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  1. Article ; Online: Prebiotic Potential and Value-Added Products Derived from

    Sankarapandian, Vidya / Nitharsan, Kirubakaran / Parangusadoss, Kavitha / Gangadaran, Prakash / Ramani, Prasanna / Venmathi Maran, Balu Alagar / Jogalekar, Manasi P

    Biotech (Basel (Switzerland))

    2022  Volume 11, Issue 2

    Abstract: Lately, microalgae-based value-added products have been gaining market value because they moderate the dependency on fossil fuel and high-value chemical products. To this end, the purpose of this study was to develop prebiotic products from the ... ...

    Abstract Lately, microalgae-based value-added products have been gaining market value because they moderate the dependency on fossil fuel and high-value chemical products. To this end, the purpose of this study was to develop prebiotic products from the microalgae
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6284
    ISSN (online) 2673-6284
    DOI 10.3390/biotech11020013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer.

    Sankarapandian, Vidya / Venmathi Maran, Balu Alagar / Rajendran, Ramya Lakshmi / Jogalekar, Manasi P / Gurunagarajan, Sridharan / Krishnamoorthy, Rajapandiyan / Gangadaran, Prakash / Ahn, Byeong-Cheol

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: Probiotics are living microbes that play a significant role in protecting the host in various ways. Gut microbiota is one of the key players in maintaining homeostasis. Cancer is considered one of the most significant causes of death worldwide. Although ... ...

    Abstract Probiotics are living microbes that play a significant role in protecting the host in various ways. Gut microbiota is one of the key players in maintaining homeostasis. Cancer is considered one of the most significant causes of death worldwide. Although cancer treatment has received much attention in recent years, the number of people suffering from neoplastic syndrome continues to increase. Despite notable improvements in the field of cancer therapy, tackling cancer has been challenging due to the multiple properties of cancer cells and their ability to evade the immune system. Probiotics alter the immunological and cellular responses by enhancing the epithelial barrier and stimulating the production of anti-inflammatory, antioxidant, and anticarcinogenic compounds, thereby reducing cancer burden and growth. The present review focuses on the various mechanisms underlying the role of probiotics in the prevention and treatment of cancer.
    Language English
    Publishing date 2022-01-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12010059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel Plasmodium falciparum k13 gene polymorphisms from Kisii County, Kenya during an era of artemisinin-based combination therapy deployment.

    Maniga, Josephat Nyabayo / Samuel, Mong'are / John, Odda / Rael, Masai / Muchiri, Jacqueline Njeri / Bwogo, Pacifica / Martin, Odoki / Sankarapandian, Vidya / Wilberforce, Mfitundinda / Albert, Ochweri / Onkoba, Sarah Kemuma / Adebayo, Ismail Abiola / Adeyemo, Rasheed Omotayo / Akinola, Saheed Adekunle

    Malaria journal

    2023  Volume 22, Issue 1, Page(s) 87

    Abstract: Background: Currently, chemotherapy stands out as the major malaria intervention strategy, however, anti-malarial resistance may hamper global elimination programs. Artemisinin-based combination therapy (ACT) stands as the drug of choice for the ... ...

    Abstract Background: Currently, chemotherapy stands out as the major malaria intervention strategy, however, anti-malarial resistance may hamper global elimination programs. Artemisinin-based combination therapy (ACT) stands as the drug of choice for the treatment of Plasmodium falciparum malaria. Plasmodium falciparum kelch13 gene mutations are associated with artemisinin resistance. Thus, this study was aimed at evaluating the circulation of P. falciparum k13 gene polymorphisms from Kisii County, Kenya during an era of ACT deployment.
    Methods: Participants suspected to have malaria were recruited. Plasmodium falciparum was confirmed using the microscopy method. Malaria-positive patients were treated with artemether-lumefantrine (AL). Blood from participants who tested positive for parasites after day 3 was kept on filter papers. DNA was extracted using chelex-suspension method. A nested polymerase chain reaction (PCR) was conducted and the second-round products were sequenced using the Sanger method. Sequenced products were analysed using DNAsp 5.10.01 software and then blasted on the NCBI for k13 propeller gene sequence identity using the Basic Local Alignment Search Tool (BLAST). To assess the selection pressure in P. falciparum parasite population, Tajima' D statistic and Fu & Li's D test in DnaSP software 5.10.01 was used.
    Results: Out of 275 enrolled participants, 231 completed the follow-up schedule. 13 (5.6%) had parasites on day 28 hence characterized for recrudescence. Out of the 13 samples suspected of recrudescence, 5 (38%) samples were positively amplified as P. falciparum, with polymorphisms in the k13-propeller gene detected. Polymorphisms detected in this study includes R539T, N458T, R561H, N431S and A671V, respectively. The sequences have been deposited in NCBI with bio-project number PRJNA885380 and accession numbers SAMN31087434, SAMN31087433, SAMN31087432, SAMN31087431 and SAMN31087430 respectively.
    Conclusions: WHO validated polymorphisms in the k13-propeller gene previously reported to be associated with ACT resistance were not detected in the P. falciparum isolates from Kisii County, Kenya. However, some previously reported un-validated k13 resistant single nucleotide polymorphisms were reported in this study but with limited occurrences. The study has also reported new SNPs. More studies need to be carried out in the entire country to understand the association of reported mutations if any, with ACT resistance.
    MeSH term(s) Humans ; Plasmodium falciparum ; Antimalarials/therapeutic use ; Antimalarials/pharmacology ; Artemisinins/therapeutic use ; Kenya ; Artemether, Lumefantrine Drug Combination/therapeutic use ; Protozoan Proteins/genetics ; Protozoan Proteins/therapeutic use ; Artemether/therapeutic use ; Malaria, Falciparum/epidemiology ; Polymorphism, Single Nucleotide ; Drug Resistance/genetics
    Chemical Substances Antimalarials ; Artemisinins ; Artemether, Lumefantrine Drug Combination ; Protozoan Proteins ; Artemether (C7D6T3H22J)
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-023-04517-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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