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  1. Article ; Online: Perfil clínico de los pacientes con hematomas retroperitoneales espontáneos.

    Sánchez-González, Amada / Riancho-Zarrabeitia, Leyre / Salmón-González, Zaida / Riancho, José Antonio / Valero, Carmen

    Medicina clinica

    2015  Volume 145, Issue 7, Page(s) 301–304

    Abstract: Introduction and objective: Spontaneous retroperitoneal hematoma (SRH) is a potentially fatal clinical entity requiring immediate recognition and intervention.: Material and methods: The clinical records of 18-year-old and older patients admitted to ... ...

    Title translation Clinical spectrum of patients with spontaneous retroperitoneal hematomas.
    Abstract Introduction and objective: Spontaneous retroperitoneal hematoma (SRH) is a potentially fatal clinical entity requiring immediate recognition and intervention.
    Material and methods: The clinical records of 18-year-old and older patients admitted to the University Hospital Marqués de Valdecilla from 2003 to 2013 were reviewed. "Spontaneous" was defined as unrelated to trauma, invasive procedures or bleeding due to aortic aneurysm rupture.
    Results: Thirty-four patients with SRH (44% were on anticoagulant drugs). One-third of cases had chronic renal insufficiency. Abdominal pain was the most common symptom both in anticoagulated and non-anticoagulated patients (80% in anticoagulated and 89% in non-anticoagulated patients). About one half of the patients developed shock. A CT scan was the most commonly performed diagnostic test, followed by abdominal ultrasound. Most cases were managed conservatively (80%). More than half of the patients (66%) restarted anticoagulation therapy after the acute event with a mean delay of 19 days (range 2-90 days). None of them suffered a new bleeding episode.
    Conclusion: Restarting the anticoagulation treatment after hematoma resolution seems to be a safe practice. There is an increasing frequency of SRH in non-anticoagulated patients.
    MeSH term(s) Abdominal Pain/etiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; Female ; Hematoma/diagnosis ; Hematoma/etiology ; Hematoma/therapy ; Humans ; Male ; Middle Aged ; Retroperitoneal Space ; Retrospective Studies ; Risk Factors ; Young Adult
    Chemical Substances Anticoagulants
    Language Spanish
    Publishing date 2015-10-05
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2015.04.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Safety and immunogenicity of the inactivated whole-virus adjuvanted COVID-19 vaccine VLA2001: A randomized, dose escalation, double-blind phase 1/2 clinical trial in healthy adults.

    Lazarus, Rajeka / Taucher, Christian / Brown, Claire / Čorbic Ramljak, Irena / Danon, Leon / Dubischar, Katrin / Duncan, Christopher J A / Eder-Lingelbach, Susanne / Faust, Saul N / Green, Christopher / Gokani, Karishma / Hochreiter, Romana / Wright, Johanna Kellett / Kwon, Dowan / Middleditch, Alexander / Munro, Alasdair P S / Naker, Kush / Penciu, Florentina / Price, David /
    Querton, Benedicte / Riaz, Tawassal / Ross-Russell, Amy / Sanchez-Gonzalez, Amada / Wardle, Hayley / Warren, Sarah / Finn, Adam

    The Journal of infection

    2022  Volume 85, Issue 3, Page(s) 306–317

    Abstract: Objectives: We aimed to evaluate the safety and optimal dose of a novel inactivated whole-virus adjuvanted vaccine against SARS-CoV-2: VLA2001.: Methods: We conducted an open-label, dose-escalation study followed by a double-blind randomized trial ... ...

