Article ; Online: Fermentative Production of Cysteine by Pantoea ananatis.
Applied and environmental microbiology
2017 Volume 83, Issue 5
Abstract: Cysteine is a commercially important amino acid; however, it lacks an efficient fermentative production method. Due to its cytotoxicity, intracellular cysteine levels are stringently controlled via several regulatory modes. Managing its toxic effects as ... ...
| Abstract | Cysteine is a commercially important amino acid; however, it lacks an efficient fermentative production method. Due to its cytotoxicity, intracellular cysteine levels are stringently controlled via several regulatory modes. Managing its toxic effects as well as understanding and deregulating the complexities of regulation are crucial for establishing the fermentative production of cysteine. The regulatory modes include feedback inhibition of key metabolic enzymes, degradation, efflux pumps, and the transcriptional regulation of biosynthetic genes by a master cysteine regulator, CysB. These processes have been extensively studied using |
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| MeSH term(s) | Amino Acids/biosynthesis ; Amino Acids/genetics ; Bacterial Proteins/genetics ; Biotechnology/methods ; Cystathionine gamma-Lyase/metabolism ; Cysteine/biosynthesis ; Cysteine/genetics ; Cysteine/pharmacology ; Down-Regulation ; Drug Resistance, Bacterial ; Escherichia coli/genetics ; Fermentation ; Gene Expression Regulation, Bacterial ; Genetic Engineering/methods ; Metabolic Networks and Pathways/genetics ; Pantoea/enzymology ; Pantoea/genetics ; Pantoea/metabolism ; Sequence Deletion |
| Chemical Substances | Amino Acids ; Bacterial Proteins ; CcdA protein, Bacteria ; CysB protein, Bacteria ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Cysteine (K848JZ4886) |
| Language | English |
| Publishing date | 2017-02-15 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 223011-2 |
| ISSN | 1098-5336 ; 0099-2240 |
| ISSN (online) | 1098-5336 |
| ISSN | 0099-2240 |
| DOI | 10.1128/AEM.02502-16 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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