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  1. Article ; Online: Promoting insight and recovery in the context of the "insight paradox".

    Yang, Lawrence H / Samuel, Shana S / Tay, Charisse / Cho, Young

    Schizophrenia research

    2020  Volume 222, Page(s) 6–7

    Language English
    Publishing date 2020-05-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2020.03.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2351: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 543: Show issues

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  2. Article ; Online: Recency and intensification of positive symptoms enhance prediction of conversion to syndromal psychosis in clinical high-risk patients.

    Brucato, Gary / First, Michael B / Dishy, Gabriella A / Samuel, Shana S / Xu, Qing / Wall, Melanie M / Small, Scott A / Masucci, Michael D / Lieberman, Jeffrey A / Girgis, Ragy R

    Psychological medicine

    2019  Volume 51, Issue 1, Page(s) 112–120

    Abstract: Background: Early detection and intervention strategies in patients at clinical high-risk (CHR) for syndromal psychosis have the potential to contain the morbidity of schizophrenia and similar conditions. However, research criteria that have relied on ... ...

    Abstract Background: Early detection and intervention strategies in patients at clinical high-risk (CHR) for syndromal psychosis have the potential to contain the morbidity of schizophrenia and similar conditions. However, research criteria that have relied on severity and number of positive symptoms are limited in their specificity and risk high false-positive rates. Our objective was to examine the degree to which measures of recency of onset or intensification of positive symptoms [a.k.a., new or worsening (NOW) symptoms] contribute to predictive capacity.
    Methods: We recruited 109 help-seeking individuals whose symptoms met criteria for the Progression Subtype of the Attenuated Positive Symptom Psychosis-Risk Syndrome defined by the Structured Interview for Psychosis-Risk Syndromes and followed every three months for two years or onset of syndromal psychosis.
    Results: Forty-one (40.6%) of 101 participants meeting CHR criteria developed a syndromal psychotic disorder [mostly (80.5%) schizophrenia] with half converting within 142 days (interquartile range: 69-410 days). Patients with more NOW symptoms were more likely to convert (converters: 3.63 ± 0.89; non-converters: 2.90 ± 1.27; p = 0.001). Patients with stable attenuated positive symptoms were less likely to convert than those with NOW symptoms. New, but not worsening, symptoms, in isolation, also predicted conversion.
    Conclusions: Results suggest that the severity and number of attenuated positive symptoms are less predictive of conversion to syndromal psychosis than the timing of their emergence and intensification. These findings also suggest that the earliest phase of psychotic illness involves a rapid, dynamic process, beginning before the syndromal first episode, with potentially substantial implications for CHR research and understanding the neurobiology of psychosis.
    MeSH term(s) Adolescent ; Adult ; Disease Progression ; Female ; Humans ; Male ; Prodromal Symptoms ; Psychiatric Status Rating Scales ; Psychotic Disorders/diagnosis ; Psychotic Disorders/psychology ; Risk Factors ; Schizophrenia/diagnosis ; Schizophrenic Psychology ; Syndrome ; Young Adult
    Language English
    Publishing date 2019-10-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S0033291719003040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Naturalistic conceptions of genetic optimism and precision psychiatry among those at clinical high-risk for psychosis.

    Blasco, Drew / Stortz, Saige William / Grivel, Margaux Marie-Rose / Dishy, Gabriella A / Samuel, Shana S / Pilla, David / Crump, Francesca M / Lieff, Sarah A / Williams, Jourdan / Phoummavong, Phetsamone / Guo, Xufei / Brucato, Gary / Girgis, Ragy R / Yang, Lawrence H

    Early intervention in psychiatry

    2020  Volume 15, Issue 3, Page(s) 742–745

    Abstract: Aim: Fuelled by genomics advances, recent emphasis on the concept of "precision medicine," and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive ... ...

    Abstract Aim: Fuelled by genomics advances, recent emphasis on the concept of "precision medicine," and public optimism towards genetic advances, it is important to understand how those who are considered to be at clinical high-risk for psychosis (CHR) perceive possible benefits of genetic testing to inform future stakeholder education efforts.
    Methods: Semistructured interviews were completed with 20 participants who met CHR criteria. Coding for genetic optimism was completed.
    Results: Participants endorsed many conceptualizations of the link between genetics, the development of psychosis, and the benefits of genetic testing. Specifically, themes emerged surrounding how genetic testing may lead to greater genetic knowledge and tailored treatment.
    Conclusions: Our results demonstrate that CHR participants generally endorse several precision psychiatry concepts, including how genetic testing may lead to tailored treatment advances. This knowledge may aid development of best communication practices regarding forthcoming genetic advances in diagnosis and treatment among CHR.
    MeSH term(s) Genetic Testing ; Humans ; Optimism ; Psychiatry ; Psychotic Disorders/diagnosis ; Psychotic Disorders/genetics
    Language English
    Publishing date 2020-06-01
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.12983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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