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Article ; Online: Scalable Production of Ambient Stable Hybrid Bismuth-Based Materials: AACVD of Phenethylammonium Bismuth Iodide Films*.

Wang, M / Sanchez-Perez, C / Habib, F / Blunt, M O / Carmalt, C J

Chemistry (Weinheim an der Bergstrasse, Germany)

2021 Volume 27, Issue 36, Page(s) 9406–9413

Abstract: Large homogeneous and adherent coatings of phenethylammonium bismuth iodide were produced using the cost-effective and scalable aerosol-assisted chemical vapor deposition (AACVD) methodology. The film morphology was found to depend on the deposition ... ...

Abstract	Large homogeneous and adherent coatings of phenethylammonium bismuth iodide were produced using the cost-effective and scalable aerosol-assisted chemical vapor deposition (AACVD) methodology. The film morphology was found to depend on the deposition conditions and substrates, resulting in different optical properties to those reported from their spin-coated counterparts. Optoelectronic characterization revealed band bending effects occurring between the hybrid material and semiconducting substrates (TiO
Language	English
Publishing date	2021-05-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202100774
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Article: Infección periprotésica de rodilla ¿influye la estrategia quirúrgica en el resultado funcional?

Crego-Vita, D / Sánchez-Pérez, C / Espigares-Correa, A / Aedo-Martín, D

Acta ortopedica mexicana

2020 Volume 33, Issue 5, Page(s) 297–302

Abstract: Introduction: Surgical strategy in dealing with periprosthetic knee infections remains controversial. The goals of treatment are to eradicate infection, improve pain and joint function. Surgical management includes implant debridement and retention, ... ...

Title translation	Total knee arthroplasty infection, what is the best strategy for better functional outcomes?
Abstract	Introduction: Surgical strategy in dealing with periprosthetic knee infections remains controversial. The goals of treatment are to eradicate infection, improve pain and joint function. Surgical management includes implant debridement and retention, prosthetic replacement in one-time, or two-stage replacement. This latest surgical strategy is considered the «gold standard», reaching healing rates up to 80%-100%, although little has been published about functional results. Material and methods: Retrospective study of 65 patients with periprosthetic knee infection. In 20 patients a replacement was made in a time and in 45 patients were in two stages. Pre- and post-operative evaluation with the modified HSS scale. All patients were treated with intravenous antibiotherapy, we evaluated the analytical and clinical response to confirm the eradication or not of the infection. Results: The infection was resolved in 39 out of 65 patients, 12 in the replacement group in a time and 27 for the two-stages group. No significant difference between the groups in relation to healing or functional result. However, there is a statistically significant difference between those patients who received oral antibiotic treatment prior to diagnosis and those who did not. Conclusions: The healing rate is similarly treated with replacement in a time and replacement in two times. We were unable to demonstrate superiority in the functional results between the two groups.
MeSH term(s)	Anti-Bacterial Agents ; Arthroplasty, Replacement, Knee ; Debridement ; Humans ; Knee Prosthesis ; Prosthesis-Related Infections ; Reoperation ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	Spanish
Publishing date	2020-04-06
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	2205424-8
ISSN	2306-4102
ISSN	2306-4102
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Article ; Online: Optical device for thermal diffusivity determination in liquids by reflection of a thermal wave.

Sánchez-Pérez, C / De León-Hernández, A / García-Cadena, C

The Review of scientific instruments

2017 Volume 88, Issue 8, Page(s) 84901

Abstract: In this work, we present a device for determination of the thermal diffusivity using the oblique reflection of a thermal wave within a solid slab that is in contact with the medium to be characterized. By using the reflection near a critical angle under ... ...

