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  1. Article ; Online: Re: Prevalence and distribution of cervical lymph node metastases in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma. Radiother Oncol, 2021. 157: p. 122-129.

    Sanguineti, Giuseppe

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2021  Volume 161, Page(s) 251–252

    MeSH term(s) Carcinoma, Squamous Cell ; Humans ; Lymph Nodes ; Lymphatic Metastasis ; Oropharyngeal Neoplasms ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Prevalence ; Squamous Cell Carcinoma of Head and Neck
    Language English
    Publishing date 2021-05-19
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2021.05.011
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  2. Article: A Systematic Review on the Impact of Hypofractionated and Stereotactic Radiotherapy on Immune Cell Subpopulations in Cancer Patients.

    Takanen, Silvia / Bottero, Marta / Nisticò, Paola / Sanguineti, Giuseppe

    Cancers

    2022  Volume 14, Issue 21

    Abstract: We investigated how hypofractionated radiotherapy (HFRT) and stereotactic body radiotherapy (SBRT) may impact immune cells in different type of tumors. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews ... ...

    Abstract We investigated how hypofractionated radiotherapy (HFRT) and stereotactic body radiotherapy (SBRT) may impact immune cells in different type of tumors. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The PubMed, Embase and Cochrane databases were searched. Overall, 11 studies met the inclusion criteria and were eligible for the present analysis. Both HFRT and SBRT have different impact on lymphocyte subpopulations, confirming their immunomodulatory effect which may have a crucial role in future combined treatment with new emergent therapies such as immunotherapy. Further studies are needed to shed more light on this emerging topic to ultimately improve patient care, treatment and clinical benefits for cancer patients.
    Language English
    Publishing date 2022-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14215190
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  3. Article ; Online: Organ motion in linac-based SBRT for glottic cancer.

    Perillo, Annarita / Landoni, Valeria / Farneti, Alessia / Sanguineti, Giuseppe

    Radiation oncology (London, England)

    2021  Volume 16, Issue 1, Page(s) 106

    Abstract: Purpose: The purpose of this study is to evaluate inter- and intra-fraction organ motion as well as to quantify clinical target volume (CTV) to planning target volume (PTV) margins to be adopted in the stereotactic treatment of early stage glottic ... ...

    Abstract Purpose: The purpose of this study is to evaluate inter- and intra-fraction organ motion as well as to quantify clinical target volume (CTV) to planning target volume (PTV) margins to be adopted in the stereotactic treatment of early stage glottic cancer.
    Methods and materials: Stereotactic body radiotherapy (SBRT) to 36 Gy in 3 fractions was administered to 23 patients with early glottic cancer T1N0M0. Patients were irradiated with a volumetric intensity modulated arc technique delivered with 6 MV FFF energy. Each patient underwent a pre-treatment cone beam computed tomography (CBCT) to correct the setup based on the thyroid cartilage position. Imaging was repeated if displacement exceeded 2 mm in any direction. CBCT imaging was also performed after each treatment arc as well as at the end of the delivery. Swallowing was allowed only during the beam-off time between arcs. CBCT images were reviewed to evaluate inter- and intra-fraction organ motion. The relationships between selected treatment characteristics, both beam-on and delivery times as well as organ motion were investigated.
    Results: For the population systematic (Ʃ) and random (σ) inter-fraction errors were 0.9, 1.3 and 0.6 mm and 1.1, 1.3 and 0.7 mm in the left-right (X), cranio-caudal (Y) and antero-posterior (Z) directions, respectively. From the analysis of CBCT images acquired after treatment, systematic (Ʃ) and random (σ) intra-fraction errors resulted 0.7, 1.6 and 0.7 mm and 1.0, 1.5 and 0.6 mm in the X, Y and Z directions, respectively. Margins calculated from the intra-fraction errors were 2.4, 5.1 and 2.2 mm in the X, Y and Z directions respectively. A statistically significant difference was found for the displacement in the Z direction between patients irradiated with > 2 arcs versus ≤ 2 arcs, (MW test, p = 0.038). When analyzing mean data from CBCT images for the whole treatment, a significant correlation was found between the time of delivery and the three dimensional displacement vector (r = 0.489, p = 0.055), the displacement in the Y direction (r = 0.553, p = 0.026) and the subsequent margins to be adopted (r = 0.626, p = 0.009). Finally, displacements and the subsequent margins to be adopted in Y direction were significantly greater for treatments with more than 2 arcs (MW test p = 0.037 and p = 0.019, respectively).
    Conclusions: In the setting of controlled swallowing during treatment delivery, intra-fraction motion still needs to be taken into account when planning with estimated CTV to PTV margins of 3, 5 and 3 mm in the X, Y and Z directions, respectively. Selected treatments may require additional margins.
    MeSH term(s) Cone-Beam Computed Tomography/methods ; Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/surgery ; Organ Motion ; Prognosis ; Prospective Studies ; Radiosurgery/instrumentation ; Radiosurgery/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Setup Errors/prevention & control ; Radiotherapy, Intensity-Modulated/methods ; Surgery, Computer-Assisted/methods
    Language English
    Publishing date 2021-06-12
    Publishing country England
    Document type Journal Article
    ISSN 1748-717X
    ISSN (online) 1748-717X
    DOI 10.1186/s13014-021-01833-2
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  4. Article ; Online: Oncology scan--rethinking treatment strategies for cancers of the larynx and pharynx.

