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Article ; Online: Cordova Formula, A Better Alternative to Martin's Formula for the Calculation of LDL-C in Patients with TG above 350 mg/dL.

Tomo, Sojit / Sankanagoudar, Shrimanjunath

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir

2022 Volume 50, Issue 4, Page(s) 308–309

MeSH term(s)	Cholesterol, LDL ; Humans ; Triglycerides
Chemical Substances	Cholesterol, LDL ; Triglycerides
Language	English
Publishing date	2022-06-17
Publishing country	Turkey
Document type	Letter ; Comment
ZDB-ID	1215217-1
ISSN	1308-4488 ; 1016-5169
ISSN (online)	1308-4488
ISSN	1016-5169
DOI	10.5543/tkda.2022.22368
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Zs.A 4156: Show issues

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Article: Effectiveness and perceptions of MBBS students about process-oriented guided inquiry learning in biochemistry.

Sonoli, Smita S / Sankanagoudar, Shrimanjunath

The National medical journal of India

2021 Volume 33, Issue 6, Page(s) 362–365

Abstract: Background: On reviewing our teaching methods through students' feedback, we realized they were dissatisfied with the present teaching methodology of lectures in terms of knowledge retention and problem-solving. This issue was addressed using student- ... ...

Abstract	Background: On reviewing our teaching methods through students' feedback, we realized they were dissatisfied with the present teaching methodology of lectures in terms of knowledge retention and problem-solving. This issue was addressed using student-centred and cooperative learning methodology, i.e. process-oriented guided inquiry learning (POGIL) where pre-designed questions guide students to enquire concepts, with reflection writing exercise helping students to strengthen their concepts. This study analysed the effectiveness and perceptions of POGIL sessions conducted after lectures. Methods: The study was approved by the institutional ethical committee. A total of 42 (7 groups; each group with 6 members of high, low and average achievers) consented and POGIL-sensitized MBBS phase I students were part of the study. One-hour POGIL sessions were conducted a week after lecturing with reading material. Pre-, post- and retention test multiple-choice questions (MCQs) were administered for assessment of effectiveness and a close-ended questionnaire for recording perception. Results: Post-test and retention test MCQ scores were statistically higher than pre-test scores both in all participants and low achievers (p<0.05). Around 60% of the students felt that the POGIL activities and working in teams helped them to understand concepts. Reflection analysis revealed the best and least understood concept and students came up with memory aids to remember complex metabolic regulation. Conclusion: POGIL might be a promising reinforcement strategy to lectures in biochemistry and preferred tool to address the issue of low achievers in the class.
MeSH term(s)	Curriculum ; Educational Measurement ; Humans ; Learning ; Perception ; Students
Language	English
Publishing date	2021-08-02
Publishing country	India
Document type	Journal Article
ZDB-ID	645116-0
ISSN	0970-258X
ISSN	0970-258X
DOI	10.4103/0970-258X.321143
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Zs.A 2493: Show issues

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Article ; Online: Cordova Formula for Low-Density Lipoprotein- Cholesterol Estimation: Not Only the Simplest of All But Also Superior to Other Formulae at a Higher Range of Triglyceride.

Tomo, Sojit / Sankanagoudar, Shrimanjunath / Sharma, Praveen

Anatolian journal of cardiology

2022 Volume 26, Issue 7, Page(s) 520–524

MeSH term(s)	Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Triglycerides
Chemical Substances	Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides
Language	English
Publishing date	2022-07-05
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2278670-3
ISSN	2149-2271 ; 2149-2271
ISSN (online)	2149-2271
ISSN	2149-2271
DOI	10.5152/AnatolJCardiol.2022.1356
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Article ; Online: Enhanced ability of Cordova formula for estimation of LDL cholesterol in distinguishing patient requiring lipid lowering treatment.

Tomo, Sojit / Sankanagoudar, Shrimanjunath / Shukla, Ravindra K

Minerva endocrinology

2022 Volume 48, Issue 2, Page(s) 247–250

MeSH term(s)	Humans ; Cholesterol, LDL ; Triglycerides
Chemical Substances	Cholesterol, LDL ; Triglycerides
Language	English
Publishing date	2022-02-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.22.03697-1
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Zs.A 2105: Show issues

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Article ; Online: Validation of a novel method for determination of low-density lipoprotein cholesterol levels in Indian patients with type 2 diabetes.

