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  1. Article ; Online: Defining the role of abdominal surgery and its impact on the disease course in patients with Crohn's disease: Unsolved issues and novel insights.

    Pellino, Gianluca / Sampietro, Gianluca M

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 5, Page(s) 587–588

    MeSH term(s) Humans ; Crohn Disease/surgery ; Disease Progression ; Risk Factors
    Language English
    Publishing date 2023-02-09
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.01.159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1134: Show issues Location:
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  2. Article ; Online: Colorectal cancer after restorative proctocolectomy: Ready to reduce the extent of surgery?

    Sorrentino, Luca / Battaglia, Luigi / Sampietro, Gianluca M

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2022  Volume 54, Issue 10, Page(s) 1289–1290

    MeSH term(s) Adenomatous Polyposis Coli ; Colitis, Ulcerative/surgery ; Humans ; Postoperative Complications/prevention & control ; Postoperative Complications/surgery ; Proctocolectomy, Restorative
    Language English
    Publishing date 2022-07-27
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2022.07.006
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    Zs.A 1134: Show issues Location:
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  3. Article ; Online: Laparoscopy and survival in colon cancer: A further step beyond the non-inferiority?

    Sorrentino, Luca / Cosimelli, Maurizio / Sampietro, Gianluca M

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2021  Volume 53, Issue 8, Page(s) 935–936

    MeSH term(s) Colonic Neoplasms/surgery ; Humans ; Laparoscopy
    Language English
    Publishing date 2021-06-08
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2021.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Towards a greener endoscopy: Considerations on the strategies to improve sustainability.

    Cunha Neves, João A / Roseira, Joana / Cunha, Miguel F / Pellino, Gianluca / Sampietro, Gianluca M / Rodríguez de Santiago, Enrique

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 4, Page(s) 429–430

    MeSH term(s) Humans ; Endoscopy, Gastrointestinal
    Language English
    Publishing date 2023-01-21
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2022.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of COVID-19 Outbreak on the Management of Patients With Severe IBD: A Domino Effect.

    Occhipinti, Vincenzo / Saibeni, Simone / Sampietro, Gianluca M / Pastorelli, Luca

    Gastroenterology

    2020  Volume 160, Issue 6, Page(s) 2196–2197

    MeSH term(s) COVID-19 ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/epidemiology ; Crohn Disease ; Disease Outbreaks ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.05.027
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  6. Article ; Online: Surgical site infections caused by multi-drug resistant organisms: a case-control study in general surgery.

    Foschi, Diego / Yakushkina, Al'ona / Cammarata, Francesco / Lamperti, Giulia / Colombo, Francesco / Rimoldi, Sara / Antinori, Spinello / Sampietro, Gianluca M

    Updates in surgery

    2022  Volume 74, Issue 5, Page(s) 1763–1771

    Abstract: Multi-drug resistant organisms (MDR-Os) are emerging as a significant cause of surgical site infections (SSI), but clinical outcomes and risk factors associated to MDR-Os-SSI have been poorly investigated in general surgery. Aims were to investigate risk ...

    Abstract Multi-drug resistant organisms (MDR-Os) are emerging as a significant cause of surgical site infections (SSI), but clinical outcomes and risk factors associated to MDR-Os-SSI have been poorly investigated in general surgery. Aims were to investigate risk factors, clinical outcomes and costs of care of multi-drug resistant organisms (MDR-Os-SSI) in general surgery. From January 2018 to December 2019, all the consecutive, unselected patients affected by MDR-O SSI were prospectively evaluated. In the same period, patients with non-MDR-O SSI and without SSI, matched for clinical and surgical data were used as control groups. Risk factors for infection, clinical outcome, and costs of care were compared by univariate and multivariate analysis. Among 3494 patients operated on during the study period, 47 presented an MDR-O SSI. Two control groups of 47 patients with non-MDR-O SSI and without SSI were identified. MDR-Os SSI were caused by poly-microbial etiology, meanly related to Gram negative Enterobacteriales. MDR-Os-SSI were related to major postoperative complications. At univariate analysis, iterative surgery, open abdomen, intensive care, hospital stay, and use of aggressive and expensive therapies were associated to MDR-Os-SSI. At multivariate analysis, only iterative surgery and the need of total parenteral and immune-nutrition were significantly associated to MDR-Os-SSI. The extra-cost of MDR-Os-SSI treatment was 150% in comparison to uncomplicated patients. MDR-Os SSI seems to be associated with major postoperative complications and reoperative surgery, they are demanding in terms of clinical workload and costs of care, they are rare but increasing, and difficult to prevent with current strategies.
    MeSH term(s) Abdomen/surgery ; Case-Control Studies ; Drug Resistance, Multiple ; Humans ; Length of Stay ; Postoperative Complications ; Risk Factors ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control
    Language English
    Publishing date 2022-03-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01243-3
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    Zs.B 101: Show issues Location:
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  7. Article: Impact of COVID-19 outbreak on the management of patients with severe IBD: a domino effect

