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Article ; Online: Intradiploic meningioma- A rare osteolytic calvarial lesion

Sandeep B V

Asian Journal of Medical Sciences, Vol 7, Iss 6, Pp 103-

A case report and review of literature

2016 Volume 105

Abstract: Meningiomas are most commonest benign intracranial neoplasm which are encountered in clinical practice. One of the most uncommon variant is intradiploic meningiomas, which can present as osteoblastic or osteolytic calvarial lesion and should be ... ...

Abstract	Meningiomas are most commonest benign intracranial neoplasm which are encountered in clinical practice. One of the most uncommon variant is intradiploic meningiomas, which can present as osteoblastic or osteolytic calvarial lesion and should be considered as differential diagnosis. We here present a rare case report of osteolytic intradiploic meningioma of skull presenting as scalp mass with a background of head injury and discuss its management.
Keywords	intradiploic meningioma ; osteolytic lesion ; calvarial lesion ; Medicine ; R
Language	English
Publishing date	2016-10-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A rare case of intracranial malignant melanoma with an unusual presentation

Sandeep B V

Asian Journal of Medical Sciences, Vol 7, Iss 6, Pp 91-

2016 Volume 93

Abstract: Among the common skin cancers, melanoma is the most lethal. Although, it comprises only 3% of all skin cancers diagnosed , it accounts for about 75% of all skin cancer-related deaths. Melanoma is a relatively uncommon skin cancer in geographical ... ...

Abstract	Among the common skin cancers, melanoma is the most lethal. Although, it comprises only 3% of all skin cancers diagnosed , it accounts for about 75% of all skin cancer-related deaths. Melanoma is a relatively uncommon skin cancer in geographical locations like India. Its highest incidence is seen in sixth decade . Head and neck melanomas constitute approximately 17% of all cutaneous melanomas .We present a 15 year old male patient who presented with a intracranial melanoma with osteolytic skull lesion.
Keywords	melanoma ; osteolytic skull lesions ; intracranial melanoma ; Medicine ; R
Language	English
Publishing date	2016-10-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Calming the Storm: Natural Immunosuppressants as Adjuvants to Target the Cytokine Storm in COVID-19.

Peter, Angela E / Sandeep, B V / Rao, B Ganga / Kalpana, V Lakshmi

Frontiers in pharmacology

2021 Volume 11, Page(s) 583777

Abstract: The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat the infection and the absence of a suitable vaccine to prevent it. While some individuals contracting the SARS-CoV-2 infection exhibit a well coordinated immune ... ...

Abstract	The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat the infection and the absence of a suitable vaccine to prevent it. While some individuals contracting the SARS-CoV-2 infection exhibit a well coordinated immune response and recover, others display a dysfunctional immune response leading to serious complications including ARDS, sepsis, MOF; associated with morbidity and mortality. Studies revealed that in patients with a dysfunctional immune response, there is a massive cytokine and chemokine release, referred to as the 'cytokine storm'. As a result, such patients exhibit higher levels of pro-inflammatory/modulatory cytokines and chemokines like TNFα, INFγ, IL-1β, IL-2, IL-4, IL-6, IL-7, IL-9, IL-10, IL-12, IL-13, IL-17, G-CSF, GM-CSF, MCSF, HGF and chemokines CXCL8, MCP1, IP10, MIP1α and MIP1β. Targeting this cytokine storm is a novel, promising treatment strategy to alleviate this excess influx of cytokines observed at the site of infection and their subsequent disastrous consequences. Natural immunosuppressant compounds, derived from plant sources like curcumin, luteolin, piperine, resveratrol are known to inhibit the production and release of pro-inflammatory cytokines and chemokines. This inhibitory effect is mediated by altering signal pathways like NF-κB, JAK/STAT, MAPK/ERK that are involved in the production and release of cytokines and chemokines. The use of these natural immunosuppressants as adjuvants to ameliorate the cytokine storm; in combination with antiviral agents and other treatment drugs currently in use presents a novel, synergistic approach for the treatment and effective cure of COVID-19. This review briefly describes the immunopathogenesis of the cytokine storm observed in SARS-CoV-2 infection and details some natural immunosuppressants that can be used as adjuvants in treating COVID-19 disease.
Language	English
Publishing date	2021-01-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.583777
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Neurosurgical experiences of a Bengaluru teaching hospital during the COVID-19 pandemic.

