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Article ; Online: Comparison of conventional unstained lymph nodal harvesting vs methylene blue-stained lymph nodal harvesting in colorectal specimen in staging left-sided colorectal carcinoma: a randomized controlled trial.

Chilaka, Suresh / Samuel, Evangeline Mary Kiruba / Mude, Naveen Naik / G, Balasubramanian / Badhe, Bhawana / Nagarajan, Raj Kumar

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2024 Volume 28, Issue 3, Page(s) 199–204

Abstract: Background: The management and prognosis of colorectal carcinomas (CRCs) are related to the stage of the disease, which, in turn, relies on the lymph node harvest from the surgical specimen. The guidelines recommend that at least 12 lymph nodes are ... ...

Abstract	Background: The management and prognosis of colorectal carcinomas (CRCs) are related to the stage of the disease, which, in turn, relies on the lymph node harvest from the surgical specimen. The guidelines recommend that at least 12 lymph nodes are required, which is not achieved in most resections. In this study, we propose a method to improve the lymph node yield in such cases. This study aimed to determine whether ex vivo injection of methylene blue into the inferior mesenteric artery or its branches improves lymph node retrieval in left-sided CRCs. Methods: This study was conducted as a single-center, double-blinded, superiority randomized controlled trial. Patients who underwent elective surgery for left-sided CRCs with curative intent were randomized into 2 groups: stained and unstained. The sample size was calculated as 66. In all patients, details of disease stage, history of neoadjuvant therapy, and number of isolated lymph nodes were recorded. Results: The mean number of lymph nodes extracted from the stained group was significantly higher than that from the unstained group (15.9 ± 5.2 vs 9.1 ± 5.7, respectively; P < .001). Among the patients who had received neoadjuvant therapy, the yield was higher in the stained group (P < .001). The yield was found to be greater in patients who had undergone upfront surgery than in those who had undergone neoadjuvant therapy, even in the stained group (100% vs 66.7%, respectively). Conclusion: The use of methylene blue injection into resected specimens of left-sided CRCs significantly improved the lymph node yield.
MeSH term(s)	Humans ; Methylene Blue ; Lymph Nodes/surgery ; Elective Surgical Procedures ; Neoadjuvant Therapy ; Transforming Growth Factor beta ; Colorectal Neoplasms/surgery
Chemical Substances	Methylene Blue (T42P99266K) ; Transforming Growth Factor beta
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1016/j.gassur.2023.11.021
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 354: Show issues

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Article ; Online: Comparison of Tissue Adhesive Glue with Subcuticular Absorbable Suture for Skin Closure Following Thyroid Surgery: A single-blinded randomised controlled trial.

Musham, Aditya / Samuel, Evangeline M K / Sahoo, Ashok K / Elamurugan, T P / Manwar, A S

Sultan Qaboos University medical journal

2023 Volume 23, Issue 1, Page(s) 42–47

Abstract: Objectives: This study aimed to compare the skin closure time, postoperative pain and the scar outcome between tissue adhesive and sub-cuticular sutures in thyroid surgery.: Methods: This study was conducted in Jawaharlal Institute of Postgraduate ... ...

Abstract	Objectives: This study aimed to compare the skin closure time, postoperative pain and the scar outcome between tissue adhesive and sub-cuticular sutures in thyroid surgery. Methods: This study was conducted in Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, a tertiary care hospital in India from March 2017 to December 2019. Adult patients undergoing thyroid surgery were included while those with previous neck surgery, history of keloids/hypertrophic scars and those undergoing concomitant neck dissections were excluded. Following platysma closure, patients were randomised into two groups (tissue adhesive and subcuticular sutures) using the Serially Numbered Opaque Sealed Envelopes technique. A sample size of 64 in each group was calculated for this prospective, single-blinded and randomised controlled trial. The primary outcome was the skin closure time. The secondary outcomes were postoperative pain at 24 hours and scar scoring at 1 Results: A total sample of 124 patients were included in this study, with 61 patients assigned to the suture group and 63 assigned to the tissue adhesive group. The median skin closure time and postoperative pain was significantly lower in the tissue adhesive group as compared to the suture group ( Conclusion: The use of tissue adhesive leads to lower operative time and less postoperative pain in thyroid surgeries. The scar outcome is comparable between tissue adhesives and subcuticular sutures.
MeSH term(s)	Adult ; Humans ; Tissue Adhesives/pharmacology ; Tissue Adhesives/therapeutic use ; Adhesives ; Thyroid Gland ; Prospective Studies ; Pain, Postoperative ; Cicatrix, Hypertrophic ; Sutures
Chemical Substances	Tissue Adhesives ; Adhesives
Language	English
Publishing date	2023-02-23
Publishing country	Oman
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2650196-X
ISSN	2075-0528 ; 2075-0528
ISSN (online)	2075-0528
ISSN	2075-0528
DOI	10.18295/squmj.1.2022.005
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Article: An update on adjuvant systemic therapies in melanoma.

