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  1. Article: Biological evaluation of chemically synthesized sulfated maltodextrin as an immunomodulator

    Sambyal, Shainy / Sravanthi, Vemireddy / Sampath Kumar, Halmuthur M.

    Bioactive carbohydrates and dietary fibre. 2022 Nov., v. 28

    2022  

    Abstract: Sulfated polysaccharides have been reported to exhibit an array of biological activities like anti-proliferative, anti-inflammatory, anti-tumoral, antiviral, etc. In the present study, we have synthesized and evaluated immunomodulatory attributes of ... ...

    Abstract Sulfated polysaccharides have been reported to exhibit an array of biological activities like anti-proliferative, anti-inflammatory, anti-tumoral, antiviral, etc. In the present study, we have synthesized and evaluated immunomodulatory attributes of sulfated maltodextrin. Maltodextrin was sulfated using chlorosulfonic acid and was characterized by analytical techniques like ¹H NMR spectroscopy and elemental analysis. The sulfated maltodextrin was then evaluated for immunostimulatory activity using Dendritic Cells and macrophages. In vitro cytotoxicity assay was performed on macrophages which indicate the non toxicity of the modified polymer at a highest concentration of 10 μg/mL, other immunological assays on dendritic cells reveal that sulfated maltodextrin activated DC which was quantified by production of IL-12 and IFN-γ along with CD 86 and MHC II surface markers expression using flowcytometry. Based on the immunological data, we infer that sulfated maltodextrin possesses potential immune stimulatory activity.
    Keywords biological assessment ; dietary fiber ; immunostimulants ; interleukin-12 ; macrophages ; maltodextrins ; nuclear magnetic resonance spectroscopy ; polymers ; toxicity ; toxicity testing
    Language English
    Dates of publication 2022-11
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2212-6198
    DOI 10.1016/j.bcdf.2022.100313
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Synthesis and Immunological Activity of Novel Oligo(ethylene glycol) Analogues of α-Galactosylceramide.

    Pawar, Mithun S / Vemireddy, Sravanthi / Sambyal, Shainy / Sampath Kumar, Halmuthur M

    ACS omega

    2022  Volume 7, Issue 25, Page(s) 21891–21900

    Abstract: CD1d-arbitrated activation of i-NKT cells by α-galactosylceramide results in the effective secretion of Th1 and Th2 cytokines, with adjuvanticity skewed toward Th2 immunity. However, the polarization of immune response could be achieved by suitable ... ...

    Abstract CD1d-arbitrated activation of i-NKT cells by α-galactosylceramide results in the effective secretion of Th1 and Th2 cytokines, with adjuvanticity skewed toward Th2 immunity. However, the polarization of immune response could be achieved by suitable modification of the glycolipid structure. In the current study, novel glycolipids with an amphiphilic oligo ethylene glycol lipid moiety bearing the benzyloxy group at the terminus on the acyl arm of sphingosine, exhibited CD1d ligand binding as quantified by IL-2 cytokine production. When immunized with quadrivalent split influenza virus in BALB/c mice, the novel ceramide analogues with a longer oligo (ethylene glycol) chain length induced significant levels of antibody (IgG) with Th1-polarized immune response.
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c02125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Properties, optimized morphologies, and advanced strategies for photocatalytic applications of WO

    Shandilya, Pooja / Sambyal, Shabnam / Sharma, Rohit / Mandyal, Parteek / Fang, Baizeng

    Journal of hazardous materials

    2022  Volume 428, Page(s) 128218

    Abstract: The development of ... ...

    Abstract The development of WO
    MeSH term(s) Anti-Bacterial Agents ; Catalysis ; Nanocomposites ; Oxides
    Chemical Substances Anti-Bacterial Agents ; Oxides
    Language English
    Publishing date 2022-01-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.128218
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  4. Article ; Online: Design, synthesis, and preliminary immunopotentiating activity of new analogues of nojirimycin.

    Thangarasu, Arun K / Sambyal, Shainy / Kumar, Halmuthur Mahabalarao Sampath / Lankalapalli, Ravi S

    Carbohydrate research

    2021  Volume 511, Page(s) 108479

    Abstract: Three new classes of nojirimycin analogues viz. N-alkyl with C1-substituent (4-phenylbutyl), N-substituted 1-deoxynojirimycin and its congener δ-lactam, and a 4-phenylbutyl-β-C-glycoside were designed and synthesized for immunological studies. The ... ...

