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  1. Book ; Online: Latin American Immigration Ethics

    Reed-Sandoval, Amy / Díaz Cepeda, Luis Rubén

    2022  

    Keywords Social & political philosophy ; Migration, immigration & emigration ; Ethics & moral philosophy ; Philosophy ; Social ; Social Science ; Emigration & Immigration ; Ethics & Moral Philosophy
    Language 0|e
    Size 1 Online-Ressource
    Publisher University of Arizona Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021611218
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Plasmodium vivax pre-erythrocytic vaccines.

    Reyes-Sandoval, Arturo

    Parasitology international

    2021  Volume 84, Page(s) 102411

    Abstract: An estimated 229 million cases of malaria occurred worldwide in 2019. Both, Plasmodium falciparum and P. vivax are responsible for most of the malaria disease burden in the world. Despite difficulties in obtaining an accurate number, the global estimates ...

    Abstract An estimated 229 million cases of malaria occurred worldwide in 2019. Both, Plasmodium falciparum and P. vivax are responsible for most of the malaria disease burden in the world. Despite difficulties in obtaining an accurate number, the global estimates of cases in 2019 are approximately 229 million of which 2.8% are due to P. vivax, and the total number of malaria deaths are approximately 409 million. Regional elimination or global eradication of malaria will be a difficult task, particularly for P. vivax due to the particular biological features related to the hypnozoite, leading to relapse. Countries that have shown successful episodes of a decrease in P. falciparum malaria, are left with remaining P. vivax malaria cases. This is caused by the mechanism that the parasite has evolved to remain dormant in the liver forming hypnozoites. Furthermore, while clinical trials of vaccines against P. falciparum are making fast progress, a very different picture is seen with P. vivax, where only few candidates are currently active in clinical trials. We discuss the challenge that represent the hypnozoite for P. vivax vaccine development, the potential of Controlled Human Malaria Challenges (CHMI) and the leading vaccine candidates assessed in clinical trials.
    MeSH term(s) Animals ; Humans ; Malaria Vaccines/analysis ; Malaria Vaccines/pharmacology ; Malaria Vaccines/therapeutic use ; Malaria, Vivax/prevention & control ; Plasmodium vivax/immunology
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2021-06-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1363151-2
    ISSN 1873-0329 ; 1383-5769
    ISSN (online) 1873-0329
    ISSN 1383-5769
    DOI 10.1016/j.parint.2021.102411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2322: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Compounded Pain Formulations: What is the Evidence?

    Asbill, Scott / Sweitzer, Sarah M / Spigener, Shuler / Romero-Sandoval, Alfonso

    International journal of pharmaceutical compounding

    2024  Volume 28, Issue 2, Page(s) 100–109

    Abstract: Pain syndromes are among the most widespread, costly, and debilitating of all neurological disorders. The number of patients living with chronic pain is expected to increase with the aging population and with the rise in obesity and diabetes across the ... ...

    Abstract Pain syndromes are among the most widespread, costly, and debilitating of all neurological disorders. The number of patients living with chronic pain is expected to increase with the aging population and with the rise in obesity and diabetes across the nation. This type of pain is often insensitive to the traditional pain pharmacopeia or surgical intervention. Over the last 10 years the number of prescriptions that have been compounded by pharmacists has increased dramatically. There are a number of drugs in the area of pain management that have been formulated and compounded by pharmacists to treat conditions such as diabetic neuropathy, fibromyalgia, postherpetic neuralgia, joint pain, arthritis, and a variety of other conditions. A significant portion of these compounded analgesic preparations is made up of topical/transdermal dosage forms such as gels and creams. While the efficacy and doses of these drugs in systemic dosage forms have been widely established, little is known about the permeation and efficacy of these compounds from topical/transdermal gels. This review will provide an overview of chronic pain as a disease, the mechanisms of chronic pain, current treatment approaches to chronic pain, and a discussion of the drugs that are typically compounded into these topical formulations and studied in clinical trials.
    MeSH term(s) Humans ; Aged ; Chronic Pain/drug therapy ; Neuralgia/drug therapy ; Analgesics ; Neuralgia, Postherpetic/drug therapy ; Gels/therapeutic use
    Chemical Substances Analgesics ; Gels
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1092-4221
    ISSN 1092-4221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Balanced immunity is key for a successful dengue vaccine.

