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  1. AU="Sang Yup Lee"
  2. AU=Ahuja Preeti
  3. AU=Zulhendri Felix
  4. AU=Suhail Shanzay
  5. AU="Masum, Hassan"
  6. AU="Del Águila, Javier García"
  7. AU="Balian, Dikran Raffi"
  8. AU="Starr, Megan M"
  9. AU=Rajapaksa Shabna
  10. AU="Mohammed Aly Abdou" AU="Mohammed Aly Abdou"
  11. AU=Cooper Isabella D
  12. AU="Luis Rivera-Armenta, Jose"
  13. AU="Zahid Shaikh"
  14. AU="Scovil, Carol"
  15. AU="Grove, Nico"
  16. AU="McGuire, K J"
  17. AU="Martin, Bianca Aparecida"
  18. AU="Hampton, Joshua Trae"
  19. AU=Thesen Thomas
  20. AU=Oliveira Giuliano da Paz
  21. AU="García, Patricia J"
  22. AU="Hosseinpanah, Farhad"
  23. AU="Mayuni, Grace"
  24. AU="Volkova, Yulia L"
  25. AU="Dauwerse, Sierk"

Suchergebnis

Treffer 1 - 10 von insgesamt 84

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  1. Buch: Systems metabolic engineering

    Wittmann, Christoph / Lee, Sang Yup

    2012  

    Verfasserangabe Christoph Wittmann ; Sang Yup Lee, ed
    Sprache Englisch
    Umfang XII, 387 S. : Ill., graph. Darst.
    Verlag Springer
    Erscheinungsort Dordrecht u.a.
    Erscheinungsland Niederlande
    Dokumenttyp Buch
    HBZ-ID HT017366199
    ISBN 978-94-007-4534-6 ; 978-94-007-4533-9 ; 94-007-4534-6 ; 94-007-4533-8
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2012 A 3500 bestellbar zur Ausleihe Magazin

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  2. Artikel ; Online: Document vectorization method using network information of words.

    Sang Yup Lee

    PLoS ONE, Vol 14, Iss 7, p e

    2019  Band 0219389

    Abstract: We propose a new method for vectorizing a document using the relational characteristics of the words in the document. For the relational characteristics, we use two types of relational information of a word: 1) the centrality measures of the word and 2) ... ...

    Abstract We propose a new method for vectorizing a document using the relational characteristics of the words in the document. For the relational characteristics, we use two types of relational information of a word: 1) the centrality measures of the word and 2) the number of times that the word is used with other words in the document. We propose these methods mainly because information regarding the relations of a word to other words in the document are likely to better represent the unique characteristics of the document than the frequency-based methods (e.g., term frequency and term frequency-inverse document frequency). In experiments using a corpus consisting of 14 documents pertaining to four different topics, the results of clustering analysis using cosine similarities between vectors of relational information for words were comparable to (and more accurate than in some cases) those obtained using vectors of frequency-based methods. The clustering analysis using vectors of tie weights between words yielded the most accurate result. Although the results obtained for the small dataset used in this study can hardly be generalized, they suggest that at least in some cases, vectorization of a document using the relational characteristics of the words can provide more accurate results than the frequency-based vectors.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 410
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: A case report of embryo transfer with air-transported fresh bovine embryo produced by multiple ovulation in Hanwoo

    Sang-Yup Lee / Seong-Eun Heo / Won-Jae Lee

    Journal of Animal Reproduction and Biotechnology, Vol 38, Iss 2, Pp 84-

    2023  Band 88

    Abstract: Because multiple ovulation embryo transfer (MOET) in cattle includes several benefits such as wide spreading of genetically superior offspring for long distance, this biotechnological method has been widely applied to Hanwoo. When the recipients are not ... ...

