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Article ; Online: The scenario of delayed graft function in Brazil.

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

2019 Volume 41, Issue 2, Page(s) 166–167

MeSH term(s)	Brazil ; Delayed Graft Function ; Graft Survival ; Humans ; Kidney Transplantation ; Tissue Donors
Language	Portuguese
Publishing date	2019-02-25
Publishing country	Brazil
Document type	Editorial ; Comment
ZDB-ID	2057873-8
ISSN	2175-8239 ; 0101-2800
ISSN (online)	2175-8239
ISSN	0101-2800
DOI	10.1590/2175-8239-JBN-2018-0221
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Article ; Online: Long-term Comparison of Everolimus and Mycophenolate in Tacrolimus-based and Steroid-free Immunosuppressive Regimen.

Sandes-Freitas, Tainá Veras de / Costa, Silvana Daher / Pinheiro, Petrucia Maria Antero / Sales, Maria Luíza de Mattos Brito Oliveira / Girão, Celi Melo / Esmeraldo, Ronaldo de Matos

Transplantation

2024 Volume 108, Issue 5, Page(s) e72–e73

MeSH term(s)	Humans ; Everolimus/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Immunosuppressive Agents/adverse effects ; Tacrolimus/therapeutic use ; Mycophenolic Acid/therapeutic use ; Mycophenolic Acid/adverse effects ; Sirolimus/therapeutic use ; Sirolimus/adverse effects ; Kidney Transplantation ; Graft Rejection/prevention & control ; Graft Rejection/immunology ; Treatment Outcome ; Middle Aged ; Female ; Time Factors ; Male ; Drug Therapy, Combination ; Adult
Chemical Substances	Everolimus (9HW64Q8G6G) ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM) ; Mycophenolic Acid (HU9DX48N0T) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Letter ; Comparative Study ; Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004941
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Article ; Online: Expanded donor criteria in kidney transplantation: a suitable option to increase the donor pool in Brazil?

Sandes-Freitas, Tainá Veras de

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

2016 Volume 38, Issue 3, Page(s) 273–274

Language	Portuguese
Publishing date	2016-07
Publishing country	Brazil
Document type	Editorial
ZDB-ID	2057873-8
ISSN	2175-8239 ; 0101-2800
ISSN (online)	2175-8239
ISSN	0101-2800
DOI	10.5935/0101-2800.20160040
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Article ; Online: Organ Transplant From SARS-CoV-2-Positive Donors: A Brazilian Experience.

Sandes-Freitas, Taina Veras De / De Almeida, Eliana Regia Barbosa / Garcia, Regina Célia Ferreira Gomes / Girão, Evelyne Santana / Coelho, Gustavo Rego / Garcia, José Huygens Parente

Transplantation proceedings

2022

Abstract: Since March 2022, donors with detectable SARS-CoV-2 RNA have been accepted for extrapulmonary organ transplants in Brazil. In this report, we described 11 successful organ transplants (6 kidney, 5 liver) from 5 asymptomatic infected donors. ...

Abstract	Since March 2022, donors with detectable SARS-CoV-2 RNA have been accepted for extrapulmonary organ transplants in Brazil. In this report, we described 11 successful organ transplants (6 kidney, 5 liver) from 5 asymptomatic infected donors.
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2022.08.013
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Article ; Online: Estimated glomerular filtration rate in clinical practice: Consensus positioning of the Brazilian Society of Nephrology (SBN) and Brazilian Society of Clinical Pathology and Laboratory Medicine (SBPC/ML).

Kirsztajn, Gianna Mastroianni / Silva Junior, Geraldo Bezerra da / Silva, Artur Quintiliano Bezerra da / Abensur, Hugo / Romão Junior, João Egídio / Bastos, Marcus Gomes / Calice-Silva, Viviane / Carmo, Lilian Pires de Freitas do / Sandes-Freitas, Tainá Veras de / Abreu, Patrícia Ferreira / Andreguetto, Bruna Dolci / Cortes, Luiz Gustavo Ferreira / Oliveira, Maria Gabriela de Lucca / Vieira, Luisane Maria Falci / Moura-Neto, José A / Andriolo, Adagmar

Jornal brasileiro de nefrologia

2024 Volume 46, Issue 3, Page(s) e20230193

Abstract: Chronic kidney disease (CKD) represents one of today's main public health problems. Serum creatinine measurement and estimation of the glomerular filtration rate (GFR) are the main tools for evaluating renal function. There are several equations to ... ...

