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Article ; Online: Distribution patterns of occlusal contact areas on natural posterior teeth - Evaluations of a cross-sectional population-based study with the Greifswald Digital Analyzing System (GEDAS).

Kordaß, Bernd / Behrendt, Christoph / Amlang, Alexandra / Hugger, Sybille / Hugger, Alfons / Ruge, Sebastian / Samietz, Stefanie

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

2023 Volume 250, Page(s) 152112

Abstract: Aim: The aim of our investigations is to optimize the anatomical basis for the design of a sufficient occlusal relationship, especially in view of the innovative technologies by analyzing the occlusal contact point patterns at cusp structures according ... ...

Abstract	Aim: The aim of our investigations is to optimize the anatomical basis for the design of a sufficient occlusal relationship, especially in view of the innovative technologies by analyzing the occlusal contact point patterns at cusp structures according to A-, B-, C- localization tooth by tooth on the individual occlusal surfaces in the posterior region in static habitual occlusal position. Materials and methods: In 3300 subjects of the population-based Study of Health in Pomerania (SHIP 1) the interocclusal registration in habitual intercuspation using silicone registration was used and analyzed by using the special evaluation software Greifswald Digital Analyzing System (GEDAS II). Chi square test was used to investigate whether the distribution of contact areas differed in the group of premolars or molars - each considered separately for maxilla and mandible - on the basis of the probability of error p < 0.05. Results: In 709 subjects (446 male with a mean age of 48.9 ± 13.04 years; 283 female with a mean age of 52.4 ± 14.23 years) the antagonistic situation was specifically considered on natural posterior teeth without conservative or restorative-prosthetic interventions, i.e. without caries, fillings, crowns or other restorations. On the basis of these subjects, the silicone registrations were analyzed using GEDAS II. For the first and second upper molars, the ABC contact distribution was the most frequent: 20.4 % for the first and 15.3 % for the second molar. The second most frequent contact area for maxillary molars was area 0. The upper molars had contact areas only at the maxillary palatal cusp (B-/C-contacts). This contact relationship was most frequent in the maxillary premolar (18.1-18.6 %). In mandibular premolars, with the buccal cusps areas A and B were frequently involved (15.4-16.7 %). Mandibular molars showed a frequent contact pattern involving all A-, B-, C- and 0- contact areas (13.3-24.2 %). To capture the possible influence of the antagonistic dentition situation, the antagonistic situation was specifically considered and except for the mandibular premolars (p < 0.05) the contact distribution did not differ for molars and maxillary premolars regarding the dental status of the antagonistic teeth. Natural posterior teeth without occlusal contacts were observed from 20.0 % in the second lower molars to 9.7 % in the first upper molars. Conclusion: Our results suggest a clinically relevant due to the fact, that this study is the first population-based epidemiological study to analyze the occlusal contact point patterns at cusp structures according to A-, B-, C- localization tooth by tooth on the individual occlusal surfaces in the posterior region in static habitual occlusal position in order to optimize the anatomical basis for the design of a sufficient occlusal relationship.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Cross-Sectional Studies ; Molar ; Bicuspid ; Mandible ; Silicones
Chemical Substances	Silicones
Language	English
Publishing date	2023-06-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1106738-x
ISSN	1618-0402 ; 0940-9602
ISSN (online)	1618-0402
ISSN	0940-9602
DOI	10.1016/j.aanat.2023.152112
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Article ; Online: Powered tooth brushes are beneficial for long-term oral health: Results from the Study of Health in Pomerania (SHIP-TREND).

Sager, Pauline / Kocher, Thomas / Pitchika, Vinay / Samietz, Stefanie / Völzke, Henry / Walter, Clemens / Holtfreter, Birte

Journal of clinical periodontology

2023 Volume 50, Issue 5, Page(s) 548–558

Abstract: Aim: To determine the long-term effects of the use of powered tooth brush (PTB) in comparison to manual tooth brush (MTB) on periodontitis severity, coronal caries experience, and the number of missing teeth using in a population-based cohort study.: ... ...

