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Article ; Online: Survive and Thrive in Brazil

Alexandra Brentani / Ana Paula Scolezze Ferrer / Luana Bessa / Susan Chang / Susan Walker / Christine Powell / Jena Hamadani / Sandra Grisi / Günther Fink

Trials, Vol 21, Iss 1, Pp 1-

The Boa Vista Early Childhood Program: study protocol of a stepped-wedge, randomized controlled trial

2020 Volume 10

Abstract: Abstract Background A growing body of evidence suggests that early life health and developmental outcomes can be improved through parental support programs. The objective of this project was to test the feasibility, impact, and relative cost- ... ...

Abstract	Abstract Background A growing body of evidence suggests that early life health and developmental outcomes can be improved through parental support programs. The objective of this project was to test the feasibility, impact, and relative cost-effectiveness of an adapted “Reach Up and Learn” program delivered through home-visiting programs as well as through center-based parenting groups on child health and development in the municipality of Boa Vista, Brazil. Methods A randomized, stepped-wedge design was used to roll out and evaluate the two parenting platforms in Boa Vista municipality. A total of 39 neighborhoods with a high Neighborhood Vulnerability Index were selected for the study. For the first phase of the program, nine neighborhoods were randomly selected for home visits, and two were randomly selected for the center-based parenting groups. In the second phase of the program, 10 neighborhoods were added to the home-visiting program, and eight were added to the center-based program. In the final phase of the program, the remaining 10 control areas will also be assigned to treatment. Study eligibility will be assessed through a baseline survey completed by all pregnant women in the 39 study areas. Pregnant women will be eligible to participate in the study if they are either classified as poor, were under age 20 years when they became pregnant, or if they indicate to have been exposed to domestic or sexual violence. To assess program impact, an endline survey will be conducted when children reach age 2 years. The primary study outcome is child development at age 2 years as measured by the PRIDI instrument. Secondary outcome will be infant mortality, which will be assessed linking municipal vital registration systems to the program rollout. Discussion This trial will assess the feasibility and impact of parenting programs rolled out at medium scale. The results from the trial should create evidence urgently needed for guiding Brazil’s national Criança Feliz program as well as similar efforts in other ...
Keywords	Child development ; Parenting interventions ; Infant mortality ; Neonatal mortality ; Early childhood development ; Medicine (General) ; R5-920
Subject code	796
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Custos hospitalares da meningite causada por Streptococcus pneumoniae na cidade de São José dos Campos, São Paulo, Brasil Hospital costs related to streptococcal meningitis among children in São José dos Campos, São Paulo State, Brazil

Bianca Rezende Lucarevschi / Ana Maria de Ulhôa Escobar / Sandra Grisi

Cadernos de Saúde Pública, Vol 28, Iss 4, Pp 740-

2012 Volume 748

Abstract: O conhecimento dos custos hospitalares é de grande importância para os processos de tomada de decisão em saúde pública. O objetivo deste estudo foi estimar os custos hospitalares diretos relacionados à meningite pneumocócica em crianças com até 13 anos ( ... ...