Samuel, Evangeline / Moore, Maggie / Voskoboynik, Mark / Shackleton, Mark / Haydon, Andrew

Melanoma management

2019 Volume 6, Issue 3, Page(s) MMT28

Abstract: There is a global increase in the incidence of melanoma, with approximately 300,000 new cases in 2018 worldwide, according to statistics from the International Agency for Research on Cancer. With this rising incidence, it is important to optimize ... ...

Abstract	There is a global increase in the incidence of melanoma, with approximately 300,000 new cases in 2018 worldwide, according to statistics from the International Agency for Research on Cancer. With this rising incidence, it is important to optimize treatment strategies in all stages of the disease to provide better patient outcomes. The role of adjuvant therapy in patients with resected stage 3 melanoma is a rapidly evolving field. Interferon was the first agent shown to have any utility in this space, however, recent advances in both targeted therapies and immunotherapies have led to a number of practice changing adjuvant trials in resected stage 3 disease.
Language	English
Publishing date	2019-11-13
Publishing country	England
Document type	Journal Article ; Review
ISSN	2045-0885
ISSN	2045-0885
DOI	10.2217/mmt-2019-0009
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Article ; Online: Response to letter commenting on: Fulvestrant falsely elevates oestradiol levels in immunoassays in postmenopausal women with breast cancer.

Samuel, Evangeline / Chiang, Cherie / Jennens, Ross / Faulkner, David / Francis, Prudence A

European journal of cancer (Oxford, England : 1990)

2020 Volume 136, Page(s) 206

MeSH term(s)	Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/drug therapy ; Estradiol/therapeutic use ; Female ; Fulvestrant/therapeutic use ; Humans ; Immunoassay ; Postmenopause
Chemical Substances	Antineoplastic Agents, Hormonal ; Fulvestrant (22X328QOC4) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2020.06.006
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article ; Online: Levamisole in Frequently-relapsing and Steroid-dependent Nephrotic Syndrome.

Kiruba Samuel, Evangeline Mary / Krishnamurthy, Sriram / Bhanudeep, Singanamalla / Muske, Sravani

Indian pediatrics

2017 Volume 54, Issue 10, Page(s) 831–834

Abstract: Objective: To evaluate the efficacy of levamisole in children with frequently relapsing nephrotic syndrome (FRNS) and steroid dependent nephrotic syndrome (SDNS) when administered on an alternate day ('initial therapy' in all cases) or daily basis (' ... ...

