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  1. Article ; Online: Mpox in Young Woman with No Epidemiologic Risk Factors, Massachusetts, USA.

    Siedner, Mark J / Trinidad, John / Berto, Cesar G / Brown, Catherine M / Madoff, Lawrence C / Lee, Ellen H / Iqbal, Maryam / Samson, Olivia / Albin, John / Turbett, Sarah E / Davies, Olivia / Kroshinsky, Daniela / Hooper, David / Hohmann, Elizabeth / Ard, Kevin / Shenoy, Erica S

    Emerging infectious diseases

    2023  Volume 29, Issue 4, Page(s) 846–848

    Abstract: We describe a case of mpox characterized by a circularly distributed facial rash but no identified risk factors. Fomite transmission of monkeypox virus from contaminated linen at a massage spa was suspected. Clinicians should consider mpox in patients ... ...

    Abstract We describe a case of mpox characterized by a circularly distributed facial rash but no identified risk factors. Fomite transmission of monkeypox virus from contaminated linen at a massage spa was suspected. Clinicians should consider mpox in patients with consistent clinical syndromes, even in the absence of epidemiologic risk factors.
    MeSH term(s) Female ; Humans ; Risk Factors ; Massachusetts ; Bedding and Linens ; Monkeypox virus ; Syndrome ; Mpox (monkeypox)
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2904.221921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epidemiologic and Clinical Features of Mpox-Associated Deaths - United States, May 10, 2022-March 7, 2023.

    Riser, Aspen P / Hanley, Allison / Cima, Michael / Lewis, Linda / Saadeh, Kayla / Alarcón, Jemma / Finn, Lauren / Kim, Moon / Adams, Jeremy / Holt, Douglas / Feldpausch, Amanda / Pavlick, Jessica / English, Andrew / Smith, Marguerite / Rehman, Tyler / Lubelchek, Ronald / Black, Stephanie / Collins, Matthew / Mounsey, Layne /
    Blythe, David / Avalos, Meredith Hodach / Lee, Ellen H / Samson, Olivia / Wong, Marcia / Stokich, B Denise / Salehi, Ellen / Denny, Lynn / Waller, Kirsten / Talley, Pamela / Schuman, Julie / Fischer, Michael / White, Stephen / Davis, Kenneth / Caeser Cuyler, Ashley / Sabzwari, Rabeeya / Anderson, Robert N / Byrd, Katrina / Gold, Jeremy A W / Kindilien, Shannon / Lee, James T / O'Connor, Siobhán / O'Shea, Jesse / Salmon-Trejo, LaTweika A T / Velazquez-Kronen, Raquel / Zelaya, Carla / Bower, William / Ellington, Sascha / Gundlapalli, Adi V / McCollum, Andrea M / Zilversmit Pao, Leah / Rao, Agam K / Wong, Karen K / Guagliardo, Sarah Anne J

    MMWR. Morbidity and mortality weekly report

    2023  Volume 72, Issue 15, Page(s) 404–410

    Abstract: As of March 7, 2023, a total of 30,235 confirmed and probable monkeypox (mpox) cases were reported in the United States, ...

    Abstract As of March 7, 2023, a total of 30,235 confirmed and probable monkeypox (mpox) cases were reported in the United States,
    MeSH term(s) Adult ; Humans ; Male ; Black or African American ; Disease Outbreaks ; Mpox (monkeypox)/mortality ; Public Health ; United States/epidemiology
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7215a5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effect of cleaning agents on the ability to obtain DNA profiles using the Identifiler™ and PowerPlex® Y multiplex kits.

    Bright, Jo-Anne / Cockerton, Sarah / Harbison, SallyAnn / Russell, Amanda / Samson, Olivia / Stevenson, Kate

    Journal of forensic sciences

    2011  Volume 56, Issue 1, Page(s) 181–185

    Abstract: A year after the introduction of Identifiler™ into the forensic DNA laboratories of the Institute of Environmental Science and Research Limited (ESR), increasing occurrences of dropout of the three loci, D7S820, D18S51, and FGA, were observed in samples ... ...

    Abstract A year after the introduction of Identifiler™ into the forensic DNA laboratories of the Institute of Environmental Science and Research Limited (ESR), increasing occurrences of dropout of the three loci, D7S820, D18S51, and FGA, were observed in samples where the DNA was not degraded and sufficient DNA was present that full DNA profiles were to be expected. The dropout was either partial or complete at these loci. Full profiles could sometimes be obtained by reamplification of samples using the same input amount of DNA. After a thorough investigation of the methods and procedures used in the laboratory, the cause of this inhibition was identified as the cleaning agent TriGene™ ADVANCE. This was determined after the deliberate addition of varying amounts of different cleaning reagents into the DNA amplification reactions. At concentrations of 0.004% TriGene™ ADVANCE caused inhibition resulting in tri-loci dropout. At concentrations of 0.04% and higher, complete inhibition was observed. An effect was also seen on the amplification of samples using the Y STR profiling system PowerPlex(®) Y. This work highlights the importance of checking all reagents and chemicals prior to use, even those with no apparent direct influence on the DNA profiling process.
    MeSH term(s) Chromosomes, Human, Y ; DNA/analysis ; DNA/drug effects ; DNA Fingerprinting/methods ; Detergents/adverse effects ; Electrophoresis ; Humans ; Laboratories ; Male ; Polymerase Chain Reaction
    Chemical Substances Detergents ; DNA (9007-49-2)
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/j.1556-4029.2010.01564.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mpox Cases Among Cisgender Women and Pregnant Persons - United States, May 11-November 7, 2022.

