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  1. Article ; Online: The grade of individual prostate cancer lesions predicted by magnetic resonance imaging and positron emission tomography.

    Nilsson, Erik / Sandgren, Kristina / Grefve, Josefine / Jonsson, Joakim / Axelsson, Jan / Lindberg, Angsana Keeratijarut / Söderkvist, Karin / Karlsson, Camilla Thellenberg / Widmark, Anders / Blomqvist, Lennart / Strandberg, Sara / Riklund, Katrine / Bergh, Anders / Nyholm, Tufve

    Communications medicine

    2023  Volume 3, Issue 1, Page(s) 164

    Abstract: Background: Multiparametric magnetic resonance imaging (mpMRI) and positron emission tomography (PET) are widely used for the management of prostate cancer (PCa). However, how these modalities complement each other in PCa risk stratification is still ... ...

    Abstract Background: Multiparametric magnetic resonance imaging (mpMRI) and positron emission tomography (PET) are widely used for the management of prostate cancer (PCa). However, how these modalities complement each other in PCa risk stratification is still largely unknown. We aim to provide insights into the potential of mpMRI and PET for PCa risk stratification.
    Methods: We analyzed data from 55 consecutive patients with elevated prostate-specific antigen and biopsy-proven PCa enrolled in a prospective study between December 2016 and December 2019. [
    Results: We find that the maximum standardized uptake value (SUV
    Conclusions: By co-registering whole-mount histopathology and in-vivo imaging we show that mpMRI and PET can distinguish between lower- and higher-grade prostate cancer, using partially discriminative cut-off values.
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-023-00394-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Histopathology-validated lesion detection rates of clinically significant prostate cancer with mpMRI, [ 68 Ga]PSMA-11-PET and [ 11 C]Acetate-PET.

    Sandgren, Kristina / Strandberg, Sara N / Jonsson, Joakim H / Grefve, Josefine / Keeratijarut Lindberg, Angsana / Nilsson, Erik / Bergh, Anders / Söderkvist, Karin / Thellenberg Karlsson, Camilla / Friedrich, Bengt / Widmark, Anders / Blomqvist, Lennart / Berg Loegager, Vibeke / Axelsson, Jan / Ögren, Mattias / Ögren, Margareta / Nyholm, Tufve / Riklund, Katrine

    Nuclear medicine communications

    2023  Volume 44, Issue 11, Page(s) 997–1004

    Abstract: Objective: PET/CT and multiparametric MRI (mpMRI) are important diagnostic tools in clinically significant prostate cancer (csPC). The aim of this study was to compare csPC detection rates with [ 68 Ga]PSMA-11-PET (PSMA)-PET, [ 11 C]Acetate (ACE)-PET, ... ...

    Abstract Objective: PET/CT and multiparametric MRI (mpMRI) are important diagnostic tools in clinically significant prostate cancer (csPC). The aim of this study was to compare csPC detection rates with [ 68 Ga]PSMA-11-PET (PSMA)-PET, [ 11 C]Acetate (ACE)-PET, and mpMRI with histopathology as reference, to identify the most suitable imaging modalities for subsequent hybrid imaging. An additional aim was to compare inter-reader variability to assess reproducibility.
    Methods: During 2016-2019, all study participants were examined with PSMA-PET/mpMRI and ACE-PET/CT prior to radical prostatectomy. PSMA-PET, ACE-PET and mpMRI were evaluated separately by two observers, and were compared with histopathology-defined csPC. Statistical analyses included two-sided McNemar test and index of specific agreement.
    Results: Fifty-five study participants were included, with 130 histopathological intraprostatic lesions >0.05 cc. Of these, 32% (42/130) were classified as csPC with ISUP grade ≥2 and volume >0.5 cc. PSMA-PET and mpMRI showed no difference in performance ( P  = 0.48), with mean csPC detection rate of 70% (29.5/42) and 74% (31/42), respectively, while with ACE-PET the mean csPC detection rate was 37% (15.5/42). Interobserver agreement was higher with PSMA-PET compared to mpMRI [79% (26/33) vs 67% (24/38)]. Including all detected lesions from each pair of observers, the detection rate increased to 90% (38/42) with mpMRI, and 79% (33/42) with PSMA-PET.
    Conclusion: PSMA-PET and mpMRI showed high csPC detection rates and superior performance compared to ACE-PET. The interobserver agreement indicates higher reproducibility with PSMA-PET. The combined result of all observers in both PSMA-PET and mpMRI showed the highest detection rate, suggesting an added value of a hybrid imaging approach.
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Registration of histopathology to magnetic resonance imaging of prostate cancer.

