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  1. Article ; Online: Quantifying phonological knowledge in children with phonological disorder.

    Combiths, Philip N / Barlow, Jessica A / Sanchez, Emilie

    Clinical linguistics & phonetics

    2019  Volume 33, Issue 10-11, Page(s) 885–898

    Abstract: Generative phonologists use contrastive minimal pairs to determine functional phonological units in a language. This technique has been extended for clinical purposes to derive phonemic inventories for children with phonological disorder, providing a ... ...

    Abstract Generative phonologists use contrastive minimal pairs to determine functional phonological units in a language. This technique has been extended for clinical purposes to derive phonemic inventories for children with phonological disorder, providing a qualitative analysis of a given child's phonological system that is useful for assessment, treatment, and progress monitoring. In this study, we examine the single-word productions of 275 children with phonological disorder from the Learnability Project (Gierut, 2015b) to confirm the relationship between phonemic inventory - a measure of phonological knowledge - and consonant accuracy - a quantitative, relational measure that directly compares a child's phonological productions to the target (i.e. adult-like) form. Further, we identify potential percentage accuracy cutoff scores that reliably classify sounds as in or out of a child's phonemic inventory in speech-sound probes of varying length. Our findings indicate that the phonemic function of up to 90% of English consonants can be identified from percentage accuracy for preschool-age children with phonological disorder when a sufficiently large and thorough speech sample is used.
    MeSH term(s) Child, Preschool ; Female ; Humans ; Language Tests ; Male ; Midwestern United States ; Phonetics ; Speech Production Measurement ; Speech Sound Disorder/diagnosis ; Speech Sound Disorder/therapy
    Language English
    Publishing date 2019-08-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639459-0
    ISSN 1464-5076 ; 0269-9206
    ISSN (online) 1464-5076
    ISSN 0269-9206
    DOI 10.1080/02699206.2019.1584247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antibody responses to SARS-CoV-2 vaccination in patients with acute myeloid leukaemia and high risk MDS on active anti-cancer therapies.

    Chan, Wei Yee / Zhu, Catherine / Sanchez, Emilie / Gupta, Rajeev / Fielding, Adele K / Khwaja, Asim / Payne, Elspeth M / O'Nions, Jenny

    British journal of haematology

    2022  Volume 198, Issue 3, Page(s) 478–481

    MeSH term(s) Antibodies, Viral ; Antibody Formation ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Improved COVID-19 outcomes in CAR-T patients in the age of vaccination and preemptive pharmacotherapeutics.

    Cheok, Kathleen P L / Kirkwood, Amy A / Creasey, Thomas / Tholouli, Eleni / Chaganti, Sridhar / Mathew, Amrith / Dulobdas, Vaishali / Irvine, David / Besley, Caroline / Neil, Lorna / Lown, Robert / Menne, Tobias / Townsend, William / Kuhnl, Andrea / O'Reilly, Maeve / Sanderson, Robin / Sanchez, Emilie / Roddie, Claire

    Leukemia & lymphoma

    2023  Volume 64, Issue 12, Page(s) 2037–2041

    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; COVID-19/prevention & control ; Vaccination ; Immunotherapy, Adoptive
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2248329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Influenza vaccination and interruption of methotrexate in adult patients in the COVID-19 era: an ongoing dilemma.

    Mehta, Puja / Sanchez, Emilie / Moraitis, Elena / Longley, Nicky / Lendrem, Dennis W / Giles, Ian P / Chambers, Rachel C / Ciurtin, Coziana / Isaacs, John D

    The Lancet Rheumatology

    2020  Volume 3, Issue 1, Page(s) e9–e10

    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30392-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19: consider cytokine storm syndromes and immunosuppression.

