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  1. Article ; Online: Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09

    Pavithra Daulagala / Samuel M.S. Cheng / Alex Chin / Leo L.H. Luk / Kathy Leung / Joseph T. Wu / Leo L.M. Poon / Malik Peiris / Hui-Ling Yen

    Emerging Infectious Diseases, Vol 30, Iss 1, Pp 168-

    2024  Volume 171

    Abstract: We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% ...

    Abstract We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.
    Keywords influenza ; viruses ; influenza A(H5N1) ; influenza A(H1N1)pdm09 ; respiratory infections ; clade 2.3.4.4.b ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals

    Haogao Gu / Ahmed Abdul Quadeer / Pavithra Krishnan / Daisy Y. M. Ng / Lydia D. J. Chang / Gigi Y. Z. Liu / Samuel M. S. Cheng / Tommy T. Y. Lam / Malik Peiris / Matthew R. McKay / Leo L. M. Poon

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: There is limited data on within-host SARS-CoV-2 genetic diversity and how it is affected by vaccination. The authors analysed intra-host sequence diversity and found that VOCs may have more sequence variations than non-VOCs and that breakthrough ... ...

    Abstract There is limited data on within-host SARS-CoV-2 genetic diversity and how it is affected by vaccination. The authors analysed intra-host sequence diversity and found that VOCs may have more sequence variations than non-VOCs and that breakthrough infections in vaccinated individuals do not seem to increase non-silent mutations.
    Keywords Science ; Q
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Replication of Novel Zoonotic-Like Influenza A(H3N8) Virus in Ex Vivo Human Bronchus and Lung

    Kenrie P.Y. Hui / John C.W. Ho / Ka-Chun Ng / Samuel M.S. Cheng / Ko-Yung Sit / Timmy W.K. Au / Leo L.M. Poon / John M. Nicholls / Malik Peiris / Michael C.W. Chan

    Emerging Infectious Diseases, Vol 29, Iss 6, Pp 1210-

    2023  Volume 1214

    Abstract: Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication efficiency in bronchial and lung tissue ... ...

    Abstract Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication efficiency in bronchial and lung tissue but had a higher replication than avian H3N8 virus in lung tissue.
    Keywords influenza ; H3N8 ; risk assessment ; human bronchus ; human lung ; influenza A virus ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Phylogenetic Analysis of MERS-CoV in a Camel Abattoir, Saudi Arabia, 2016–2018

    Maged Gomaa Hemida / Daniel K.W. Chu / Yen Y. Chor / Samuel M.S. Cheng / Leo L.M. Poon / Abdelmohsen Alnaeem / Malik Peiris

    Emerging Infectious Diseases, Vol 26, Iss 12, Pp 3089-

    2020  Volume 3091

    Abstract: We detected Middle East respiratory syndrome coronavirus (MERS-CoV) RNA in 305/1,131 (27%) camels tested at an abattoir in Al Hasa, Eastern Province, Saudi Arabia, during January 2016–March 2018. We characterized 48 full-length MERS-CoV genomes and noted ...

    Abstract We detected Middle East respiratory syndrome coronavirus (MERS-CoV) RNA in 305/1,131 (27%) camels tested at an abattoir in Al Hasa, Eastern Province, Saudi Arabia, during January 2016–March 2018. We characterized 48 full-length MERS-CoV genomes and noted the viruses clustered in MERS-CoV lineage 5 clade B.
    Keywords MERS ; coronavirus ; dromedary ; camels ; Saudi Arabia ; phylogeny ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong

    Ruopeng Xie / Kimberly M. Edwards / Dillon C. Adam / Kathy S. M. Leung / Tim K. Tsang / Shreya Gurung / Weijia Xiong / Xiaoman Wei / Daisy Y. M. Ng / Gigi Y. Z. Liu / Pavithra Krishnan / Lydia D. J. Chang / Samuel M. S. Cheng / Haogao Gu / Gilman K. H. Siu / Joseph T. Wu / Gabriel M. Leung / Malik Peiris / Benjamin J. Cowling /
    Leo L. M. Poon / Vijaykrishna Dhanasekaran

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract Hong Kong experienced a surge of Omicron BA.2 infections in early 2022, resulting in one of the highest per-capita death rates of COVID-19. The outbreak occurred in a dense population with low immunity towards natural SARS-CoV-2 infection, high ... ...

    Abstract Abstract Hong Kong experienced a surge of Omicron BA.2 infections in early 2022, resulting in one of the highest per-capita death rates of COVID-19. The outbreak occurred in a dense population with low immunity towards natural SARS-CoV-2 infection, high vaccine hesitancy in vulnerable populations, comprehensive disease surveillance and the capacity for stringent public health and social measures (PHSMs). By analyzing genome sequences and epidemiological data, we reconstructed the epidemic trajectory of BA.2 wave and found that the initial BA.2 community transmission emerged from cross-infection within hotel quarantine. The rapid implementation of PHSMs suppressed early epidemic growth but the effective reproduction number (R e ) increased again during the Spring festival in early February and remained around 1 until early April. Independent estimates of point prevalence and incidence using phylodynamics also showed extensive superspreading at this time, which likely contributed to the rapid expansion of the epidemic. Discordant inferences based on genomic and epidemiological data underscore the need for research to improve near real-time epidemic growth estimates by combining multiple disparate data sources to better inform outbreak response policy.
    Keywords Science ; Q
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Neutralizing antibody titres in SARS-CoV-2 infections

    Eric H. Y. Lau / Owen T. Y. Tsang / David S. C. Hui / Mike Y. W. Kwan / Wai-hung Chan / Susan S. Chiu / Ronald L. W. Ko / Kin H. Chan / Samuel M. S. Cheng / Ranawaka A. P. M. Perera / Benjamin J. Cowling / Leo L. M. Poon / Malik Peiris

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 7

    Abstract: Here, the authors perform plaque reduction neutralization (PRNT) assays quantitating SARS-CoV-2 specific neutralizing antibodies from 195 patients in different disease states and find that patients with severe disease exhibit higher peaks of neutralizing ...

