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  1. Book ; Online: The Routledge Handbook of Nature-Based Tourism Development

    Mandić, Ante / Walia, Sandeep K

    2023  

    Keywords Tourism industry ; art-based methods; participatory design; stakeholder engagement; nature-based site; cultural tourism; cultural sensitivity; sustainability
    Language English
    Size 1 Online-Ressource
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English
    HBZ-ID HT030382901
    ISBN 9781003230748 ; 1003230741
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The loss of profilin1 is catastrophic to podocytes.

    Mallipattu, Sandeep K

    The Journal of clinical investigation

    2023  Volume 133, Issue 24

    Abstract: Profilin1 belongs to a family of small monomeric actin-binding proteins with diverse roles in fundamental actin-dependent cellular processes required for cell survival. Podocytes are postmitotic visceral epithelial cells critical for the structure and ... ...

    Abstract Profilin1 belongs to a family of small monomeric actin-binding proteins with diverse roles in fundamental actin-dependent cellular processes required for cell survival. Podocytes are postmitotic visceral epithelial cells critical for the structure and function of the kidney filtration barrier. There is emerging evidence that the actin-related mode of cell death known as mitotic catastrophe is an important pathway involved in podocyte loss. In this issue of the JCI, Tian, Pedigo, and colleagues demonstrate that profilin1 deficiency in podocytes triggered cell cycle reentry, resulting in abortive cytokinesis with a loss in ribosomal RNA processing that leads to podocyte loss and glomerulosclerosis. This study demonstrates the essential role of actin dynamics in mediating this fundamental mode of podocyte cell death.
    MeSH term(s) Humans ; Podocytes/metabolism ; Actins/metabolism ; Kidney Diseases/metabolism ; Cell Cycle ; Cell Death
    Chemical Substances Actins
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI175594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Book: Thermal processing of foods

    Sandeep, K. P.

    control and automation

    (IFT press series)

    2011  

    Author's details ed. by K. P. Sandeep
    Series title IFT press series
    Language English
    Size X, 212 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell u.a.
    Publishing place Ames, Iowa u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014651733
    ISBN 978-0-8138-1007-2 ; 0-8138-1007-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    118/529 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Bioenergetics of Axon Integrity and Its Regulation by Oligodendrocytes and Schwann Cells.

    Mishra, Sandeep K / Tiwari, Sandip Prasad

    Molecular neurobiology

    2024  

    Abstract: Axons are long slender portions of neurons that transmit electrical impulses to maintain proper physiological functioning. Axons in the central nervous system (CNS) and peripheral nervous system (PNS) do not exist in isolation but are found to form a ... ...

    Abstract Axons are long slender portions of neurons that transmit electrical impulses to maintain proper physiological functioning. Axons in the central nervous system (CNS) and peripheral nervous system (PNS) do not exist in isolation but are found to form a complex association with their surrounding glial cells, oligodendrocytes and Schwann cells. These cells not only myelinate them for faster nerve impulse conduction but are also known to provide metabolic support. Due to their incredible length, continuous growth, and distance from the cell body (where major energy synthesis takes place), axons are in high energetic demand. The stability and integrity of axons have long been associated with axonal energy levels. The current mini-review is thus focused on how axons accomplish their high energetic requirement in a cell-autonomous manner and how the surrounding glial cells help them in maintaining their integrity by fulfilling their energy demands (non-cell autonomous trophic support). The concept that adjacent glial cells (oligodendrocytes and Schwann cells) provide trophic support to axons and assist them in maintaining their integrity comes from the conditional knockout research and the studies in which the metabolic pathways controlling metabolism in these glial cells are modulated and its effect on axonal integrity is evaluated. In the later part of the mini-review, the current knowledge of axon-glial metabolic coupling during various neurodegenerative conditions was discussed, along with the potential lacunae in our current understanding of axon-glial metabolic coupling.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-03950-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Frozen too: Adopt the new or let it go?

    Dhande, Mehak / Jain, Sandeep K

    Journal of cardiovascular electrophysiology

    2024  Volume 35, Issue 4, Page(s) 843–845

    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.16233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Pharmacologic Management of Non-Eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases.