Abstract	Aim: To determine the long-term effects of the use of powered tooth brush (PTB) in comparison to manual tooth brush (MTB) on periodontitis severity, coronal caries experience, and the number of missing teeth using in a population-based cohort study. Materials and methods: Using 7-year follow-up data of 2214 participants of the Study of Health in Pomerania (SHIP-TREND), comprehensively adjusted linear models using generalized least squares and ordinal regression models estimated the effects of PTB usage on dental outcomes in complete case and imputed data. Results: At follow-up, PTB users had lower medians for mean probing depth (PD; 2.21 mm) and mean clinical attachment levels (1.73 mm) than MTB users (2.30 and 1.96 mm, respectively). Adjusted models revealed the beneficial effects of PTB usage on follow-up levels of plaque, bleeding on probing, mean PD, percentage of sites with PDs ≥4 mm, mean clinical attachment levels (all, interdental, and non-interdental sites, respectively), and the number of missing teeth. For the number of missing teeth, the effects were more pronounced in participants aged ≥50 years. No significant effects of PTB usage on the number of decayed or filled surfaces (all and interdental sites) were found. Conclusions: A recommendation of PTB usage in dental practice could contribute to the long-term promotion of oral health.
MeSH term(s)	Humans ; Oral Health ; Cohort Studies ; Toothbrushing ; Dental Caries/epidemiology ; Dental Caries/prevention & control ; Tooth ; Tooth Loss
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.13763
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Article ; Online: Is Continuous Eruption Related to Periodontal Changes? A 16-Year Follow-up.

Wiedemann, C / Pink, C / Daboul, A / Samietz, S / Völzke, H / Schulz-Kornas, E / Krey, K F / Holtfreter, B / Kocher, T

Journal of dental research

2021 Volume 100, Issue 8, Page(s) 875–882

Abstract: The aims of this study were to 1) determine if continuous eruption occurs in the maxillary teeth, 2) assess the magnitude of the continuous eruption, and 3) evaluate the effects of continuous eruption on the different periodontal parameters by using data ...

Abstract	The aims of this study were to 1) determine if continuous eruption occurs in the maxillary teeth, 2) assess the magnitude of the continuous eruption, and 3) evaluate the effects of continuous eruption on the different periodontal parameters by using data from the population-based cohort of the Study of Health in Pomerania (SHIP). The jaw casts of 140 participants from the baseline (SHIP-0) and 16-y follow-up (SHIP-3) were digitized as 3-dimensional models. Robust reference points were set to match the tooth eruption stage at SHIP-0 and SHIP-3. Reference points were set on the occlusal surface of the contralateral premolar and molar teeth, the palatal fossa of an incisor, and the rugae of the hard palate. Reference points were combined to represent 3 virtual occlusal planes. Continuous eruption was measured as the mean height difference between the 3 planes and rugae fix points at SHIP-0 and SHIP-3. Probing depth, clinical attachment levels, gingiva above the cementoenamel junction (gingival height), and number of missing teeth were clinically assessed in the maxilla. Changes in periodontal variables were regressed onto changes in continuous eruption after adjustment for age, sex, number of filled teeth, and education or tooth wear. Continuous tooth eruption >1 mm over the 16 y was found in 4 of 140 adults and averaged to 0.33 mm, equaling 0.021 mm/y. In the total sample, an increase in continuous eruption was significantly associated with decreases in mean gingival height (
MeSH term(s)	Adult ; Dental Occlusion ; Follow-Up Studies ; Humans ; Incisor ; Maxilla ; Tooth Eruption
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/0022034521999363
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Article ; Online: Ten-year trends in DMF-S and DMF-T in a northeast German adult population.

Schmoeckel, J / Haq, J / Samietz, S / Santamaría, R M / Mourad, M S / Völzke, H / Kocher, T / Splieth, C H / Holtfreter, B

Journal of dentistry

2021 Volume 111, Page(s) 103727

Abstract: Objective: The aim of this study was to assess 10-year trends in coronal caries in adults aged 20-83 years using data from the two-representative population-based Studies of Health in Pomerania (SHIP-0/SHIP-Trend-0).: Methods: Repeated cross- ... ...