    Sanguineti, Giuseppe

    International journal of radiation oncology, biology, physics

    2013  Volume 86, Issue 5, Page(s) 805–807

    Language English
    Publishing date 2013-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2013.03.009
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  5. Article ; Online: Is postoperative radiotherapy routinely indicated after total laryngectomy for pT3N0-1 supraglottic carcinoma?

    Sanguineti, Giuseppe / Vidiri, Antonello / Pellini, Raul

    Oral oncology

    2020  Volume 107, Page(s) 104825

    MeSH term(s) Female ; Humans ; Laryngeal Neoplasms/radiotherapy ; Laryngectomy/methods ; Male ; Postoperative Period
    Language English
    Publishing date 2020-05-31
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.104825
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    Zs.A 4869: Show issues Location:
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    Zs.A 456: Show issues Location:
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  6. Article: Editorial: Modeling for Prediction of Radiation-Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era.

    Rancati, Tiziana / Fiorino, Claudio / Sanguineti, Giuseppe / Valdagni, Riccardo / Orlandi, Ester

    Frontiers in oncology

    2021  Volume 11, Page(s) 690649

    Language English
    Publishing date 2021-05-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.690649
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  7. Article: Moraxella nonliquefaciens

    Giovannini-Sanguineti, Giancarlo / Hanze-Villavicencio, Karen / Sanchez-Vegas, Carolina

    IDCases

    2021  Volume 24, Page(s) e01145

    Abstract: A 2-year-old, previously healthy, male presented with an insidious history of intermittent left knee pain and edema who had been evaluated in the emergency department on multiple occasions with unremarkable imaging and normal laboratory results. On the ... ...

    Abstract A 2-year-old, previously healthy, male presented with an insidious history of intermittent left knee pain and edema who had been evaluated in the emergency department on multiple occasions with unremarkable imaging and normal laboratory results. On the day of presentation, he had mild edema of the left knee and inability to bear weight. Synovial fluid analysis showed an elevated white cell count with neutrophil predominance and mildly elevated inflammatory markers, consistent with septic arthritis. He underwent knee arthrotomy with irrigation and debridement and was initiated on broad spectrum antibiotics. Cultures were negative, polymerase chain reaction for MRSA and
    Language English
    Publishing date 2021-04-30
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2021.e01145
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  8. Article ; Online: A new lateral cervical approach for salvage total laryngo-pharyngectomy.

    Spriano, G / Mercante, G / Manciocco, V / Cristalli, G / Sanguineti, G / Ferreli, F

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2019  Volume 39, Issue 1, Page(s) 61–64

    MeSH term(s) Aged ; Carcinoma, Squamous Cell/surgery ; Dermatologic Surgical Procedures ; Humans ; Hyoid Bone/surgery ; Hypopharyngeal Neoplasms/surgery ; Hypopharynx/surgery ; Laryngeal Neoplasms/surgery ; Laryngectomy/methods ; Larynx/surgery ; Male ; Myocutaneous Flap ; Neck/surgery ; Neck Dissection/methods ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Pectoralis Muscles/surgery ; Pharyngectomy/methods ; Pharynx/pathology ; Pharynx/surgery ; Reconstructive Surgical Procedures ; Salvage Therapy/methods ; Surgical Flaps
    Language English
    Publishing date 2019-04-01
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-1753
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    Zs.B 2608: Show issues Location:
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  9. Article: The Prognostic Value of DCE-MRI Findings before Salvage Radiotherapy after Radical Prostatectomy.

    Farneti, Alessia / Bottero, Marta / Faiella, Adriana / Giannarelli, Diana / Bertini, Luca / Landoni, Valeria / Vici, Patrizia / D'Urso, Pasqualina / Sanguineti, Giuseppe

    Cancers

    2023  Volume 15, Issue 4

    Abstract: Background: To investigate the predictive role of dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI) findings before salvage radiotherapy after radical prostatectomy (RP).: Methods: This retrospective study selected patients with ... ...