    Abstract Because multiple ovulation embryo transfer (MOET) in cattle includes several benefits such as wide spreading of genetically superior offspring for long distance, this biotechnological method has been widely applied to Hanwoo. When the recipients are not stayed close after embryo recovery from donor, the embryos are moved to other farms via several vehicles (car, train, and airplane). However, air travel induces lesser oxygen level, increased vibration, lower air pressure, higher noise, and increased exposure of cosmic radiation to living things than ground level. It was still unknown that fresh embryos obtained from multiple ovulation of Hanwoo could maintain their fertility after being transported via air plane, the present case report introduced a clinical case of MOET in Hanwoo after shipping fresh embryos via air transportation. The donor was multi-ovulated via follicle-stimulating hormone series of injection, which was followed by a gonadotrophin-releasing hormone injection and artificial insemination twice. The embryos were recovered by the uterine flushing, packed in ministraws, transported to recipients for 6 h including 1 h air flight, and then transferred to the synchronized recipients. During pregnancy diagnosis of early gestation period, 5 of 7 recipients (71.4%) presented no heat signs and showed fetal sacs with fluid under transrectal ultrasonography. After normal gestation period, all recipients naturally delivered healthy calves (male n = 2 and female n = 3) without abortion, stillbirth, and premature birth. The present case report indicated that transportation of fresh embryos for MOET via domestic flight in Korea did not affect to their fertility.
    Schlagwörter air plane ; embryo transfer ; hanwoo ; multiple ovulation ; Biotechnology ; TP248.13-248.65 ; Medicine (General) ; R5-920 ; Internal medicine ; RC31-1245
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag The Korean Society of Animal Reproduction and Biotechnology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Production of Rainbow Colorants by Metabolically Engineered Escherichia coli

    Dongsoo Yang / Seon Young Park / Sang Yup Lee

    Advanced Science, Vol 8, Iss 13, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract There has been much interest in producing natural colorants to replace synthetic colorants of health concerns. Escherichia coli has been employed to produce natural colorants including carotenoids, indigo, anthocyanins, and violacein. However, ... ...

    Abstract Abstract There has been much interest in producing natural colorants to replace synthetic colorants of health concerns. Escherichia coli has been employed to produce natural colorants including carotenoids, indigo, anthocyanins, and violacein. However, production of natural green and navy colorants has not been reported. Many natural products are hydrophobic, which are accumulated inside or on the cell membrane. This causes cell growth limitation and consequently reduces production of target chemicals. Here, integrated membrane engineering strategies are reported for the enhanced production of rainbow colorants—three carotenoids and four violacein derivatives—as representative hydrophobic natural products in E. coli. By integration of systems metabolic engineering, cell morphology engineering, inner‐ and outer‐membrane vesicle formation, and fermentation optimization, production of rainbow colorants are significantly enhanced to 322 mg L–1 of astaxanthin (red), 343 mg L–1 of β‐carotene (orange), 218 mg L–1 of zeaxanthin (yellow), 1.42 g L–1 of proviolacein (green), 0.844 g L–1 of prodeoxyviolacein (blue), 6.19 g L–1 of violacein (navy), and 11.26 g L–1 of deoxyviolacein (purple). The membrane engineering strategies reported here are generally applicable to microbial production of a broader range of hydrophobic natural products, contributing to food, cosmetic, chemical, and pharmaceutical industries.
    Schlagwörter membrane engineering ; metabolic engineering ; natural products ; rainbow colorants ; vesicle ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Buch: Metabolic engineering

    Lee, Sang Yup

    (Bioprocess technology ; 24)

    1999  

    Verfasserangabe ed. by Sang Yup Lee
    Serientitel Bioprocess technology ; 24
    Überordnung
    Schlagwörter Mikroorganismus ; Stoffwechsel ; Biotechnologie
    Schlagwörter Technische Biochemie ; Technische Biologie ; Biotechnik ; Biotech ; Metabolismus ; Verstoffwechselung ; Metabolische Regulation ; Keim ; Mikrobe ; Mikroben
    Sprache Englisch
    Umfang XXII, 423 S. : Ill., graph. Darst.
    Verlag Dekker
    Erscheinungsort New York u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT011140696
    ISBN 0-8247-7390-X ; 978-0-8247-7390-8
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    1999 A 7090 bestellbar zur Ausleihe Magazin

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: Metabolic engineering of microorganisms for production of aromatic compounds

    Damla Huccetogullari / Zi Wei Luo / Sang Yup Lee

    Microbial Cell Factories, Vol 18, Iss 1, Pp 1-

    2019  Band 29

    Abstract: Abstract Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals ... ...