    Dellon, Evan S / Gupta, Sandeep K

    Immunology and allergy clinics of North America

    2024  Volume 44, Issue 2, Page(s) 397–406

    Abstract: Data for pharmacologic treatments for non-eosinophilic esophagitis (EoE) eosinophilic gastrointestinal diseases (EGIDs) are limited. Nevertheless, because of the increasing understanding of EGID pathogenesis, a number of medications are used to treat ... ...

    Abstract Data for pharmacologic treatments for non-eosinophilic esophagitis (EoE) eosinophilic gastrointestinal diseases (EGIDs) are limited. Nevertheless, because of the increasing understanding of EGID pathogenesis, a number of medications are used to treat EGIDs, though all are currently off-label. Initial therapy generally starts with corticosteroids, and "topical" delivery is preferred over systemic due to long-term side effects. A number of other small molecules could potentially be used, ranging from allergy medications to immunosuppressants. Biologics are also being used and investigated for EGIDs and represent promising targeted therapies. Multiple therapeutic targets have also been identified, many of which overlap with EoE targets.
    MeSH term(s) Humans ; Eosinophilia/diagnosis ; Eosinophilia/drug therapy ; Esophagitis/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Immunosuppressive Agents ; Enteritis/diagnosis ; Enteritis/drug therapy ; Enteritis/etiology
    Chemical Substances Adrenal Cortex Hormones ; Immunosuppressive Agents
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2024.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 710: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A Systematic Review on the Effects of Acute Aerobic Exercise on Neurophysiological, Molecular, and Behavioral Measures in Chronic Stroke.

    Sivaramakrishnan, Anjali / Subramanian, Sandeep K

    Neurorehabilitation and neural repair

    2023  Volume 37, Issue 2-3, Page(s) 151–164

    Abstract: Background: A single bout of aerobic exercise (AE) can produce changes in neurophysiological and behavioral measures in healthy individuals and those with stroke. However, the effects of AE-priming effects on neuroplasticity markers and behavioral ... ...

    Abstract Background: A single bout of aerobic exercise (AE) can produce changes in neurophysiological and behavioral measures in healthy individuals and those with stroke. However, the effects of AE-priming effects on neuroplasticity markers and behavioral measures are unclear.
    Objectives: This systematic review aimed to examine the effects of AE on neuroplasticity measures, such as corticomotor excitability (CME), molecular markers, cortical activation, motor learning, and performance in stroke.
    Methods: A literature search was performed in MEDLINE, CINAHL, Scopus, and PsycINFO databases. Randomized and non-randomized studies incorporating acute AE in stroke were selected. Two reviewers independently assessed the risk of bias and methodological rigor of the studies and extracted data on participant characteristics, exercise interventions, and neuroplasticity related outcomes. The quality of transcranial magnetic stimulation reported methods was assessed using a standardized checklist.
    Results: A total of 16 studies were found suitable for inclusion. Our findings suggest mixed evidence for the effects of AE on CME, limited to no effects on intracortical inhibition and facilitation and some evidence for modulating brain derived neurotrophic factor levels, motor learning, and cortical activation. Exercise intensities in the moderate to vigorous range showed a trend towards better effects on neuroplasticity measures.
    Conclusion: It appears that choosing a moderate to vigorous exercise paradigm for at least 20 to 30 minutes may induce changes in some neuroplasticity parameters in stroke. However, these findings necessitate prudent consideration as the studies were diverse and had moderate methodological quality. There is a need for a consensus on an exercise priming paradigm and for good-quality, larger controlled studies.
    MeSH term(s) Humans ; Exercise/physiology ; Stroke ; Transcranial Magnetic Stimulation ; Neuronal Plasticity/physiology ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1491637-x
    ISSN 1552-6844 ; 1545-9683 ; 0888-4390
    ISSN (online) 1552-6844
    ISSN 1545-9683 ; 0888-4390
    DOI 10.1177/15459683221146996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3096: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Dialysis resource allocation in critical care: the impact of the COVID-19 pandemic and the promise of big data analytics.

    Koraishy, Farrukh M / Mallipattu, Sandeep K

    Frontiers in nephrology

    2023  Volume 3, Page(s) 1266967

    Abstract: The COVID-19 pandemic resulted in an unprecedented burden on intensive care units (ICUs). With increased demands and limited supply, critical care resources, including dialysis machines, became scarce, leading to the undertaking of value-based cost- ... ...