Abstract	Objective: To evaluate the efficacy of levamisole in children with frequently relapsing nephrotic syndrome (FRNS) and steroid dependent nephrotic syndrome (SDNS) when administered on an alternate day ('initial therapy' in all cases) or daily basis ('rescue therapy' in whom alternate day therapy failed). Methods: The records of 95 children (age 1-18y) with FRNS (62) and SDNS (33), who were treated at the Pediatric nephrology clinic, and received levamisole therapy (maximum 2 y duration, between 2010-2013) with a follow-up period of minimum 1 y, were included. Results: Alternate day levamisole therapy was efficacious in 73.7% (n=70). The overall efficacy of levamisole therapy was 88.4% (n=84). Levamisole therapy decreased the mean (SD) number of relapses from 4.22 (0.46)/y to 1.35 (0.36)/y (P<0.01); and cumulative median (IQR) prednisolone dosage from 4200 (3200-4300) mg/m2 to 1100 (IQR 500-2900) mg/m2 (P<0.001). On a one-year follow up of the cases in whom levamisole therapy was efficacious during therapy (median 24 mo) (n=84), a frequently relapsing or steroid dependent course continued to persist in 48.8% (41), necessitating oral cyclophosphamide (n= 22) or mycophenolate mofetil (n=19). Conclusion: Daily levamisole therapy was useful in 56% of children who demonstrated failure while on alternate day levamisole therapy, and could be a useful therapeutic option in FRNS and SDNS.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Glucocorticoids/therapeutic use ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Infant ; Levamisole/adverse effects ; Levamisole/therapeutic use ; Male ; Nephrotic Syndrome/drug therapy ; Proteinuria ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Glucocorticoids ; Immunosuppressive Agents ; Levamisole (2880D3468G)
Language	English
Publishing date	2017-07-11
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
DOI	10.1007/s13312-017-1144-9
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Zs.A 859: Show issues

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Article ; Online: Patterns of care for people with small cell lung cancer in Victoria, 2011-19: a retrospective, population-based registry data study.

The Medical journal of Australia

2023 Volume 219, Issue 3, Page(s) 120–126

Abstract: Objectives: To report stage-specific patterns of treatment and the influence of management and treatment type on survival rates for people newly diagnosed with small cell lung cancer (SCLC).: Design: Cross-sectional patterns of care study; analysis ... ...

Abstract	Objectives: To report stage-specific patterns of treatment and the influence of management and treatment type on survival rates for people newly diagnosed with small cell lung cancer (SCLC). Design: Cross-sectional patterns of care study; analysis of data prospectively collected for the Victorian Lung Cancer Registry (VLCR). Setting, participants: All people diagnosed with SCLC in Victoria during 1 April 2011 - 18 December 2019. Main outcome measures: Stage-specific management and treatment of people with SCLC; median survival time. Results: During 2011-19, 1006 people were diagnosed with SCLC (10.5% of all lung cancer diagnoses in Victoria); their median age was 69 years (interquartile range [IQR], 62-77 years), 429 were women (43%), and 921 were current or former smokers (92%). Clinical stage was defined for 896 people (89%; TNM stages I-III, 268 [30%]; TNM stage IV, 628 [70%]) and ECOG performance status at diagnosis for 663 (66%; 0 or 1, 489 [49%]; 2-4, 174 [17%]). The cases of 552 patients had been discussed at multidisciplinary meetings (55%), 377 people had received supportive care screening (37%), and 388 had been referred for palliative care (39%). Active treatment was received by 891 people (89%): chemotherapy, 843 (84%); radiotherapy, 460 (46%); chemotherapy and radiotherapy, 419 (42%); surgery, 23 (2%). Treatment had commenced within fourteen days of diagnosis for 632 of 875 patients (72%). Overall median survival time from diagnosis was 8.9 months (IQR, 4.2-16 months; stage I-III: 16.3 [IQR, 9.3-30] months; stage IV: 7.2 [IQR, 3.3-12] months). Multidisciplinary meeting presentation (hazard ratio [HR], 0.66; 95% CI, 0.58-0.77), multimodality treatment (HR, 0.42; 95% CI, 0.36-0.49), and chemotherapy within fourteen days of diagnosis (HR, 0.68; 95% CI, 0.48-0.94) were each associated with lower mortality during follow-up. Conclusion: Rates of supportive care screening, multidisciplinary meeting evaluation, and palliative care referral for people with SCLC could be improved. A national registry of SCLC-specific management and outcomes data could improve the quality and safety of care.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Male ; Small Cell Lung Carcinoma/drug therapy ; Retrospective Studies ; Cross-Sectional Studies ; Routinely Collected Health Data ; Lung Neoplasms/epidemiology ; Lung Neoplasms/therapy
Language	English
Publishing date	2023-06-26
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186082-3
ISSN	1326-5377 ; 0025-729X
ISSN (online)	1326-5377
ISSN	0025-729X
DOI	10.5694/mja2.52017
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Ua VI Zs.398: Show issues

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Article ; Online: Impact of Radiotherapy on the Efficacy and Toxicity of anti-PD-1 Inhibitors in Metastatic NSCLC.

