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Book ; Online: Inclusión y discapacidad visual. Aristas para el abordaje en educación superior

Ambrozio, Alan César / Ocampo González, Aldo / Frías López, Aurora Kristell / Reyes Anaya, Cecilia / Bautista Angulo, Dayana Vanessa / Cortes Coss, Dina Elizabeth / González Jiménez, Dulfay Astrid / Medina Morales, Gladyz del Carmen / Gómes Sanchez, Jeison Felipe / Rodríguez Cortés, Karina / Valencia, Karol Dayana / Navarro Zamora, Lizy / Izquierdo Sandoval, Manuel Jesus / López Reis, Márcia / María del Mar, Ospina / Díaz Rico, María Elena / González Isasi, Rosa María / Ávalos Magaña, Sergio Arturo / Aquino Zúñiga, Silvia Patricia /

De la cruz Villegas, Veronika / Valencia Estrada, Claudio / Medina Gladys

2022

Keywords	Humanities
Language	Spanish
Size	1 electronic resource (295 pages)
Publisher	Editorial Bonaventuriana, Universidad de San Buenaventura Cali
Publishing place	Santiago de Cali, Colombia
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030377918
ISBN	9786287559059 ; 6287559055
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: La interpretación biocéntrica del enfoque integral ecosistémico contenida en la Constitución de la República del Ecuador

Serrano Sandoval, Manuel Alberto / Medina Peña, Rolando

Agroecosistemas, Vol 9, Iss 3, Pp 179-

2021 Volume 190

Abstract: En la presente investigación, se aborda la interpretación biocéntrica de enfoque integral ecosistémico contenida en la Constitución de la República del Ecuador 2008, como base para poder comprender y aplicar las técnicas de constitucionalización del ... ...

Abstract	En la presente investigación, se aborda la interpretación biocéntrica de enfoque integral ecosistémico contenida en la Constitución de la República del Ecuador 2008, como base para poder comprender y aplicar las técnicas de constitucionalización del medio ambiente, así como mejorar garantía normativa del equilibrio entre el interés público y el interés particular, para conciliar los derechos de la naturaleza y las actividades antrópicas. Los resultados se asocian a la constante preocupación por preservar desde el derecho al Medio Ambiente, específicamente para establecer la necesaria Justicia Ambiental. Como métodos científicos de investigación se emplearon el Hipotético-deductivo, Histórico-Lógico, Exegético-analítico, Derecho Comparado y el Doctrinal.
Keywords	derecho ambiental ; derechos de la naturaleza ; biocentrismo ; derecho administrativo ; ecosistemas ; Agriculture (General) ; S1-972 ; Environmental sciences ; GE1-350
Language	Spanish
Publishing date	2021-12-01T00:00:00Z
Publisher	Universidad de Cienfuegos
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Trends, characteristics, and impact of global scientific production on mental health of health workers in the context of coronavirus disease 2019 (COVID-19).

Puchuri-Lopez, Javier / Galvez-Sandoval, Manuel / Guerrero, Maria E / Munive-Degregori, Arnaldo / Mauricio-Vilchez, Cesar / Barja-Ore, John / Mayta-Tovalino, Frank

Journal of family & community medicine

2022 Volume 30, Issue 1, Page(s) 12–17

Abstract: Background: Healthcare workers are under significant constant stress as a result of the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study, therefore, was to analyze bibliometrically the impact, trend, and characteristics of scientific ... ...

Abstract	Background: Healthcare workers are under significant constant stress as a result of the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study, therefore, was to analyze bibliometrically the impact, trend, and characteristics of scientific production related to the mental health of health professionals during the COVID-19 pandemic. Materials and methods: A bibliometric analysis of the scientific production on the mental health of health professionals and COVID-19 in Scopus from December 2019 to December 2021 was performed. An advanced search was designed using Boolean operators in Scopus and applied in April 2022. The metadata was entered into Microsoft Excel for the elaboration of the tables, SciVal to obtain the bibliometric indicators, and VosViewer to plot collaborative networks. Results: A total of 1393 manuscripts, 1007 of which met the eligibility criteria, were found on the mental health of health workers and COVID-19. The country with the highest academic production was the United States and Harvard University with 27 manuscripts as the most productive institution. The scientific journal with the highest scientific production was the Conclusion: The countries with the highest economic income occupy the first places in scientific production on the mental health of health workers during the COVID-19 pandemic, with the United States as the leader. There is a gap in the scientific knowledge on the mental health of healthcare workers during the COVID-19 pandemic in middle- and low-income countries.
Language	English
Publishing date	2022-12-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2580509-5
ISSN	2229-340X ; 1319-1683
ISSN (online)	2229-340X
ISSN	1319-1683
DOI	10.4103/jfcm.jfcm_228_22
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Article ; Online: Age patterns of human papillomavirus infection as primary screening test for cervical cancer and subsequent triage with visual inspection in Honduras.