    Abstract Three new classes of nojirimycin analogues viz. N-alkyl with C1-substituent (4-phenylbutyl), N-substituted 1-deoxynojirimycin and its congener δ-lactam, and a 4-phenylbutyl-β-C-glycoside were designed and synthesized for immunological studies. The resulting diverse compound library exhibited proliferation of B Cells and T cells induced by LPS and Con A, respectively. The majority of the analogues augmented the secretion of IL-12 in dendritic cells and TNF-α secretion in murine peritoneal macrophages compared to LPS (10 μg/ml). A deoxynojirimycin-triazole conjugate of phytosphingosine analogue was superior in the responses mentioned above and exhibited nitric oxide response equal to LPS. In comparison to findings on its congeners with immunosuppressive action, early immunological tests show that the novel nojirimycin analogues have immunopotentiating effect. Hence, nojirimycin analogues offer tremendous potential in tuning the immunomodulatory activity of iminosugars by subtle to substantial structural variations.
    MeSH term(s) 1-Deoxynojirimycin/analogs & derivatives ; Animals ; Mice ; Tumor Necrosis Factor-alpha
    Chemical Substances Tumor Necrosis Factor-alpha ; 1-Deoxynojirimycin (19130-96-2) ; nojirimycin (W40512EP9K)
    Language English
    Publishing date 2021-11-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2021.108479
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    In stock of ZB MED Bonn / Germany

    Z 2002/704: Show issues
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  5. Article: Pulmonary function test: A critical domain in oral submucous fibrosis patients.

    Mehrotra, Vishal / Sambyal, Sheenam / Mishra, Gauri / Garg, Kriti / Srivastava, Rahul / Ishrat, Saman

    Journal of education and health promotion

    2022  Volume 11, Page(s) 26

    Abstract: Introduction: The study aims to measure and compare pulmonary function tests (PFTs) in oral submucous fibrosis (OSMF) patients (smokers/nonsmokers) and normal individuals.: Materials and methods: The study population included 150 participants that ... ...

    Abstract Introduction: The study aims to measure and compare pulmonary function tests (PFTs) in oral submucous fibrosis (OSMF) patients (smokers/nonsmokers) and normal individuals.
    Materials and methods: The study population included 150 participants that comprised 50 nonsmoker OSMF patients, 50 OSMF patients who smoke as well, and 50 patients with no deleterious habits. Spirometer was used to assess PFT.
    Results: Results showed that a significant
    Conclusion: Thus, the decrease in pulmonary function can be an alarming sign for restrictive type of pulmonary disease.
    Language English
    Publishing date 2022-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_587_21
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  6. Article ; Online: Synthesis and immunopharmacological evaluation of novel TLR7 agonistic triazole tethered imidazoquinolines.

    Avoni, Ayyappa / Vemireddy, Sravanthi / Sambyal, Shainy / Shafi, Syed / Khan, Imran / Khan, Aarif / Sampath Kumar, Halmuthur M

    RSC advances

    2023  Volume 13, Issue 2, Page(s) 1066–1077

    Abstract: Toll-like receptors-7 and -8 are expressed abundantly on antigen-presenting cells, and their agonists make potential adjuvant candidates for the development of new efficacious vaccines. In view of the importance of new efficacious imidazoquinoline based ... ...

    Abstract Toll-like receptors-7 and -8 are expressed abundantly on antigen-presenting cells, and their agonists make potential adjuvant candidates for the development of new efficacious vaccines. In view of the importance of new efficacious imidazoquinoline based adjuvants, herein we have synthesized a focused library of a new class of imidazoquinolines retaining the
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra06395f
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  7. Article ; Online: Design, synthesis and biological evaluation of novel lipophilic 2, 5-disubstituted tetrazole analogues of muramyl dipeptide as NOD2 agonists.

    Mhamane, Tukaram B / Sambyal, Shainy / Vemireddy, Sravanthi / Paturu, Rama Subba Reddy / Katragadda, Suresh Babu / Syed, Shafi / Khan, Arif / Halmuthur M, Sampath Kumar

    Bioorganic & medicinal chemistry

    2023  Volume 88-89, Page(s) 117296

    Abstract: A focused library of six new 2, 5-disubstituted tetrazole (2, 5-DST) analogues of N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) as potential immunomodulators were synthesized by the bioisosteric replacement of α-amide of d-isoglutamine with 5-substituted ...