    Abstract Objectives: We aimed to evaluate the safety and optimal dose of a novel inactivated whole-virus adjuvanted vaccine against SARS-CoV-2: VLA2001.
    Methods: We conducted an open-label, dose-escalation study followed by a double-blind randomized trial using low, medium and high doses of VLA2001 (1:1:1). The primary safety outcome was the frequency and severity of solicited local and systemic reactions within 7 days after vaccination. The primary immunogenicity outcome was the geometric mean titre (GMT) of neutralizing antibodies against SARS-CoV-2 two weeks after the second vaccination. The study is registered as NCT04671017.
    Results: Between December 16, 2020, and June 3, 2021, 153 healthy adults aged 18-55 years were recruited in the UK. Overall, 81.7% of the participants reported a solicited AE, with injection site tenderness (58.2%) and headache (46.4%) being the most frequent. Only 2 participants reported a severe solicited event. Up to day 106, 131 (85.6%) participants had reported any AE. All observed incidents were transient and non-life threatening in nature. Immunogenicity measured at 2 weeks after completion of the two-dose priming schedule, showed significantly higher GMTs of SARS-CoV-2 neutralizing antibody titres in the highest dose group (GMT 545.6; 95% CI: 428.1, 695.4) which were similar to a panel of convalescent sera (GMT 526.9; 95% CI: 336.5, 825.1). Seroconversion rates of neutralizing antibodies were also significantly higher in the high-dose group (>90%) compared to the other dose groups. In the high dose group, antigen-specific IFN-γ expressing T-cells reactive against the S, M and N proteins were observed in 76, 36 and 49%, respectively.
    Conclusions: VLA2001 was well tolerated in all tested dose groups, and no safety signal of concern was identified. The highest dose group showed statistically significantly stronger immunogenicity with similar tolerability and safety, and was selected for phase 3 clinical development.
    MeSH term(s) Adult ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19 Vaccines/adverse effects ; Double-Blind Method ; Humans ; Immunization, Passive ; Immunogenicity, Vaccine ; SARS-CoV-2 ; COVID-19 Serotherapy
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
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  3. Article ; Online: Single-cell multi-omics analysis of the immune response in COVID-19.

    Stephenson, Emily / Reynolds, Gary / Botting, Rachel A / Calero-Nieto, Fernando J / Morgan, Michael D / Tuong, Zewen Kelvin / Bach, Karsten / Sungnak, Waradon / Worlock, Kaylee B / Yoshida, Masahiro / Kumasaka, Natsuhiko / Kania, Katarzyna / Engelbert, Justin / Olabi, Bayanne / Spegarova, Jarmila Stremenova / Wilson, Nicola K / Mende, Nicole / Jardine, Laura / Gardner, Louis C S /
    Goh, Issac / Horsfall, Dave / McGrath, Jim / Webb, Simone / Mather, Michael W / Lindeboom, Rik G H / Dann, Emma / Huang, Ni / Polanski, Krzysztof / Prigmore, Elena / Gothe, Florian / Scott, Jonathan / Payne, Rebecca P / Baker, Kenneth F / Hanrath, Aidan T / Schim van der Loeff, Ina C D / Barr, Andrew S / Sanchez-Gonzalez, Amada / Bergamaschi, Laura / Mescia, Federica / Barnes, Josephine L / Kilich, Eliz / de Wilton, Angus / Saigal, Anita / Saleh, Aarash / Janes, Sam M / Smith, Claire M / Gopee, Nusayhah / Wilson, Caroline / Coupland, Paul / Coxhead, Jonathan M / Kiselev, Vladimir Yu / van Dongen, Stijn / Bacardit, Jaume / King, Hamish W / Rostron, Anthony J / Simpson, A John / Hambleton, Sophie / Laurenti, Elisa / Lyons, Paul A / Meyer, Kerstin B / Nikolić, Marko Z / Duncan, Christopher J A / Smith, Kenneth G C / Teichmann, Sarah A / Clatworthy, Menna R / Marioni, John C / Göttgens, Berthold / Haniffa, Muzlifah

    Nature medicine

    2021  Volume 27, Issue 5, Page(s) 904–916

    Abstract: Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, ... ...