    Mehta, Puja / McAuley, Daniel F / Brown, Michael / Sanchez, Emilie / Tattersall, Rachel S / Manson, Jessica J

    Lancet (London, England)

    2020  Volume 395, Issue 10229, Page(s) 1033–1034

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Cytokines/metabolism ; Humans ; Immunization, Passive ; Immunoglobulins, Intravenous/therapeutic use ; Immunosuppression/methods ; Immunosuppressive Agents ; Inflammation/drug therapy ; Inflammation/etiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Steroids/therapeutic use
    Chemical Substances Antirheumatic Agents ; Cytokines ; Immunoglobulins, Intravenous ; Immunosuppressive Agents ; Steroids
    Keywords covid19
    Language English
    Publishing date 2020-03-16
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30628-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Natural History of Epstein-Barr Virus Replication and Viral Load Dynamics after Alemtuzumab-Based Allogeneic Stem Cell Transplantation.

    Marzolini, Maria A V / Wilson, Andrew J / Sanchez, Emilie / Carpenter, Ben / Chakraverty, Ronjon / Hough, Rachael / Kottaridis, Panos / Morris, Emma C / Thomson, Kirsty J / Peggs, Karl S

    Transplantation and cellular therapy

    2021  Volume 27, Issue 8, Page(s) 682.e1–682.e12

    Abstract: Epstein-Barr virus (EBV) load monitoring after allogeneic hematopoietic stem cell transplantation (HSCT) enables earlier detection of EBV replication and often serves as a trigger for preemptive therapies aimed at reducing EBV-related diseases. Our ... ...

    Abstract Epstein-Barr virus (EBV) load monitoring after allogeneic hematopoietic stem cell transplantation (HSCT) enables earlier detection of EBV replication and often serves as a trigger for preemptive therapies aimed at reducing EBV-related diseases. Our institutional strategy is to treat patients with clinical signs of EBV-related disease accompanied by a rising viral load, rather than to intervene based solely on viral load. This affords an opportunity to study the natural history of EBV replication and to assess whether our strategy reduces overtreatment without compromising outcomes. The objectives of the present study were to assess the natural history of untreated EBV replication in patients who underwent an alemtuzumab-based allogeneic HSCT and to examine whether our clinical strategy reduced overtreatment without compromising patient outcomes. In this retrospective single-center observational study of 515 consecutive patients (age ≥18 years) undergoing T cell-depleted allogeneic HSCT incorporating alemtuzumab, patients underwent surveillance monitoring for EBV by quantitative PCR in the peripheral blood at least weekly up to 100 days post-transplantation and longer if they remained on immunosuppressive therapy. The cumulative incidence of EBV detection and EBV-related disease were assessed. Among the 515 patients, 192 had EBV DNA detectable on ≥1 occasion, with a cumulative incidence of 35.8% (31.8% to 40.4%), although this remained below the limit of quantification in 93 patients. The median time to first detection was 89.5 days (range, 0 to 2254 days). The incidence was higher in recipients of sibling donor transplants (45.4% versus 30%; P = .00021) compared with recipients of unrelated donor transplants. Twenty patients developed EBV-related disease (cumulative incidence, 3.9%). Two patients had immunosuppression reduction alone, 18 received rituximab, and 5 required additional therapies. Five patients died from post-transplantation lymphoproliferative disorder, all of whom had received rituximab. The positive predictive value of EBV load for disease was higher in the unrelated donor cohort but remained <75% regardless of EBV threshold (57.1% to 72.7%). The cumulative incidence of EBV-related disease in our study (3.9%) is comparable to that reported in other studies incorporating alemtuzumab, and our clinical strategy reduced overtreatment in this patient population. PCR-based surveillance strategies have limitations, as reflected in the relatively low sensitivity of the assay coupled with the low positive predictive value, which may influence the potential choice of a threshold for preemptive intervention. We conclude that it remains unclear whether treatment based on a rising EBV viral load alone provides superior overall results to treatment based on the development of clinical signs of EBV-related disease in the context of a rising viral load.
    MeSH term(s) Adolescent ; Alemtuzumab/therapeutic use ; DNA, Viral ; Epstein-Barr Virus Infections/drug therapy ; Hematopoietic Stem Cell Transplantation ; Herpesvirus 4, Human/genetics ; Humans ; Retrospective Studies ; Transplantation, Homologous ; Viral Load
    Chemical Substances DNA, Viral ; Alemtuzumab (3A189DH42V)
    Language English
    Publishing date 2021-05-04
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2021.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Patients with plasma cell disorders undergoing autologous stem cell transplant retain their humoral response to COVID-19 vaccination but falling titers emphasize the importance of re-vaccination.