    Abstract A focused library of six new 2, 5-disubstituted tetrazole (2, 5-DST) analogues of N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) as potential immunomodulators were synthesized by the bioisosteric replacement of α-amide of d-isoglutamine with 5-substituted tetrazole (5-ST). Another parameter 'lipophilicity' was also considered to improve the pharmacological properties of MDP through the alkylation of 5-substituted tetrazole during synthesis. In total, six 2, 5-DST analogues of MDP were synthesized and bio-evaluated for the study of human NOD2 stimulation activity in the innate immune response. Interestingly, among the varied lengths of the alkyl chain in 2, 5-disubstituted tetrazole derivatives, the tetrazole analogues 12b bearing the -Butyl (C4) and 12c having -Octyl (C8) chain showed the best NOD2 stimulation potency equivalent with reference compound MDP. These analogues were evaluated for their adjuvanticity against dengue antigen and analogues 12b and 12c have elicited a potent humoral and cell mediated response.
    MeSH term(s) Humans ; Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Adjuvants, Immunologic/pharmacology ; Immunity, Innate ; Antigens ; Nod2 Signaling Adaptor Protein/metabolism
    Chemical Substances Acetylmuramyl-Alanyl-Isoglutamine (53678-77-6) ; Adjuvants, Immunologic ; Antigens ; Nod2 Signaling Adaptor Protein ; NOD2 protein, human
    Language English
    Publishing date 2023-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2023.117296
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Synthesis and biological evaluation of novel 2-azido muramyl dipeptide as NOD2 agonistic adjuvants.

    Reddy, Paturu Rama Subba / Sambyal, Shainy / Mhamane, Tukaram B / Sravanthi, Vemireddy / Shafi, Syed / Khan, Imran A / Sampath Kumar, Halmuthur M

    Bioorganic & medicinal chemistry

    2022  Volume 66, Page(s) 116781

    Abstract: Novel 2-Azido muramyl dipeptide was synthesized by the bio-isosteric replacement of the N-acetyl group of the muramic acid fragment with the azide functionality at the C2 position. In order to examine the effect of hydrophilic-lipophilic balance on the ... ...

    Abstract Novel 2-Azido muramyl dipeptide was synthesized by the bio-isosteric replacement of the N-acetyl group of the muramic acid fragment with the azide functionality at the C2 position. In order to examine the effect of hydrophilic-lipophilic balance on the adjuvant activity, derivatives were synthesized by removing protecting groups sequentially to tune the polarity. Amongst five novel azido derivatives of MDP studied here, di- and mono-benzylated azido derivatives 10 and 11 exhibited good DENV specific antibody(IgG) response with Th1 polarization compared to parent compound Muramyl dipeptide (MDP) whereas all five new derivatives responded positively to NOD2 agonistic assays with compound 10 showing highest stimulation.
    MeSH term(s) Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Adjuvants, Immunologic/chemistry ; Adjuvants, Pharmaceutic ; Hydrophobic and Hydrophilic Interactions ; Nod2 Signaling Adaptor Protein
    Chemical Substances Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Nod2 Signaling Adaptor Protein ; Acetylmuramyl-Alanyl-Isoglutamine (53678-77-6)
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2022.116781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Novel 1,2,3-triazole-tethered Pam

    Mhamane, Tukaram B / Sambyal, Shainy / Vemireddy, Sravanthi / Khan, Imran A / Shafi, Syed / Halmuthur M, Sampath Kumar

    Bioorganic chemistry

    2021  Volume 111, Page(s) 104838

    Abstract: A focused library of water soluble 1,2,3-triazole tethered glycopeptide conjugates derived from variety of azido-monosaccharides and aliphatic azido-alcohols were synthesized through manipulation at the C-terminus of ... ...

    Abstract A focused library of water soluble 1,2,3-triazole tethered glycopeptide conjugates derived from variety of azido-monosaccharides and aliphatic azido-alcohols were synthesized through manipulation at the C-terminus of Pam
    MeSH term(s) Adjuvants, Immunologic/chemistry ; Adjuvants, Immunologic/pharmacology ; Cell Line ; Dose-Response Relationship, Drug ; Humans ; Immunity, Cellular/drug effects ; Molecular Structure ; Structure-Activity Relationship ; Toll-Like Receptor 2/agonists ; Triazoles/chemistry ; Triazoles/pharmacology ; Vaccines/chemistry ; Vaccines/pharmacology
    Chemical Substances Adjuvants, Immunologic ; Toll-Like Receptor 2 ; Triazoles ; Vaccines
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2021.104838
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Synthesis and antiproliferative activities of novel piscidinol a derivatives as potential anticancer agents.

    Gaja, Swarna Kumari / Bandi, Siva / Pavuluri, Pavan Kumar / Sambyal, Shainy / Jaina, Vinod Kumar / Sampath Kumar, H M / Andugulapati, Sai Balaji / V, Ramalingam / Babu, K Suresh

    Natural product research

    2022  Volume 37, Issue 15, Page(s) 2568–2574

    Abstract: Piscidinol A ( ...

    Abstract Piscidinol A (
    MeSH term(s) Male ; Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Cell Proliferation ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Apoptosis ; Drug Screening Assays, Antitumor ; Molecular Structure
    Chemical Substances piscidinol A ; Antineoplastic Agents
    Language English
    Publishing date 2022-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2056889
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