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  1. Article: Journal Summary: Procalcitonin Levels to Govern Antibiotic Use in Acute Pancreatitis: Are We There Yet?

    Samanta, Jayanta

    Journal of Gastrointestinal Infections

    2022  Volume 12, Issue 02, Page(s) 135–137

    Language English
    Publishing date 2022-07-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2583-844X
    ISSN (online) 2583-844X
    DOI 10.1055/s-0042-1760424
    Database Thieme publisher's database

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  2. Article: Endoscopic ultrasound-guided vascular interventions: An expanding paradigm.

    Dhar, Jahnvi / Samanta, Jayanta

    World journal of gastrointestinal endoscopy

    2023  Volume 15, Issue 4, Page(s) 216–239

    Abstract: Endoscopic ultrasound (EUS) has expanded its arena from a mere diagnostic modality to an essential therapeutic tool in managing gastrointestinal (GI) diseases. The proximity of the GI tract to the vascular structures in the mediastinum and the abdomen ... ...

    Abstract Endoscopic ultrasound (EUS) has expanded its arena from a mere diagnostic modality to an essential therapeutic tool in managing gastrointestinal (GI) diseases. The proximity of the GI tract to the vascular structures in the mediastinum and the abdomen has facilitated the growth of EUS in the field of vascular interventions. EUS provides important clinical and anatomical information related to the vessels' size, appearance and location. Its excellent spatial resolution, use of colour doppler with or without contrast enhancement and ability to provide images "real-time" helps in precision while intervening vascular structures. Additionally, structures such as venous collaterals or varices can be dealt with optimally using EUS. EUS-guided vascular therapy with coil and glue combination has revolutionized the management of portal hypertension. It also helps to avoid radiation exposure in addition to being minimally invasive. These advantages have led EUS to become an upcoming modality to complement traditional interventional radiology in the field of vascular interventions. EUS-guided portal vein (PV) access and therapy is a new kid on the block. EUS-guided portal pressure gradient measurement, injecting chemotherapy in PV and intrahepatic portosystemic shunt has expanded the horizons of endo-hepatology. Lastly, EUS has also forayed into cardiac interventions allowing pericardial fluid aspiration and tumour biopsy with experimental data on access to valvular apparatus. Herein, we provide a comprehensive review of the expanding paradigm of EUS-guided vascular interventions in GI bleeding, portal vein access and its related therapeutic interventions, cardiac access, and therapy. A synopsis of all the technical details involving each procedure and the available data has been tabulated, and the future trends in this area have been highlighted.
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573698-X
    ISSN 1948-5190
    ISSN 1948-5190
    DOI 10.4253/wjge.v15.i4.216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Water-Soluble Triazolium Covalent Cages for ATP Sensing.

    Maji, Suman / Samanta, Jayanta / Natarajan, Ramalingam

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 15, Page(s) e202303596

    Abstract: Water-soluble organic cages are attractive targets for their molecular recognition and sensing features of biologically relevant molecules. Here, we have successfully designed and synthesized a pair of water-soluble cationic cages employing click ... ...

    Abstract Water-soluble organic cages are attractive targets for their molecular recognition and sensing features of biologically relevant molecules. Here, we have successfully designed and synthesized a pair of water-soluble cationic cages employing click reaction as the fundamental step followed by the N-methylation of the triazole rings. The rigid and shape-persistent 3D hydrophobic cavity, positively charged surface, H-bonding triazolium rings, and excellent water solubility empower both cages to exhibit a superior affinity and selectivity for binding with adenosine-5'-triphosphate (ATP) compared to cyclophanes and other macrocyclic receptors. Both cage molecules (PCC⋅Cl and BCC⋅Cl) can bind a highly emissive dye HPTS (8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt) to form non-fluorescent complexes. The addition of ATP resulted in the stronger cage⊂ATP complexes with the retention of HPTS emission upon its displacement. The resultant indicator-displacement assay system can efficiently sense and quantify ATP in nanomolar detection limits in buffer solutions and human serum matrix. Spectroscopic and theoretical studies revealed the synergistic effect of π⋅⋅⋅π stacking interaction between the aromatic moiety of the cationic cages and the adenine moiety of ATP, as well as the electrostatic and hydrogen bonding interaction between the phosphate anion of ATP and triazole protons of cages, played the pivotal roles in the sensing process.
    MeSH term(s) Humans ; Adenine ; Adenosine Triphosphate ; Biological Assay ; Cyclophanes ; Protons ; Triazoles
    Chemical Substances Adenine (JAC85A2161) ; Adenosine Triphosphate (8L70Q75FXE) ; Cyclophanes ; Protons ; Triazoles
    Language English
    Publishing date 2024-01-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303596
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  4. Article ; Online: Venous Thrombosis in Acute Pancreatitis: What to and Not to Do?