    Howells, Lara / Chan, Wei Yee / Sanchez, Emilie / Horder, Jacqueline / Newrick, Fiona / Marfil, Jotham / McMillan, Annabel / Wisniowski, Brendan / Mahmood, Shameem / Papanikolaou, Xenofon / Lee, Lydia / Wechalekar, Ashutosh / Popat, Rakesh / Sive, Jonathan / Kyriakou, Charalampia / Xu, Ke / Nastouli, Eleni / Yong, Kwee L / Rabin, Neil

    Leukemia & lymphoma

    2022  Volume 63, Issue 10, Page(s) 2489–2493

    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Immunity, Humoral ; Plasma Cells ; Vaccination
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2074989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diagnosis and investigation of suspected haemophagocytic lymphohistiocytosis in adults: 2023 Hyperinflammation and HLH Across Speciality Collaboration (HiHASC) consensus guideline.

    Cox, Miriam F / Mackenzie, Strachan / Low, Ryan / Brown, Michael / Sanchez, Emilie / Carr, Aisling / Carpenter, Ben / Bishton, Mark / Duncombe, Andrew / Akpabio, Akpabio / Kulasekararaj, Austin / Sin, Fang En / Jones, Alexis / Kavirayani, Akhila / Sen, Ethan S / Quick, Vanessa / Dulay, Gurdeep S / Clark, Sam / Bauchmuller, Kris /
    Tattersall, Rachel S / Manson, Jessica J

    The Lancet. Rheumatology

    2023  Volume 6, Issue 1, Page(s) e51–e62

    Abstract: Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterised by persistently activated cytotoxic lymphocytes and macrophages, which, if untreated, leads to multiorgan dysfunction and death. HLH should be considered in any ... ...

    Abstract Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterised by persistently activated cytotoxic lymphocytes and macrophages, which, if untreated, leads to multiorgan dysfunction and death. HLH should be considered in any acutely unwell patient not responding to treatment as expected, with prompt assessment to look for what we term the three Fs-fever, falling blood counts, and raised ferritin. Worldwide, awareness of HLH and access to expert management remain inequitable. Terminology is not standardised, classification criteria are validated in specific patient groups only, and some guidelines rely on specialised and somewhat inaccessible tests. The consensus guideline described in this Health Policy was produced by a self-nominated working group from the UK network Hyperinflammation and HLH Across Speciality Collaboration (HiHASC), a multidisciplinary group of clinicians experienced in managing people with HLH. Combining literature review and experience gained from looking after patients with HLH, it provides a practical, structured approach for all health-care teams managing adult (>16 years) patients with possible HLH. The focus is on early recognition and diagnosis of HLH and parallel identification of the underlying cause. To ensure wide applicability, the use of inexpensive, readily available tests is prioritised, but the role of specialist investigations and their interpretation is also addressed.
    MeSH term(s) Adult ; Humans ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Macrophages ; Accidental Falls ; Consensus ; Ferritins
    Chemical Substances Ferritins (9007-73-2)
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(23)00273-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Influenza vaccination and interruption of methotrexate in adult patients in the COVID-19 era

    Mehta, Puja / Sanchez, Emilie / Moraitis, Elena / Longley, Nicky / Lendrem, Dennis W / Giles, Ian P / Chambers, Rachel C / Ciurtin, Coziana / Isaacs, John D

    The Lancet Rheumatology ; ISSN 2665-9913

    an ongoing dilemma

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/s2665-9913(20)30392-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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