Abstract	In this work, we present a device for determination of the thermal diffusivity using the oblique reflection of a thermal wave within a solid slab that is in contact with the medium to be characterized. By using the reflection near a critical angle under the assumption that thermal waves obey Snell's law of refraction with the square root of the thermal diffusivities, the unknown thermal diffusivity is obtained by simple formulae. Experimentally, the sensor response is measured using the photothermal beam deflection technique within a slab that results in a compact device with no contact of the laser probing beam with the sample. We describe the theoretical basis and provide experimental results to validate the proposed method. We determine the thermal diffusivity of tridistilled water and glycerin solutions with an error of less than 0.5%.
Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.4998983
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Article: Periprosthetic joint infections in femoral neck fracture patients treated with hemiarthroplasty - should we use antibiotic-loaded bone cement?

Crego-Vita, Diana / Aedo-Martín, Daniel / Garcia-Cañas, Rafael / Espigares-Correa, Andrea / Sánchez-Pérez, Coral / Berberich, Christof Ernst

World journal of orthopedics

2022 Volume 13, Issue 2, Page(s) 150–159

Abstract: Background: Hemiarthroplasty is the most common treatment in elderly patients with displaced intra-capsular femoral neck fracture (FNF). Prosthetic joint infection (PJI) is one of the most feared and frequent complications post-surgery because of the ... ...

Abstract	Background: Hemiarthroplasty is the most common treatment in elderly patients with displaced intra-capsular femoral neck fracture (FNF). Prosthetic joint infection (PJI) is one of the most feared and frequent complications post-surgery because of the frail health status of these patients and the need for fast track surgery. Therefore, priorities should lie in effective preventive strategies to mitigate this burden. Aim: To determine how much the implementation of the routine use of antibiotic-loaded bone cement (ALBC) as a relatively easy-to-apply amendment to the surgical practice reduces the infection rate in our hemiarthroplasty cohort. Methods: We retrospectively assessed all demographic, health status and treatment-related data of our FNF patients undergoing cemented hemiarthroplasty in the period from 2011 to 2017; 241 patients were further analyzed after exclusion of patients with cancer-related sequelae and those who died before the end of the 1-year observation period. The PJI rate as diagnosed on basis of the Musculoskeletal Infection Society (MSIS) criteria 2011 was determined for each included patient and compared in function of the bone cement used for hip stem fixation. Patients were split into a group receiving a plain bone cement in the period from January 2011 to June 2013 (non-ALBC group) and into a group receiving an ALBC in the period July 2013 to December 2017 (ALBC group). Data analysis was performed with statistical software. We further calculated the cost-efficacy of the implementation of routine use of ALBC in the second group balancing the in-hospital infection related treatment costs with the extra costs of use of ALBC. Results: In total 241 FNF patients who received cemented hemiarthroplasty in the period from January 2011 to January 2017 were eligible for inclusion in this retrospective study. There were 8 PJI cases identified in the ALBC group among Conclusion: Use of ALBC is a potent infection preventive factor in FNF patients receiving cemented hemiarthroplasties. It was further found to be highly cost-effective.
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Clinical Trial
ZDB-ID	2649712-8
ISSN	2218-5836
ISSN	2218-5836
DOI	10.5312/wjo.v13.i2.150
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Article: Effective Capacitance from Equivalent Electrical Circuit as a Tool for Monitoring Non-Adherent Cell Suspensions at Low Frequencies.

De León-Hernández, Alma / Romero-Ornelas, Luisa / Ramírez-Chavarría, Roberto G / Ramón-Gallegos, Eva / Sánchez-Pérez, Celia

Bioengineering (Basel, Switzerland)

2022 Volume 9, Issue 11

Abstract: Analyzing the electrical double layer (EDL) in electrical impedance spectroscopy (EIS) measurement at low frequencies remains a challenging task for sensing purposes. In this work, we propose two approaches to deal with the EDL in measuring impedance for ...