Sandoval, Manuel / Holme, Francesca / Lobo, Saul / Slavkovsky, Rose / Thomson, Kerry A / Jeronimo, Jose / Figueroa, Jacqueline / Sanjose, Silvia de

Salud publica de Mexico

2020 Volume 62, Issue 5, Page(s) 487–493

Abstract: Objective: To evaluate age patterns in human papillomavi-rus (HPV) prevalence and visual inspection with acetic acid (VIA) positivity among women participating in cervical cancerscreening in Honduras.: Materials and methods: Data on the HPV status ( ... ...

Title translation	Patrones de edad de infección por el virus del papiloma humano como prueba primaria en el tamizajede cáncer de cuello uterino y triaje posterior coninspección visual en Honduras.
Abstract	Objective: To evaluate age patterns in human papillomavi-rus (HPV) prevalence and visual inspection with acetic acid (VIA) positivity among women participating in cervical cancerscreening in Honduras. Materials and methods: Data on the HPV status (careHPV) and subsequent VIA in HPV-positivewomen were retrieved from three provinces within the PublicHealth Sector. Results: Between 2015 and 2018, 60 883 women aged 15-85 years were screened. HPV was detected in 15%, with variation by age, peaking at 20-24 years (27.8%) decreasing to 16% at 30-49 years. Differences in point age-specific HPV prevalence were observed between provinces,but with similar age pattern. VIA was positive in 24.5% of the women aged 30-44 year. Conclusions: The age pattern of the HPV prevalence supports starting HPV testing at age 30+. The low positivity of VIA in ages close to menopause suggest underdetection of cervical lesions in this age group.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; DNA, Viral ; Early Detection of Cancer ; Female ; Honduras/epidemiology ; Humans ; Mass Screening ; Middle Aged ; Papillomaviridae ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/epidemiology ; Triage ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/virology ; Young Adult
Chemical Substances	DNA, Viral
Language	English
Publishing date	2020-07-15
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	954220-6
ISSN	1606-7916 ; 0036-3634
ISSN (online)	1606-7916
ISSN	0036-3634
DOI	10.21149/10979
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Article ; Online: Recall Efforts Successfully Increase Follow-Up for Cervical Cancer Screening Among Women With Human Papillomavirus in Honduras.

Thomson, Kerry A / Sandoval, Manuel / Bain, Carolyn / Holme, Francesca / Bansil, Pooja / Figueroa, Jacqueline / de Sanjosé, Silvia

Global health, science and practice

2020 Volume 8, Issue 2, Page(s) 290–299

Abstract: Scaling up coverage of routine cervical screening in low-resource settings must be accompanied by efforts to retain women throughout the screening cascade and continuum of care, including adequate follow-up of abnormal results. The Scale-Up Project ... ...