Abstract	Chronic kidney disease (CKD) represents one of today's main public health problems. Serum creatinine measurement and estimation of the glomerular filtration rate (GFR) are the main tools for evaluating renal function. There are several equations to estimate GFR, and CKD-EPI equation (Chronic Kidney Disease - Epidemiology) is the most recommended one. There are still some controversies regarding serum creatinine measurement and GFR estimation, since several factors can interfere in this process. An important recent change was the removal of the correction for race from the equations for estimating GFR, which overestimated kidney function, and consequently delayed the implementation of treatments such as dialysis and kidney transplantation. In this consensus document from the Brazilian Societies of Nephrology and Clinical Pathology and Laboratory Medicine, the main concepts related to the assessment of renal function are reviewed, as well as possible existing controversies and recommendations for estimating GFR in clinical practice.
MeSH term(s)	Humans ; Glomerular Filtration Rate ; Nephrology ; Creatinine ; Brazil ; Consensus ; Renal Dialysis ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Pathology, Clinical
Chemical Substances	Creatinine (AYI8EX34EU)
Language	Portuguese
Publishing date	2024-04-05
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2057873-8
ISSN	2175-8239 ; 2175-8239
ISSN (online)	2175-8239
ISSN	2175-8239
DOI	10.1590/2175-8239-JBN-2023-0193en
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Article ; Online: Fall in organ donations and transplants in Ceará in the COVID-19 pandemic: a descriptive study, April - June 2020.

Araújo, Anna Yáskara Cavalcante Carvalho de / Almeida, Eliana Régia Barbosa de / Lima, Lúcio Kildare E Silva / Sandes-Freitas, Tainá Veras de / Pinto, Antonio Germane Alves

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

2020 Volume 30, Issue 1, Page(s) e2020754

Abstract: Objective: To describe organ donations and transplants in Ceará state, Brazil, following the declaration of the COVID-19 pandemic.: Methods: This was a descriptive study using data from the Brazilian Organ Transplantation Association. The number of ... ...

Title translation	Declínio nas doações e transplantes de órgãos no Ceará durante a pandemia da COVID-19: estudo descritivo, abril a junho de 2020.
Abstract	Objective: To describe organ donations and transplants in Ceará state, Brazil, following the declaration of the COVID-19 pandemic. Methods: This was a descriptive study using data from the Brazilian Organ Transplantation Association. The number of donors and transplants from April to June 2020 was compared to the same period in 2019 and to the first quarter of 2020. Results: In the first half of 2020, the state registered 72 effective donors, just 17 (23.6%) of whom related to the second quarter. Of the 352 transplants in the first half of 2020, 37 (10.7%) were performed in the second quarter. Compared with the period from April to June 2019, there was a reduction of 67.9% and 89.3% in the number of donors and transplants, respectively, in the same period of 2020. Conclusion: The number of donors and transplants in Ceará showed an important fall in the three months following the declaration of the COVID-19 pandemic, especially for kidney, heart and cornea transplants.
MeSH term(s)	Brazil ; COVID-19 ; Humans ; Organ Transplantation/statistics & numerical data ; Tissue Donors/statistics & numerical data ; Tissue and Organ Procurement/statistics & numerical data
Language	Portuguese
Publishing date	2020-12-18
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2880588-4
ISSN	2237-9622 ; 1679-4974
ISSN (online)	2237-9622
ISSN	1679-4974
DOI	10.1590/S1679-49742021000100016
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Article ; Online: Migratory pattern of the coronavirus disease 2019 and high fatality rates among kidney transplant recipients: report from the Brazilian Multicenter Cohort Study.

Cristelli, Marina Pontello / Sandes-Freitas, Tainá Veras de / Viana, Laila Almeida / Requião-Moura, Lúcio R / Andrade, Luis Gustavo Modelli de / Tedesco-Silva, Helio / Medina-Pestana, José

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

2021 Volume 44, Issue 3, Page(s) 428–433

Abstract: Introduction: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report ... ...

