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Article ; Online: Refer with CLOTHS.

Patel, J / Tyers, C / Sandhu, P

2020 Volume 228, Issue 3, Page(s) 137

MeSH term(s)	Mouth Diseases/diagnosis
Language	English
Publishing date	2020-02-14
Publishing country	England
Document type	Letter
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-020-1249-8
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Article ; Online: Winter is coming.

Sandhu, P / Grossman, S / Sproat, C / Patel, V

British dental journal

2020 Volume 229, Issue 8, Page(s) 500

MeSH term(s)	COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Seasons ; United Kingdom
Keywords	covid19
Language	English
Publishing date	2020-10-20
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-020-2296-x
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Article ; Online: The impact of COVID-19 on the undergraduate medical curriculum.

Sandhu, Preeti / de Wolf, Maisie

Medical education online

2020 Volume 25, Issue 1, Page(s) 1764740

Abstract: The coronavirus pandemic has impacted medical education globally. As universities seek to deliver medical education through new methods of modalities, this continuing of education ensures the learning of the future workforce of the NHS. Novel ways of ... ...

Abstract	The coronavirus pandemic has impacted medical education globally. As universities seek to deliver medical education through new methods of modalities, this continuing of education ensures the learning of the future workforce of the NHS. Novel ways of online teaching should be considered in new medical curricula development, as well as methods of delivering practical skills for medical students online.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Curriculum ; Education, Distance ; Education, Medical ; Education, Medical, Undergraduate ; Humans ; Learning ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Students, Medical ; Teaching ; Universities
Keywords	covid19
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Letter
ISSN	1087-2981
ISSN (online)	1087-2981
DOI	10.1080/10872981.2020.1764740
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Article ; Online: Standardizing mammogram screening in primary care: Integrating an evidence-based approach.

Go, Lacrisha / Sandhu, Prabjot

Journal of the American Association of Nurse Practitioners

2020 Volume 33, Issue 9, Page(s) 688–697

Abstract: Background: Mammogram screening for surveillance and detection of breast cancer has been long recognized as a preventive health measure in primary care for women. However, a clear consensus on when to start screening individual women, based on age and ... ...

Abstract	Background: Mammogram screening for surveillance and detection of breast cancer has been long recognized as a preventive health measure in primary care for women. However, a clear consensus on when to start screening individual women, based on age and risk factors, lacks guidance. Reputable organizations uphold varying breast cancer screening (BCS) guidelines for women potentiating the risk for fragmented and inconsistent practices among health care providers (HCPs). Objectives: This review aims to evaluate the current literature on the possible risks, benefits, and limitations associated with BCS for women between 40 and 49 years and to discuss the need for a more individualized, evidence-based approach to BCS. Data sources: A comprehensive systematic review of eight articles, along with five clinical practice guidelines published within the past 10 years that address advantages and disadvantages of receiving mammography for women in their fourth decade was completed. Conclusions: There is insufficient evidence to promote adherence to any single clinical practice guideline for the benefit of all patients. Further high-level research is needed, as well as the assessment of individual risk factors influencing breast cancer development and screening outcomes. Implications for practice: There is a significant need for further education for HCPs and the development of tools that incorporate a BCS shared decision-making process. Current practice lacks the ability to easily screen individual patients with a method that identifies the appropriate age to screen and addresses the benefits, risks, and limitations of mammography.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Early Detection of Cancer ; Female ; Humans ; Mammography ; Mass Screening ; Primary Health Care
Language	English
Publishing date	2020-06-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2716317-9
ISSN	2327-6924 ; 1745-7599 ; 2327-6886 ; 1041-2972
ISSN (online)	2327-6924 ; 1745-7599
ISSN	2327-6886 ; 1041-2972
DOI	10.1097/JXX.0000000000000418
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Article: Effect of various stratification regimes on seed germination in cold-hardy garden roses

Sandhu, P / R. Conev

Acta horticulturae. 2016 Nov. 25, , no. 1127

2016

Abstract: Garden roses have notoriously low and lengthy seed germination, which is a serious limitation to the effectiveness of breeding protocols. A series of experiments have been conducted at Vineland, Canada, to study the effect of achene acid scarification ... ...

