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  1. Article: Anticholinergics: A potential option for preventing posttraumatic epilepsy.

    Sanabria, Viviam / Romariz, Simone / Braga, Matheus / Foresti, Maira Licia / Naffah-Mazzacoratti, Maria da Graça / Mello, Luiz Eugênio / Longo, Beatriz M

    Frontiers in neuroscience

    2023  Volume 16, Page(s) 1100256

    Abstract: Interest in the use of anticholinergics to prevent the development of epilepsy after traumatic brain injury (TBI) has grown since recent basic studies have shown their effectiveness in modifying the epileptogenic process. These studies demonstrated that ... ...

    Abstract Interest in the use of anticholinergics to prevent the development of epilepsy after traumatic brain injury (TBI) has grown since recent basic studies have shown their effectiveness in modifying the epileptogenic process. These studies demonstrated that treatment with anticholinergics, in the acute phase after brain injury, decreases seizure frequency, and severity, and the number of spontaneous recurrent seizures (SRS). Therefore, anticholinergics may reduce the risk of developing posttraumatic epilepsy (PTE). In this brief review, we summarize the role of the cholinergic system in epilepsy and the key findings from using anticholinergic drugs to prevent PTE in animal models and new clinical trial protocols. Furthermore, we discuss why treatment with anticholinergics is more likely to prevent PTE than treatment for other epilepsies.
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.1100256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High Concentrations of Cannabidiol Induce Neurotoxicity in Neurosphere Culture System.

    Romariz, Simone A A / Sanabria, Viviam / da Silva, Karina Ribeiro / Quintella, Miguel L / de Melo, Bruna A G / Porcionatto, Marimélia / de Almeida, Danilo Candido / Longo, Beatriz M

    Neurotoxicity research

    2024  Volume 42, Issue 1, Page(s) 14

    Abstract: Recent studies have demonstrated that cannabinoids are potentially effective in the treatment of various neurological conditions, and cannabidiol (CBD), one of the most studied compounds, has been proposed as a non-toxic option. However, the adverse ... ...

    Abstract Recent studies have demonstrated that cannabinoids are potentially effective in the treatment of various neurological conditions, and cannabidiol (CBD), one of the most studied compounds, has been proposed as a non-toxic option. However, the adverse effects of CBD on neurodevelopmental processes have rarely been studied in cell culture systems. To better understand CBD's influence on neurodevelopment, we exposed neural progenitor cells (NPCs) to different concentrations of CBD (1 µM, 5 µM, and 10 µM). We assessed the morphology, migration, differentiation, cell death, and gene expression in 2D and 3D bioprinted models to stimulate physiological conditions more effectively. Our results showed that CBD was more toxic at higher concentrations (5 µM and 10 µM) and affected the viability of NPCs than at lower concentrations (1 µM), in both 2D and 3D models. Moreover, our study revealed that higher concentrations of CBD drastically reduced the size of neurospheres and the number of NPCs within neurospheres, impaired the morphology and mobility of neurons and astrocytes after differentiation, and reduced neurite sprouting. Interestingly, we also found that CBD alters cellular metabolism by influencing the expression of glycolytic and β-oxidative enzymes in the early and late stages of metabolic pathways. Therefore, our study demonstrated that higher concentrations of CBD promote important changes in cellular functions that are crucial during CNS development.
    MeSH term(s) Humans ; Cannabidiol/toxicity ; Neurotoxicity Syndromes ; Neurons ; Astrocytes ; Carbidopa
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Carbidopa (MNX7R8C5VO)
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036826-4
    ISSN 1476-3524 ; 1029-8428
    ISSN (online) 1476-3524
    ISSN 1029-8428
    DOI 10.1007/s12640-024-00692-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5749: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: What we have learned from non-human primates as animal models of epilepsy.

    Sanabria, Viviam / Romariz, Simone A A / Braga, Matheus / Pires, Jaime Moreira / Naffah-Mazzacoratti, Maria da Graça / Mello, Luiz Eugênio / Longo, Beatriz M / Foresti, Maira Licia

    Epilepsy & behavior : E&B

    2024  Volume 154, Page(s) 109706

    Abstract: Non-human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic ... ...

    Abstract Non-human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic seizures, and they have proven invaluable allies in developing anti-seizure therapies. This review explores the history of NHPs as natural models of epilepsy, discusses the findings obtained after exposure to various chemoconvulsant drugs and focal electrical stimulation protocols that helped uncover important mechanisms related to epilepsy, examines diverse treatments to prevent and manage epilepsy, and addresses essential ethical issues in research. In this review, we aim to emphasize the important role of NHPs in epilepsy research and summarize the benefits and challenges associated with their use as models.
    MeSH term(s) Animals ; Epilepsy/physiopathology ; Primates ; Disease Models, Animal ; Humans
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2024.109706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Distinctive Neuroanatomic Regions Involved in Cocaine-Induced Behavioral Sensitization in Mice.