Abstract	Introduction: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has affected kidney transplant (KT) recipients, with worldwide fatality rates around 25%. Considering the well-known Brazilian socio-demographic disparities, this report describes for the first time the main outcomes of COVID-19 in KT recipients according to Brazilian geographic regions. Methods: This multicenter national retrospective analysis included data from KT recipients with confirmed COVID-19 between March and November 2020. Results: Thirty-five of the 81 centers (57% of KT activity in Brazil) reported 1,680 patients with COVID-19. The Northeast was the first to reach the peak in the number of infections. The Southeast, due to its population density, contributed with the largest number of patients. Patients had a median age of 52 years, 76% had hypertension and 34% diabetes, 75% were recipients of a deceased donor, and the time interval between diagnosis and transplantation was 5.9 years. In 53% of patients, immunosuppression was adjusted, and clinical support varied according to geographic region. Hospitalization was required for 65% of the patients, 35% of them needed intensive care, 25% mechanical ventilation, and 23% renal replacement therapy. The 90-day overall fatality was 21%, being 23% in the Southeast, 16% in the Northeast, and 19% in the Central-west and South regions. Conclusion: The migratory pattern of the pandemic among KT recipients followed that of the general population and the outcomes were influenced by regional features. COVID-19 in KT recipients was associated with high utilization of health-care resources and higher fatality rates than those reported in the general population.
MeSH term(s)	Brazil/epidemiology ; COVID-19 ; Humans ; Kidney Transplantation ; Middle Aged ; Retrospective Studies ; SARS-CoV-2
Language	Portuguese
Publishing date	2021-07-31
Publishing country	Brazil
Document type	Journal Article ; Multicenter Study
ZDB-ID	2057873-8
ISSN	2175-8239 ; 2175-8239
ISSN (online)	2175-8239
ISSN	2175-8239
DOI	10.1590/2175-8239-JBN-2021-0063
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Article ; Online: Prevalência e fatores associados a não inscrição para transplante renal.

Santos, Francisca Maria Rodrigues Dos / Pessoa, Vera Lucia Mendes de Paula / Florêncio, Raquel Sampaio / Figueirêdo, Webertty Mayk Eufrásio de / Nobre, Paulo Henrique Pessoa / Sandes-Freitas, Tainá Veras de

Cadernos de saude publica

2021 Volume 37, Issue 6, Page(s) e00043620

Abstract: This study evaluated the prevalence and factors associated with lack of enrollment for kidney transplant among patients in chronic dialysis in Greater Metropolitan Fortaleza, Ceará, Brazil. The sample excluded patients with insufficient clinical status ... ...

Title translation	Prevalence and factors associated with non-enrollment for kidney transplant.
Abstract	This study evaluated the prevalence and factors associated with lack of enrollment for kidney transplant among patients in chronic dialysis in Greater Metropolitan Fortaleza, Ceará, Brazil. The sample excluded patients with insufficient clinical status and those already in pre-kidney transplant evaluation. A semi-structured questionnaire was applied, including options for the question, "What is the main reason why you are not enrolled for kidney transplant?" Prevalence of patients considered fit but not enrolled or in pre- kidney transplant evaluation was 50.7%. The main reasons were fear of failure/loss of grafting (32.5%), difficulty with transportation or access to tests (20.9%), and temporary personal or family problems (13.7%). In the multivariate analysis, the variables associated with fear of failure or loss of graft were female sex (OR = 1.763; 95%CI: 1.224-2.540) and end-stage renal disease (ESRD) due to hypertension (OR = 1.732; 95%CI: 1.178-2.547), while monthly income (number of minimum wages) showed a protective association (OR = 0.882; 95%CI: 0.785-0.991). Time on dialysis (months) was a risk factor for difficulty with transportation and access to tests (OR = 1.004; 95%CI: 1.001-1.007), and female sex showed a protective association (OR = 0.576; 95%CI: 0.368-0.901). These results show high prevalence of patients in dialysis not enrolled on the kidney transplant waitlist. The main causes were lack of information and lack of access. Female sex, low income, and ESRD due to hypertension were risk factors for lack of enrollment on the kidney transplant waitlist due to fear of loss of graft, resulting from lack of information on this treatment modality. Male sex and longer time on dialysis were risk factors for difficulty in access to kidney transplant.
MeSH term(s)	Brazil/epidemiology ; Female ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Male ; Prevalence ; Renal Dialysis ; Risk Factors
Language	Portuguese
Publishing date	2021-06-04
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311X00043620
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Article ; Online: The impact of deceased donor maintenance on delayed kidney allograft function: A machine learning analysis.

Costa, Silvana Daher / de Andrade, Luis Gustavo Modelli / Barroso, Francisco Victor Carvalho / Oliveira, Cláudia Maria Costa de / Daher, Elizabeth De Francesco / Fernandes, Paula Frassinetti Castelo Branco Camurça / Esmeraldo, Ronaldo de Matos / Sandes-Freitas, Tainá Veras de

PloS one

2020 Volume 15, Issue 2, Page(s) e0228597

Abstract: Background: This study evaluated the risk factors for delayed graft function (DGF) in a country where its incidence is high, detailing donor maintenance-related (DMR) variables and using machine learning (ML) methods beyond the traditional regression- ... ...