Abstract	Scaling up coverage of routine cervical screening in low-resource settings must be accompanied by efforts to retain women throughout the screening cascade and continuum of care, including adequate follow-up of abnormal results. The Scale-Up Project implemented human papillomavirus (HPV) testing for cervical cancer screening within public-sector health facilities in Honduras between 2015 and 2019. Women who were HPV-positive but did not have visually confirmed cervical lesions upon visual inspection with acetic acid (VIA-negative) were instructed to return to the health center after 1 year for repeat HPV testing. The current evaluation assessed the effectiveness of recall strategies to prompt women to return for retesting. Clinic staff placed reminder phone calls and followed up with short message service (SMS) or home visits, if needed. We summarized number of contacts, type of contacts, and time elapsed until return to the clinic, and used log-binomial regression to identify factors associated with return to the clinic. We identified 558 women who were initially HPV-positive VIA-negative from 8 clinics as needing repeat HPV testing 1 year later. Mean age was 43.2 years. Nearly all women (98.6%) were successfully contacted and 75.1% completed repeat HPV testing. The majority of contacts (65.4%) were phone calls, and nearly half of women who returned to the clinic (42.9%) did so after 1 contact. Mean days between contact and presentation at the clinic was 10.7 (standard deviation: 14.7). Women who required 3 or more contacts were 21% less likely to return for repeat HPV testing (prevalence ratio: 0.79; 95% confidence interval=0.69,0.90;
MeSH term(s)	Acetic Acid ; Adult ; Alphapapillomavirus ; Cervix Uteri/pathology ; Cervix Uteri/virology ; Communication ; Continuity of Patient Care ; Early Detection of Cancer ; Female ; Honduras ; Humans ; Mass Screening/methods ; Middle Aged ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/pathology ; Papillomavirus Infections/virology ; Patient Dropouts ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology
Chemical Substances	Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2020-06-30
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2710875-2
ISSN	2169-575X ; 2169-575X
ISSN (online)	2169-575X
ISSN	2169-575X
DOI	10.9745/GHSP-D-19-00404
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health Outcomes at 1 Year After Thermal Ablation for Cervical Precancer Among Human Papillomavirus- and Visual Inspection With Acetic Acid-Positive Women in Honduras.

Slavkovsky, Rose C / Bansil, Pooja / Sandoval, Manuel A / Figueroa, Jacqueline / Rodriguez, Doris M / Lobo, Jose Saul / Jeronimo, Jose A / de Sanjosé, Silvia

JCO global oncology

2020 Volume 6, Page(s) 1565–1573

Abstract: Purpose: This study aims to assess the detection of cervical intraepithelial lesions grades 2 and 3 (CIN2-3) at 1 year after treatment with thermal ablation among human papillomavirus (HPV)-positive and visual inspection with acetic acid (VIA)-positive ... ...

Abstract	Purpose: This study aims to assess the detection of cervical intraepithelial lesions grades 2 and 3 (CIN2-3) at 1 year after treatment with thermal ablation among human papillomavirus (HPV)-positive and visual inspection with acetic acid (VIA)-positive women. Methods: All women screened and triaged for cervical cancer at four government health facilities in Honduras who were eligible for ablative treatment were enrolled and treated with thermal ablation. Women with confirmed CIN2-3 and a subset of women with CIN1/normal diagnoses at baseline were evaluated at 12 months. Follow-up procedures included HPV testing ( Results: Among the 319 women treated with thermal ablation, baseline histologic diagnoses were available for 317. Two (0.6%) had invasive cancer, 36 (11.4%) had CIN3, 40 (12.6%) had CIN2, and 239 (75.4%) had CIN1/normal histology. Among the 127 women eligible for follow-up, 118 (92.9%) completed all study procedures at 1 year. Overall, 98 (83.1%) had no evidence of CIN2-3 or persistent low-grade infection, 13 (11.2%) had CIN1/atypical squamous cells of undetermined significance, six (5.1%) had CIN2/high-grade squamous intraepithelial lesion, and 1 (0.8%) had a persistent CIN3. No adverse events associated with thermal ablation at 1 year were registered. Conclusion: A high proportion of women had no evidence of CIN2-3 at 1 year after thermal ablation treatment. Thermal ablation is an alternative to cryotherapy that may facilitate greater treatment coverage and prevent unnecessary deaths from cervical cancer.
MeSH term(s)	Acetic Acid ; Alphapapillomavirus ; Female ; Honduras/epidemiology ; Humans ; Outcome Assessment, Health Care ; Papanicolaou Test ; Papillomaviridae ; Papillomavirus Infections/diagnosis
Chemical Substances	Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.20.00400
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Acceptability and safety of thermal ablation for the treatment of precancerous cervical lesions in Honduras.

Sandoval, Manuel / Slavkovsky, Rose / Bansil, Pooja / Jeronimo, Jose / Lim, Jeanette / Figueroa, Jacqueline / de Sanjose, Silvia

Tropical medicine & international health : TM & IH

2019 Volume 24, Issue 12, Page(s) 1391–1399

Abstract: Objective: To evaluate the acceptability and safety of thermal ablation (TA) for the treatment of precancerous cervical lesions in women in Honduras.: Methods: Human papillomavirus (HPV) and visual inspection with acetic acid (VIA) screen-positive ... ...