    Santos-Baldaia, Renan Dos / Wuo-Silva, Raphael / Sanabria, Viviam / Baldaia, Marilia A / Yokoyama, Thais S / Coppi, Antonio Augusto / Hollais, André W / Marinho, Eduardo A V / Oliveira-Lima, Alexandre J / Longo, Beatriz M

    Biomedicines

    2023  Volume 11, Issue 2

    Abstract: The present study aimed to characterize the phenomenon of behavioral sensitization to cocaine and to identify neuroanatomical structures involved in the induction and expression phases of this phenomenon. For this, in experiment 1 (induction phase), mice ...

    Abstract The present study aimed to characterize the phenomenon of behavioral sensitization to cocaine and to identify neuroanatomical structures involved in the induction and expression phases of this phenomenon. For this, in experiment 1 (induction phase), mice were treated with saline or cocaine every second day for 15 days (conditioning period), in the open-field or in their home-cages. In experiment 2 (expression phase), the same protocol was followed, except that after the conditioning period the animals were not manipulated for 10 days, and after this interval, animals were challenged with cocaine. Neuroanatomical structures involved in the induction and expression phases were identified by stereological quantification of c-Fos staining in the dorsomedial prefrontal cortex (dmPFC), nucleus accumbens core (NAc core and shell (NAc shell), basolateral amygdala (BLA), and ventral tegmental area (VTA). Neuroanatomical analysis indicated that in the induction phase, cocaine-conditioned animals had higher expression of c-Fos in the dmPFC, NAc core, BLA, and VTA, whereas in the expression phase, almost all areas had higher expression except for the VTA. Therefore, environmental context plays a major role in the induction and expression of behavioral sensitization, although not all structures that compose the mesolimbic system contribute to this phenomenon.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11020383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Characterization of the estrous cycle in the Amazon spiny rat (

    Sanabria, Viviam / Bittencourt, Simone / de la Rosa, Tomás / Livramento, Jomênica / Tengan, Célia / Scorza, Carla A / Cavalheiro, Esper / Amado, Débora

    Heliyon

    2019  Volume 5, Issue 12, Page(s) e03007

    Abstract: ... Males ... ...

    Abstract Males of
    Language English
    Publishing date 2019-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2019.e03007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus.

    Sanabria, Viviam / Bittencourt, Simone / Perosa, Sandra R / de la Rosa, Tomás / da Graça Naffah-Mazzacoratti, Maria / Andersen, Monica L / Tufik, Sergio / Cavalheiro, Esper A / Amado, Débora

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 20982

    Abstract: The Amazon rodent Proechimys guyannensis is widely studied for hosting various pathogens, though rarely getting sick. Previous studies on male Proechimys have revealed an endogenous resistance to epilepsy. Here, we assess in female Proechimys, whether ... ...

    Abstract The Amazon rodent Proechimys guyannensis is widely studied for hosting various pathogens, though rarely getting sick. Previous studies on male Proechimys have revealed an endogenous resistance to epilepsy. Here, we assess in female Proechimys, whether sex hormones and biochemical aspects can interfere with the induction of status epilepticus (SE). The lithium-pilocarpine ramp-up protocol was used to induce SE, and blood sera were collected at 30 and 90 min after SE, alongside brains, for biochemical, western blot and immunohistochemical analyses. Results from non-ovariectomised (NOVX) Proechimys were compared to ovariectomised (OVX) animals. Data from female Wistars were used as a positive control of SE inductions. SE latency was similar in NOVX, OVX, and female Wistars groups. However, the pilocarpine dose required to induce SE in Proechimys was higher (25- to 50-folds more). Despite a higher dose, Proechimys did not show strong SE like Wistars; they only reached stage 2 of the Racine scale. These data suggest that female Proechimys are resistant to SE induction. Glucose and progesterone levels increased at 30 min and returned to normal at 90 min after SE. A relevant fact because in humans and rodents, SE leads to hypoglycaemia after 30 min of SE and does not return to normal levels in a short time, a typical adverse effect of SE. In OVX animals, a decrease in GABAergic receptors within 90 min of SE may suggest that ovariectomy produces changes in the hippocampus, including a certain vulnerability to seizures. We speculate that progesterone and glucose increases form part of the compensatory mechanisms that provide resistance in Proechimys against SE induction.
    MeSH term(s) Animals ; Anticonvulsants/therapeutic use ; Blood Glucose/analysis ; Disease Models, Animal ; Drug Resistant Epilepsy/drug therapy ; Drug Resistant Epilepsy/metabolism ; Drug Resistant Epilepsy/physiopathology ; Female ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/physiopathology ; Ovariectomy ; Pilocarpine/therapeutic use ; Progesterone/blood ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Rodentia/metabolism ; Rodentia/physiology ; Status Epilepticus/drug therapy ; Status Epilepticus/metabolism ; Status Epilepticus/physiopathology
    Chemical Substances Anticonvulsants ; Blood Glucose ; Receptors, Estrogen ; Receptors, Progesterone ; Pilocarpine (01MI4Q9DI3) ; Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-77879-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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