    Sandgren, Kristina / Nilsson, Erik / Keeratijarut Lindberg, Angsana / Strandberg, Sara / Blomqvist, Lennart / Bergh, Anders / Friedrich, Bengt / Axelsson, Jan / Ögren, Margareta / Ögren, Mattias / Widmark, Anders / Thellenberg Karlsson, Camilla / Söderkvist, Karin / Riklund, Katrine / Jonsson, Joakim / Nyholm, Tufve

    Physics and imaging in radiation oncology

    2021  Volume 18, Page(s) 19–25

    Abstract: Background and purpose: The diagnostic accuracy of new imaging techniques requires validation, preferably by histopathological verification. The aim of this study was to develop and present a registration procedure between histopathology and : ... ...

    Abstract Background and purpose: The diagnostic accuracy of new imaging techniques requires validation, preferably by histopathological verification. The aim of this study was to develop and present a registration procedure between histopathology and
    Materials and methods: For twenty-five prostate cancer patients, planned for radical prostatectomy, a 3D-printed prostate mold based on
    Results: Eighty-four landmarks were identified, located in the urethra (62%), prostatic cysts (33%), and the ejaculatory ducts (5%). The median number of landmarks was 3 per patient. We showed a median in-plane error of 1.8 mm before and 1.7 mm after the contour-correcting deformable registration. In patients with extraprostatic margins, the median in-plane error improved from 2.1 mm to 1.8 mm after the contour-correcting deformable registration.
    Conclusions: Our registration procedure accurately registers histopathology to
    Language English
    Publishing date 2021-04-12
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-6316
    ISSN (online) 2405-6316
    DOI 10.1016/j.phro.2021.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Imaging for the Detection of Locoregional Recurrences in Biochemical Progression After Radical Prostatectomy-A Systematic Review.

    Sandgren, Kristina / Westerlinck, Philippe / Jonsson, Joakim H / Blomqvist, Lennart / Thellenberg Karlsson, Camilla / Nyholm, Tufve / Dirix, Piet

    European urology focus

    2017  Volume 5, Issue 4, Page(s) 550–560

    Abstract: Context: Local and regional recurrence after radical prostatectomy (RP) can be treated using salvage radiotherapy (SRT). If the recurrence can be delineated on diagnostic imaging, this could allow for increasingly individualized SRT.: Objective: This ...

    Abstract Context: Local and regional recurrence after radical prostatectomy (RP) can be treated using salvage radiotherapy (SRT). If the recurrence can be delineated on diagnostic imaging, this could allow for increasingly individualized SRT.
    Objective: This systematic review aimed at evaluating the evidence regarding the usefulness of positron emission tomography (PET) and magnetic resonance imaging (MRI) in identifying local and regional recurrences, with the aim to further individualize the SRT treatment.
    Evidence acquisition: A systematic PubMed/Medline search was conducted in December 2015. Studies included were imaging studies of post-RP patients focusing on local and/or regional recurrence where sensitivity and specificity of MRI or PET were the primary end points. Only studies using biopsy, other histological analysis, and/or treatment follow-up as reference standard were included. Quality Assessment of Diagnostic Accuracy Studies-2 was used to score the study quality. Twenty-five articles were deemed of sufficient quality and included in the review.
    Evidence synthesis: [
    Conclusions: Both MRI and PET have adequate sensitivity and specificity for the detection of prostate cancer recurrences post-RP. Multiparametric MRI, using diffusion-weighted and/or DCE imaging, and the choline-labeled tracers showed high pooled sensitivity and specificity, although their ranges were broad.
    Patient summary: After reviewing imaging studies of recurrent prostate cancer after prostatectomy, we concluded that choline positron emission tomography and diffusion-weighted magnetic resonance imaging can be proposed as the current standard, with high sensitivity and specificity.
    MeSH term(s) Disease Progression ; Humans ; Magnetic Resonance Imaging ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/radiotherapy ; Positron-Emission Tomography ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Salvage Therapy
    Language English
    Publishing date 2017-11-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2017.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Radiation dosimetry of [

    Sandgren, Kristina / Johansson, Lennart / Axelsson, Jan / Jonsson, Joakim / Ögren, Mattias / Ögren, Margareta / Andersson, Martin / Strandberg, Sara / Nyholm, Tufve / Riklund, Katrine / Widmark, Anders

    EJNMMI physics

    2019  Volume 6, Issue 1, Page(s) 2

    Abstract: Background: 68: Methods: Six low-risk prostate cancer patients were injected with 133-178 MBq [: Results: [: Conclusion: The effective dose for [ ...

    Abstract Background: 68
    Methods: Six low-risk prostate cancer patients were injected with 133-178 MBq [
    Results: [
    Conclusion: The effective dose for [
    Language English
    Publishing date 2019-01-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2768912-8
    ISSN 2197-7364
    ISSN 2197-7364
    DOI 10.1186/s40658-018-0239-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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