Abstract	Analyzing the electrical double layer (EDL) in electrical impedance spectroscopy (EIS) measurement at low frequencies remains a challenging task for sensing purposes. In this work, we propose two approaches to deal with the EDL in measuring impedance for particles and non-adherent cells in an electrolytic suspension. The first approach is a simple procedure to compute a normalized electrical impedance spectrum named dispersed medium index (DMi). The second is the EIS modeling through an equivalent electric circuit based on the so-called effective capacitance (Cef), which unifies the EDL phenomena. Firstly, as an experiment under controlled conditions, we examine polymer particles of 6, 15, and 48 μm in diameter suspended in a 0.9% sodium chloride solution. Subsequently, we used K-562 cells and leukocytes suspended in a culture medium (RPMI-1640 supplemented) for a biological assay. As the main result, the DMi is a function of the particle concentration. In addition, it shows a tendency with the particle size; regardless, it is limited to a volume fraction of 0.03 × 10
Language	English
Publishing date	2022-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2746191-9
ISSN	2306-5354
ISSN	2306-5354
DOI	10.3390/bioengineering9110697
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Article ; Online: Validation of 3D-Printed Swabs for Sampling in SARS-CoV-2 Detection: A Pilot Study.

Bolaños-Suaréz, Verónica / Villalobos-Osnaya, Alma / García-García, José Antonio / De León-Hernández, Alma / Sánchez-Pérez, Celia / Espinosa-García, Ana María

Annals of biomedical engineering

2022 Volume 51, Issue 3, Page(s) 527–537

Abstract: In this pilot study, we characterize and evaluate 3D-printed swabs for the collection of nasopharyngeal and oropharyngeal secretion samples for the SARS-CoV-2 detection. Swabs are made with the fused deposition modeling technique using the biopolymer ... ...

Abstract	In this pilot study, we characterize and evaluate 3D-printed swabs for the collection of nasopharyngeal and oropharyngeal secretion samples for the SARS-CoV-2 detection. Swabs are made with the fused deposition modeling technique using the biopolymer polylactic acid (PLA) which is a medical-grade, biodegradable and low-cost material. We evaluated six swabs with mechanical tests in a laboratory and in an Adult Human Simulator performed by healthcare professionals. We proved the adequacy of the PLA swab to be used in the gold standard reverse transcriptase-polymerase chain reaction (qRT-PCR) for viral RNA detection. Then, we did in vitro validation for cell collection using the 3D-printed swabs and RNA extraction for samples from 10 healthy volunteers. The 3D-printed swabs showed good flexibility and maneuverability for sampling and at the same time robustness to pass into the posterior nasopharynx. The PLA did not interfere with the RNA extraction process and qRT-PCR test. When we evaluated the expression of the reference gene (RNase P) used in the SARS-CoV-2 detection, the 3D-printed swabs showed good reproducibility in the threshold cycle values (Ct = 23.5, range 19-26) that is comparable to control swabs (Ct = 24.7, range 20.8-32.6) with p value = 0.47. The 3D-printed swabs demonstrated to be a reliable, and an economical alternative for mass use in the detection of SARS-CoV-2.
MeSH term(s)	Adult ; Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Pilot Projects ; Reproducibility of Results ; Polyesters ; Printing, Three-Dimensional ; RNA
Chemical Substances	Polyesters ; RNA (63231-63-0)
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-022-03057-1
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Article ; Online: Assessment of the characterization of nonabsorbing nanoparticles in suspension from effective optical properties.

Márquez-Islas, R / Sánchez-Pérez, C / García-Valenzuela, A

Applied optics

2015 Volume 54, Issue 31, Page(s) 9082–9092

Abstract: We analyze a method recently proposed to retrieve the size, refractive index, and concentration of particles in nonabsorbing nanofluids from measurements of the complex effective refractive index of two dilutions of the nanofluid [Opt. Lett.39, 559 (2014) ...