Abstract	O conhecimento dos custos hospitalares é de grande importância para os processos de tomada de decisão em saúde pública. O objetivo deste estudo foi estimar os custos hospitalares diretos relacionados à meningite pneumocócica em crianças com até 13 anos (inclusive), na cidade de São José dos Campos, São Paulo, Brasil, de janeiro de 1999 a dezembro de 2008. Foram obtidos dados de prontuários médicos. O cálculo foi realizado pelo método misto de mensuração das quantidades dos itens de custos e atribuição de valor aos itens consumidos (micro-costing e gross-costing). Os valores monetários referem-se a novembro de 2009, sendo expressos em reais. A análise das frequências e médias foi realizada pelo programa Epi Info versão 3.5.1. Foram notificados 41 casos. Os custos hospitalares diretos variaram de R$ 1.277,90 a R$ 19.887,56 (média = R$ 5.666,43), ou seja, 10 a 20 vezes maiores que o custo médio de internações pago pelo SUS. Os custos dos honorários profissionais foram os mais relevantes, seguidos pelos custos dos medicamentos, procedimentos, materiais e exames laboratoriais. Knowledge of hospital costs is highly important for public health decision-making. This study aimed to estimate direct hospital costs related to pneumococcal meningitis in children 13 years or younger in the city of São José dos Campos, São Paulo State, Brazil, from January 1999 to December 2008. Data were obtained from medical records. Hospital costs were calculated according to the mixed method for measurement of quantities of items with identified costs and value attribution to items consumed (micro-costing and gross-costing). All costs were calculated according to monetary values for November 2009 and in Brazilian currency (Real). Epi Info 3.5.1 was used for frequencies and means analysis. Forty-one cases were reported. Direct hospital costs varied from R$ 1,277.90 to R$ 19,887.56 (mean = R$ 5,666.43), or 10 to 20 times the mean cost of hospitalization for other diseases. Hospital staff labor was the highest cost, followed by medication, ...
Keywords	Meningite Pneumocócica ; Custos de Cuidados de Saúde ; Custos e Análise de Custo ; Pneumococcal Meningitis ; Health Care Costs ; Costs and Cost Analysis ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2012-04-01T00:00:00Z
Publisher	Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Time to change focus? Transitioning from higher neonatal to higher stillbirth mortality in São Paulo State, Brazil.

Kathryn Andrews / Maria Lúcia Moraes Bourroul / Günther Fink / Sandra Grisi / Ana Paula Scoleze Ferrer / Edna Maria de Albuquerque Diniz / Alexandra Brentani

PLoS ONE, Vol 12, Iss 12, p e

2017 Volume 0190060

Abstract: Differential trends in mortality suggest that stillbirths may dominate neonatal mortality in the medium to long run. Brazil has made major efforts to improve data collection on health indicators at granular geographic levels, and provides an ideal ... ...

Abstract	Differential trends in mortality suggest that stillbirths may dominate neonatal mortality in the medium to long run. Brazil has made major efforts to improve data collection on health indicators at granular geographic levels, and provides an ideal environment to test this hypothesis. Our goals were to examine levels and trends in stillbirths and neonatal deaths and the extent to which the mortality burden caused by stillbirths dominates neonatal mortality at the municipality- and state-level.We used data from the Brazilian Ministry of Health's repository on births, fetal, and neonatal deaths (2010-2014) to calculate stillbirth and neonatal mortality rates for São Paulo state's 645 municipalities.At the state level, 7.9 per 1000 pregnancies ended in stillbirth (fetal death >22 weeks gestation or fetal weight >500g), but this varied from 0.0 to 28.4 per 1000 across municipalities. 7.9 per 1000 live births also died within the first 28 days. 42% of municipalities had a higher stillbirth rate than neonatal mortality rate, and in 61% of areas with low neonatal mortality (<8.0 per 1000), stillbirth rates exceeded neonatal mortality rates.This analysis suggests large variability and inequality in mortality outcomes at the sub-national level. The results also imply that stillbirth mortality may exceed neonatal mortality in Brazil and similar settings in the next few decades, which suggests a need for a shift in policy. This work further underscores the importance of continued research into causes and prevention of stillbirth.
Keywords	Medicine ; R ; Science ; Q
Subject code	310
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bronchiolitis, respiratory syncytial virus, and recurrent wheezing

Claudia de Brito Fonseca / Sandra Grisi

Revista do Hospital das Clínicas, Vol 58, Iss 1, Pp 39-

what is the relationship? A bronquiolite pelo virus sincicial respiratório e o chiado recorrente: qual a relação?

2003 Volume 48

Abstract: Various follow-up studies of children hospitalized with bronchiolitis caused by respiratory syncytial virus have demonstrated that a significant proportion of infants (50%) have recurrent wheezing during childhood. Nevertheless, the relationship between ... ...