    Oakley, Lisa P / Hufstetler, Kaitlin / O'Shea, Jesse / Sharpe, J Danielle / McArdle, Cristin / Neelam, Varsha / Roth, Nicole M / Olsen, Emily O / Wolf, Maren / Pao, Leah Zilversmit / Gold, Jeremy A W / Davis, K Meryl / Perella, Dana / Epstein, Shara / Lash, Maura K / Samson, Olivia / Pavlick, Jessica / Feldpausch, Amanda / Wallace, Jennifer /
    Nambiar, Atmaram / Ngo, Van / Halai, Umme-Aiman / Richardson, Claudia W / Fowler, Traci / Taylor, Burnestine P / Chou, Joyce / Brandon, Lindsey / Devasia, Rose / Ricketts, Erin K / Stockdale, Catherine / Roskosky, Mellisa / Ostadkar, Rachel / Vang, Yeng / Galang, Romeo R / Perkins, Kiran / Taylor, Melanie / Choi, Mary Joung / Weidle, Paul J / Dawson, Patrick / Ellington, Sascha

    MMWR. Morbidity and mortality weekly report

    2023  Volume 72, Issue 1, Page(s) 9–14

    Abstract: Monkeypox (mpox) cases in the 2022 outbreak have primarily occurred among adult gay, bisexual, and other men who have sex with men (MSM); however, other populations have also been affected (1). To date, data on mpox in cisgender women and pregnant ... ...

    Abstract Monkeypox (mpox) cases in the 2022 outbreak have primarily occurred among adult gay, bisexual, and other men who have sex with men (MSM); however, other populations have also been affected (1). To date, data on mpox in cisgender women and pregnant persons have been limited. Understanding transmission in these populations is critical for mpox prevention. In addition, among pregnant persons, Monkeypox virus can be transmitted to the fetus during pregnancy or to the neonate through close contact during or after birth (2-5). Adverse pregnancy outcomes, including spontaneous abortion and stillbirth, have been reported in previous mpox outbreaks (3). During May 11-November 7, 2022, CDC and U.S. jurisdictional health departments identified mpox in 769 cisgender women aged ≥15 years, representing 2.7% of all reported mpox cases.
    MeSH term(s) Female ; Humans ; Pregnancy ; Black or African American ; Ethnicity ; Hispanic or Latino ; Sexual Behavior ; United States/epidemiology ; White ; Mpox (monkeypox)/epidemiology
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7201a2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical Sequelae Associated with Unresolved Tropical Splenomegaly in a Cohort of Recently Resettled Congolese Refugees in the United States-Multiple States, 2015-2018.

    Zambrano, Laura Divens / Jentes, Emily / Phares, Christina / Weinberg, Michelle / Kachur, S Patrick / Basnet, Mukunda Singh / Klosovsky, Alexander / Mwesigwa, Moses / Naoum, Marwan / Nsobya, Samuel Lubwama / Samson, Olivia / Goers, Matthew / McDonald, Robert / Morawski, Bozena / Njuguna, Henry / Peak, Corey / Laws, Rebecca / Bakhsh, Yasser / Iverson, Sally Ann /
    Bezold, Carla / Allkhenfr, Hayder / Horth, Roberta / Yang, Jun / Miller, Susan / Kacka, Michael / Davids, Abby / Mortimer, Margaret / Stauffer, William / Marano, Nina

    The American journal of tropical medicine and hygiene

    2020  Volume 103, Issue 1, Page(s) 485–493

    Abstract: Tropical splenomegaly is often associated with malaria and schistosomiasis. In 2014 and 2015, 145 Congolese refugees in western Uganda diagnosed with splenomegaly during predeparture medical examinations underwent enhanced screening for various ... ...