Abstract	We analyze a method recently proposed to retrieve the size, refractive index, and concentration of particles in nonabsorbing nanofluids from measurements of the complex effective refractive index of two dilutions of the nanofluid [Opt. Lett.39, 559 (2014)]. The method uses simple formulas to retrieve the particles' parameters. First, we discuss precautions needed with the new method when inferring the refractive index of the particles from measurements of the imaginary part of the effective refractive index of two dilutions of the original nanofluid. Then we analyze the use of this methodology to obtain some average radius in the size of polydisperse suspensions and in the case of suspensions of weakly absorbing particles. We also perform an error analysis considering fixed errors in measurements and calculating the errors in the retrieved size, refractive index, and concentration of particles. Finally, we characterize experimentally nanofluids of polymeric particles fabricated of poly(methyl-methacrylate) (PMMA) and polystyrene (PS) for which we achieved an uncertainty of 5×10(-3) and 1×10(-2) in the determination of the particle refractive index, respectively, and a precision better than 3% in the determination of their radii.
MeSH term(s)	Absorption, Physicochemical ; Absorption, Radiation ; Algorithms ; Computer Simulation ; Materials Testing/methods ; Models, Chemical ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Particle Size ; Refractometry/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Suspensions/analysis ; Suspensions/chemistry
Chemical Substances	Suspensions
Language	English
Publishing date	2015-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.54.009082
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Article ; Online: Periprosthetic infection in elderly patients treated with hemiarthroplasty of the hip following intracapsular fracture. Should we use antibiotic-loaded bone cement?

Aedo-Martín, D / Crego-Vita, D / García-Cañas, R / Espigares-Correa, A / Sánchez-Pérez, C / Areta-Jiménez, F J

Revista espanola de cirugia ortopedica y traumatologia

2019 Volume 64, Issue 1, Page(s) 28–34

Abstract: Introduction: Prosthetic infections are a potentially devastating complication, especially in elderly patients. Antibiotic-loaded bone cement has been used both as a treatment and prophylaxis in prosthetic infection, and its use is not well documented ... ...

Title translation	Infección periprótesica en pacientes ancianos tratados mediante hemiartroplastia de cadera tras fractura intracapsular. ¿Debemos usar cementación con antibiótico?
Abstract	Introduction: Prosthetic infections are a potentially devastating complication, especially in elderly patients. Antibiotic-loaded bone cement has been used both as a treatment and prophylaxis in prosthetic infection, and its use is not well documented in the prophylaxis of infection in patients who have suffered a hip fracture. Material: A retrospective descriptive was performed. The data were obtained from all the patients who underwent hip hemiarthroplasty due to a subcapital fracture between 2011 and 2017 (N=241). An epidemiological study of the patients studied was carried out. We analysed the incidence of periprosthetic infection in the groups treated with cement without antibiotic and antibiotic-loaded bone cement, as well as the protective effect of the antibiotic-loaded bone cement. At the same time, a pilot cost analysis study was carried out. Results: In the group that received antibiotic-loaded bone cement (n=94) there were 8 infections (8%), while in the group with cement without antibiotic (n=147) there were 28 infections (19%). The odds ratio (OR) was calculated, showing a 55.3% reduction in the risk of developing late infection in the group that received cement with antibiotic (95% CI: 6.2-78.7%, P=.0025). The use of antibiotic-loaded bone cement led to significant cost savings per patient. Conclusions: The use of antibiotic-loaded bone cement is a protective factor in the development of late infection after hip hemiarthroplasty surgery in elderly patients with hip fracture.
MeSH term(s)	Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Bone Cements/economics ; Bone Cements/therapeutic use ; Cost Savings ; Female ; Hemiarthroplasty/adverse effects ; Hemiarthroplasty/economics ; Hemiarthroplasty/methods ; Hip Fractures/surgery ; Humans ; Incidence ; Male ; Odds Ratio ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/prevention & control ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Bone Cements
Language	Spanish
Publishing date	2019-12-03
Document type	Journal Article
ISSN	2173-576X
ISSN (online)	2173-576X
DOI	10.1016/j.recot.2019.07.005
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Article: Correlation of liver fibrosis quantification by morphometry using HepaScan with the analysis of liver biopsies. A pilot study.