Abstract	Objective: To evaluate the acceptability and safety of thermal ablation (TA) for the treatment of precancerous cervical lesions in women in Honduras. Methods: Human papillomavirus (HPV) and visual inspection with acetic acid (VIA) screen-positive eligible women received TA. After treatment, women rated the level of pain experienced during treatment using the Wong-Baker FACES® pain-rating scale from 0 to 10. Short-term safety outcomes that could require medical attention were assessed one month after treatment. Results: A total of 319 women received TA treatment. The average pain rating was 2.5 (95% CI: 2.3-2.8), and 85% rated their pain levels as less than 6. No significant differences in low (below 6) or high (6 and above) pain were found by age or number of biopsies performed, but there was a significant difference by the number of TA applications (P < 0.01). When asked if they would recommend this treatment, all women said they would. At the one-month follow-up visit, the most common reported discomforts were bleeding (10%) and cramping (8.4%); 11 women reported severe lower abdominal pain, and none required medical attention. Conclusions: TA is safe and acceptable to patients as a treatment option for precancerous cervical lesions in low-resource settings.
MeSH term(s)	Adolescent ; Adult ; Catheter Ablation ; Female ; Honduras ; Humans ; Middle Aged ; Pain Measurement ; Papillomaviridae ; Papillomavirus Infections/surgery ; Patient Satisfaction ; Precancerous Conditions ; Treatment Outcome ; Uterine Cervical Neoplasms/surgery ; Young Adult
Language	English
Publishing date	2019-11-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1314080-2
ISSN	1365-3156 ; 1360-2276
ISSN (online)	1365-3156
ISSN	1360-2276
DOI	10.1111/tmi.13315
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Article ; Online: Introduction of HPV testing for cervical cancer screening in Central America: The Scale-Up project.

Holme, Francesca / Jeronimo, Jose / Maldonado, Francisco / Camel, Claudia / Sandoval, Manuel / Martinez-Granera, Benito / Montenegro, Mirna / Figueroa, Jacqueline / Slavkovsky, Rose / Thomson, Kerry A / de Sanjose, Silvia

Preventive medicine

2020 Volume 135, Page(s) 106076

Abstract: The Scale-Up project introduced vaginal self-sampling and low-cost human papillomavirus (HPV) testing as the primary approach for cervical cancer screening in selected public health centers in Guatemala, Honduras, and Nicaragua. We evaluate the country- ... ...

Abstract	The Scale-Up project introduced vaginal self-sampling and low-cost human papillomavirus (HPV) testing as the primary approach for cervical cancer screening in selected public health centers in Guatemala, Honduras, and Nicaragua. We evaluate the country-specific accomplishments in screening: target-coverage, triage, and treatment. Between 2015 and 2018, cervical cancer screening was offered to women at least 30 years of age. Triage of HPV-positive women was based on visual inspection with acetic acid or Pap. Aggregated data included total women screened, use of self-sampling, age, time elapsed since last screening, HPV results, triage tests, triage results, and treatment. A total of 231,741 women were screened for HPV, representing 85.8% of the target populations within the project. HPV positivity was lower in Guatemala (12.4%) compared to Honduras and Nicaragua (14.5% and 14.2%, respectively, p < 0.05). A follow-up triage test was completed for 84.2%, 85.8%, and 50.1% of HPV-positive women in Guatemala, Nicaragua, and Honduras, respectively. Of those with a positive triage test, 84.7%, 67.1%, and 58.8% were treated in Guatemala, Nicaragua, and Honduras, respectively. First-time screening was highest in Nicaragua (55.8%) where self-sampling was also widely used (97.1%). The Scale-Up project demonstrated that large-scale cervical cancer screening and treatment intervention in a high-burden, low-resource setting can be achieved. Self-sampling and ablative treatment were key to the project's achievements. Data monitoring, loss to follow-up, and triage methods of screen- positive women remain critical to full success.
MeSH term(s)	Adult ; Alphapapillomavirus/isolation & purification ; Central America ; Early Detection of Cancer/statistics & numerical data ; Female ; Humans ; Middle Aged ; Papillomavirus Infections/diagnosis ; Triage/statistics & numerical data ; Uterine Cervical Neoplasms/prevention & control
Language	English
Publishing date	2020-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2020.106076
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Article: Optimised N-acetyl-d-lactosamine synthesis using Thermus thermophilus β-galactosidase in bio-solvents