Samuel, Evangeline / Lie, Gabrielle / Balasubramanian, Adithya / Hiong, Alison / So, Yeojeong / Voskoboynik, Mark / Moore, Maggie / Shackleton, Mark / Haydon, Andrew / John, Tom / Mitchell, Paul L R / Markman, Ben / Briggs, Peter / Parakh, Sagun

Clinical lung cancer

2020 Volume 22, Issue 3, Page(s) e425–e430

Abstract: Background: The impact of radiotherapy (RT) on the efficacy and toxicity of immune checkpoint inhibitors (ICIs) in patients with metastatic non-small-cell lung cancer (NSCLC) is unclear.: Materials and methods: We identified patients with metastatic ... ...

Abstract	Background: The impact of radiotherapy (RT) on the efficacy and toxicity of immune checkpoint inhibitors (ICIs) in patients with metastatic non-small-cell lung cancer (NSCLC) is unclear. Materials and methods: We identified patients with metastatic NSCLC treated with the anti-programmed death 1 antibodies nivolumab or pembrolizumab between January 2016 and May 2019 at 3 tertiary centers, who were also treated with palliative RT either during or within 3 months of starting anti-programmed death 1 treatment. Patient demographics, tumor characteristics, and treatment history were collected. Response rates, progression-free survival (PFS), and overall survival (OS) were analyzed and correlated with RT use. Results: A total of 269 patients were identified, with a median follow-up of 19.4 months. The median age was 70 years (range, 35-90 years), and they were 63% male, 60% smokers, and 65% had adenocarcinoma histology. At the commencement of ICI treatment, the majority (86%) had ≥ 1 line of prior therapy and 34% had brain metastases. A total of 102 (38%) patients received RT within 3 months of starting ICI or subsequently during ICI treatment. Of patients that received RT, 86 (84%) received conventional hypofractionated RT, and, in the majority, 81 (79%) the intent of RT was symptom control. The use of RT did not increase grade 3/4 immune-related adverse events. The overall median PFS was 2.0 months (95% confidence interval, 1.3-2.6 months) and the median OS was 9.0 months (95% confidence interval, 6.4-9.5 months). There were no significant differences in median PFS (3.0 vs. 2.0 months; P = .515) and median OS (9.0 vs. 9.0 months; P = .917) in the patients who received RT versus those that did not. Conclusions: In patients with metastatic NSCLC, the addition of RT to ICI was not associated with increased toxicity or improved survival.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Immune Checkpoint Inhibitors/administration & dosage ; Immune Checkpoint Inhibitors/adverse effects ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Metastasis ; Nivolumab/administration & dosage ; Nivolumab/adverse effects ; Palliative Care/methods ; Progression-Free Survival ; Retrospective Studies ; Survival Rate ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; Immune Checkpoint Inhibitors ; Nivolumab (31YO63LBSN) ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2020-06-10
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2020.06.001
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 440: Show issues

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Article ; Online: Comparison of conventional unstained lymph nodal harvesting vs methylene blue-stained lymph nodal harvesting in colorectal specimen in staging left-sided colorectal carcinoma: a randomized controlled trial.

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Article ; Online: Comparison of Tissue Adhesive Glue with Subcuticular Absorbable Suture for Skin Closure Following Thyroid Surgery: A single-blinded randomised controlled trial.

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Article: An update on adjuvant systemic therapies in melanoma.

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Article ; Online: Response to letter commenting on: Fulvestrant falsely elevates oestradiol levels in immunoassays in postmenopausal women with breast cancer.

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Article ; Online: Levamisole in Frequently-relapsing and Steroid-dependent Nephrotic Syndrome.

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Article ; Online: Patterns of care for people with small cell lung cancer in Victoria, 2011-19: a retrospective, population-based registry data study.

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Article ; Online: Impact of Radiotherapy on the Efficacy and Toxicity of anti-PD-1 Inhibitors in Metastatic NSCLC.

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