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  1. Article ; Online: Child mask mandates for COVID-19: a systematic review.

    Sandlund, Johanna / Duriseti, Ram / Ladhani, Shamez N / Stuart, Kelly / Noble, Jeanne / Høeg, Tracy Beth

    Archives of disease in childhood

    2024  Volume 109, Issue 3, Page(s) e2

    Abstract: Background: Mask mandates for children during the COVID-19 pandemic varied in different locations. A risk-benefit analysis of this intervention has not yet been performed. In this study, we performed a systematic review to assess research on the ... ...

    Abstract Background: Mask mandates for children during the COVID-19 pandemic varied in different locations. A risk-benefit analysis of this intervention has not yet been performed. In this study, we performed a systematic review to assess research on the effectiveness of mask wearing in children.
    Methods: We performed database searches up to February 2023. The studies were screened by title and abstract, and included studies were further screened as full-text references. A risk-of-bias analysis was performed by two independent reviewers and adjudicated by a third reviewer.
    Results: We screened 597 studies and included 22 in the final analysis. There were no randomised controlled trials in children assessing the benefits of mask wearing to reduce SARS-CoV-2 infection or transmission. The six observational studies reporting an association between child masking and lower infection rate or antibody seropositivity had critical (n=5) or serious (n=1) risk of bias; all six were potentially confounded by important differences between masked and unmasked groups and two were shown to have non-significant results when reanalysed. Sixteen other observational studies found no association between mask wearing and infection or transmission.
    Conclusions: Real-world effectiveness of child mask mandates against SARS-CoV-2 transmission or infection has not been demonstrated with high-quality evidence. The current body of scientific data does not support masking children for protection against COVID-19.
    MeSH term(s) Child ; Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Pandemics/prevention & control ; Bias ; Antibodies
    Chemical Substances Antibodies
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-326215
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  2. Article ; Online: Ultrasensitive Detection of Clostridium difficile Toxins Reveals Suboptimal Accuracy of Toxin Gene Cycle Thresholds for Toxin Predictions.

    Sandlund, Johanna / Wilcox, Mark H

    Journal of clinical microbiology

    2019  Volume 57, Issue 6

    Abstract: The use of nucleic acid amplification tests (NAATs) for the diagnosis ... ...

    Abstract The use of nucleic acid amplification tests (NAATs) for the diagnosis of
    MeSH term(s) Clostridium Infections/diagnosis ; Clostridium Infections/microbiology ; Clostridium difficile/classification ; Clostridium difficile/genetics ; Enterotoxins/genetics ; Humans ; Polymerase Chain Reaction/methods ; Polymerase Chain Reaction/standards ; Reproducibility of Results
    Chemical Substances Enterotoxins
    Language English
    Publishing date 2019-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01885-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to Tenover et al., "Guidelines Support the Value of Stand-Alone Nucleic Acid Amplification Tests for

    Sandlund, Johanna / Wilcox, Mark H

    Journal of clinical microbiology

    2019  Volume 57, Issue 10

    MeSH term(s) Clostridium Infections ; Clostridium difficile/genetics ; Enterocolitis, Pseudomembranous ; Humans ; Nucleic Acid Amplification Techniques
    Language English
    Publishing date 2019-09-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01157-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ultrasensitive Clostridioides difficile Toxin Testing for Higher Diagnostic Accuracy.

    Sandlund, Johanna / Davies, Kerrie / Wilcox, Mark H

    Journal of clinical microbiology

    2020  Volume 58, Issue 6

    Abstract: Currently available diagnostic tests ... ...

    Abstract Currently available diagnostic tests for
    MeSH term(s) Clostridioides ; Clostridioides difficile ; Clostridium Infections/diagnosis ; Enterotoxins ; Feces ; Humans ; Sensitivity and Specificity
    Chemical Substances Enterotoxins
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01913-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Traveler's encounter with nymphs in a hotel bed.

    Sandlund, Johanna / Banaei, Niaz

    IDCases

    2014  Volume 1, Issue 2, Page(s) 24–25

    Abstract: This case illustrates skin lesions in a traveler staying in a hotel bed infested with tics. Although infestation of hotels with bedbugs belonging to the Cimex genus is a growing problem worldwide, tick infestation has never been reported before. ...