Tomo, Sojit / Sankanagoudar, Shrimanjunath / Shukla, Ravindra / Sharma, Praveen

Diabetes & metabolic syndrome

2022 Volume 16, Issue 4, Page(s) 102448

Abstract: Background and aims: LDL-cholesterol (LDL-C), being the primary predictor of cardiovascular disease in Type 2 diabetes (T2D), is associated with cardiovascular risk stratification and requires to be estimated with better accuracy with minimal bias. ... ...

Abstract	Background and aims: LDL-cholesterol (LDL-C), being the primary predictor of cardiovascular disease in Type 2 diabetes (T2D), is associated with cardiovascular risk stratification and requires to be estimated with better accuracy with minimal bias. Different formulae have been devised to calculate the LDL-C from the measured lipid profile parameters. Methods: In this analytical cross-sectional study, a total of 150 patients with T2D were studied, and blood samples were subjected for lipid profile analysis at the Central Biochemistry laboratory. Different formulae assessed calculated LDL-C. Results: We observed that all formulae, except Ahmadi, underestimated the LDL-C compared to direct assay. A significant difference was observed between all calculated LDL-C and directly measured LDL-C. On linear regression analysis, the newer formula Martin's has a better approximation with direct assay (slope: 0.9708) than Friedewald (slope: 0.9477). Similarly, Martin's formula exhibited lesser bias (-13.56) in calculating LDL-C in patients with T2D compared with Friedewald's formula. Conclusions: The study demonstrated that in patients with T2D, all formulae except Ahmadi significantly underestimated the LDL-C when compared with the direct assay. The newer Martin's formula appeared to more precisely calculate LDL-C in T2D when compared with the traditional Friedewald's formula.
MeSH term(s)	Cardiovascular Diseases ; Cholesterol, LDL ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 ; Humans ; Triglycerides
Chemical Substances	Cholesterol, LDL ; Triglycerides
Language	English
Publishing date	2022-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2022.102448
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Article ; Online: Calculated small dense LDL-cholesterol and its correlation with the atherogenic index of plasma.

Tomo, Sojit / Sankanagoudar, Shrimanjunath / Shukla, Ravindra / Sharma, Praveen

Annals of clinical biochemistry

2022 Volume 59, Issue 6, Page(s) 454–456

MeSH term(s)	Humans ; Cholesterol, LDL ; Cholesterol, HDL ; Lipoproteins, LDL ; Triglycerides
Chemical Substances	Cholesterol, LDL ; Cholesterol, HDL ; Lipoproteins, LDL ; Triglycerides
Language	English
Publishing date	2022-05-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1177/00045632221102767
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Zs.A 889: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Positive association of branched-chain amino acids with triglyceride and glycated haemoglobin in Indian patients with type 2 diabetes mellitus.

Sankanagoudar, Shrimanjunath / Shukla, Ravindra / Shukla, Kamla Kant / Sharma, Praveen

Diabetes & metabolic syndrome

2022 Volume 16, Issue 4, Page(s) 102481

Abstract: Background and aims: Over the past few years, branched-chain amino acids (BCAAs) are increasingly being linked to insulin resistance and type 2 diabetes mellitus (T2DM), but their relevance for metabolic dyslipidaemia in T2DM is unclear. This study aims ...