    Reyes-Sandoval, Arturo

    The Lancet. Infectious diseases

    2020  Volume 20, Issue 7, Page(s) 761–762

    MeSH term(s) Brazil ; Dengue ; Dengue Vaccines ; Dengue Virus/immunology ; Double-Blind Method ; Humans
    Chemical Substances Dengue Vaccines
    Language English
    Publishing date 2020-03-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30082-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The genomic footprint of social stratification in admixing American populations.

    Mas-Sandoval, Alex / Mathieson, Sara / Fumagalli, Matteo

    eLife

    2023  Volume 12

    Abstract: Cultural and socioeconomic differences stratify human societies and shape their genetic structure beyond the sole effect of geography. Despite mating being limited by sociocultural stratification, most demographic models in population genetics often ... ...

    Abstract Cultural and socioeconomic differences stratify human societies and shape their genetic structure beyond the sole effect of geography. Despite mating being limited by sociocultural stratification, most demographic models in population genetics often assume random mating. Taking advantage of the correlation between sociocultural stratification and the proportion of genetic ancestry in admixed populations, we sought to infer the former process in the Americas. To this aim, we define a mating model where the individual proportions of the genome inherited from Native American, European, and sub-Saharan African ancestral populations constrain the mating probabilities through ancestry-related assortative mating and sex bias parameters. We simulate a wide range of admixture scenarios under this model. Then, we train a deep neural network and retrieve good performance in predicting mating parameters from genomic data. Our results show how population stratification, shaped by socially constructed racial and gender hierarchies, has constrained the admixture processes in the Americas since the European colonization and the subsequent Atlantic slave trade.
    MeSH term(s) Humans ; Genetics, Population ; Genome, Human ; Genomics/methods ; Racial Groups ; Social Status
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.84429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Meropenem en infusión convencional versus infusión prolongada en sepsis neonatal tardía por bacilos gramnegativos.

    Sandoval, Alejandra

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2017  Volume 34, Issue 2, Page(s) 193

    Title translation Conventional versus prolonged infusion of meropenem in neonates with Gram-negative late-onset sepsis: a randomized controlled trial.
    MeSH term(s) Bacteremia ; Gram-Negative Bacterial Infections ; Humans ; Infant, Newborn ; Sepsis
    Language Spanish
    Publishing date 2017
    Publishing country Chile
    Document type Journal Article ; Comment
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182017000200016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Recent Developments in Vaccines against Flaviviruses and Alphaviruses.

    Kim, Young Chan / Reyes-Sandoval, Arturo

    Vaccines

    2023  Volume 11, Issue 2

    Abstract: In the twenty-first century, newly emerging viruses which are mostly zoonotic or vector-borne have continuously threatened public health and caused outbreaks of global concern [ ... ]. ...

    Abstract In the twenty-first century, newly emerging viruses which are mostly zoonotic or vector-borne have continuously threatened public health and caused outbreaks of global concern [...].
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11020448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Advancing spinal cord injury research with optical clearing, light sheet microscopy, and artificial intelligence-based image analysis.

    Li, Qiang / Sandoval, Alfredo / Chen, Bo

    Neural regeneration research

    2023  Volume 18, Issue 12, Page(s) 2661–2662

    Language English
    Publishing date 2023-07-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.373708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?

    Dempsey, Naomi / Sandoval, Ana / Mahtani, Reshma

    Current treatment options in oncology

    2023  Volume 24, Issue 9, Page(s) 1120–1137

    Abstract: Opinion statement: Approximately 20% of breast cancers overexpress human epidermal growth factor receptor 2 (HER2+), conferring a particularly aggressive subtype of the disease with an increased risk for the development of systemic and brain metastases. ...

