Article ; Online: Secretory Leukocyte Protease Inhibitor (SLPI) in mucosal tissues: Protects against inflammation, but promotes cancer.
Cytokine & growth factor reviews
2021 Volume 59, Page(s) 22–35
Abstract: The immune system is continuously challenged with large quantities of exogenous antigens at the barriers between the external environment and internal human tissues. Antimicrobial activity is essential at these sites, though the immune responses must be ... ...
| Abstract | The immune system is continuously challenged with large quantities of exogenous antigens at the barriers between the external environment and internal human tissues. Antimicrobial activity is essential at these sites, though the immune responses must be tightly regulated to prevent tissue destruction by inflammation. Secretory Leukocyte Protease Inhibitor (SLPI) is an evolutionarily conserved, pleiotropic protein expressed at mucosal surfaces, mainly by epithelial cells. SLPI inhibits proteases, exerts antimicrobial activity and inhibits nuclear factor-kappa B (NF-κB)-mediated inflammatory gene transcription. SLPI maintains homeostasis at barrier tissues by preventing tissue destruction and regulating the threshold of inflammatory immune responses, while protecting the host from infection. However, excessive expression of SLPI in cancer cells may have detrimental consequences, as recent studies demonstrate that overexpression of SLPI increases the metastatic potential of epithelial tumors. Here, we review the varied functions of SLPI in the respiratory tract, skin, gastrointestinal tract and genitourinary tract, and then discuss the mechanisms by which SLPI may contribute to cancer. |
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| MeSH term(s) | Epithelial Cells ; Humans ; Inflammation ; NF-kappa B ; Neoplasms ; Secretory Leukocyte Peptidase Inhibitor |
| Chemical Substances | NF-kappa B ; SLPI protein, human ; Secretory Leukocyte Peptidase Inhibitor |
| Language | English |
| Publishing date | 2021-02-10 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 1330534-7 |
| ISSN | 1879-0305 ; 1359-6101 |
| ISSN (online) | 1879-0305 |
| ISSN | 1359-6101 |
| DOI | 10.1016/j.cytogfr.2021.01.005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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