Abstract	Background and aims: Over the past few years, branched-chain amino acids (BCAAs) are increasingly being linked to insulin resistance and type 2 diabetes mellitus (T2DM), but their relevance for metabolic dyslipidaemia in T2DM is unclear. This study aims to determine the plasma and urinary BCAAs and their association with insulin resistance, lipid profile and glycated haemoglobin in patients with T2DM among Indian adults. Methods: In this analytical cross-sectional study, a total of eighty subjects were recruited, 40 T2DM cases and 40 healthy controls. Blood samples collected were subjected to fasting blood sugar (FBS), lipid profile, HbA1c, insulin and BCAAs analysis and urine samples were assessed for BCAAs. All associations were assessed using Spearman Rank Correlation. Results: The plasma levels of BCAAs were significantly higher (p < 0.05) in subjects with T2DM than in control subjects. Spearman Rank Correlation analyses revealed a non-significant (p = 0.21) but positive association between BCAAs and homeostasis model assessment of insulin resistance (HOMA-IR) in patients with T2DM (Rho: 0.27). Among lipid profile parameters, only triglycerides had a significant positive correlation to plasma BCAAs in cases (Rho: 0.5971) but not in control subjects. Findings also revealed a significant positive (p < 0.05) association between plasma BCAAs and HbA1c in patients with T2DM (Rho: 0.5325). Urinary BCAAs levels had a non-significant increase in T2DM subjects and did not show any significant correlation with other parameters assessed. Conclusion: Elevated levels of plasma BCAAs are positively associated with triglyceride and HbA1c. They could serve as an effective marker for the assessment of metabolic dyslipidaemia in subjects with T2DM. Further, large scale studies are needed for confirmation of the same.
MeSH term(s)	Adult ; Amino Acids, Branched-Chain/metabolism ; Blood Glucose/analysis ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 ; Dyslipidemias ; Glycated Hemoglobin A/analysis ; Humans ; Insulin Resistance ; Triglycerides
Chemical Substances	Amino Acids, Branched-Chain ; Blood Glucose ; Glycated Hemoglobin A ; Triglycerides
Language	English
Publishing date	2022-04-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2022.102481
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Article ; Online: Expression of stem cell markers as predictors of therapeutic response in metastatic prostate cancer patients.

Nandagopal, Srividhya / Choudhary, Gautam / Sankanagoudar, Shrimanjunath / Banerjee, Mithu / Elhence, Poonam / Jena, Rahul / Selvi, Maithili Karpaga / Shukla, Kamla Kant

Urologic oncology

2024 Volume 42, Issue 3, Page(s) 68.e21–68.e31

Abstract: Background: Cancer stem cells (CSCs) have been implicated in prostate cancer (PCA) progression and therapeutic resistance. This study aimed to compare the expression levels of CSC CD (CD 44, CD 133, and CD 24) markers in treatment-naive patients with ... ...

Abstract	Background: Cancer stem cells (CSCs) have been implicated in prostate cancer (PCA) progression and therapeutic resistance. This study aimed to compare the expression levels of CSC CD (CD 44, CD 133, and CD 24) markers in treatment-naive patients with metastatic PCA before and after treatment. Methods: The study included 60 treatment-naïve patients with metastatic PCA who received androgen deprivation therapy (ADT) alone (n = 30) and ADT plus chemotherapy (n = 30). The level of CD44, CD133, and CD24 were obtained by flow cytometric analysis before and after treatment. Baseline characteristics were also assessed, including age, pretreatment testosterone levels, and pretreatment prostate-specific antigen (PSA) levels. Results: The baseline characteristics analysis showed no significant difference in pre-treatment testosterone levels between the ADT+ chemotherapy and ADT-alone groups. In the flow cytometric analysis, no significant difference was observed in pre-treatment CD44 Conclusion: Combination therapy involving chemotherapy and ADT appears to have a greater impact on suppressing CSCs compared to ADT alone. These findings highlight the potential of targeting CSCs as a prognostic and predictive marker therapeutic strategy in metastatic PCA.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Prostate-Specific Antigen/therapeutic use ; Androgen Antagonists/adverse effects ; Testosterone/therapeutic use ; Stem Cells/pathology
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77) ; Androgen Antagonists ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2023.12.012
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Zs.A 4817: Show issues

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Article ; Online: Long Non Coding RNA in Triple Negative Breast Cancer: A Promising Biomarker in Tumorigenesis.

