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  1. Article: Implementation of the Fast-track Protocol for Total Hip Arthroplasty in a Public Hospital in the State of São Paulo - Brazil.

    Lima, Leandro Gregorut / Sampaio, Barbara Fialho Carvalho / Neves, Marco Aurélio Silvério / Barbosa, Alexandre Póvoa / Seid, Victor Edmond / Lopes, Fernanda Degobbi T Q S

    Revista brasileira de ortopedia

    2024  Volume 59, Issue 2, Page(s) e297–e306

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2024-04-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2411301-3
    ISSN 1982-4378 ; 0102-3616
    ISSN (online) 1982-4378
    ISSN 0102-3616
    DOI 10.1055/s-0043-1771489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Implantação do protocolo de recuperação rápida para artroplastia total do quadril em hospital público do estado de São Paulo – Brasil

    Lima, Leandro Gregorut / Sampaio, Barbara Fialho Carvalho / Neves, Marco Aurélio Silvério / Barbosa, Alexandre Póvoa / Seid, Victor Edmond / Lopes, Fernanda Degobbi T. Q. S.

    Revista Brasileira de Ortopedia

    2024  Volume 59, Issue 02, Page(s) e297–e306

    Abstract: Objetivo: Avaliar os resultados da implantação do Protocolo de Recuperação Rápida (PRR), prática médica baseada em evidências científicas, para cirurgia eletiva de artroplastia total do quadril principalmente comparando à Taxa Média de Internação ... ...

    Abstract Objetivo: Avaliar os resultados da implantação do Protocolo de Recuperação Rápida (PRR), prática médica baseada em evidências científicas, para cirurgia eletiva de artroplastia total do quadril principalmente comparando à Taxa Média de Internação Hospitalar nacional de 7.1 dias.
    Métodos: 98 pacientes submetidos a cirurgia eletiva de artroplastia total do quadril pela via direta anterior, via anterolateral e via posterior foram incluídos no PRR no período de dezembro de 2018 a março de 2020 sendo acompanhados no pré-operatório, intraoperatório e pós-operatório imediato.
    Resultados: a Taxa Média de Permanência Hospitalar foi de 2,8 dias, sendo 2,1 dias para a Via de Acesso Anterior, 3,0 dias para via de acesso anterolateral e 4,1 dias para via de acesso posterior. O tempo médio de cirurgia foi de 90 minutos, 19 (19,39%) dos pacientes foram encaminhados à UTI no pós-operatório, no entanto nenhum deles operado pela via direta anterior. Não tivemos casos de trombose venosa profunda (TVP), embolia pulmonar (TEP) ou lesão neurológica, 19 (19,39%) pacientes tiveram sangramento pós-operatório com necessidade de troca de curativo, 4 (4,08%) necessidade de transfusão sanguínea, 2 (2,04%) pacientes apresentaram instabilidade do implante, 1(1,02%) paciente teve fratura durante a cirurgia e 1(1,02%) paciente faleceu por complicações cardíacas.
    Conclusão: O PRR pode ser uma alternativa viável para diminuir o tempo de internação e as complicações pós-operatórias imediatas para a cirurgia eletiva de artroplastia total do quadril diminuindo 2 a 3 vezes o tempo de internação dos pacientes quando comparado com a média nacional de 7,1 dias. ; Objective: Evaluate the results of the implementation of the Fast Track Protocol (FTP), a medical practice based on scientific evidence, for elective total hip arthroplasty surgery, mainly comparing the National Average Hospital Admission Rate of 7.1 days.
    Methods: 98 patients who underwent elective total hip arthroplasty surgery via the direct anterior approach, anterolateral approach and posterior approach were included in the FTP from December 2018 to March 2020, being followed up preoperatively, intraoperatively and immediately postoperatively.
    Results: The average length of hospital stay was 2.8 days, being 2.1 days for the direct anterior approach, 3.0 days for the anterolateral access approach and 4.1 days for the posterior access approach. The average surgery time was 90 minutes, 19 (19.39%) of the patients were referred to the ICU in the postoperative period, however, none of them underwent surgery using the direct anterior approach. We had no cases of deep vein thrombosis (DVT), pulmonary embolism (PTE) or neurological injury, 19 (19.39%) patients had postoperative bleeding requiring dressing change, 4 (4.08%) needed blood transfusion, 2 (2.04%) patients had implant instability, 1 (1.02%) patient had a fracture during surgery and 1 (1.02%) patient died of cardiac complications.
    Conclusion: FTP may be a viable alternative to reduce the length of stay and immediate postoperative complications for elective total hip arthroplasty surgery decreasing the length of stay of patients by 2 to 3 times when compared to the national average of 7.1 days.
    Keywords artroplastia do quadril ; artroplastia do joelho ; protocolos clínicos ; arthroplasty, replacement, hip ; arthroplasty, replacement, knee ; clinical protocols
    Language Portuguese
    Publishing date 2024-04-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2411301-3
    ISSN 1982-4378 ; 0102-3616 ; 1982-4378
    ISSN (online) 1982-4378
    ISSN 0102-3616 ; 1982-4378
    DOI 10.1055/s-0043-1771489
    Database Thieme publisher's database

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  3. Article ; Online: Saliva collection and detection of anti- T. gondii antibodies of low-income school-age children as a learning strategy on hygiene, prevention and transmission of toxoplasmosis.

