Article ; Online: LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells.
2021 Volume 11, Issue 1, Page(s) 4742
Abstract: Insulin-like Growth Factor-1 (IGF-1) is involved in the normal development and survival of retinal cells. Low-density lipoprotein Receptor-related Protein-1 (LRP1) plays a key role on the regulation of several membrane proteins, such as the IGF-1 ... ...
| Abstract | Insulin-like Growth Factor-1 (IGF-1) is involved in the normal development and survival of retinal cells. Low-density lipoprotein Receptor-related Protein-1 (LRP1) plays a key role on the regulation of several membrane proteins, such as the IGF-1 receptor (IGF-1R). In brain astrocytes, LRP1 interact with IGF-1R and the glucose transporter type 1 (GLUT1), regulating the glucose uptake in these cells. Although GLUT1 is expressed in retinal Müller Glial Cells (MGCs), its regulation is not clear yet. Here, we investigated whether IGF-1 modulates GLUT1 traffic to plasma membrane (PM) and glucose uptake, as well as the involvement of LRP1 in this process in the human Müller glial-derived cell line (MIO-M1). We found that IGF-1 produced GLUT1 translocation to the PM, in a time-dependent manner involving the intracellular signaling activation of MAPK/ERK and PI |
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| MeSH term(s) | Biological Transport ; Cell Line ; Cell Membrane/metabolism ; Ependymoglial Cells/metabolism ; Glucose/metabolism ; Glucose Transporter Type 1/metabolism ; Humans ; Insulin-Like Growth Factor I/metabolism ; Low Density Lipoprotein Receptor-Related Protein-1/metabolism ; Receptor, IGF Type 1/metabolism ; Signal Transduction |
| Chemical Substances | Glucose Transporter Type 1 ; IGF1 protein, human ; IGF1R protein, human ; Low Density Lipoprotein Receptor-Related Protein-1 ; Insulin-Like Growth Factor I (67763-96-6) ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Glucose (IY9XDZ35W2) |
| Language | English |
| Publishing date | 2021-02-26 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-84090-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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