    Abstract Here, the authors perform plaque reduction neutralization (PRNT) assays quantitating SARS-CoV-2 specific neutralizing antibodies from 195 patients in different disease states and find that patients with severe disease exhibit higher peaks of neutralizing antibody titres than patients with mild or asymptomatic infections and that serum neutralizing antibody persists for over 6 months in most people.
    Keywords Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection

    Carolyn A. Cohen / Athena P. Y. Li / Asmaa Hachim / David S. C. Hui / Mike Y. W. Kwan / Owen T. Y. Tsang / Susan S. Chiu / Wai Hung Chan / Yat Sun Yau / Niloufar Kavian / Fionn N. L. Ma / Eric H. Y. Lau / Samuel M. S. Cheng / Leo L. M. Poon / Malik Peiris / Sophie A. Valkenburg

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 14

    Abstract: Why children are generally less susceptible than adults to COVID-19 is unclear and has not extensively been examined longitudinally. Here the authors compare antibodies, cytokines and immune cell responses in adults and children over 6 months post- ... ...

    Abstract Why children are generally less susceptible than adults to COVID-19 is unclear and has not extensively been examined longitudinally. Here the authors compare antibodies, cytokines and immune cell responses in adults and children over 6 months post-infection showing, among other things, a reduced CD4+ and CD8+ T cell response in children.
    Keywords Science ; Q
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: SARS-CoV-2 accessory proteins reveal distinct serological signatures in children

    Asmaa Hachim / Haogao Gu / Otared Kavian / Masashi Mori / Mike Y. W. Kwan / Wai Hung Chan / Yat Sun Yau / Susan S. Chiu / Owen T. Y. Tsang / David S. C. Hui / Chris K. P. Mok / Fionn N. L. Ma / Eric H. Y. Lau / Gaya K. Amarasinghe / Abraham J. Qavi / Samuel M. S. Cheng / Leo L. M. Poon / J. S. Malik Peiris / Sophie A. Valkenburg /
    Niloufar Kavian

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: The antibody response of children to SARS-CoV-2 is less well studied than in adults. Here Hachim et al. show that children have reduced antibody levels to structural proteins and suggest that the predominance of antibody responses to non-structural ... ...

    Abstract The antibody response of children to SARS-CoV-2 is less well studied than in adults. Here Hachim et al. show that children have reduced antibody levels to structural proteins and suggest that the predominance of antibody responses to non-structural proteins can be used to discriminate infection and vaccination.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease

    Ranawaka A.P.M. Perera / Eugene Tso / Owen T.Y. Tsang / Dominic N.C. Tsang / Kitty Fung / Yonna W.Y. Leung / Alex W.H. Chin / Daniel K.W. Chu / Samuel M.S. Cheng / Leo L.M. Poon / Vivien W.M. Chuang / Malik Peiris

    Emerging Infectious Diseases, Vol 26, Iss 11, Pp 2701-

    2020  Volume 2704

    Abstract: We investigated 68 respiratory specimens from 35 coronavirus disease patients in Hong Kong, of whom 32 had mild disease. We found that severe acute respiratory syndrome coronavirus 2 and subgenomic RNA were rarely detectable beyond 8 days after onset of ... ...

    Abstract We investigated 68 respiratory specimens from 35 coronavirus disease patients in Hong Kong, of whom 32 had mild disease. We found that severe acute respiratory syndrome coronavirus 2 and subgenomic RNA were rarely detectable beyond 8 days after onset of illness. However, virus RNA was detectable for many weeks by reverse transcription PCR.
    Keywords severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; coronavirus ; viruses ; coronavirus disease ; COVID-19 ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

    Jaime S. Rosa Duque / Xiwei Wang / Daniel Leung / Samuel M. S. Cheng / Carolyn A. Cohen / Xiaofeng Mu / Asmaa Hachim / Yanmei Zhang / Sau Man Chan / Sara Chaothai / Kelvin K. H. Kwan / Karl C. K. Chan / John K. C. Li / Leo L. H. Luk / Leo C. H. Tsang / Wilfred H. S. Wong / Cheuk Hei Cheang / Timothy K. Hung / Jennifer H. Y. Lam /
    Gilbert T. Chua / Winnie W. Y. Tso / Patrick Ip / Masashi Mori / Niloufar Kavian / Wing Hang Leung / Sophie Valkenburg / Malik Peiris / Wenwei Tu / Yu Lung Lau

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 15

    Abstract: There are adverse events associated with COVID-19 vaccines, such as myocarditis for adolescents following receipt of SARS-CoV-2 mRNA vaccines. Here the authors compare the immunogenicity and reactogenicity of two widely available SARS-CoV-2 vaccines ( ... ...

    Abstract There are adverse events associated with COVID-19 vaccines, such as myocarditis for adolescents following receipt of SARS-CoV-2 mRNA vaccines. Here the authors compare the immunogenicity and reactogenicity of two widely available SARS-CoV-2 vaccines (BNT162b2, an mRNA vaccine, and CoronaVac, a whole-virus inactivated vaccine) in healthy adolescents.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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