ; Vaccination ; RNA, Messenger ; Immunity ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI167955
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Article: mRNA bivalent booster enhances neutralization against BA.2.75.2 and BQ.1.1.

Davis-Gardner, Meredith E / Lai, Lilin / Wali, Bushra / Samaha, Hady / Solis, Daniel / Lee, Matthew / Porter-Morrison, Andrea / Hentenaar, Ian Thomas / Yamamoto, Fumiko / Godbole, Sucheta / Douek, Daniel C / Lee, Frances Eun-Hyung / Rouphael, Nadine / Moreno, Alberto / Pinsky, Benjamin A / Suthar, Mehul S

bioRxiv : the preprint server for biology

2022

Abstract: The emergence of the highly divergent SARS-CoV-2 Omicron variant has jeopardized the efficacy of vaccines based on the ancestral spike. The bivalent COVID-19 mRNA booster vaccine within the United States is comprised of the ancestral and the Omicron BA.5 ...

Abstract	The emergence of the highly divergent SARS-CoV-2 Omicron variant has jeopardized the efficacy of vaccines based on the ancestral spike. The bivalent COVID-19 mRNA booster vaccine within the United States is comprised of the ancestral and the Omicron BA.5 spike. Since its approval and distribution, additional Omicron subvariants have been identified with key mutations within the spike protein receptor binding domain that are predicted to escape vaccine sera. Of particular concern is the R346T mutation which has arisen in multiple subvariants, including BA.2.75.2 and BQ.1.1. Using a live virus neutralization assay, we evaluated serum samples from individuals who had received either one or two monovalent boosters or the bivalent booster to determine neutralizing activity against wild-type (WA1/2020) virus and Omicron subvariants BA.1, BA.5, BA.2.75.2, and BQ.1.1. In the one monovalent booster cohort, relative to WA1/2020, we observed a reduction in neutralization titers of 9-15-fold against BA.1 and BA.5 and 28-39-fold against BA.2.75.2 and BQ.1.1. In the BA.5-containing bivalent booster cohort, the neutralizing activity improved against all the Omicron subvariants. Relative to WA1/2020, we observed a reduction in neutralization titers of 3.7- and 4-fold against BA.1 and BA.5, respectively, and 11.5- and 21-fold against BA.2.75.2 and BQ.1.1, respectively. These data suggest that the bivalent mRNA booster vaccine broadens humoral immunity against the Omicron subvariants.
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.10.31.514636
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Article ; Online: Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster.

Davis-Gardner, Meredith E / Lai, Lilin / Wali, Bushra / Samaha, Hady / Solis, Daniel / Lee, Matthew / Porter-Morrison, Andrea / Hentenaar, Ian T / Yamamoto, Fumiko / Godbole, Sucheta / Liu, Yuan / Douek, Daniel C / Lee, Frances Eun-Hyung / Rouphael, Nadine / Moreno, Alberto / Pinsky, Benjamin A / Suthar, Mehul S

The New England journal of medicine

2022 Volume 388, Issue 2, Page(s) 183–185

Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2214293
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