    Abstract The COVID-19 pandemic resulted in an unprecedented burden on intensive care units (ICUs). With increased demands and limited supply, critical care resources, including dialysis machines, became scarce, leading to the undertaking of value-based cost-effectiveness analyses and the rationing of resources to deliver patient care of the highest quality. A high proportion of COVID-19 patients admitted to the ICU required dialysis, resulting in a major burden on resources such as dialysis machines, nursing staff, technicians, and consumables such as dialysis filters and solutions and anticoagulation medications. Artificial intelligence (AI)-based big data analytics are now being utilized in multiple data-driven healthcare services, including the optimization of healthcare system utilization. Numerous factors can impact dialysis resource allocation to critically ill patients, especially during public health emergencies, but currently, resource allocation is determined using a small number of traditional factors. Smart analytics that take into account all the relevant healthcare information in the hospital system and patient outcomes can lead to improved resource allocation, cost-effectiveness, and quality of care. In this review, we discuss dialysis resource utilization in critical care, the impact of the COVID-19 pandemic, and how AI can improve resource utilization in future public health emergencies. Research in this area should be an important priority.
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2813-0626
    ISSN (online) 2813-0626
    DOI 10.3389/fneph.2023.1266967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Systematic review of assessment in undergraduate competency-based medical education and extrapolation of an assessment framework for Indian context - A study protocol.

    Gupta, Sandeep K / Srivastava, Tripti

    Journal of education and health promotion

    2023  Volume 12, Page(s) 242

    Abstract: There is a lack of studies that have systematically synthesized the existing literature related to the competency-based medical education (CBME) assessment process and identified gaps in existing knowledge about the assessment process structure. The aims ...

    Abstract There is a lack of studies that have systematically synthesized the existing literature related to the competency-based medical education (CBME) assessment process and identified gaps in existing knowledge about the assessment process structure. The aims of this study are as follows: 1. A systematic review of the assessment framework of CBME 2. Designing a model framework of assessment for CBME that will be relevant in the Indian context. The databases searched will be PubMed, MEDLINE (Ovid), EMBASE (Ovid), Scopus, Web of Science, and Google Scholar. General limits to the search will be set in the English language, published between January 2006 and December 2020, specific to competency-based education and assessment methods. After initial screening for duplicates and search limits, the title and abstract of the remaining studies will be screened. Subsequently, the full text of the articles will be screened against the inclusion and exclusion criteria for final selection. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart of the systematic review will be used to describe the selection of the studies. The article quality will be assessed using the quality assessment tool for diverse study designs (QATSDD). The data synthesis will start with a descriptive summary (in tabular form) of the included studies. This study will try to provide comprehensive data to address challenges related to the CBME assessment process, which can help in evolving the robust assessment framework of CBME.
    Language English
    Publishing date 2023-07-29
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2715449-X
    ISSN 2319-6440 ; 2277-9531
    ISSN (online) 2319-6440
    ISSN 2277-9531
    DOI 10.4103/jehp.jehp_1434_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Monitoring of surrogate zoonotic parasites of Anisakidae and

    Yadav, Anita / Malhotra, Sandeep K

    Journal of parasitic diseases : official organ of the Indian Society for Parasitology

    2023  Volume 47, Issue 4, Page(s) 793–806

    Abstract: The unique characteristic of quickly altered but stable response by helminth parasites against metals and elements in a variety of aquatic ecosystems because of pollution conditions merit these as significant markers of fish health as well as of marine ... ...

    Abstract The unique characteristic of quickly altered but stable response by helminth parasites against metals and elements in a variety of aquatic ecosystems because of pollution conditions merit these as significant markers of fish health as well as of marine and freshwater ecosystems. Biomagnification of toxicants released in aquatic reservoirs by human mediated processes incorporating mining in coastal zones, industrial and agricultural inputs contributed to damaging consequences of human health due particularly to human consumption of edible fish and other biota that are exposed to contaminants in aquatic ecosystems. The metals and elements analysed could be arranged in decreasing order of concentration were found to be, P > Ca > Cd > Mn > Hg > Pb > As > Zn > S > Fe > Al > Cr > Mg > Cl. The association between
    Language English
    Publishing date 2023-09-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 2548456-4
    ISSN 0975-0703 ; 0971-7196
    ISSN (online) 0975-0703
    ISSN 0971-7196
    DOI 10.1007/s12639-023-01625-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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