    Occhipinti, Vincenzo / Saibeni, Simone / Sampietro, Gianluca M / Pastorelli, Luca

    Gastroenterology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #232616
    Database COVID19

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  8. Article ; Online: Impact of COVID-19 outbreak on the management of patients with severe IBD

    Occhipinti, Vincenzo / Saibeni, Simone / Sampietro, Gianluca M. / Pastorelli, Luca

    Gastroenterology ; ISSN 0016-5085

    a domino effect

    2020  

    Keywords Gastroenterology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1053/j.gastro.2020.05.027
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Has the Removing of the Mesentery during Ileo-Colic Resection an Impact on Post-Operative Complications and Recurrence in Crohn's Disease? Results from the Resection of the Mesentery Study (Remedy).

    Mineccia, Michela / Maconi, Giovanni / Daperno, Marco / Cigognini, Maria / Cherubini, Valeria / Colombo, Francesco / Perotti, Serena / Baldi, Caterina / Massucco, Paolo / Ardizzone, Sandro / Ferrero, Alessandro / Sampietro, Gianluca M

    Journal of clinical medicine

    2022  Volume 11, Issue 7

    Abstract: Some evidence suggests a reduction in clinical and surgical recurrence after mesenteric resection in Crohn's Disease (CD). The aim of the REsection of the MEsentery StuDY (Remedy) was to assess whether mesenteric removal during surgery for ileocolic CD ... ...

    Abstract Some evidence suggests a reduction in clinical and surgical recurrence after mesenteric resection in Crohn's Disease (CD). The aim of the REsection of the MEsentery StuDY (Remedy) was to assess whether mesenteric removal during surgery for ileocolic CD has an impact in terms of postoperative complications, endoscopic and ultrasonographic recurrences, and long-term surgical recurrence. Among the 326 patients undergoing primary resection between 2009 and 2019 in two referral centers, in 204 (62%) the mesentery was resected (Group A) and in 122 (38%) it was retained (Group B). Median follow-up was 4.7 ± 3 years. Groups were similar in the peri-operative course. Endoscopic and ultrasonographic recurrences were 44.6% and 40.4% in Group A, and 46.7% and 41.2% in Group B, respectively, without statistically significant differences. The five-year time-to-event estimates, compared with the Log-rank test, were 3% and 4% for normal or thickened mesentery (
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11071961
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  10. Article ; Online: Segmental Versus Total Colectomy for Crohn's Disease in the Biologic Era: Results From The SCOTCH International, Multicentric Study.

    Pellino, Gianluca / Rottoli, Matteo / Mineccia, Michela / Frontali, Alice / Celentano, Valerio / Colombo, Francesco / Baldi, Caterina / Ardizzone, Sandro / Martí Gallostra, Marc / Espín-Basany, Eloy / Ferrero, Alessandro / Panis, Yves / Poggioli, Gilberto / Sampietro, Gianluca M

    Journal of Crohn's & colitis

    2022  Volume 16, Issue 12, Page(s) 1853–1861

    Abstract: Background: The extent of resection in colonic Crohn's disease [cCD] is still a topic of debate, depending on the number of locations, the risk of recurrence and permanent stoma, and the role of medical therapy.: Methods: The Segmental COlecTomy for ... ...

    Abstract Background: The extent of resection in colonic Crohn's disease [cCD] is still a topic of debate, depending on the number of locations, the risk of recurrence and permanent stoma, and the role of medical therapy.
    Methods: The Segmental COlecTomy for CroHn's disease [SCOTCH] international study is a retrospective analysis on six tertiary centre prospective databases, comprising all consecutive, unselected patients operated on between 2000 and 2019 with segmental colectomy [SC] or total colectomy [TC] for cCD. The primary aim was long-term surgical recurrence. Secondary aims were perioperative complications, stoma formation and predictors of recurrence.
    Results: Among 687 patients, SC was performed in 285 [41.5%] and TC in 402 [58.5%]. Mean age at diagnosis and surgery, disease duration, and follow-up were 30 ± 15.8, 40.4 ± 15.4, 10.4 ± 8.6 and 7.1 ± 5.2 years respectively. Isolated cCD, inflammatory pattern, perianal CD, younger age, longer disease duration and preoperative maximal therapy were more frequent in TC, while SC presented more small bowel locations and perforating disease, required fewer 90-day re-admissions, and fewer temporary and definitive stomas. Morbidity and mortality were similar. The 15-year surgical recurrence was 44% in TC and 27% in SC [p = 0.006]. In patients with one to three diseased segments, recurrence risk was related to the omission of biological therapy (hazard ratio [HR] 5.6), the number of segments [HR 2.5], perianal disease [HR 1.9] and paediatric diagnosis [HR 2.8].
    Conclusion: When technically feasible, SC is safe and reduces temporary and permanent stoma. Young age, number of locations and perianal disease adversely affect, but postoperative biological therapy significantly reduces, the long-term surgical recurrence.
    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjac096
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