Lavadi, Raj Swaroop / Sandeep, B V / Banga, Manpreet Singh / Halhalli, Sangamesh / Kishan, Anantha

Surgical neurology international

2022 Volume 13, Page(s) 3

Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_1179_2021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analyzing variability of craniometric parameters using computed tomography scan in Indian population

Sandeep B V / Raj Swaroop Lavadi / Manpreet Singh Banga / Sangamesh Halhalli / Anantha Kishan / Hiba Salam

Asian Journal of Medical Sciences, Vol 13, Iss 11, Pp 238-

2022 Volume 245

Abstract: Background: The craniovertebral junction (CVJ) is a crucial region of the spine designed for optimal movements of head and is also a frequent site for various pathological processes. The importance of knowing the CVJ parameters in normal population ... ...

Abstract	Background: The craniovertebral junction (CVJ) is a crucial region of the spine designed for optimal movements of head and is also a frequent site for various pathological processes. The importance of knowing the CVJ parameters in normal population cannot be overstated when instrumentation and correction of deformities in this region is so frequently being performed. There is paucity of data defining the craniometrics of CVJ osteology in Indian population on the literature search. Accordingly, we present a study in an attempt to quantitate the normal craniometric indices for anatomically normal CVJ in Indian population and compare them with the existing literature from other regions. Aims and Objectives: The aims of this study were to quantitate the normal craniometric indices for anatomically normal CVJ in Indian population and compare them with the existing literature from other regions. Materials and Methods: Two hundred and forty computed tomography (CTs) belonging to Indians were looked at over a 6-month period retrospectively. These patients had normal CVJs and were ordered imaging for other health reasons. A total of eight parameters were analyzed for each CT. Results: There were 166 (69.2%) males and 74 (30.8%) females in our study. The values (in mm) were as follows: anterior atlantodental interval (AADI), 1.78±0.42; PADI (posterior atlantodental interval), 18.12±1.97; distance of tip of odontoid process to chamberlain’s line, –2.73±2.63; distance of tip of odontoid process to McGregor’s line, –2.29±2.79; distance of tip of odontoid process to McRae’s line, –5.91±1.4; Clivus-canal angle, 160.82°±7.14°; basion dens interval, 5.6±1.45; and powers ratio, 0.71±0.07. No patient had an odontoid process extending beyond the McRae’s line. Males were more likely to have higher AADI and PADI values than females. Our study shared significant differences between the other studies (even the studies where an Indian population was used) except one. The AADI, from our study, did not vary significantly when compared to ...
Keywords	craniovertebral junction ; craniometry ; skull base ; computed tomography ; Medicine ; R
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Chronic Epidural Hematoma: Still a Rare Entity?

Banga, Manpreet Singh / Sandeep, B. V. / Dixit, Sourabh

Indian Journal of Neurotrauma

2021 Volume 19, Issue 01, Page(s) 23–28

Abstract: Introduction: Extradural hematoma diagnosed more than 14 days after head injury is classified as a chronic extradural hematoma (CEDH). In the present study, we presented a series of 8 patients with CEDH in a span of 6 months.: Materials and Methods: ... ...

Abstract	Introduction: Extradural hematoma diagnosed more than 14 days after head injury is classified as a chronic extradural hematoma (CEDH). In the present study, we presented a series of 8 patients with CEDH in a span of 6 months. Materials and Methods: In this article, we reported 8 cases of CEDH who presented to Nil Ratan Sircar Medical College, Kolkata, West Bengal, India, within a span of 6 months. Discussion: Extratemporal epidural hematomas (EDHs) are often due to venous bleeding from the diploic veins or dural sinuses or to delayed rupture of a middle meningeal pseudoaneurysm. In these cases, cerebrospinal fluid may redistribute from the lateral ventricles and thus allowing room for the enlarging hematoma producing vague neurological symptoms and signs. The incidence rate of CEDH reported in the literature ranges from 3.9 to 30% of all EDHs. Computed tomography (CT) scan in CEDH often shows a low-density center surrounded by a high-density margin. Calcification of the displaced dura mater may also occur. Some are identified incidentally, whereas others are diagnosed when investigating for persistent and/or progressive neurological symptoms. Symptomatic CEDH should be surgically evacuated and has an excellent outcome the earlier it is done. In patients with no or mild symptoms, normal neurological status, and a small-sized CEDH spontaneous resolution may be expected. Conclusion: In the post-CT era, it is always said that CEDH is a rare entity. However, in developing countries we still encounter a large number of such cases and the question arises whether CEDH is still a rare entity.
Keywords	epidural hematoma ; uncal herniation ; neurodeficits ; head injury ; craniotomy
Language	English
Publishing date	2021-04-15
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2266738-6
ISSN	2213-3739 ; 0973-0508 ; 2213-3739
ISSN (online)	2213-3739
ISSN	0973-0508 ; 2213-3739
DOI	10.1055/s-0041-1727555
Database	Thieme publisher's database