    Macre, Miriam de Souza / Meireles, Luciana Regina / Sampaio, Barbara Fialho Carvalho / Andrade Júnior, Heitor Franco de

    Revista do Instituto de Medicina Tropical de Sao Paulo

    2019  Volume 61, Page(s) e48

    Abstract: School-age children are a social group in which blood collection for laboratory testing can be perceived as an invasive procedure, with low acceptance and tolerance of stakeholders. This problem could be circumvented by replacing serum samples with ... ...

    Abstract School-age children are a social group in which blood collection for laboratory testing can be perceived as an invasive procedure, with low acceptance and tolerance of stakeholders. This problem could be circumvented by replacing serum samples with saliva. For this purpose, and to make the collection of saliva samples playful and instructive for children, educational activities on hygiene and toxoplasmosis transmission and prevention were performed using toys and audiovisual tools. The target audience consisted of 7-10 year-old children from low-income families who attended public schools in the city of São Paulo. Saliva samples were used in a previously described in-house Enzyme-Linked Immunosorbent Assays (ELISA) to detect anti- Toxoplasma gondii IgG antibodies and establish the immunological status of each of the participants. One year later, children's memory and fixation of concepts regarding hygiene habits, as well as transmission and prevention of toxoplasmosis were tested in the same schools, by means of a questionnaire application, using students who did not participate in the first intervention as controls. The prevalence of positive anti- T. gondii IgG among students was 50% (82/164). One year later, 45 children had more knowledge on toxoplasmosis (28/45 vs 29/147) and they drew the cat's involvement in the transmission of toxoplasmosis more often than controls (28/45 vs 29/147). Sorted according to the presence of specific IgG in saliva, recovered positive students presented worse memory of the above cited knowledge as did saliva-negative IgG students, but both groups had isolated higher frequency of fixed knowledge than non-intervened students. Our data show that there is a high prevalence of T. gondii infection in school-children from low-income areas; saliva is an alternative to blood for anti- T. gondii IgG detection; and a one-day educational intervention in school-children was effective in promoting knowledge fixation on hygiene and toxoplasmosis transmission and prevention after one year.
    MeSH term(s) Antibodies, Protozoan/analysis ; Child ; Enzyme-Linked Immunosorbent Assay ; Female ; Health Education/methods ; Health Knowledge, Attitudes, Practice ; Humans ; Hygiene ; Immunoglobulin G/analysis ; Male ; Poverty ; Saliva/parasitology ; Surveys and Questionnaires ; Toxoplasma/immunology
    Chemical Substances Antibodies, Protozoan ; Immunoglobulin G
    Language English
    Publishing date 2019-09-12
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 128928-7
    ISSN 1678-9946 ; 0036-4665
    ISSN (online) 1678-9946
    ISSN 0036-4665
    DOI 10.1590/S1678-9946201961048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Smoking induces increased apoptosis in osteoblasts: changes in bone matrix organic components.

    Kohler, Júlia Benini / da Silva, Alex Ferreira / Farias, Walleson Alves / Sampaio, Barbara Fialho Carvalho / Neves, Marco Aurélio Silveiro / Lima, Leandro Gregorut / Lourenço, Juliana Dias / Moreira, Alyne Riani / Barbosa, Alexandre Póvoa / de Fátima Lopes Calvo Tibério, Iolanda / Teodoro, Walcy Rosolia / Dos Santos Lopes, Fernanda Degobbi Tenorio Quirino

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6938

    Abstract: Clinical studies demonstrate the impact of smoking on bone tissue fragility and higher incidence of fractures. However, it is not totally understood which physiological mechanisms could be involved in these events. Previously, we showed important changes ...

    Abstract Clinical studies demonstrate the impact of smoking on bone tissue fragility and higher incidence of fractures. However, it is not totally understood which physiological mechanisms could be involved in these events. Previously, we showed important changes in bone tissue components in experimental model of cigarette smoke (CS) exposure. CS exposure induces worsening in bone mineralization and a decrease in collagen type I deposition, leading to bone fragility. Considering that the majority of clinical studies described bone structural changes by radiographic images, in this study we performed analyses "in situ" using tissue samples from smokers, former smokers and non-smokers to better understand how the increase in inflammatory mediators induced by smoking exposure could interfere in bone cells activity leading bone structural changes. We observed increased levels of IL-1β, IL-6 and TNF-α in bone tissue homogenates with a concomitant increase in osteoblast apoptosis in smokers and former smokers compared with non-smokers. Histological changes in both smokers and former smokers were characterized by reduction in collagen type I. Only in smokers, it was observed decrease in trabecular area, suggesting increased bone resorption and increase in collagen type V. These results showed that osteoblasts apoptosis in association with increased bone resorption leads bone structural changes in smokers.
    MeSH term(s) Humans ; Collagen Type I ; Bone Matrix ; Osteoblasts ; Bone Resorption ; Apoptosis ; Smoking/adverse effects
    Chemical Substances Collagen Type I
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33965-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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