Abstract	Various follow-up studies of children hospitalized with bronchiolitis caused by respiratory syncytial virus have demonstrated that a significant proportion of infants (50%) have recurrent wheezing during childhood. Nevertheless, the relationship between these two entities, if any, has not been established. In order to explain this observation, several hypotheses have been proposed. The first suggests that some children could have an individual predisposition to bronchiolitis caused by respiratory syncytial virus and recurrent wheezing. The virus could be a marker of this condition, and the individual predisposition could in turn be related to an individual hypersensitivity to common allergens (atopy), airway hyperreactivity, or to some disorder related to pulmonary anatomy or physiology that was present before the acute episode of bronchiolitis. Another hypothesis proposes that respiratory syncytial virus could be directly responsible for recurrent wheezing. During an episode of bronchiolitis, the damage in the airway mucosa caused by the vital inflammatory response to infection contributes to sensitivity to other allergens or exposes irritant receptors, resulting in recurrent wheezing. For this review, we analyzed the studies that discuss these hypotheses with the purpose of clarifying the mechanisms for the important issue of recurrent wheezing in childhood. Os diversos estudos de seguimento de crianças hospitalizadas por bronquiolite pelo virus sincicial respiratório demonstram, em média, 50% de chance de evoluir com novos episódios de chiado no peito. Apesar desta constatação, não foi estabelecida a relação entre a bronquiolite pelo virus sincicial respiratório e a recorrência dos episódios de chiado. A primeira hipótese é de que o indivíduo poderia ter uma predisposição para a repetição do quadro de chiado e também para a própria bronquiolite como manifestação da infecção pelo virus sincicial respiratório. O vírus seria um marcador desta condição. Esta predisposição pode estar relacionada a uma hipersensibilidade a alérgenos comuns (atopia), hiper-reatividade a estímulos não específicos ou alguma alteração pulmonar anátomo-fisiológica presentes antes da bronquiolite. Outra hipótese é a de que o virus sincicial respiratório é o responsável por esta evolução. Durante um episódio de bronquiolite, a lesão da mucosa respiratória decorrente do intenso processo inflamatório, principalmente nos quadros mais graves, facilitaria a sensibilização para outros alérgenos ou provocaria uma exposição de receptores para irritantes, resultando nos quadros de chiado recorrentes. Nesta revisão, os autores analisam as pesquisas que sustentam essas hipóteses com o objetivo de sistematizar o conhecimento sobre este assunto e apresentá-lo de forma organizada, como uma contribuição à compreensão da recorrência dos episódios de chiado.
Keywords	Vírus sincicial respiratório ; Infecções respiratórias ; Bronquiolite aguda ; Chiado recorrente ; Revisão da literatura ; Respiratory Syncytial Virus ; Respiratory Tract Infections ; Acute Bronchiolitis ; Recurrent Wheezing ; Literature Review ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	600
Language	English
Publishing date	2003-01-01T00:00:00Z
Publisher	Universidade de São Paulo - FM/USP
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: O Instituto Nacional de Ciência e Tecnologia de Psiquiatria do Desenvolvimento para a Infância e Adolescência

Euripedes C. Miguel / Marcos T. Mercadante / Sandra Grisi / Luiz A. Rohde

Revista Brasileira de Psiquiatria, Vol 31, Iss 2, Pp 85-

um novo paradigma para a Psiquiatria Brasileira tendo como foco as nossas crianças e o seu futuro The National Science and Technology Institute in Child and Adolescence Developmental Psychiatry: a new paradigm for Brazilian Psychiatry focused on our children and their future

2009 Volume 88

Keywords	Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Psychiatry ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2009-06-01T00:00:00Z
Publisher	Associação Brasileira de Psiquiatria (ABP)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência Epidemiological aspects of Helicobacter pylori infection in childhood and adolescence

Marcia S Kodaira / Ana Maria de Ulhôa Escobar / Sandra Grisi

Revista de Saúde Pública, Vol 36, Iss 3, Pp 356-

2002 Volume 369

Abstract: Realizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, ... ...

