Article ; Online: Clinical impact of recreational drug use among people living with HIV in southern Taiwan.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
2020 Volume 54, Issue 5, Page(s) 952–962
Abstract: Background: It is unclear about the impact of recreational drug use on the adherence, drug-drug interaction and the occurrence of sexual transmitted diseases (STDs) among people living with HIV.: Material and methods: A retrospective study was ... ...
| Abstract | Background: It is unclear about the impact of recreational drug use on the adherence, drug-drug interaction and the occurrence of sexual transmitted diseases (STDs) among people living with HIV. Material and methods: A retrospective study was conducted between Dec 2016, and July 2018 to assess the clinical impact of recreational drug consumption in people living with HIV with antiretroviral therapy. We collected data of the demographics, recreational drug use, laboratory results and STDs diagnoses. Potential drug-drug interactions were checked with reference databases. The association between recreational drug use and STDs, HIV viral load suppression and drug interactions were evaluated. Results: A total of 462 participants were enrolled, included 384 recreational drug users and 78 non-recreational drug users. Younger age (adjusted odds ratio [aOR], 0.94; 95% CI: 0.91-0.98; p = 0.001), longer HIV infection period (aOR, 1.11; 95% CI: 1.03-1.20; p = 0.009) and poor antiretroviral drug adherence (1-2 pills missing per month: aOR, 6.82; 95% CI: 3.50-13.27; p < 0.001; >2 pills missing per month: aOR, 3.50; 95% CI: 1.28-9.61; p = 0.015) were factors associated with recreational drug use. Methamphetamine and nitrites were two most common recreational drugs. Recreational drug use was significantly associated with STDs in one-year follow-up period (aOR, 2.43; 95% CI: 1.11-5.32; p = 0.027) but was not significantly associated with unsuppressed viral load, though a trend was observed (OR, 2.23; 95% CI: 0.92-5.37; p = 0.074). Potential interactions with recreational drugs included 33.1% antiretroviral drugs and 31.3% medications for comorbidities. Conclusion: Recreational drug was associated with STDs. A great proportion of the patients consuming recreational drugs had potential interactions with antiretroviral drugs and medications for comorbidities. The association of recreational drug use and unsuppressed viral load warrants further investigation. |
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| MeSH term(s) | Adult ; Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Drug Interactions ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Recreational Drug Use/statistics & numerical data ; Retrospective Studies ; Sexually Transmitted Diseases/epidemiology ; Taiwan/epidemiology ; Viral Load/drug effects | |||||
| Chemical Substances | Anti-Retroviral Agents | |||||
| Language | English | |||||
| Publishing date | 2020-08-12 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1497590-7 | |||||
| ISSN | 1995-9133 ; 1684-1182 ; 0253-2662 | |||||
| ISSN (online) | 1995-9133 | |||||
| ISSN | 1684-1182 ; 0253-2662 | |||||
| DOI | 10.1016/j.jmii.2020.07.016 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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