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  1. Article ; Online: Lupus enteritis: a narrative review.

    Muñoz-Urbano, Marcela / Sangle, Shirish / D'Cruz, David P

    Rheumatology (Oxford, England)

    2024  

    Abstract: Lupus enteritis (LE) is a rare manifestation of systemic lupus erythematosus. The pathophysiology of LE has not been fully elucidated, although inflammatory and thrombotic processes are likely important factors. The underlying pathophysiological ... ...

    Abstract Lupus enteritis (LE) is a rare manifestation of systemic lupus erythematosus. The pathophysiology of LE has not been fully elucidated, although inflammatory and thrombotic processes are likely important factors. The underlying pathophysiological mechanisms may depend on which portion of the intestine is affected. Over half of the patients with LE also present with renal or haematological complications. The diagnosis of LE is based on clinical, histopathological, and imaging findings; abdominal computed tomography (CT) is the gold standard in diagnosis. Abdominal CT can also identify factors that predict complications and could potentially guide pharmacological and nutritional management. Timely identification and prompt treatment initiation are paramount to avoid life and organ threatening complications. Glucocorticoids are often the first line treatment. Additional therapy including immunosuppressive therapy is utilised on a case-by-case basis as there are no clinical trials to define the optimal therapeutic approach. Surgical intervention may be needed especially if there is bowel perforation or peritonitis. In general the prognosis of LE is good.
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead689
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  2. Book: Clinician's manual on lupus

    Hughes, Graham R. V. / Sangle, Shirish

    2013  

    Author's details ed. Graham Hughes ; Sirish Sangle
    Keywords Lupus--Handbooks, manuals, etc. ; Lupus erythematosus--Handbooks, manuals, etc.
    Language English
    Size IX, 100 S. : Ill., graph. darst., Kt.
    Publisher Springer Healthcare
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017593405
    ISBN 978-1-908517-48-7 ; 1-908517-48-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 247 available for loan (reading room) Lesesaal EG

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  3. Book: Sjögren's syndrome in clinical practrice

    Hughes, Graham R. V. / Sangle, Shirish / Bowman, Simon

    2014  

    Author's details Graham Hughes ; Shirish Sangle ; Simon Bowman
    Language English
    Size VIII, 82 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018344480
    ISBN 978-3-319-06058-3 ; 9783319060590 ; 3-319-06058-9 ; 3319060597
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Transverse myelitis associated with systemic lupus erythematosus (SLE-TM): A review article.

    Jain, Sahil / Khormi, Abdulrahman / Sangle, Shirish R / D'Cruz, David P

    Lupus

    2023  Volume 32, Issue 9, Page(s) 1033–1042

    Abstract: Systemic lupus erythematosus-related transverse myelitis (SLE-TM) is a rare but serious complication of SLE, which may result in significant morbidity. Its incidence is estimated between 0.5% and 1% of all SLE patients but may be the presenting feature ... ...

    Abstract Systemic lupus erythematosus-related transverse myelitis (SLE-TM) is a rare but serious complication of SLE, which may result in significant morbidity. Its incidence is estimated between 0.5% and 1% of all SLE patients but may be the presenting feature in 30%-60% of these patients. Unfortunately, due to lack of high-quality studies, data regarding this condition remains limited. Its pathogenesis remains largely unknown and clinical presentation is variable. There are still no set guidelines regarding diagnosis, management, or monitoring and the role of autoantibodies remains controversial. In this review, we aim to summarize the available data regarding the epidemiology, pathogenesis, clinical features, management, and prognosis of this rare disease.
    MeSH term(s) Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Myelitis, Transverse/diagnosis ; Myelitis, Transverse/etiology ; Prognosis ; Autoantibodies ; Magnetic Resonance Imaging ; Myelitis/complications
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033231185612
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  5. Book: Hughes syndrome

    Hughes, Graham R. V. / Sangle, Shirish

    the antiphospholipid syndrome

    2012  

    Author's details Graham Hughes ; Shirish Sangle
    Language English
    Size XVII, 102 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017071033
    ISBN 978-0-85729-738-9 ; 0-85729-738-4 ; 9780857297396 ; 0857297392
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2011 A 5486 order for loan Magazin

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  6. Article: Lupus Nephritis Outcomes after Stopping Immunosuppression.

    Alenzi, Fahidah / Ateka-Barrutia, Oier / Ken Cheah, Chee / Khamashta, Munther / Sangle, Shirish R / D'Cruz, David P

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Background/Objectives: ...

    Abstract Background/Objectives:
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082211
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  7. Article ; Online: Relapsing polychondritis - A single Centre study in the United Kingdom.

    Sangle, Shirish R / Hughes, Catherine D / Barry, Lucinda / Qureshi, Sumera / Cheah, Chee Ken / Poh, Yih Jia / D'Cruz, David P

    Autoimmunity reviews

    2023  Volume 22, Issue 8, Page(s) 103352

    Abstract: Introduction and objectives: Relapsing Polychondritis (RP) is a rare immune mediated inflammatory disorder that may result in damage and destruction of cartilaginous tissues.: Patients and methods: We retrospectively analysed patients with a clinical ...