Abstract	Objective: The aim of this study was to assess 10-year trends in coronal caries in adults aged 20-83 years using data from the two-representative population-based Studies of Health in Pomerania (SHIP-0/SHIP-Trend-0). Methods: Repeated cross-sectional data from 4,286 SHIP-0 and 3,913 SHIP-Trend-0 participants were analysed. Carious, filled and missing teeth/surfaces were recorded in a half-mouth design and the DMF-T/S scores and sound surfaces/teeth were calculated according to WHO criteria. Trends in DMF-T/S scores and its single components were presented stratified by age group and sex. Results: A statistically significant decline in coronal caries experience (DMF-T and DMF-S) in adults aged 20 to 83 years as well as for D-T/S components was observed. The proportion of edentulous participants was almost halved from 8.7% (SHIP-0) to 5.1% (SHIP-Trend-0), while the number of M-T declined from 4.4 to 3.5 revealing an overall clear shift to a higher retention rate of teeth. In younger adults (25-34 years) 3.8 more sound teeth (17.2 sound surfaces) were found in average in the mouth and in elderly (65-74 years) a clear shift from extracted to filled teeth was observed (M-T reduced by 5.4, while F-T increased by 4). Regarding sex differences, females had consistently on average higher MF-T/S values, but lower D-T/S values than males. Conclusion: A clinically relevant drop in the severity of coronal caries experience in all adult age groups in Northeast Germany shows that not only reductions in caries experience in adolescence translated into adulthood but also later improvements led to long-term oral health.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; DMF Index ; Dental Caries/epidemiology ; Female ; Humans ; Male ; Prevalence ; Tooth Loss/epidemiology
Language	English
Publishing date	2021-06-11
Publishing country	England
Document type	Journal Article
ZDB-ID	186068-9
ISSN	1879-176X ; 0300-5712
ISSN (online)	1879-176X
ISSN	0300-5712
DOI	10.1016/j.jdent.2021.103727
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Article ; Online: Routine Data Analyses for Estimating the Caries Treatment Experience of Children.

Raedel, Michael / Wagner, Yvonne / Priess, Heinz-Werner / Samietz, Stefanie / Bohm, Steffen / Walter, Michael H

Caries research

2021 Volume 55, Issue 5, Page(s) 546–553

Abstract: Oral health surveys are considered the gold standard for assessing the caries experience of children. Analyses of routine data offer additional opportunities not yet fully explored. This study aimed at estimating the caries treatment experience by mining ...

Abstract	Oral health surveys are considered the gold standard for assessing the caries experience of children. Analyses of routine data offer additional opportunities not yet fully explored. This study aimed at estimating the caries treatment experience by mining an insurance claims database. Comprehensive claims data sets were extracted from the data warehouse of a major health insurance company (BARMER, Germany). A surrogate variable for caries experience was formed that reflected the proportion of children without any former potentially caries-related treatment (filling, root canal treatment, and extraction) at ages from 1 to 14 years. The statistical calculations were based on Kaplan-Meier survival analyses. The evaluation for the permanent dentition comprised N = 593,330 children at 6 years and N = 114,568 at 12 years. At 12 years of age, 66.8% had not yet experienced potentially caries-related treatments. This value hints at a significantly higher caries experience at 12 years compared to available epidemiological data. For the deciduous dentition, the respective rates were 74.0% at 6 years and 45.8% at 10 years. Although various sources of bias have to be taken into account, the potential of routine data mining is evident. The approach is supplemental to oral health surveys. It can be useful in coming closer to reality when estimating the caries experience of children. From our results, we conclude that the oral health of up to 14-year-olds in Germany remains in urgent need of improvement.
MeSH term(s)	Adolescent ; Aged ; Child ; Child, Preschool ; Data Analysis ; Dental Caries/epidemiology ; Dental Caries/therapy ; Dental Caries Susceptibility ; Dental Health Surveys ; Humans ; Infant ; Oral Health ; Tooth, Deciduous
Language	English
Publishing date	2021-06-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390575-5
ISSN	1421-976X ; 0008-6568
ISSN (online)	1421-976X
ISSN	0008-6568
DOI	10.1159/000518075
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Article ; Online: Polypharmacy and saliva volumes in the northeast of Germany - The Study of Health in Pomerania.

Laugisch, Oliver / Holtfreter, Birte / Pink, Christiane / Samietz, Stefanie / Völzke, Henry / Kocher, Thomas

Community dentistry and oral epidemiology

2021 Volume 50, Issue 2, Page(s) 139–146

Abstract: Objectives: Associations between saliva volumes or salivary flow rates and potentially xerogenic medication are rarely evaluated in cohorts with a wide age range. This cross-sectional cohort study investigated possible relationships between the regular ... ...