Sandoval, Manuel / Civera, Concepción / Berenguer, José / García-Blanco, Francisco / Hernaiz, María J

Tetrahedron. 2013 Jan. 21, v. 69, no. 3

2013

Abstract: Synthesis of N-acetyl-d-lactosamine (Gal-β[1→4]GlcNAc, LacNAc) catalyzed by β-galactosidase from Thermus thermophilus (TTP0042) is affected by side reactions that give as result very low yields (about 20%) of LAcNAc when the reaction is performed in ... ...

Abstract	Synthesis of N-acetyl-d-lactosamine (Gal-β[1→4]GlcNAc, LacNAc) catalyzed by β-galactosidase from Thermus thermophilus (TTP0042) is affected by side reactions that give as result very low yields (about 20%) of LAcNAc when the reaction is performed in buffer. The process is improved (up to 91% of disaccharide yield) when the reaction takes place in the presence of solvents from biomass (bio-solvents) at 2.0 M concentration. Most of the solvents tested increased the LacNAc synthesis and reduced the undesired side reactions. In order to understand the possible effects of these solvents over the enzyme regioselectivity, we developed a conformational study of the enzyme structure in the presence of a selected bio-solvent by circular dichroism and fluorescence. According to this study, we were able to conclude that the presence of bio-solvents in the reaction media modifies the enzyme secondary and tertiary structure and this may be the cause of the regioselectivity changes observed in the transglycosylation reaction.
Keywords	Thermus thermophilus ; beta-galactosidase ; biomass ; chemical reactions ; chemical structure ; fluorescence ; organic compounds ; solvents
Language	English
Dates of publication	2013-0121
Size	p. 1148-1152.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2012.11.053
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Chemoenzymatic synthesis of carbohydrates as antidiabetic and anticancer drugs.

Alcántara, Andrés R / Pace, Vittorio / Hoyos, Pilar / Sandoval, Manuel / Holzer, Wolfgang / Hernáiz, María J

Current topics in medicinal chemistry

2014 Volume 14, Issue 23, Page(s) 2694–2711

Abstract: Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases ( ...

Abstract	Different chemoenzymatic strategies for the preparation of carbohydrates and analogues possessing antidiabetic or anticancer activity are summarized. In this sense, some examples illustrating the use of enzymes such as aldolases, lipases or glycosidases (in some cases improved by genetic engineering techniques) are presented, showing the advantages of the implementation of chemoenzymatic protocols, which combine the flexibility of chemical synthesis with the efficiency, selectivity and sustainability of biotransformations to obtain diverse complex carbohydrates, glycoconjugates and glycomimetics.
MeSH term(s)	Aldehyde-Lyases/chemistry ; Aldehyde-Lyases/genetics ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Biomimetic Materials/chemistry ; Biomimetic Materials/metabolism ; Biotransformation ; Candida/chemistry ; Candida/enzymology ; Candida/genetics ; Fungal Proteins/chemistry ; Fungal Proteins/genetics ; Gluconobacter oxydans/chemistry ; Gluconobacter oxydans/enzymology ; Gluconobacter oxydans/genetics ; Glycoconjugates/chemical synthesis ; Glycoconjugates/metabolism ; Glycoside Hydrolases/chemistry ; Glycoside Hydrolases/genetics ; Humans ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/metabolism ; Lipase/chemistry ; Lipase/genetics ; Protein Engineering ; Pseudomonas/chemistry ; Pseudomonas/enzymology ; Pseudomonas/genetics
Chemical Substances	Antineoplastic Agents ; Bacterial Proteins ; Fungal Proteins ; Glycoconjugates ; Hypoglycemic Agents ; Lipase (EC 3.1.1.3) ; Glycoside Hydrolases (EC 3.2.1.-) ; Aldehyde-Lyases (EC 4.1.2.-)
Language	English
Publishing date	2014-10-27
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026614666141215151056
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