    Samanta, Jayanta / Dhar, Jahnvi / Gupta, Pankaj / Kochhar, Rakesh

    Digestive diseases and sciences

    2024  

    Abstract: Acute pancreatitis is an acute inflammatory condition of the pancreas that has not only local but systemic effects as well. Venous thrombosis is one such complication which can give rise to thrombosis of the peripheral vasculature in the form of deep ... ...

    Abstract Acute pancreatitis is an acute inflammatory condition of the pancreas that has not only local but systemic effects as well. Venous thrombosis is one such complication which can give rise to thrombosis of the peripheral vasculature in the form of deep vein thrombosis, pulmonary embolism, and splanchnic vein thrombosis. The prevalence of these complications increases with the severity of the disease and adds to the adverse outcomes profile. With better imaging and awareness, more cases are being detected, although many at times it can be an incidental finding. However, it remains understudied and strangely, most of the guidelines on the management of acute pancreatitis are silent on this aspect. This review offers an overview of the incidence, pathophysiology, symptomatology, diagnostic work-up, and management of venous thrombosis that develops in AP.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-024-08418-5
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  5. Article ; Online: Procalcitonin-guided use of antibiotics in acute pancreatitis.

    Samanta, Jayanta / Dhar, Jahnvi

    The lancet. Gastroenterology & hepatology

    2022  Volume 7, Issue 12, Page(s) 1073–1074

    MeSH term(s) Humans ; Procalcitonin ; Pancreatitis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Acute Disease ; Biomarkers
    Chemical Substances Procalcitonin ; Anti-Bacterial Agents ; Biomarkers
    Language English
    Publishing date 2022-11-04
    Publishing country Netherlands
    Document type Letter
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00272-2
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  6. Article ; Online: Role of therapeutic endoscopic ultrasound in gastrointestinal malignancy- current evidence and future directions.

    Dhar, Jahnvi / Samanta, Jayanta

    Clinical journal of gastroenterology

    2022  Volume 15, Issue 1, Page(s) 11–29

    Abstract: Endoscopic ultrasound (EUS) has come a long way from a mere diagnostic tool to an advanced therapeutic modality. With the advent of better technologies and accessories, EUS has found ground in the management of gastrointestinal (GI) malignancies, not ... ...

    Abstract Endoscopic ultrasound (EUS) has come a long way from a mere diagnostic tool to an advanced therapeutic modality. With the advent of better technologies and accessories, EUS has found ground in the management of gastrointestinal (GI) malignancies, not only for diagnosis but also for therapeutic purposes. EUS can tackle a host of conditions, including hepato-pancreatico-biliary malignancies. Advances and experience in various EUS-guided biliary drainage techniques have enabled the endosonologist to tackle biliary obstruction when conventional techniques of endoscopic retrograde cholangiopancreatography (ERCP) and/or percutaneous transhepatic biliary drainage (PTBD) fails. More and more emerging data not only establishes the safety of EUS-BD but also demonstrates superior efficacy over PTBD and sometimes even ERCP. Malignant gastric outlet obstruction can now be safely managed with EUS-guided gastroenterostomy. Starting from pain management in malignant tumors through celiac plexus neurolysis to various tumor ablative therapies, EUS has forged ahead over percutaneous treatment or surgical options in the management of GI malignancies. Additional data is now coming up on the prospects of EUS-guided immunotherapy and biological therapy for tumor management. The future of EUS therapeutics in the field of GI malignancies is bright. With increasing evidence, this modality becoming a key player in management of a host of complex clinical conditions arising out of GI malignancies is in the offing. This review focuses on elucidating the role of therapeutic EUS in the management of GI malignancies, a synopsis of various techniques, data on its safety and efficacy as well as future advancements in this domain.
    MeSH term(s) Cholangiopancreatography, Endoscopic Retrograde ; Cholestasis/surgery ; Drainage/methods ; Endosonography ; Gastrointestinal Neoplasms/diagnostic imaging ; Gastrointestinal Neoplasms/therapy ; Humans
    Language English
    Publishing date 2022-01-14
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-021-01559-4
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  7. Article ; Online: The expanding role of endoscopic ultrasound elastography.

    Dhar, Jahnvi / Samanta, Jayanta

    Clinical journal of gastroenterology

    2022  Volume 15, Issue 5, Page(s) 841–858

    Abstract: Endoscopic ultrasound (EUS) is an invaluable tool for assessing various GI diseases. However, using just the conventional B-mode EUS imaging may not be sufficient to accurately delineate the lesion's character. Using the principle of stress-induced ... ...