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Article: Spinal intramedullary tuberculoma in a 3-year-old girl.

Lavadi, Raj Swaroop / Sandeep, B V / Banga, Manpreet Singh / Halhalli, Sangamesh / Kishan, Anantha

Surgical neurology international

2021 Volume 12, Page(s) 609

Abstract: Background: Spinal intramedullary tuberculoma (IMT) is a rare manifestation of extrapulmonary tuberculosis (TB). Presentation of TB in the pediatric age group is a significant contributor to mortality.: Case description: A young vaccinated girl ... ...

Abstract	Background: Spinal intramedullary tuberculoma (IMT) is a rare manifestation of extrapulmonary tuberculosis (TB). Presentation of TB in the pediatric age group is a significant contributor to mortality. Case description: A young vaccinated girl presented to the neurosurgery department with difficulty walking and urinary incontinence. A magnetic resonance imaging performed outside the hospital showed a hyperintense intramedullary lesion extending from T6 to T9. The patient underwent T6-T9 laminoplasty with intramedullary lesion decompression under neuromonitoring. The dense adherence of the lesion to the cord and nerve roots permitted only debulking. Histopathological examination confirmed the diagnosis of tuberculoma. The patient was started on antitubercular treatment and was then subsequently discharged. After 8 months, the patient was reviewed and showed improvement in her symptoms and complete resolution of the lesion on imaging. The patient has now developed hydrocephalus on the latest computed tomography imaging, which may be due to tubercular meningitis or arachnoiditis. Conclusion: Complete resolution of spinal IMT is possible with a combined treatment approach.
Language	English
Publishing date	2021-12-14
Publishing country	United States
Document type	Case Reports
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_1043_2021
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Article: Cerebral venous thrombosis with a catch.

Lavadi, Raj Swaroop / Sandeep, B V / Banga, Manpreet Singh / Halhalli, Sangamesh / Kishan, Anantha

Surgical neurology international

2021 Volume 12, Page(s) 590

Abstract: Background: Cerebral venous thrombosis (CVT) is a rare entity typically occurring in patients in hypercoagulable states. They can also occur in cases of trauma. The symptoms are nonspecific.: Case description: A 28-year-old male presented to the ... ...

Abstract	Background: Cerebral venous thrombosis (CVT) is a rare entity typically occurring in patients in hypercoagulable states. They can also occur in cases of trauma. The symptoms are nonspecific. Case description: A 28-year-old male presented to the emergency department with a head injury. During the necessary imaging, it was found that he had a depressed skull fracture and other signs of traumatic brain injury. Unbeknownst to the patient and the patient party, it was also revealed that the patient only had one kidney. Wound debridement and excision of the depressed fracture were performed. A postoperative MRI revealed that the patient had CVT. Conclusion: There should be a high index of suspicion for CVT in case of traumatic head injuries. The surgeon should plan management according to the patient's comorbidities.
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Case Reports
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_1021_2021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bilateral abducens palsy in closed head injury

Sandeep B V / Rekha K R / Manpreet Singh Banga / Anantha Kishan / Vittal I Nayak / Sneha Priya Prabhakar

Asian Journal of Medical Sciences, Vol 12, Iss 10, Pp 164-

A comprehensive review of literature based on a case report

2021 Volume 170

Abstract: Isolated bilateral sixth nerve palsies are rare, particularly in the setting of trauma. Most post-head injury cases with bilateral abducens palsy involve either basal skull fractures, particularly clival fractures. We present a case of bilateral abducens ...

