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  1. Article ; Online: Modifications in Gene Expression in the Process of Osteoblastic Differentiation of Multipotent Bone Marrow-Derived Human Mesenchymal Stem Cells Induced by a Novel Osteoinductive Porous Medical-Grade 3D-Printed Poly(ε-caprolactone)/β-tricalcium Phosphate Composite.

    López-González, Ivan / Zamora-Ledezma, Camilo / Sanchez-Lorencio, María Isabel / Tristante Barrenechea, Elena / Gabaldón-Hernández, José Antonio / Meseguer-Olmo, Luis

    International journal of molecular sciences

    2021  Volume 22, Issue 20

    Abstract: In this work, we evaluated the influence of a novel hybrid 3D-printed porous composite scaffold based on poly(ε-caprolactone) (PCL) and β-tricalcium phosphate (β-TCP) microparticles in the process of adhesion, proliferation, and osteoblastic ... ...

    Abstract In this work, we evaluated the influence of a novel hybrid 3D-printed porous composite scaffold based on poly(ε-caprolactone) (PCL) and β-tricalcium phosphate (β-TCP) microparticles in the process of adhesion, proliferation, and osteoblastic differentiation of multipotent adult human bone marrow mesenchymal stem cells (
    MeSH term(s) Alkaline Phosphatase/metabolism ; Calcium Phosphates/chemistry ; Cell Adhesion ; Cell Differentiation/genetics ; Cell Proliferation ; Cells, Cultured ; Gene Expression Regulation ; Humans ; Mesenchymal Stem Cells/cytology ; Osteoblasts/cytology ; Osteogenesis/genetics ; Osteogenesis/physiology ; Polyesters/chemistry ; Porosity ; Printing, Three-Dimensional ; Tissue Scaffolds ; X-Ray Microtomography
    Chemical Substances Calcium Phosphates ; Polyesters ; beta-tricalcium phosphate ; polycaprolactone (24980-41-4) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2021-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222011216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Usefulness of PIVKA-II for monitoring after liver transplantation in patients with hepatocellular carcinoma.

    Villalba-López, Francisco / Sáenz-Mateos, Luis Francisco / Sánchez-Lorencio, Maria Isabel / De La Orden-García, Virginia / Alconchel-Gago, Felipe / Cascales-Campos, Pedro Antonio / García-Bernardo, Carmen / Noguera-Velasco, José Antonio / Baroja-Mazo, Alberto / Ramírez-Romero, Pablo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5621

    Abstract: The high morbidity and mortality of hepatocellular carcinoma (HCC) has encouraged the search for new biomarkers to be used alongside alpha-foetoprotein (AFP) and imaging tests. The aim of this study was to evaluate the clinical contribution of protein ... ...

    Abstract The high morbidity and mortality of hepatocellular carcinoma (HCC) has encouraged the search for new biomarkers to be used alongside alpha-foetoprotein (AFP) and imaging tests. The aim of this study was to evaluate the clinical contribution of protein induced by vitamin K absence or antagonist-II (PIVKA-II) for HCC monitoring after liver transplantation (LT) and compare it with AFP, a routinely used tumour marker. A total of 46 HCC patients (Milan criteria) were enrolled in this study. Serum levels of PIVKA-II and AFP were measured before and after transplantation. Clinical features were determined for all the patients that were included. Significant correlations were found between PIVKA-II expression levels and some clinicopathological features, such as tumour size and number of pre-transplant transarterial chemoembolizations (TACEs). Serum levels of PIVKA-II and AFP decreased significantly after LT and increased in patients with tumour recurrence. Serum PIVKA-II levels may play an important role in predicting disease severity. Furthermore, monitoring PIVKA-II levels in HCC transplant recipients reflects the tumor early recurrence after transplantation and could be used, complementing AFP and imaging tests, as a novel biomarker of this pathology.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; alpha-Fetoproteins/metabolism ; Liver Neoplasms/pathology ; Liver Transplantation ; Neoplasm Recurrence, Local ; Biomarkers ; Prothrombin ; Biomarkers, Tumor
    Chemical Substances acarboxyprothrombin (53230-14-1) ; alpha-Fetoproteins ; Biomarkers ; Prothrombin (9001-26-7) ; Biomarkers, Tumor
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32879-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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