Abstract	Background: This study evaluated the risk factors for delayed graft function (DGF) in a country where its incidence is high, detailing donor maintenance-related (DMR) variables and using machine learning (ML) methods beyond the traditional regression-based models. Methods: A total of 443 brain dead deceased donor kidney transplants (KT) from two Brazilian centers were retrospectively analyzed and the following DMR were evaluated using predictive modeling: arterial blood gas pH, serum sodium, blood glucose, urine output, mean arterial pressure, vasopressors use, and reversed cardiac arrest. Results: Most patients (95.7%) received kidneys from standard criteria donors. The incidence of DGF was 53%. In multivariable logistic regression analysis, DMR variables did not impact on DGF occurrence. In post-hoc analysis including only KT with cold ischemia time<21h (n = 220), urine output in 24h prior to recovery surgery (OR = 0.639, 95%CI 0.444-0.919) and serum sodium (OR = 1.030, 95%CI 1.052-1.379) were risk factors for DGF. Using elastic net regularized regression model and ML analysis (decision tree, neural network and support vector machine), urine output and other DMR variables emerged as DGF predictors: mean arterial pressure, ≥ 1 or high dose vasopressors and blood glucose. Conclusions: Some DMR variables were associated with DGF, suggesting a potential impact of variables reflecting poor clinical and hemodynamic status on the incidence of DGF.
MeSH term(s)	Brazil ; Cold Ischemia/adverse effects ; Delayed Graft Function/epidemiology ; Delayed Graft Function/etiology ; Humans ; Incidence ; Kidney Transplantation/methods ; Kidney Transplantation/standards ; Machine Learning ; Retrospective Studies ; Risk Factors ; Tissue Donors ; Transplantation, Homologous
Language	English
Publishing date	2020-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0228597
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Article: Clinical Features of Kidney Transplant Recipients Admitted to the Intensive Care Unit.

Freitas, Flávio Geraldo Rezende / Lombardi, Fábio / Pacheco, Eduardo Souza / Sandes-Freitas, Tainá Veras de / Viana, Laila Almeida / Junior, Hélio Tedesco-Silva / Medina-Pestana, José Osmar / Bafi, Antônio Tonete / Machado, Flavia Ribeiro

Progress in transplantation (Aliso Viejo, Calif.)

2017 Volume 28, Issue 1, Page(s) 56–62

Abstract: Introduction: There is a paucity of data regarding the complications in kidney transplant patients who may require intensive care unit (ICU) management, despite being the most common solid organ transplant worldwide.: Objective: To identify the main ... ...

Abstract	Introduction: There is a paucity of data regarding the complications in kidney transplant patients who may require intensive care unit (ICU) management, despite being the most common solid organ transplant worldwide. Objective: To identify the main reasons for ICU admission and to determine the factors associated with hospital mortality in kidney transplant recipients. Design: This single-center retrospective cohort study was conducted between September 2013 and June 2014, including all consecutive kidney transplant patients requiring ICU admission. We collected data on patient demographics, transplant characteristics, clinical data, and prognostic scores. The independent determinants of hospital mortality were identified by multiple logistic regression analysis. We also assessed the performance of Simplified Acute Physiology Score 3 (SAPS 3) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores. Results: We analyzed data from 413 patients, the majority of whom were admitted late after renal transplantation (1169 days; 63-3003 days). The main reason for admission was sepsis (33.2%), followed by cardiovascular disease (16%). Age (odds ratio [OR] 1.05, confidence interval [CI], 1.01-1.09), SAPS 3 score (OR 1.04, CI, 1.01-1.08), the need for mechanical ventilation (OR 26.47, CI, 10.30-68.08), and vasopressor use (OR 3.34, CI, 1.37-8.13) were independently associated with hospital mortality. The performance of SAPS 3 and APACHE II scores was poor in this population and overestimated the mortality rates. Conclusion: Sepsis was the main reason for ICU admission in kidney transplant recipients, followed by cardiovascular disease. Age and disease severity were associated with hospital mortality.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Critical Care/statistics & numerical data ; Female ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Length of Stay/statistics & numerical data ; Logistic Models ; Male ; Middle Aged ; Postoperative Complications/therapy ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Transplant Recipients/statistics & numerical data
Language	English
Publishing date	2017-12-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2019786-X
ISSN	1526-9248
ISSN	1526-9248
DOI	10.1177/1526924817746685
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