Abstract	Realizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. The scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.
Keywords	Helicobacter pylori ; Infecções por helicobacter ; Prevalência ; Fatores de risco ; Fatores socioeconômicos ; Criança ; Adolescência ; Helicobacter infections ; Prevalence ; Risk factors ; Socioeconomic factors ; Child ; Adolescence ; Public aspects of medicine ; RA1-1270
Subject code	028
Language	English
Publishing date	2002-06-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Marcia S Kodaira / Ana Maria de Ulhôa Escobar / Sandra Grisi

Revista de Saúde Pública, Vol 36, Iss 3, Pp 356-

2002 Volume 369

Abstract	Realizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido.
Keywords	Helicobacter pylori ; Infecções por helicobacter ; Prevalência ; Fatores de risco ; Fatores socioeconômicos ; Criança ; Adolescência ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2002-06-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aspectos epidemiológicos da infecção por Haemophilus influenzae tipo b Epidemiologic aspects of Haemophilus influenzae type b infection

Maria Angela Loguercio Bouskela / Sandra Grisi / Ana Maria de Ulhôa Escobar

Revista Panamericana de Salud Pública, Vol 7, Iss 5, Pp 332-

2000 Volume 339

Abstract: O objetivo do presente trabalho foi revisar o papel do Haemophilus influenzae tipo b (Hib) como um dos patógenos mais importantes implicados em doenças infecciosas invasivas, especialmente nos 2 primeiros anos de vida. Nos países em desenvolvimento, o H. ...

Abstract	O objetivo do presente trabalho foi revisar o papel do Haemophilus influenzae tipo b (Hib) como um dos patógenos mais importantes implicados em doenças infecciosas invasivas, especialmente nos 2 primeiros anos de vida. Nos países em desenvolvimento, o H. Influenzae chega a causar 30% dos casos de pneumonia com cultura positiva e de 20 a 60% dos casos de meningite bacteriana. No presente estudo, dados epidemiológicos do Brasil foram comparados com dados internacionais obtidos em bancos de dados (Medline, 1966 a 1995; LILACS, 1982 a 1995; Thesis databank, 1980 a 1995; e Dissertation abstracts, 1988 a 1994). Analisámos o coeficiente de incidência do Hib no Brasil por estado e por faixa etária, com estratificação inclusive para o 1° ano de vida. A meningite foi utilizada como marcador do coeficiente de incidência devido às dificuldades para obter material adequado para a identificação do microrganismo nos outros quadros, como pneumonia, osteomielite, epiglotite ou endocardite. Nossa análise revelou que os dados nacionais mascaram a incidência e a letalidade regionais do H. influenzae: por exemplo, em 1991, a incidência no Brasil foi de 18,4 em 100 000 crianças menores de 1 ano; no mesmo período, a incidência no Distrito Federal foi de 175 em 100 000 crianças entre 4 e 6 meses. Além disso, a letalidade na região Norte foi de 35% em 1987, contra 22% para o Brasil como um todo. Nosso estudo abre a discussão sobre aspectos epidemiológicos relevantes das infecções por Hib e sobre o custo-benefício da profilaxia e vacinação nas faixas etárias de maior risco. This paper reviews the role of Haemophilus influenzae type b (Hib) as one of the most important pathogens causing invasive infectious diseases, especially in the first 2 years of life. In developing countries H. influenzae is responsible for 30% of all pneumonia cases with positive cultures and for 20% to 60% of all bacterial meningitis cases. In this study we compared Brazilian and international epidemiologic data obtained from several bibliographic databases (MEDLINE, 1966 to 1995; LILACS, 1982 to 1995; Thesis Databank, 1980 to 1995; and Dissertation Abstracts, 1988 to 1994). The incidence of Hib infection in Brazil was analyzed for individual states and for different ages, including within the first year of life. Meningitis cases were used as an incidence marker because of the difficulty in identifying the causative organism in such other infections as pneumonia, osteomyelitis, epiglottitis, cellulitis, and endocarditis. Our analysis showed that the nationwide Brazilian data masked the regional incidence and lethality of H. influenzae. For example, in 1991 the national incidence was 18.4 per 100 000 children under 1 year of age. In the same period, the Federal District had an incidence of 175 per 100 000 among children between 4 and 6 months of age. Similarly, the North of Brazil had a 35% case fatality rate in 1987, whereas the rate was 22% for Brazil as a whole. This study raises issues concerning the relevant epidemiologic factors associated with Hib infection and the costs and benefits of prophylaxis and vaccination in the age groups most at risk.
Keywords	Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences
Language	English
Publishing date	2000-05-01T00:00:00Z
Publisher	Organización Panamericana de la Salud
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Aspectos epidemiológicos da infecção por Haemophilus influenzae tipo b