    Abstract Endoscopic ultrasound (EUS) is an invaluable tool for assessing various GI diseases. However, using just the conventional B-mode EUS imaging may not be sufficient to accurately delineate the lesion's character. Using the principle of stress-induced tissue strain, EUS elastography (EUS-E) can help in the real-time sonographic assessment of the level of tissue stiffness or hardness of any organ of interest during a routine EUS procedure. Thus, EUS-E can better characterize the lesion's nature and highlight the more suspicious areas within an individual lesion. The most commonly studied lesions with EUS-E are the pancreatic lesions, namely, chronic pancreatitis, pancreatic cancer, and lymph nodes. However, EUS-E is gradually expanding its use for lesion characterization of the liver, bile duct, adrenals, gastrointestinal tract, and even therapy response. Moreover, the use of EUS-E along with other image enhancement techniques such as harmonic EUS and contrast-enhanced EUS can improve the accuracy of the diagnosis. However, several technical aspects need to be standardized before EUS-E can be truly used as a tool for "virtual biopsy". This review focuses on the various technical aspects of the use of EUS-E, it is established and expanding indications and an extensive outline of the various studies on EUS-E. We also discuss the current pitfalls and future trends in EUS-E.
    MeSH term(s) Elasticity Imaging Techniques/methods ; Endosonography/methods ; Humans ; Pancreas/pathology ; Pancreatic Neoplasms/pathology ; Pancreatitis, Chronic/diagnostic imaging
    Language English
    Publishing date 2022-07-05
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-022-01662-0
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  8. Article ; Online: Plastic is as good as metal: is the 'debris clearance' debate for walled-off necrosis drainage finally over?

    Samanta, Jayanta / Dhar, Jahnvi

    Gut

    2022  Volume 72, Issue 6, Page(s) 1223–1224

    MeSH term(s) Humans ; Plastics ; Pancreas/diagnostic imaging ; Drainage ; Necrosis ; Pancreatitis, Acute Necrotizing ; Stents ; Treatment Outcome ; Endosonography ; Endoscopy
    Chemical Substances Plastics
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2022-328172
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  9. Article ; Online: Hemostatic powders and gels in gastrointestinal endoscopy: current perspective and future recommendations.

    Dhar, Jahnvi / Ramai, Daryl / Samanta, Jayanta / Facciorusso, Antonio

    Expert review of gastroenterology & hepatology

    2023  Volume 17, Issue 11, Page(s) 1061–1065

    MeSH term(s) Humans ; Powders ; Hemostasis, Endoscopic ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Endoscopy, Gastrointestinal/adverse effects ; Hemostatics/adverse effects ; Gels ; Endoscopy
    Chemical Substances Powders ; Hemostatics ; Gels
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2023.2274913
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  10. Article: The role of endoscopy in malignant hilar obstruction.

    Dhar, Jahnvi / Gupta, Pankaj / Samanta, Jayanta

    Annals of gastroenterology

    2023  Volume 36, Issue 4, Page(s) 347–359

    Abstract: Malignant hilar biliary obstruction (MHO) is a medical challenge as regards both forming a correct diagnosis and its adequate management, in terms of treatment alternatives and palliative options. Surgical resection is the only curative treatment for the ...

    Abstract Malignant hilar biliary obstruction (MHO) is a medical challenge as regards both forming a correct diagnosis and its adequate management, in terms of treatment alternatives and palliative options. Surgical resection is the only curative treatment for the underlying disease, but the majority of patients are not suitable candidates because of an unresectable tumor or poor performance status. Biliary drainage (BD) can be achieved through the percutaneous transhepatic route or endoscopically, and the choice depends on a host of factors, including biliary anatomy and comorbidity of the patient. Though there is no consensus, the endoscopic approach is usually preferred over the former. Endoscopy can aid in both diagnosis (collection of histological as well as cytological samples, direct visualization of suspected malignant pathology, or use of endoscopic ultrasound [EUS] for evaluation and locoregional staging), and in achieving internal BD. Advances in the development of various stents, accessories and, more recently, the use of EUS have in fact further expanded its application in MHO management. The choice of stents to be used (type, make, and number), palliation methods, deployment techniques and the use of local ablative strategy are still evolving and require more data. The complexity of management of MHO mandates that each patient should receive a "personalized approach", all the way from establishing a diagnosis until final treatment, with the help of a multidisciplinary team effort. Herein, we provide a comprehensive literature review of the current role of endoscopy for MHO, according to its applications in various clinical settings.
    Language English
    Publishing date 2023-05-29
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2023.0810
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