    Abstract Background: To investigate the predictive role of dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI) findings before salvage radiotherapy after radical prostatectomy (RP).
    Methods: This retrospective study selected patients with biochemical failure (BF) after RP restaged with DCE-MRI. Patients underwent sRT in 30 fractions delivering 66-69 Gy and 73.5 Gy to the prostatic fossa and to the local failure as per DCE-MRI, respectively. Pelvic nodes were treated to 54 Gy in selected patients. The endpoint was BF after sRT.
    Results: In total, 236 patients were analyzed and 146 (61.9%) had presumed local failure at DCE-MRI: 54.8%, 23.8% and 21.4% were found at the vesico-urethral anastomosis (VUA), the bladder neck and the retro-vesical space, respectively. The presence of a local failure at DCE-MRI halved the risk of BF; VUA-only location and lesion volume were independently correlated with survival without evidence of biochemical failure (bNED) at multivariable analysis. For patients with VUA-only disease up to 0.4 cc, the 4-year-bNED was 94.6% (95%CI: 80.2-98.6%) as opposed to 80.9% (95%CI: 71.6-87.4%) and 73.7% (95%CI: 63.1-81.8%) for other lesions and no macrodisease, respectively.
    Conclusions: DCE-MRI at restaging for BF after RP provides predictive and therapeutic information. Patients with small lesions at the VUA have an excellent prognosis after sRT.
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041246
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  10. Article ; Online: Consolidative active scanning proton therapy for mediastinal lymphoma: selection criteria, treatment implementation and clinical feasibility.

    Dionisi, F / Scartoni, D / Rombi, B / Vennarini, S / Righetto, R / Farace, P / Lorentini, S / Schwarz, M / Di Murro, L / Demofonti, C / D'Angelillo, R M / Petrongari, M G / Sanguineti, G / Amichetti, M

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2022  Volume 198, Issue 6, Page(s) 558–565

    Abstract: Aims: Proton therapy (PT) represents an advanced form of radiotherapy with unique physical properties which could be of great advantage in reducing long-term radiation morbidity for cancer survivors. Here, we aim to describe the whole process leading to ...

    Abstract Aims: Proton therapy (PT) represents an advanced form of radiotherapy with unique physical properties which could be of great advantage in reducing long-term radiation morbidity for cancer survivors. Here, we aim to describe the whole process leading to the clinical implementation of consolidative active scanning proton therapy treatment (PT) for mediastinal lymphoma.
    Methods: The process included administrative, technical and clinical issues. Authorization of PT is required in all cases as mediastinal lymphoma is currently not on the list of diseases reimbursable by the Italian National Health Service. Technically, active scanning PT treatment for mediastinal lymphoma is complex, due to the interaction between actively scanned protons and the usually irregular and large volumes to be irradiated, the nearby healthy tissues and the target motion caused by breathing. A road map to implement the technical procedures was prepared. The clinical selection of patients was of utmost importance and took into account both patient and tumor characteristics.
    Results: The first mediastinal lymphoma was treated at our PT center in 2018, four years after the start of the clinical activities. The treatment technique implementation included mechanical deep inspiration breath-hold simulation computed tomography (CT), clinical target volume (CTV)-based multifield optimization planning and plan robustness analysis. The ultimate authorization rate was 93%. In 4 cases a proton-photon plan comparison was required. Between May 2018 and February, 2021, 14 patients were treated with consolidative PT. The main clinical reasons for choosing PT over photons was a bulky disease in 8 patients (57%), patient's age in 11 patients (78%) and the proximity of the lymphoma to cardiac structures in 10 patients (71%). With a median follow-up of 15 months (range, 1-33 months) all patients but one (out-of-field relapse) are without evidence of disease, all are alive and no late toxicities were observed during the follow-up period.
    Conclusions: The clinical implementation of consolidative active scanning PT for mediastinal lymphoma required specific technical procedures and a prolonged experience with PT treatments. An accurate selection of patients for which PT could be of advantage in comparison with photons is mandatory.
    MeSH term(s) Feasibility Studies ; Hodgkin Disease/pathology ; Humans ; Lymphoma/radiotherapy ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/radiotherapy ; Organs at Risk/pathology ; Patient Selection ; Proton Therapy/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Intensity-Modulated/methods ; State Medicine
    Language English
    Publishing date 2022-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-022-01918-1
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