Alemán-García, Nathalie / García-García, José A / Durán-Padilla, Marco A / Ceballos, María E Gutiérrez-Díaz-de / Rizo-Pica, Thelma / Susunaga-Notario, Ana Del C / Sánchez-Pérez, Celia

Gaceta medica de Mexico

2023 Volume 159, Issue 2, Page(s) 122–128

Abstract: Background: The gold standard for determining the degree of liver fibrosis (LF) continues to be biopsy evaluation. There are morphometry techniques that allow LF to be quantified on histopathological studies.: Objective: To measure the correlation ... ...

Title translation	Correlación de la cuantificación de fibrosis hepática por morfometría mediante HepaScan con el análisis de las biopsias hepáticas. Estudio piloto.
Abstract	Background: The gold standard for determining the degree of liver fibrosis (LF) continues to be biopsy evaluation. There are morphometry techniques that allow LF to be quantified on histopathological studies. Objective: To measure the correlation between LF histological evaluation and fibrosis percentage (FP) morphometric quantification using the HepaScan software. Material and methods: Observational, analytical, cross-sectional, prospective, prolective pilot study in which liver histological sections from 29 people who died from some liver disease and from 22 people who died from other causes (controls) were analyzed. FP was calculated with HepaScan on digital photographs of histological sections stained with the Masson technique, comparing it with the diagnosis established by three expert pathologists. Results: Four-hundred and one images from the group with liver disease and 250 from the control group were analyzed. Inter-observer agreement had a kappa index of 0.329. There were FP statistically significant differences (p = 0.0001) between histopathological classification groups. HepaScan predictive capacity based on the area under the receiver operating characteristic curve was 0.983, 0.812, and 0.895 for mild, moderate, and severe fibrosis, respectively. Conclusions: HepaScan showed very good performance for evaluating FP in histological sections, which is why it can contribute to qualitative pathological diagnosis.
MeSH term(s)	Humans ; Pilot Projects ; Prospective Studies ; Cross-Sectional Studies ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Biopsy ; Fibrosis
Language	English
Publishing date	2023-04-24
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M23000758
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Article ; Online: Clinical validation of 3D-printed swabs in adults and children for SARS-CoV-2 detection.

Sanchez-Sandoval, Ana Laura / Sánchez-Pérez, Celia / García-García, José Antonio / Uriega-González, Silvia Plata / Guerrero-Avendaño, Guadalupe Mercedes Lucía / Barrón-Palma, Eira Valeria

Biology methods & protocols

2023 Volume 8, Issue 1, Page(s) bpad009

Abstract: Throughout the entire coronavirus disease 19 (COVID-19) pandemic, there were disruptions in the supply chain of test materials around the world, primarily in poor- and middle-income countries. The use of 3D prints is an alternative to address swab supply ...

Abstract	Throughout the entire coronavirus disease 19 (COVID-19) pandemic, there were disruptions in the supply chain of test materials around the world, primarily in poor- and middle-income countries. The use of 3D prints is an alternative to address swab supply shortages. In this study, the feasibility of the clinical use of 3D-printed swabs for oropharyngeal and nasopharyngeal sampling for the detection of SARS-CoV-2 infection was evaluated. For that purpose, paired samples with the 3D printed and the control swabs were taken from 42 adult patients and 10 pediatric patients, and the results obtained in the detection of SARS-CoV-2 by reverse transcription and quantitative polymerase chain reaction (RT-qPCR) were compared. Additionally, in those cases where the result was positive for SARS-CoV-2, the viral load was calculated by means of a mathematical algorithm proposed by us. For both adults and children, satisfactory results were obtained in the detection of SARS-CoV-2 by RT-qPCR; no significant differences were found in the quantification cycle values between the 3D-printed swab samples and the control samples. Furthermore, we corroborated that the 3D-printed swabs caused less discomfort and pain at the time of sampling. In conclusion, this study shows the feasibility of routinely using 3D-printed swabs for both adults and children. In this way, it is possible to maintain local and cheaper consumption along with fewer distribution difficulties.
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article
ISSN	2396-8923
ISSN (online)	2396-8923
DOI	10.1093/biomethods/bpad009
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