    Abstract Tropical splenomegaly is often associated with malaria and schistosomiasis. In 2014 and 2015, 145 Congolese refugees in western Uganda diagnosed with splenomegaly during predeparture medical examinations underwent enhanced screening for various etiologies. After anecdotal reports of unresolved splenomegaly and complications after U.S. arrival, patients were reassessed to describe long-term clinical progression after arrival in the United States. Post-arrival medical information was obtained through medical chart abstraction in collaboration with state health partners in nine participating states. We evaluated observed splenomegaly duration and associated clinical sequelae between 130 case patients from eastern Congo and 102 controls through adjusted hierarchical Poisson models, accounting for familial clustering. Of the 130 case patients, 95 (73.1%) had detectable splenomegaly after arrival. Of the 85 patients with records beyond 6 months, 45 (52.9%) had persistent splenomegaly, with a median persistence of 14.7 months (range 6.0-27.9 months). Of the 112 patients with available results, 65 (58.0%) patients had evidence of malaria infection, and the mean splenomegaly duration did not differ by
    MeSH term(s) Adolescent ; Adult ; Alkaline Phosphatase/blood ; Anemia/blood ; Anemia/epidemiology ; Anthelmintics/therapeutic use ; Antimalarials/therapeutic use ; Artemether, Lumefantrine Drug Combination/therapeutic use ; Case-Control Studies ; Child ; Child, Preschool ; Cohort Studies ; Democratic Republic of the Congo/ethnology ; Disease Progression ; Eosinophilia/blood ; Eosinophilia/epidemiology ; Female ; Hepatitis A/epidemiology ; Hepatitis B/epidemiology ; Hepatitis C/epidemiology ; Humans ; Immunoglobulin M ; Infant ; Malaria/complications ; Malaria/diagnosis ; Malaria/drug therapy ; Malaria/epidemiology ; Male ; Middle Aged ; Polymerase Chain Reaction ; Praziquantel/therapeutic use ; Refugees ; Schistosomiasis/complications ; Schistosomiasis/drug therapy ; Schistosomiasis/epidemiology ; Splenomegaly/blood ; Splenomegaly/epidemiology ; Splenomegaly/etiology ; Thrombocytopenia/blood ; Thrombocytopenia/epidemiology ; United States/epidemiology ; Young Adult
    Chemical Substances Anthelmintics ; Antimalarials ; Artemether, Lumefantrine Drug Combination ; Immunoglobulin M ; Praziquantel (6490C9U457) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.19-0534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Unresolved Splenomegaly in Recently Resettled Congolese Refugees - Multiple States, 2015-2018.

    Zambrano, Laura D / Samson, Olivia / Phares, Christina / Jentes, Emily / Weinberg, Michelle / Goers, Matthew / Kachur, S Patrick / McDonald, Robert / Morawski, Bozena / Njuguna, Henry / Bakhsh, Yasser / Laws, Rebecca / Peak, Corey / Iverson, Sally Ann / Bezold, Carla / Allkhenfr, Hayder / Horth, Roberta / Yang, Jun / Miller, Susan /
    Kacka, Michael / Davids, Abby / Mortimer, Margaret / Khan, Nomana / Stauffer, William / Marano, Nina

    MMWR. Morbidity and mortality weekly report

    2018  Volume 67, Issue 49, Page(s) 1358–1362

    Abstract: In 2014, panel physicians from the International Organization for Migration (IOM), who conduct Department of State-required predeparture examinations for U.S.-bound refugees at resettlement sites in Uganda, noticed an unusually high number of Congolese ... ...

    Abstract In 2014, panel physicians from the International Organization for Migration (IOM), who conduct Department of State-required predeparture examinations for U.S.-bound refugees at resettlement sites in Uganda, noticed an unusually high number of Congolese refugees with enlarged spleens, or splenomegaly. Many conditions can cause splenomegaly, such as various infections, liver disease, and cancer. Splenomegaly can result in hematologic disturbances and abdominal pain and can increase the risk for splenic rupture from blunt trauma, resulting in life-threatening internal bleeding. On CDC's advice, panel physicians implemented an enhanced surveillance and treatment protocol that included screening for malaria (through thick and thin smears and rapid diagnostic testing), schistosomiasis, and several other conditions; treatment of any condition identified as potentially associated with splenomegaly; and empiric treatment for the most likely etiologies, including malaria and schistosomiasis. CDC recommended further treatment for malaria with primaquine after arrival, after glucose-6-phosphate dehydrogenase testing, to target liver-stage parasites. Despite this recommended treatment protocol, 35 of 64 patients with available follow-up records had splenomegaly that persisted beyond 6 months after resettlement. Among 85 patients who were diagnosed with splenomegaly through abdominal palpation or ultrasound at any point after resettlement, 53 had some hematologic abnormality (leukopenia, anemia, or thrombocytopenia), 16 had evidence of current or recent malaria infection, and eight had evidence of schistosomiasis. Even though primaquine was provided to a minority of patients in this cohort, it should be provided to all eligible patients with persistent splenomegaly, and repeated antischistosomal therapy should be provided to patients with evidence of current or recent schistosomiasis. Given substantial evidence of familial clustering of cases, family members of patients with known splenomegaly should be proactively screened for this condition.
    MeSH term(s) Centers for Disease Control and Prevention (U.S.) ; Cluster Analysis ; Congo/ethnology ; Female ; Humans ; Malaria/diagnosis ; Malaria/therapy ; Male ; Mass Screening ; Refugees/statistics & numerical data ; Schistosomiasis/diagnosis ; Schistosomiasis/therapy ; Splenomegaly/epidemiology ; Splenomegaly/etiology ; United States/epidemiology
    Language English
    Publishing date 2018-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm6749a2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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