    Abstract Introduction and objectives: Relapsing Polychondritis (RP) is a rare immune mediated inflammatory disorder that may result in damage and destruction of cartilaginous tissues.
    Patients and methods: We retrospectively analysed patients with a clinical diagnosis of RP. Patients were investigated using pulmonary function tests, dynamic high-resolution CT scans, bronchoscopy, laryngoscopy and/or PET-CT scans along with autoimmune serology. Patients had other specialist reviews when indicated.
    Results: We identified 68 patients with a diagnosis of RP, 55 (81%) were Caucasian, 8 (12%) Afro Caribbean, 4 (6%) Asian and 1 patient had Mixed Ethnicity. Twenty-nine (43%) had pulmonary involvement and in 16, pulmonary involvement was the initial presentation. The mean age at onset was 44 years (range 17-74). There was a mean diagnostic delay of 55 weeks. Sixty-six (97%) patients received a combination of oral Prednisolone and disease modifying anti-rheumatic drugs. Twelve of 19 (63%) received biologics, with an initial good response, and 10 remain on treatment. Eleven patients with respiratory collapse required CPAP to maintain airway patency. Twelve (18%) patients died due to RP and 9 had respiratory complications. Two patients developed myelodysplasia and one had lung carcinoma. In a multivariate regression analysis, the prognostic variables were ethnicity, nasal chondritis, laryngotracheal stricture and elevated serum creatinine.
    Conclusion: RP is a rare autoimmune condition often associated with significant delays in diagnosis and initiation of treatment. Pulmonary involvement in RP may cause significant morbidity and mortality due to organ damage. Disease modifying anti rheumatic drugs and biologics should be considered early in the disease course to minimise adverse effects of long-term corticosteroid therapy and organ damage.
    MeSH term(s) Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Polychondritis, Relapsing/diagnosis ; Polychondritis, Relapsing/drug therapy ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Delayed Diagnosis ; Biological Products/therapeutic use
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-05-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2023.103352
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    Zs.A 5913: Show issues Location:
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  8. Article: What determines environmental proactiveness in the Indian cement sector? An empirical study

    Vishwakarma, Arun Kumar / Nema, Arvind K / Sangle, Shirish

    Journal of cleaner production. 2019 Oct. 10, v. 234

    2019  

    Abstract: The lack of clarity in the environmental strategies has created uncertainty towards industrial efforts to protect the environment. However, some firms are more apprehensive regarding environmental protection in comparison to their counterparts. What ... ...

    Abstract The lack of clarity in the environmental strategies has created uncertainty towards industrial efforts to protect the environment. However, some firms are more apprehensive regarding environmental protection in comparison to their counterparts. What determines the environmental proactiveness of these firms which go beyond extant laws to adopt proactive environmental strategies (PES)? This article, through an empirical study of the Indian cement sector, identifies the determinants of adoption of PES. Quantitative analysis of survey data from 310 respondents identifies four determinants; organisational capability, market benefits, stakeholder pressure, and environmental risk management. Four hypotheses are proposed to test the Confirmatory Factor Analysis (CFA) outcome. Organisational capability and market benefits are observed to be the key determinants. The study determines the strength of the identified determinants on PES adoption using structural equation modelling (SEM) and path analysis. Path analysis ranks the determinants in the order; organisational capability, market benefits, environmental risk management and stakeholder pressure. The evidence based findings from the research are expected to be useful for the environmental management practitioners as well as academicians. On the global front, the developing countries having identical socio-economic and political structure may gain from the findings of the study.
    Keywords cement ; developing countries ; empirical research ; environmental protection ; factor analysis ; markets ; path analysis ; politics ; quantitative analysis ; risk management ; socioeconomics ; stakeholders ; structural equation modeling ; surveys ; uncertainty
    Language English
    Dates of publication 2019-1010
    Size p. 961-971.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2019.06.291
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Dermographia as a first manifestation of lupus.

    Tremble, Kathryn C / Sangle, Shirish R / D'Cruz, David P

    Rheumatology (Oxford, England)

    2020  Volume 60, Issue 5, Page(s) e154–e155

    MeSH term(s) Adult ; Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/pathology ; Skin/pathology ; Urticaria/etiology ; Urticaria/pathology
    Language English
    Publishing date 2020-12-16
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa662
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  10. Article ; Online: Physician-patient interaction and medication adherence in lupus nephritis.

    Georgopoulou, Sofia / Nel, Louise / Sangle, Shirish R / D'Cruz, David P

    Lupus

    2020  Volume 29, Issue 10, Page(s) 1168–1178

    Abstract: Objective: The quality of physician-patient interaction can have a significant impact on medication adherence. Little is known about this relationship in patients with lupus nephritis.: Methods: A cross-sectional, quantitative study. Data collected ... ...

    Abstract Objective: The quality of physician-patient interaction can have a significant impact on medication adherence. Little is known about this relationship in patients with lupus nephritis.
    Methods: A cross-sectional, quantitative study. Data collected included demographics, current medication, systemic lupus erythematosus disease activity index, medication adherence, beliefs about medicines, shared decision-making, patient-doctor depth of relationship, patient-doctor quality of relationship, interpersonal trust in a physician and illness perceptions.
    Results: Ninety-eight patients with lupus nephritis completed the questionnaires. Logistic regression indicated that medication adherence was significantly predicted by (a) interpersonal trust in a physician (B = 0.85, Wald 3.94, 95% confidence interval (CI) 1.01, 5.44;
    Conclusion: The findings highlighted two key elements: (a) the importance of trust in relation to medication adherence; and (b) a good understanding of patients' illness is linked to a better relationship with their doctor and greater participation in shared decision-making which is associated with increased trust. Tailored psycho-educational interventions could contribute to improving the patient-doctor relationship quality, trust and increased shared decision-making, which, in turn, might improve medication adherence in patients with lupus nephritis.
    MeSH term(s) Adult ; Aged ; Cross-Sectional Studies ; Decision Making, Shared ; Disease Progression ; Health Knowledge, Attitudes, Practice ; Humans ; Lupus Nephritis/drug therapy ; Lupus Nephritis/psychology ; Male ; Medication Adherence/psychology ; Medication Adherence/statistics & numerical data ; Middle Aged ; Physician-Patient Relations ; Surveys and Questionnaires ; Trust
    Keywords covid19
    Language English
    Publishing date 2020-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/0961203320935977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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