    Abstract Opinion statement: Approximately 20% of breast cancers overexpress human epidermal growth factor receptor 2 (HER2+), conferring a particularly aggressive subtype of the disease with an increased risk for the development of systemic and brain metastases. However, the advent of trastuzumab and more recently several other HER2-targeting novel therapies has led to significant improvements in the prognosis, making the diagnosis a "double-edged sword." The current standard first-line therapy for patients with HER2+ metastatic breast cancer (MBC) is a taxane combined with trastuzumab and pertuzumab. Trastuzumab deruxtecan should be used preferentially in the second line, with the only caveat being patients with CNS involvement where the tucatinib, capecitabine, and trastuzumab regimen could be considered. In the third line setting, given the survival benefits demonstrated with the tucatinib regimen in patients with and without CNS metastases, this is the preferred strategy. In the fourth line and beyond, there is no clear standard. Options include margetuximab in combination with chemotherapy, neratinib + capecitabine, or trastuzumab + chemotherapy. There are several novel therapies under investigation reporting promising results in the late-line setting. The treatment landscape of HER2-positive advanced disease is evolving constantly, with several active therapies being moved to the early-stage setting. Accordingly, it will be critical to identify biomarkers and mechanisms of resistance to optimize therapy selection and maximize patient outcomes and quality of life. Here, we provide an overview of the current and future management of HER2-positive advanced breast cancer and address the specific scenarios which may impact treatment selection including triple-positive breast cancer and the presence of brain metastases. Finally, we highlight promising novel treatments and ongoing trials that may impact future treatment sequencing.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/etiology ; Breast Neoplasms/metabolism ; Capecitabine ; Quality of Life ; Trastuzumab/therapeutic use ; Receptor, ErbB-2/metabolism ; Brain Neoplasms/secondary ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances Capecitabine (6804DJ8Z9U) ; Trastuzumab (P188ANX8CK) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-023-01108-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5523: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Palmar midcarpal instability a narrative review of the literature: Have we reached a consensus on a treatment?

    Gomez-Sierra, Maria Antonia / Sandoval, Alejandro

    Injury

    2023  Volume 54 Suppl 6, Page(s) 110722

    Abstract: Palmar midcarpal instability (PMCI) is a wrist condition that requires treatment through non-surgical rehabilitation programs or surgical stabilization. This condition's natural history is poorly understood, and the optimal treatment approach remains ... ...

    Abstract Palmar midcarpal instability (PMCI) is a wrist condition that requires treatment through non-surgical rehabilitation programs or surgical stabilization. This condition's natural history is poorly understood, and the optimal treatment approach remains unknown. Non-surgical treatments are initially implemented, followed by surgical stabilization if necessary. Arthrodesis and soft tissue stabilization are the two main surgical options for PMCI, with no established gold standard for treatment. A systematic review of 12 articles comparing arthrodesis and soft tissue stabilization was conducted to identify the optimal treatment approach for PMCI. Arthrodesis techniques, such as lunotriquetral arthrodesis, showed high functional outcomes but also high reintervention rates due to nonunion. Soft tissue stabilization techniques showed superior functional outcomes with less mobility loss and lower reintervention rates compared to arthrodesis. However, more studies are required to determine the optimal soft tissue technique. Based on this review we created a treatment algorithm for PMCI starting with non-surgical treatment first, followed by surgical stabilization if needed. Soft tissue stabilization techniques are preferred over arthrodesis due to better functional outcomes and lower reintervention rates. However, each patient's treatment approach should be individualized and evaluated independently to determine the best course of action. PMCI is a rare wrist condition, and further research is needed to better understand its natural history and establish a gold standard for treatment. The lack of literature comparing the two surgical options underscores the need for further research to determine the optimal treatment approach. Nonetheless, the current evidence suggests that soft tissue stabilization is a promising alternative to arthrodesis, providing superior functional outcomes and lower reintervention rates.
    MeSH term(s) Humans ; Consensus ; Joint Instability/surgery ; Wrist Joint/surgery ; Arthrodesis/methods
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2023.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 10: Show issues

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