Abstract	Isolated bilateral sixth nerve palsies are rare, particularly in the setting of trauma. Most post-head injury cases with bilateral abducens palsy involve either basal skull fractures, particularly clival fractures. We present a case of bilateral abducens palsy after closed head injury in a young male who presented to the emergency department and a comprehensive literature review based on our clinical case. A Medline search for bilateral abducens palsy in closed head injury showed 89 results. Articles were excluded if crush head injury, non-traumatic bilateral abducens nerve palsy, associated vascular malformations were reported. After thorough search and filtering of those articles, fifty-one publications were found which reported and discussed about traumatic bilateral abducens palsy with closed head injury. In these 51 articles, a total of 139 cases were recorded. Several theories have been postulated to explain mechanisms of abducens nerve injury in trauma both in immediate and delayed settings. In our case, patient presented with immediate onset of bilateral abducens palsy. On imaging, clival fracture was seen in CT brain, which can be attributed for the nerve injury. Cases with retroclival extradural haematoma had higher chances of multiple cranial nerve injuries. Cases with multiple basal skull fracture involving petrous temporal bone fracture had higher chances of facial nerve injury. Along with bilateral involvement, the poorer outcome for recovery can be related with the severity of the adduction deficit. Our case showed no improvement in bilateral abduction during follow-up at 6 months. Clinical presentation of traumatic bilateral abducens nerve palsy is rare following closed head trauma and is usually associated with other injuries which are incompatible with life. It can be associated with other nerve injuries depending on basal skull fractures.
Keywords	bilateral abducens palsy ; head injury ; clival fracture ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Atlantoaxial Dislocation: Surgical Outcome following Anterior Retropharyngeal Approach to Odontoid with or without Fixation

Banga, Manpreet Singh / Sandeep, B.V. / Saha, Suniti Kumar / Roy, Kaushik / Dixit, Sourabh / Ghosh, Partha

Indian Journal of Neurosurgery

2021 Volume 11, Issue 01, Page(s) 13–18

Abstract: Introduction: Atlantoaxial dislocation (AAD) refers to a loss of stability between the atlas and axis vertebra. The conventional transoral approach and the anterior retropharyngeal approach (ARPA) are adequate for the upper cervical vertebral segments. ... ...

Abstract	Introduction: Atlantoaxial dislocation (AAD) refers to a loss of stability between the atlas and axis vertebra. The conventional transoral approach and the anterior retropharyngeal approach (ARPA) are adequate for the upper cervical vertebral segments. This study was undertaken to evaluate the usefulness of the ARPA to the odontoid in patients of AAD. Materials and Methods: The study was undertaken on 20 patients admitted in Nil Ratan Sircar Medical College and Hospital, Kolkata, India, with functional disability secondary to AAD. These patients underwent surgery through ARPA to odontoid with or without fixation. Patients were analyzed between October 2014 and September 2016. Results: Maximum number of patients belonged to third decade of life. The male to female ratio was 1.5. The mean duration of symptoms was 10.86 months. Weakness of the upper and lower limbs predominated. About 65% patients had axial neck pain. Nine patients (45%) in total had difficulty in either bowel or bladder. Five patients presented with fracture odontoid and pannus formation of the odontoid process, while six had basilar invagination. One patient underwent anterior odontoid screw fixation and the other 19 patients underwent anterior retropharyngeal odontoidectomy with posterior fixation. Two patients expired in the present study. Most of the patients had improvement in Nurick grade during follow-up. Five patients had transient throat pain and dysphagia. Three patients had superficial surgical site infection. One patient had postoperative cerebrospinal fluid leak. Conclusion: The ARPA to odontoid is a feasible approach for decompression and fixation of the odontoid in AAD cases.
Keywords	atlantoaxial dislocation ; anterior retropharyngeal ; Nurick grade
Language	English
Publishing date	2021-05-07
Publisher	Thieme Medical and Scientific Publishers Private Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2698542-1
ISSN	2277-9167 ; 2277-954X ; 2277-9167
ISSN (online)	2277-9167
ISSN	2277-954X ; 2277-9167
DOI	10.1055/s-0040-1721237
Database	Thieme publisher's database

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