Nandagopal, Srividhya / Misra, Sanjeev / Sankanagoudar, Shrimanjunath / Banerjee, Mithu / Sharma, Praveen / Pane, Stacey Ellen / Guerriero, Giulia / Shukla, Kamla Kant

Asian Pacific journal of cancer prevention : APJCP

2023 Volume 24, Issue 1, Page(s) 49–59

Abstract: Globally, Triple-negative breast cancer (TNBC) is an unsurpassed variant of breast cancer (BC) with a very high fatality rate, and disease burden. Nevertheless, the deficit of diagnostic markers and focused treatment are major hurdles for potent ... ...

Abstract	Globally, Triple-negative breast cancer (TNBC) is an unsurpassed variant of breast cancer (BC) with a very high fatality rate, and disease burden. Nevertheless, the deficit of diagnostic markers and focused treatment are major hurdles for potent therapeutics. They are also the reason for bad outcomes and causes of a worse prognosis and a high rate of flare up in patients with TNBC diagnosis. Long non-coding RNAs (lncRNA) are a new class of molecules that have recently gained interest in healthcare management due to their potential as biomarkers for human diseases especially cancers. The growing interest in lncRNA in clinical practice has created an unmet need for developing assays to test lncRNA quickly and accurately for early diagnostics. These lncRNA modulate multiple stages of tumor development, including growth, proliferation, invasion, angiogenesis, and metastases, by controlling several genes and changing metabolic networks. Highly invasive phenotype and chemo resistance are prominent characteristics of TNBC subtypes that require accurate diagnostic and prognostic instruments involving lncRNA. This review focusses on the evolving purpose and coalition of lncRNAs in TNBC and accentuates their capable effects in diagnosis and treatment of cancer. Moreover, the extensive literature analysis of our review creates an opportunity in the translational application concerning the TNBC lncRNAs described until now. The depiction of lncRNAs enrolled in TNBC is comprehensive, and sufficient substantiation studies are the need of the hour to authenticate the current outcomes and create imminent upcoming of elemental research setting into clinical practice.
MeSH term(s)	Humans ; Triple Negative Breast Neoplasms/diagnosis ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Prognosis ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic
Chemical Substances	RNA, Long Noncoding ; Biomarkers, Tumor
Language	English
Publishing date	2023-01-01
Publishing country	Thailand
Document type	Review ; Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2023.24.1.49
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Article: Comparison of Diagnostic Accuracy of Presepsin and Procalcitonin for Sepsis in Critically Ill Patients: A Prospective Observational Study.

Roy, Shipra / Kothari, Nikhil / Sharma, Ankur / Goyal, Shilpa / Sankanagoudar, Shrimanjunath / Bhatia, Pradeep Kumar / Sharma, Praveen

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2023 Volume 27, Issue 4, Page(s) 289–293

Abstract: Objective: Early diagnosis of sepsis is crucial to institute appropriate therapy and then to avert a possible negative outcome. We planned this study to evaluate the diagnostic value of presepsin, its sensitivity and specificity for diagnosing sepsis in ...

Abstract	Objective: Early diagnosis of sepsis is crucial to institute appropriate therapy and then to avert a possible negative outcome. We planned this study to evaluate the diagnostic value of presepsin, its sensitivity and specificity for diagnosing sepsis in critically ill patients, and its ability to prognosticate the outcome of sepsis. Methods: In this prospective observational study, adult patients admitted to the intensive care unit (ICU) at our institute were screened, and those with features suggestive of sepsis were recruited into the study. Procalcitonin (PCT) and presepsin were assessed on the day of admission and day 7 of the ICU stay, apart from routine investigations. Patients were followed for outcome in terms of mortality till 28 days. Results: The study comprised 82 patients who satisfied the inclusion criteria. Presepsin sensitivity for sepsis diagnosis was determined to be 78%, while that of PCT was determined to be 69%. This gave a combined sensitivity of presepsin and PCT of 93% when used in parallel for the diagnosis of sepsis. Conclusion: A combination of PCT and presepsin provides higher sensitivity and can be used to screen for sepsis in the ICU. How to cite this article: Roy S, Kothari N, Sharma A, Goyal S, Sankanagoudar S, Bhatia PK,
Language	English
Publishing date	2023-06-12
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24439
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