Abstract	Objectives: Associations between saliva volumes or salivary flow rates and potentially xerogenic medication are rarely evaluated in cohorts with a wide age range. This cross-sectional cohort study investigated possible relationships between the regular consumption of potentially xerogenic medication and stimulated saliva volumes. Methods: Data from the German Studies of Health in Pomerania (SHIP-2 and SHIP-Trend-0) were pooled. Potentially xerogenic medications were identified using the Workshop on Oral Medicine VI criteria. Stimulated saliva was sampled using Salivette®, and saliva volumes expressed as μl/min were determined. Applying linear mixed models with adjustment for time point of saliva collection, associations of (a) age and sex with regularly consumed medication, (b) age and sex with saliva volumes, and (c) the number of regularly consumed xerogenic medications with saliva volumes were evaluated. Results: Six thousand seven hundred and fifty-three participants aged 20-83 years (mean 53.4 ± 14.9) were included. The average number of medications did not differ markedly between females (2.21 ± 2.46) and males (2.24 ± 2.83). Males took more potentially xerogenic medication (1.0 ± 1.3) than did females (0.9 ± 1.3). Also, males took more potentially xerogenic cardiovascular medications than did females (0.9 ± 1.2 versus 0.7 ± 1.1), while females were prescribed a higher number of potentially xerogenic medications affecting the nervous system (0.2 ± 0.5 versus 0.1 ± 0.4). The average stimulated saliva volume was 967.0 ± 433.3 µL/min. Regularly consumed and potentially xerogenic medications were associated with lower saliva volumes. Older age correlated not only with a higher number of total medications and a higher number of xerogenic medications affecting either the cardiovascular (in males) or the nervous system (in females), but also with lower saliva volumes. Conclusions: Ageing was associated with polypharmacy, especially with the intake of potentially xerogenic medication, and lower average saliva volumes. With regard to complications of dry mouth, anamnesis of medication consumption is of high importance.
MeSH term(s)	Cross-Sectional Studies ; Female ; Germany/epidemiology ; Humans ; Male ; Polypharmacy ; Saliva ; Xerostomia/etiology
Language	English
Publishing date	2021-04-07
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189172-8
ISSN	1600-0528 ; 0301-5661
ISSN (online)	1600-0528
ISSN	0301-5661
DOI	10.1111/cdoe.12644
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Article ; Online: Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of

Weiss, Stefan / Holtfreter, Silva / Meyer, Tanja C / Schmiedeke, Frieder / Cammann, Clemens / Dörr, Marcus / Felix, Stephan B / Grabe, Hans J / Homuth, Georg / Kohler, Christian / Mahncke, Cedric / Michalik, Stephan / Nauck, Matthias / Friedrich, Nele / Samietz, Stefanie / Völzke, Henry / Völker, Uwe / Bröker, Barbara M

Frontiers in immunology

2023 Volume 14, Page(s) 1229562

Abstract: Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced ... ...

Abstract	Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by
MeSH term(s)	Humans ; Staphylococcus aureus ; Alleles ; Genome-Wide Association Study ; Shock, Septic/genetics ; Superantigens/genetics ; Staphylococcal Infections/genetics
Chemical Substances	enterotoxin F, Staphylococcal ; Superantigens
Language	English
Publishing date	2023-09-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1229562
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Article ; Online: Impact of dental restorations and removable prostheses on potentially malignant oral mucosal disorders in the general population.

Kindler, Stefan / Seebauer, Christian / Mksoud, Maria / Samietz, Stefanie / Kocher, Thomas / Holtfreter, Birte / Lucas, Christian / Völzke, Henry / Metelmann, Hans-Robert / Rau, Andrea / Ittermann, Till

The Journal of prosthetic dentistry

2022

Abstract: Statement of problem: Dental restorations and removable dental prostheses have been considered as risk factors for potentially malignant disorders of the oral mucosa. It remains unclear whether amalgam, composite resins, and prosthesis materials can ... ...

Abstract	Statement of problem: Dental restorations and removable dental prostheses have been considered as risk factors for potentially malignant disorders of the oral mucosa. It remains unclear whether amalgam, composite resins, and prosthesis materials can induce potentially malignant disorders. Purpose: The purpose of this clinical study was to determine the relationship between the presence of amalgam and composite resin restorations, crowns and fixed partial dentures, and removable prostheses in potentially malignant disorders. Material and methods: The data of 6041 participants in the population-based Studies of Health in Pomerania (SHIP) were accessed. Potentially malignant disorders had been clinically diagnosed by calibrated dentists and documented with photographs. Dental treatment was subdivided into restored and replaced teeth. Dental restorations were subclassified as buccal composite resin or amalgam restorations. Prosthetic treatment was subclassified into removable partial or complete prostheses and definitive restorations with crowns and fixed partial dentures. Results: In the maxilla, participants with removable prostheses had a higher incidence of potentially malignant disorders than participants not undergoing treatment with removable prostheses (OR 2.12; 95% CI: 1.08-4.18), but not in the mandible (OR 1.30; 95% CI: 0.67-2.53). The surfaces with composite resin restorations were associated with a slightly higher risk of mucosal lesions than those without the restorations (OR 1.04; 95% CI: 1.01-1.07). No significant association was found between amalgam restorations and mucosal lesions. Conclusions: Participants with removable prostheses have a higher risk of potentially malignant disorders. Composite resin restorations are associated with a higher risk of mucosal lesions, whereas no significant association was found between amalgam restorations and mucosal lesions.
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2022.05.017
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Article ; Online: The Saliva Metabolome in Association to Oral Health Status.