    Abstract This case illustrates skin lesions in a traveler staying in a hotel bed infested with tics. Although infestation of hotels with bedbugs belonging to the Cimex genus is a growing problem worldwide, tick infestation has never been reported before.
    Language English
    Publishing date 2014-03-24
    Publishing country Netherlands
    Document type Journal Article ; Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2014.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of Cycle Threshold, Toxin Concentration, and Clinical Characteristics of Clostridioides difficile Infection in Patients with Discordant Diagnostic Test Results.

    Shah, Megan D / Balada-Llasat, Joan-Miquel / Coe, Kelci / Reed, Erica / Sandlund, Johanna / Pancholi, Preeti

    Journal of clinical microbiology

    2020  Volume 58, Issue 5

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    MeSH term(s) Adult ; Bacterial Proteins ; Bacterial Toxins ; Clostridioides ; Clostridioides difficile ; Clostridium Infections/diagnosis ; Diagnostic Tests, Routine ; Enterotoxins ; Feces ; Humans ; Sensitivity and Specificity
    Chemical Substances Bacterial Proteins ; Bacterial Toxins ; Enterotoxins
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01681-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: High Agreement Between an Ultrasensitive Clostridioides difficile Toxin Assay and a C. difficile Laboratory Algorithm Utilizing GDH-and-Toxin Enzyme Immunoassays and Cytotoxin Testing.

    Landry, Marie L / Topal, Jeffrey E / Estis, Joel / Katzenbach, Phoebe / Nolan, Niamh / Sandlund, Johanna

    Journal of clinical microbiology

    2020  Volume 58, Issue 2

    Abstract: The Singulex Clarity C. diff toxins A/B (Clarity) assay is an automated, ultrasensitive immunoassay for the detection ... ...

    Abstract The Singulex Clarity C. diff toxins A/B (Clarity) assay is an automated, ultrasensitive immunoassay for the detection of
    MeSH term(s) Adult ; Algorithms ; Automation, Laboratory ; Bacterial Proteins/analysis ; Bacterial Toxins/analysis ; Clostridioides difficile/chemistry ; Clostridioides difficile/enzymology ; Clostridium Infections/diagnosis ; Enterotoxins/analysis ; Feces/chemistry ; Female ; Glutamate Dehydrogenase/analysis ; Humans ; Immunoenzyme Techniques/standards ; Male ; Sensitivity and Specificity
    Chemical Substances Bacterial Proteins ; Bacterial Toxins ; Enterotoxins ; tcdA protein, Clostridium difficile ; toxB protein, Clostridium difficile ; Glutamate Dehydrogenase (EC 1.4.1.2)
    Language English
    Publishing date 2020-01-28
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01629-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: VEGF: A potential target for hydrocephalus

    Shim, Joon W / Sandlund, Johanna / Madsen, Joseph R

    Cell and tissue research. 2014 Dec., v. 358, no. 3

    2014  

    Abstract: Growth factors are primarily responsible for the genesis, differentiation and proliferation of cells and maintenance of tissues. Given the central role of growth factors in signaling between cells in health and in disease, it is understandable that ... ...

    Abstract Growth factors are primarily responsible for the genesis, differentiation and proliferation of cells and maintenance of tissues. Given the central role of growth factors in signaling between cells in health and in disease, it is understandable that disruption of growth factor-mediated molecular signaling can cause diverse phenotypic consequences including cancer and neurological conditions. This review will focus on the specific questions of enlarged cerebral ventricles and hydrocephalus. It is also well known that angiogenic factors, such as vascular endothelial growth factor (VEGF), affect tissue permeability through activation of receptors and adhesion molecules; hence, recent studies showing elevations of this factor in pediatric hydrocephalus led to the demonstration that VEGF can induce ventriculomegaly and altered ependyma when infused in animals. In this review, we discuss recent findings implicating the involvement of biochemical and biophysical factors that can induce a VEGF-mimicking effect in communicating hydrocephalus and pay particular attention to the role of the VEGF system as a potential pharmacological target in the treatment of some cases of hydrocephalus. The source of VEGF secretion in the cerebral ventricles, in periventricular regions and during pathologic events including hydrocephalus following hypoxia and hemorrhage is sought. The review is concluded with a summary of potential non-surgical treatments in preclinical studies suggesting several molecular targets including VEGF for hydrocephalus and related neurological disorders.
    Keywords adhesion ; animals ; ependyma ; hemorrhage ; hydrocephalus ; hypoxia ; permeability ; receptors ; secretion ; vascular endothelial growth factors
    Language English
    Dates of publication 2014-12
    Size p. 667-683.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-014-1978-6
    Database NAL-Catalogue (AGRICOLA)