Abstract	Garden roses have notoriously low and lengthy seed germination, which is a serious limitation to the effectiveness of breeding protocols. A series of experiments have been conducted at Vineland, Canada, to study the effect of achene acid scarification and enzyme maceration, as well as the synergetic effect of these techniques combined with various warm and cold stratification regimes on rose seed germination. In this experiment (2011-2012), we studied the germination response of four very hardy rose cultivars to eight stratification treatments (T) (three replications per treatment; 50 achenes per replication). Achenes from 'Cape Diamond', 'Champlain', 'Frontenac', and 'Morden Sunrise' were subjected to: T1, 5 weeks warm stratification (5WWS) + 6 weeks cold stratification (6WCS); T2, 5WWS + 9WCS; T3, 5WWS + 12WCS; T4, 5WWS + 15WCS; T5, 8WWS + 6WCS; T6, 8WWS + 9WCS; T7, 8WWS + 12 WCS; and T8, 8WWS + 15WCS. Hips in identical ripening stage were harvested on October 26, 2011, and the achenes from all treatments received uniform pre-treatment with cellulase (0.5% for 38 h) followed by leaching in water for 48 h. None of the cultivars responded to T1 or T5. 'Cape Diamond' had a gradual increase of germination in response to longer warm and cold stratification regimes, with the best performance of 23% in T8. 'Morden Sunrise' had best germination of 20% in T4. 'Champlain' and 'Frontenac' had almost identical germination responses - 17 and 19%, respectively to T3; 28 and 29%, respectively, to T4; 23 and 24%, respectively, to T7; and 25 and 24%, respectively, to T8.
Keywords	breeding ; cultivars ; endo-1,4-beta-glucanase ; fruits ; leaching ; maceration ; ripening ; Rosa ; seed germination ; synergism ; Canada
Language	English
Dates of publication	2016-1125
Size	p. 231-236.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014): International Symposium on Plant Breeding in Horticulture held August 17-22, 2014, Brisbane, Australia
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Interventional radiology and the need for specialist status in the United Kingdom.

Sandhu, Preeti / Heer, Randeep S / Adio, Binyamin

Journal of medical imaging and radiation sciences

2021 Volume 52, Issue 2, Page(s) 157–159

MeSH term(s)	Humans ; Radiology, Interventional ; Specialization ; United Kingdom
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2426513-5
ISSN	1876-7982 ; 1939-8654
ISSN (online)	1876-7982
ISSN	1939-8654
DOI	10.1016/j.jmir.2021.01.007
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Article: High-Grade Intraventricular Astroblastoma in a Young Adult: A Rare and Controversial Tumor to Manage.

Singh, Karuna / Garg, Shipra / Rani, Shilp / Sandhu, Parvinder

Asian journal of neurosurgery

2021 Volume 16, Issue 3, Page(s) 567–574

Abstract: Astroblastoma is a rare primary central nervous system tumor of controversial site of origin. They account for 0.45-2.8% of all primary neuroepithelial central nervous system. It has been reported in paediatric age group with bimodal age distribution ... ...

Abstract	Astroblastoma is a rare primary central nervous system tumor of controversial site of origin. They account for 0.45-2.8% of all primary neuroepithelial central nervous system. It has been reported in paediatric age group with bimodal age distribution affecting more females with male to female ratio being 1:11. Astroblastomas are controversial and challenging tumors in terms of diagnosis and therapeutics. Since it carries an unpredictable disease course it needs a regular follow up even for low grade tumor. Authors have tried various schedules of post op radiotherapy after maximum safe resection. Various chemotherapeutic drugs combination have also been tried without much success. We here report a 35 years old female patient who was diagnosed with high grade astroblastoma referred for post-operative radiotherapy after gross total resection. Since it is extremely rare tumor, its treatment still not well defined and also makes it difficult conduct studies to examine tumor characteristics.
Language	English
Publishing date	2021-09-14
Publishing country	India
Document type	Case Reports
ZDB-ID	2621446-5
ISSN	2248-9614 ; 1793-5482
ISSN (online)	2248-9614
ISSN	1793-5482
DOI	10.4103/ajns.AJNS_430_20
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Article ; Online: The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated during Human Cytomegalovirus Infection to Regulate Iron Levels.

Martin, Madison / Sandhu, Praneet / Kumar, Rinki / Buchkovich, Nicholas J

Journal of virology

2022 Volume 96, Issue 6, Page(s) e0180621

Abstract: Human cytomegalovirus (HCMV) modulates numerous cellular pathways to facilitate infection. Iron is essential to many cellular processes and is often incorporated into proteins and enzymes involved in oxidative phosphorylation and DNA synthesis and repair, ...

Abstract	Human cytomegalovirus (HCMV) modulates numerous cellular pathways to facilitate infection. Iron is essential to many cellular processes and is often incorporated into proteins and enzymes involved in oxidative phosphorylation and DNA synthesis and repair, among others. Despite its prominent role in the cell, little is known about the regulation of iron metabolism during HCMV infection. Herein, we observe modulation of the transferrin receptor (TfR) during infection and a corresponding change in the cellular labile iron pool. TfR and the iron pool are increased early during infection and then return to mock levels at the late stages of infection. We identified the cellular ubiquitin ligase MARCH1 as an important regulator of TfR. MARCH1 plays a proviral role during infection, as its knockdown leads to a decrease in infectious titers. Knockdown of MARCH1 also leads to an increase in ROS, lipid peroxidation, and mitochondrial dysfunction. Inhibiting an early increase in TfR expression during infection also decreases virus production. These findings indicate the importance of tightly regulating iron metabolism during HCMV infection to facilitate efficient virus production.
MeSH term(s)	Cytomegalovirus/physiology ; Cytomegalovirus Infections/enzymology ; Cytomegalovirus Infections/physiopathology ; Humans ; Iron/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Up-Regulation
Chemical Substances	Iron (E1UOL152H7) ; MARCHF1 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01806-21
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Article: The impact of the cessation of primary dental care services on oral cancer diagnosis at a single institution in the UK's epicentre during the COVID-19 pandemic.