Liebsch, C / Pitchika, V / Pink, C / Samietz, S / Kastenmüller, G / Artati, A / Suhre, K / Adamski, J / Nauck, M / Völzke, H / Friedrich, N / Kocher, T / Holtfreter, B / Pietzner, M

Journal of dental research

2019 Volume 98, Issue 6, Page(s) 642–651

Abstract: Periodontitis is one of the most prevalent oral diseases worldwide and is caused by multifactorial interactions between host and oral bacteria. Altered cellular metabolism of host and microbes releases a number of intermediary end products known as ... ...

Abstract	Periodontitis is one of the most prevalent oral diseases worldwide and is caused by multifactorial interactions between host and oral bacteria. Altered cellular metabolism of host and microbes releases a number of intermediary end products known as metabolites. There is an increasing interest in identifying metabolites from oral fluids such as saliva to widen the understanding of the complex pathogenesis of periodontitis. It is believed that some metabolites might serve as indicators toward early detection and screening of periodontitis and perhaps even for monitoring its prognosis in the future. Because contemporary periodontal screening methods are deficient, there is an urgent need for novel approaches in periodontal screening procedures. To this end, we associated oral parameters (clinical attachment level, periodontal probing depth, supragingival plaque, supragingival calculus, number of missing teeth, and removable denture) with a large set of salivary metabolites ( n = 284) obtained by mass spectrometry among a subsample ( n = 909) of nondiabetic participants from the Study of Health in Pomerania (SHIP-Trend-0). Linear regression analyses were performed in age-stratified groups and adjusted for potential confounders. A multifaceted image of associated metabolites ( n = 107) was revealed with considerable differences according to age groups. In the young (20 to 39 y) and middle-aged (40 to 59 y) groups, metabolites were predominantly associated with periodontal variables, whereas among the older subjects (≥60 y), tooth loss was strongly associated with metabolite levels. Metabolites associated with periodontal variables were clearly linked to tissue destruction, host defense mechanisms, and bacterial metabolism. Across all age groups, the bacterial metabolite phenylacetate was significantly associated with periodontal variables. Our results revealed alterations of the salivary metabolome in association with age and oral health status. Among our comprehensive panel of metabolites, periodontitis was significantly associated with the bacterial metabolite phenylacetate, a promising substance for further biomarker research.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Bacteria ; Female ; Humans ; Male ; Metabolome ; Middle Aged ; Oral Health ; Periodontal Attachment Loss ; Periodontitis/microbiology ; Saliva/microbiology ; Tooth Loss ; Young Adult
Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/0022034519842853
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Article: Comparison of Oral Microbe Quantities from Tongue Samples and Subgingival Pockets.

Göhler, André / Samietz, Stefanie / Schmidt, Carsten Oliver / Kocher, Thomas / Steinmetz, Ivo / Holtfreter, Birte

International journal of dentistry

2018 Volume 2018, Page(s) 2048390

Abstract: Objectives: To improve understanding of periodontitis pathology, we need more profound knowledge of relative abundances of single prokaryotic species and colonization dynamics between habitats. Thus, we quantified oral microbes from two oral habitats to ...

Abstract	Objectives: To improve understanding of periodontitis pathology, we need more profound knowledge of relative abundances of single prokaryotic species and colonization dynamics between habitats. Thus, we quantified oral microbes from two oral habitats to gain insights into colonization variability and correlation to the clinical periodontal status. Methods: We analyzed tongue scrapings and subgingival pocket samples from 237 subjects (35-54 years) with at least 10 teeth and no recent periodontal treatment from the 11-year follow-up of the Study of Health in Pomerania. Relative abundances of Results: Increased relative abundances of Conclusions: Relative abundances of specific oral species correlated weakly to moderately between habitats. Single species, total bacteria, and
Language	English
Publishing date	2018-04-26
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2546524-7
ISSN	1687-8736 ; 1687-8728
ISSN (online)	1687-8736
ISSN	1687-8728
DOI	10.1155/2018/2048390
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