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    Z 46/352: Show issues

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  9. Article ; Online: Bacteraemia caused by Actinobaculum schaalii: An overlooked pathogen?

    Sandlund, Johanna / Glimåker, Martin / Svahn, Anita / Brauner, Annelie

    Scandinavian journal of infectious diseases

    2014  Volume 46, Issue 8, Page(s) 605–608

    Abstract: Actinobaculum schaalii is a uropathogen resistant to ciprofloxacin and trimethoprim-sulfamethoxazole. It requires a long culture time and specific conditions, and is therefore easily overgrown by other bacteria and regarded as part of the normal ... ...

    Abstract Actinobaculum schaalii is a uropathogen resistant to ciprofloxacin and trimethoprim-sulfamethoxazole. It requires a long culture time and specific conditions, and is therefore easily overgrown by other bacteria and regarded as part of the normal bacterial flora. We review 17 cases of A. schaalii bacteraemia, demonstrating its invasive potential. A. schaalii should always be ruled out as causative agent in patients with urinary tract infection or urosepticaemia with treatment failure.
    MeSH term(s) Actinomycetaceae/classification ; Actinomycetaceae/genetics ; Actinomycetaceae/isolation & purification ; Actinomycetales Infections/microbiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacteremia/microbiology ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; Female ; Humans ; Male ; Middle Aged ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Urinary Tract Infections/complications ; Young Adult
    Chemical Substances DNA, Bacterial ; DNA, Ribosomal ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 390956-6
    ISSN 1651-1980 ; 0036-5548
    ISSN (online) 1651-1980
    ISSN 0036-5548
    DOI 10.3109/00365548.2014.913306
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  10. Article ; Online: VEGF: a potential target for hydrocephalus.

    Shim, Joon W / Sandlund, Johanna / Madsen, Joseph R

    Cell and tissue research

    2014  Volume 358, Issue 3, Page(s) 667–683

    Abstract: Growth factors are primarily responsible for the genesis, differentiation and proliferation of cells and maintenance of tissues. Given the central role of growth factors in signaling between cells in health and in disease, it is understandable that ... ...

    Abstract Growth factors are primarily responsible for the genesis, differentiation and proliferation of cells and maintenance of tissues. Given the central role of growth factors in signaling between cells in health and in disease, it is understandable that disruption of growth factor-mediated molecular signaling can cause diverse phenotypic consequences including cancer and neurological conditions. This review will focus on the specific questions of enlarged cerebral ventricles and hydrocephalus. It is also well known that angiogenic factors, such as vascular endothelial growth factor (VEGF), affect tissue permeability through activation of receptors and adhesion molecules; hence, recent studies showing elevations of this factor in pediatric hydrocephalus led to the demonstration that VEGF can induce ventriculomegaly and altered ependyma when infused in animals. In this review, we discuss recent findings implicating the involvement of biochemical and biophysical factors that can induce a VEGF-mimicking effect in communicating hydrocephalus and pay particular attention to the role of the VEGF system as a potential pharmacological target in the treatment of some cases of hydrocephalus. The source of VEGF secretion in the cerebral ventricles, in periventricular regions and during pathologic events including hydrocephalus following hypoxia and hemorrhage is sought. The review is concluded with a summary of potential non-surgical treatments in preclinical studies suggesting several molecular targets including VEGF for hydrocephalus and related neurological disorders.
    MeSH term(s) Animals ; Cadherins/metabolism ; Epithelium/metabolism ; Epithelium/pathology ; Humans ; Hydrocephalus/drug therapy ; Hydrocephalus/pathology ; Molecular Targeted Therapy ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-2/metabolism
    Chemical Substances Cadherins ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
    Language English
    Publishing date 2014-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-014-1978-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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