Sandhu, Pradeep / Grossman, Sanford / Beneng, Kiran

Oral surgery

2021 Volume 14, Issue 4, Page(s) 328–334

Abstract: Aims: COVID-19 put an unprecedented strain on healthcare services that was complicated by the widespread cessation of all face-to-face primary care dental activity from 23 March 2020 for 7 weeks. This led to a focus on telephone triage and remote ... ...

Abstract	Aims: COVID-19 put an unprecedented strain on healthcare services that was complicated by the widespread cessation of all face-to-face primary care dental activity from 23 March 2020 for 7 weeks. This led to a focus on telephone triage and remote prescribing that potentially impeded urgent referrals for suspected oral cancer. Guy's and St Thomas' NHS Foundation Trust (GSTFT) screens and diagnoses potential head and neck cancer patients via a 2-week wait (2 WW) clinic and provides access to patients with urgent oral health needs through an Acute Dental Care (ADC) service. The current service evaluation aims to assess and report on the impact of COVID-19 and the cessation of primary care dentistry on oral cancer diagnosis at GSTFT during a period of time where patients had extremely limited access to healthcare. Materials and methods: Data regarding oral cancer diagnoses were collected retrospectively from secure logbooks and clinical records from the point at which routine dental practice was nationally halted (23 March 2020) to the date at which services were permitted to resume (08 June 2020). Individual patient pathways prior to diagnosis and through to treatment were recorded. Results: Sixteen new diagnoses of oral cancer were made during the described timeframe. Findings suggest that the paralysis of routine dental services resulted in delayed referral of suspicious lesions and highlights the limitations of a predominately telephone-based assessment service in primary care. Conclusion: The importance of the role of the primary care practitioner in the early identification of oral cancer has been emphasised.
Language	English
Publishing date	2021-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2423337-7
ISSN	1752-248X ; 1752-2471
ISSN (online)	1752-248X
ISSN	1752-2471
DOI	10.1111/ors.12626
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Article ; Online: The continuation of oral anticoagulation and antiplatelet therapy for dento-alveolar surgery: a service evaluation.

Sandhu, Pradeep / Mayor, Serena / Sproat, Christopher / Kwok, Jerry / Beneng, Kiran / Patel, Vinod

British dental journal

2023 Volume 235, Issue 5, Page(s) 313–318

Abstract: Background Patients taking oral anticoagulants (OACs) and oral antiplatelets (OAPs) have a risk of post-operative bleeding when dental extractions are required. Guidance exists to assist dental practitioners on how best to clinically manage these ... ...

Abstract	Background Patients taking oral anticoagulants (OACs) and oral antiplatelets (OAPs) have a risk of post-operative bleeding when dental extractions are required. Guidance exists to assist dental practitioners on how best to clinically manage these patients, but this is based upon low-quality evidence. The current service evaluation provides real world clinical data when these drugs are not discontinued for oral surgery procedures.Materials and methods All OACs and OAPs were continued and patients requiring dental extractions had local haemostatic measures (local anaesthesia with adrenaline, socket packing with haemostat and resorbable sutures). All patients were offered a follow-up via a telephone clinic service after surgery to assess any post-operative bleeding.Results A total of 439 patients underwent 513 surgical episodes, equating to 1,001 dental extractions. Overall, 412 (95.9%) patients reported no post-operative bleeding complications. A total of 18 (4.1%) patients reported post-operative bleeding requiring further intervention. All but two patients were managed with local haemostatic measures, and no patient required hospital admission. For the single novel OAC cohort of patients, 8/185 (4.3%) procedures had post-operative bleeding.Conclusion This current service evaluation highlights that the risk of significant or life-threatening bleeding following dental extraction when OACs or OAPs are continued remains rare.
MeSH term(s)	Humans ; Platelet Aggregation Inhibitors/adverse effects ; Dentists ; Professional Role ; Anticoagulants/adverse effects ; Hemostatics ; Postoperative Hemorrhage/prevention & control ; Postoperative Complications/prevention & control
Chemical Substances	Platelet Aggregation Inhibitors ; Anticoagulants ; Hemostatics
Language	English
Publishing date	2023-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	218090-x
ISSN	1476-5373 ; 0007-0610
ISSN (online)	1476-5373
ISSN	0007-0610
DOI	10.1038/s41415-023-6227-5
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