Maria Angela Loguercio Bouskela / Sandra Grisi / Ana Maria de Ulhôa Escobar

Revista Panamericana de Salud Pública, Vol 7, Iss 5, Pp 332-

2000 Volume 339

Abstract	O objetivo do presente trabalho foi revisar o papel do Haemophilus influenzae tipo b (Hib) como um dos patógenos mais importantes implicados em doenças infecciosas invasivas, especialmente nos 2 primeiros anos de vida. Nos países em desenvolvimento, o H. Influenzae chega a causar 30% dos casos de pneumonia com cultura positiva e de 20 a 60% dos casos de meningite bacteriana. No presente estudo, dados epidemiológicos do Brasil foram comparados com dados internacionais obtidos em bancos de dados (Medline, 1966 a 1995; LILACS, 1982 a 1995; Thesis databank, 1980 a 1995; e Dissertation abstracts, 1988 a 1994). Analisámos o coeficiente de incidência do Hib no Brasil por estado e por faixa etária, com estratificação inclusive para o 1° ano de vida. A meningite foi utilizada como marcador do coeficiente de incidência devido às dificuldades para obter material adequado para a identificação do microrganismo nos outros quadros, como pneumonia, osteomielite, epiglotite ou endocardite. Nossa análise revelou que os dados nacionais mascaram a incidência e a letalidade regionais do H. influenzae: por exemplo, em 1991, a incidência no Brasil foi de 18,4 em 100 000 crianças menores de 1 ano; no mesmo período, a incidência no Distrito Federal foi de 175 em 100 000 crianças entre 4 e 6 meses. Além disso, a letalidade na região Norte foi de 35% em 1987, contra 22% para o Brasil como um todo. Nosso estudo abre a discussão sobre aspectos epidemiológicos relevantes das infecções por Hib e sobre o custo-benefício da profilaxia e vacinação nas faixas etárias de maior risco.
Keywords	Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2000-05-01T00:00:00Z
Publisher	Pan American Health Organization
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differences in children and adolescents with SARS-CoV-2 infection

Heloisa Helena de Sousa Marques / Maria Fernanda Badue Pereira / Angélica Carreira dos Santos / Thais Toledo Fink / Camila Sanson Yoshino de Paula / Nadia Litvinov / Claudio Schvartsman / Artur Figueiredo Delgado / Maria Augusta Bento Cicaroni Gibelli / Werther Brunow de Carvalho / Vicente Odone Filho / Uenis Tannuri / Magda Carneiro-Sampaio / Sandra Grisi / Alberto José da Silva Duarte / Leila Antonangelo / Rossana Pucineli Vieira Francisco / Thelma Suely Okay / Linamara Rizzo Batisttella /

Carlos Roberto Ribeiro de Carvalho / Alexandra Valéria Maria Brentani / Clovis Artur Silva / Adriana Pasmanik Eisencraft / Alfio Rossi Junior / Alice Lima Fante / Aline Pivetta Cora / Amelia Gorete A. de Costa Reis / Ana Paula Scoleze Ferrer / Anarella Penha Meirelles de Andrade / Andreia Watanabe / Angelina Maria Freire Gonçalves / Aurora Rosaria Pagliara Waetge / Camila Altenfelder Silva / Carina Ceneviva / Carolina dos Santos Lazari / Deipara Monteiro Abellan / Emilly Henrique dos Santos / Ester Cerdeira Sabino / Fabíola Roberta Marim Bianchini / Flávio Ferraz de Paes Alcantara / Gabriel Frizzo Ramos / Gabriela Nunes Leal / Isadora Souza Rodriguez / João Renato Rebello Pinho / Jorge David Avaizoglou Carneiro / Jose Albino Paz / Juliana Carvalho Ferreira / Juliana Ferreira Ferranti / Juliana de Oliveira Achili Ferreira / Juliana Valéria de Souza Framil

Clinics, Vol

a cohort study in a Brazilian tertiary referral hospital

2021 Volume 76

Abstract: OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with ... ...

Abstract	OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children ...
Keywords	COVID-19 ; Children ; Adolescent ; Outcome ; Chronic Disease ; Multisystem Inflammatory Syndrome ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Elsevier España
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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