    Abstract Abstract Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals has successfully been conducted and commercialized, there are still numerous chemicals and materials that await their efficient bio-based production. Aromatic chemicals, which are typically derived from benzene, toluene and xylene in petroleum industry, have been used in large amounts in various industries. Over the last three decades, many metabolically engineered microorganisms have been developed for the bio-based production of aromatic chemicals, many of which are derived from aromatic amino acid pathways. This review highlights the latest metabolic engineering strategies and tools applied to the biosynthesis of aromatic chemicals, many derived from shikimate and aromatic amino acids, including l-phenylalanine, l-tyrosine and l-tryptophan. It is expected that more and more engineered microorganisms capable of efficiently producing aromatic chemicals will be developed toward their industrial-scale production from renewable biomass.
    Schlagwörter Aromatic compounds ; Metabolic engineering ; Synthetic biology ; Shikimate pathway ; Phenylalanine ; Tyrosine ; Microbiology ; QR1-502
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing

    Yaojun Tong / Tue S. Jørgensen / Christopher M. Whitford / Tilmann Weber / Sang Yup Lee

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Band 11

    Abstract: CRISPR prime editing enables double-strand break free engineering of the genome. Here the authors present a toolkit for prime editing in E. coli. ...

    Abstract CRISPR prime editing enables double-strand break free engineering of the genome. Here the authors present a toolkit for prime editing in E. coli.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Janus regulation of ice growth by hyperbranched polyglycerols generating dynamic hydrogen bonding

    Sang Yup Lee / Minseong Kim / Tae Kyung Won / Seung Hyuk Back / Youngjoo Hong / Byeong-Su Kim / Dong June Ahn

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Band 10

    Abstract: Regulation of ice growth and ice growth inhibition are critical and different materials mimicking anti freeze proteins or ice binding surfaces have been developed. Here, the authors combine both concepts in a hyperbranched polyglycerols to change the ice ...

    Abstract Regulation of ice growth and ice growth inhibition are critical and different materials mimicking anti freeze proteins or ice binding surfaces have been developed. Here, the authors combine both concepts in a hyperbranched polyglycerols to change the ice growth activity.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Biotransformation of p-xylene into terephthalic acid by engineered Escherichia coli

    Zi Wei Luo / Sang Yup Lee

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Band 8

    Abstract: Terephthalic acid (TPA) is an important commodity chemical typically produced from the oxidation of fossil fuel-derivedp-xylene (pX) at high temperature and pressure. Here the authors report an engineered Escherichia coli strain that can transform pX ... ...

    Abstract Terephthalic acid (TPA) is an important commodity chemical typically produced from the oxidation of fossil fuel-derivedp-xylene (pX) at high temperature and pressure. Here the authors report an engineered Escherichia coli strain that can transform pX into TPA with a high conversion yield.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2017-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Targeted and high-throughput gene knockdown in diverse bacteria using synthetic sRNAs

    Jae Sung Cho / Dongsoo Yang / Cindy Pricilia Surya Prabowo / Mohammad Rifqi Ghiffary / Taehee Han / Kyeong Rok Choi / Cheon Woo Moon / Hengrui Zhou / Jae Yong Ryu / Hyun Uk Kim / Sang Yup Lee

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 13

    Abstract: Abstract Synthetic sRNAs allow knockdown of target genes at translational level, but have been restricted to a limited number of bacteria. Here, we report the development of a broad-host-range synthetic sRNA (BHR-sRNA) platform employing the RoxS ... ...

    Abstract Abstract Synthetic sRNAs allow knockdown of target genes at translational level, but have been restricted to a limited number of bacteria. Here, we report the development of a broad-host-range synthetic sRNA (BHR-sRNA) platform employing the RoxS scaffold and the Hfq chaperone from Bacillus subtilis. BHR-sRNA is tested in 16 bacterial species including commensal, probiotic, pathogenic, and industrial bacteria, with >50% of target gene knockdown achieved in 12 bacterial species. For medical applications, virulence factors in Staphylococcus epidermidis and Klebsiella pneumoniae are knocked down to mitigate their virulence-associated phenotypes. For metabolic engineering applications, high performance Corynebacterium glutamicum strains capable of producing valerolactam (bulk chemical) and methyl anthranilate (fine chemical) are developed by combinatorial knockdown of target genes. A genome-scale sRNA library covering 2959 C. glutamicum genes is constructed for high-throughput colorimetric screening of indigoidine (natural colorant) overproducers. The BHR-sRNA platform will expedite engineering of diverse bacteria of both industrial and medical interest.
    Schlagwörter Science ; Q
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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