    Abstract Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16
    MeSH term(s) COVID-19/immunology ; Cross-Sectional Studies ; Humans ; Monocytes/immunology ; Proteome ; Receptors, Antigen, B-Cell/immunology ; Receptors, Antigen, T-Cell/immunology ; SARS-CoV-2/immunology ; Single-Cell Analysis/methods ; T-Lymphocytes/immunology ; Transcriptome
    Chemical Substances Proteome ; Receptors, Antigen, B-Cell ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-021-01329-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4212: Show issues Location:
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  4. Article ; Online: The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres

    Stephenson, Emily / Reynolds, Gary / Botting, Rachel A / Calero-Nieto, Fernando J / Morgan, Michael / Tuong, Zewen Kelvin / Bach, Karsten / Sungnak, Waradon / Worlock, Kaylee B / Yoshida, Masahiro / Kumasaka, Natsuhiko / Kania, Katarzyna / Engelbert, Justin / Olabi, Bayanne / Spegarova, Jarmila Stremenova / Wilson, Nicola K / Mende, Nicole / Jardine, Laura / Gardner, Louis CS /
    Goh, Issac / Horsfall, Dave / McGrath, Jim / Webb, Simone / Mather, Michael W / Lindeboom, Rik GH / Dann, Emma / Huang, Ni / Polanski, Krzysztof / Prigmore, Elena / Gothe, Florian / Scott, Jonathan / Payne, Rebecca P / Baker, Kenneth F / Hanrath, Aidan T / Schim van der Loeff, Ina CD / Barr, Andrew S / Sanchez-Gonzalez, Amada / Bergamaschi, Laura / Mescia, Federica / Barnes, Josephine L / Kilich, Eliz / de Wilton, Angus / Saigal, Anita / Saleh, Aarash / Janes, Sam M / Smith, Claire M / Gopee, Nusayhah / Wilson, Caroline / Coupland, Paul / Coxhead, Jonathan M / Kiselev, Vladimir Y / van Dongen, Stijn / Bacardit, Jaume / King, Hamish W / Rostron, Anthony J / Simpson, A John / Hambleton, Sophie / Laurenti, Elisa / Lyons, Paul A / Meyer, Kerstin B / Nikolic, Marko Z / Duncan, Christopher JA / Smith, Ken / Teichmann, Sarah A / Clatworthy, Menna R / Marioni, John C / Gottgens, Berthold / Haniffa, Muzlifah

    medRxiv

    Abstract: The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in excess morbidity and mortality as well as economic decline. To characterise the systemic host immune response to SARS-CoV-2, we performed single-cell RNA-sequencing coupled ...

    Abstract The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in excess morbidity and mortality as well as economic decline. To characterise the systemic host immune response to SARS-CoV-2, we performed single-cell RNA-sequencing coupled with analysis of cell surface proteins, providing molecular profiling of over 800,000 peripheral blood mononuclear cells from a cohort of 130 patients with COVID-19. Our cohort, from three UK centres, spans the spectrum of clinical presentations and disease severities ranging from asymptomatic to critical. Three control groups were included: healthy volunteers, patients suffering from a non-COVID-19 severe respiratory illness and healthy individuals administered with intravenous lipopolysaccharide to model an acute inflammatory response. Full single cell transcriptomes coupled with quantification of 188 cell surface proteins, and T and B lymphocyte antigen receptor repertoires have provided several insights into COVID-19: 1. a new non-classical monocyte state that sequesters platelets and replenishes the alveolar macrophage pool; 2. platelet activation accompanied by early priming towards megakaryopoiesis in immature haematopoietic stem/progenitor cells and expansion of megakaryocyte-primed progenitors; 3. increased clonally expanded CD8+ effector:effector memory T cells, and proliferating CD4+ and CD8+ T cells in patients with more severe disease; and 4. relative increase of IgA plasmablasts in asymptomatic stages that switches to expansion of IgG plasmablasts and plasma cells, accompanied with higher incidence of BCR sharing, as disease severity increases. All data and analysis results are available for interrogation and data mining through an intuitive web portal. Together, these data detail the cellular processes present in peripheral blood during an acute immune response to COVID-19, and serve as a template for multi-omic single cell data integration across multiple centers to rapidly build powerful resources to help combat diseases such as COVID-19.
    Keywords covid19
    Language English
    Publishing date 2021-01-15
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.01.13.21249725
    Database COVID19

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