LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Methylation alteration of

    Loi, Eleonora / Moi, Loredana / Fadda, Antonio / Satta, Giannina / Zucca, Mariagrazia / Sanna, Sonia / Amini Nia, Shadi / Cabras, Giuseppina / Padoan, Marina / Magnani, Corrado / Miligi, Lucia / Piro, Sara / Gentilini, Davide / Ennas, Maria Grazia / Southey, Melissa C / Giles, Graham G / Wong Doo, Nicole / Cocco, Pierluigi / Zavattari, Patrizia

    Oncotarget

    2019  Volume 10, Issue 48, Page(s) 4987–5002

    Abstract: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the clonal expansion of malignant B cells. To predict the clinical course of the disease, the identification of diagnostic biomarkers is urgently needed. Aberrant ... ...

    Abstract Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the clonal expansion of malignant B cells. To predict the clinical course of the disease, the identification of diagnostic biomarkers is urgently needed. Aberrant methylation patterns may predict CLL development and its course, being very early changes during carcinogenesis. Our aim was to identify CLL specific methylation patterns and to evaluate whether methylation aberrations in selected genes are associated with changes in gene expression. Here, by performing a genome-wide methylation analysis, we identified several CLL-specific methylation alterations. We focused on the most altered one, at a CpG island located in the body of
    Language English
    Publishing date 2019-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27080
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.

    Cocco, Pierluigi / Zucca, Mariagrazia / Sanna, Sonia / Satta, Giannina / Nonne, Tinucia / Angelucci, Emanuele / Gabbas, Attilio / Rais, Marco / Malpeli, Giorgio / Campagna, Marcello / Scarpa, Aldo / G Ennas, Maria

    Hematological oncology

    2016  Volume 34, Issue 2, Page(s) 79–83

    Abstract: Genes encoding for arylamine N-acetyltransferase 1 and 2 (NAT1 and NAT2) have been investigated with alternate findings in relation to risk of non-Hodgkin lymphoma (NHL). We tested functional haplotype-based NAT1 and NAT2 gene polymorphisms in relation ... ...

    Abstract Genes encoding for arylamine N-acetyltransferase 1 and 2 (NAT1 and NAT2) have been investigated with alternate findings in relation to risk of non-Hodgkin lymphoma (NHL). We tested functional haplotype-based NAT1 and NAT2 gene polymorphisms in relation to risk of lymphoma overall and its major B cell subtypes, diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukaemia (CLL). We used allele specific primers and multiplex PCR to detect NAT1 and NAT2 haplotypes in 248 patients with incident lymphoma and 208 population controls. We inferred the NAT1 rapid and slow acetylator and the NAT2 rapid, intermediate or slow acetylator phenotype, based on published functional data on the respective genotypes. Odds ratios and 95% confidence intervals (95% CIs) for lymphoma, B-NHL, DLBCL, FL, CLL, and other B-NHL combined associated with the inferred rapid NAT1 acetylator and with the intermediate and slow NAT2 acetylator phenotypes were estimated with unconditional and polytomous logistic regression analysis, adjusting for age, gender and education. NAT1 rapid acetylators showed a 2.8-fold excess risk (95% CI 1.5-5.2) for lymphoma (all subtypes combined). Risk was highest for CLL and FL, with significant heterogeneity detected across subtypes. Risk also increased with decreasing NAT2 acetylating capacity with no heterogeneity detected across B cell lymphoma subtypes. Risks did not vary by gender. Although poor statistical power was a major limitation in our study, larger studies and pooled analyses are warranted to test whether NAT1 and NAT2 gene polymorphisms might modulate risk of specific lymphoma subtypes through the varying metabolic activity of their products. Copyright © 2015 John Wiley & Sons, Ltd.
    MeSH term(s) Aged ; Arylamine N-Acetyltransferase/genetics ; Female ; Humans ; Isoenzymes/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/enzymology ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Lymphoma, Follicular/enzymology ; Lymphoma, Follicular/genetics ; Lymphoma, Large B-Cell, Diffuse/enzymology ; Lymphoma, Large B-Cell, Diffuse/genetics ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Polymorphism, Genetic
    Chemical Substances Isoenzymes ; Neoplasm Proteins ; Arylamine N-Acetyltransferase (EC 2.3.1.5) ; N-acetyltransferase 1 (EC 2.3.1.5) ; NAT2 protein, human (EC 2.3.1.5)
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1816: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Activation of the aryl hydrocarbon receptor and risk of lymphoma subtypes.

    Sanna, Sonia / Satta, Giannina / Padoan, Marina / Piro, Sara / Gambelunghe, Angela / Miligi, Lucia / Ferri, Giovanni Maria / Magnani, Corrado / Muzi, Giacomo / Rigacci, Luigi / Cabras, Maria Giuseppina / Angelucci, Emanuele / Latte, Gian Carlo / Gabbas, Attilio / Ennas, Maria Grazia / Cocco, Pierluigi

    International journal of molecular epidemiology and genetics

    2017  Volume 8, Issue 4, Page(s) 40–44

    Abstract: The aryl hydrocarbon receptor (AhR) is a transcription factor implicated in several pathways known to be relevant in lymphomagenesis. Aim of our study was to explore the link between AhR activation and risk of lymphoma subtypes. We used a Dual-Luciferase ...

    Abstract The aryl hydrocarbon receptor (AhR) is a transcription factor implicated in several pathways known to be relevant in lymphomagenesis. Aim of our study was to explore the link between AhR activation and risk of lymphoma subtypes. We used a Dual-Luciferase Assay
    Language English
    Publishing date 2017-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2553441-5
    ISSN 1948-1756
    ISSN 1948-1756
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Risk of lymphoma subtypes and dietary habits in a Mediterranean area.

    Campagna, Marcello / Cocco, Pierluigi / Zucca, Mariagrazia / Angelucci, Emanuele / Gabbas, Attilio / Latte, Gian Carlo / Uras, Antonella / Rais, Marco / Sanna, Sonia / Ennas, Maria Grazia

    Cancer epidemiology

    2015  Volume 39, Issue 6, Page(s) 1093–1098

    Abstract: Background: Previous studies have suggested that diet might affect risk of lymphoma subtypes. We investigated risk of lymphoma and its major subtypes associated with diet in the Mediterranean island of Sardinia, Italy.: Methods: In 1998-2004, 322 ... ...

    Abstract Background: Previous studies have suggested that diet might affect risk of lymphoma subtypes. We investigated risk of lymphoma and its major subtypes associated with diet in the Mediterranean island of Sardinia, Italy.
    Methods: In 1998-2004, 322 incident lymphoma cases and 446 randomly selected population controls participated in a case-control study on lymphoma etiology in central-southern Sardinia. Questionnaire interviews included frequency of intake of 112 food items. Risk associated with individual dietary items and groups thereof was explored by unconditional and polytomous logistic regression analysis, adjusting by age, gender and education.
    Results: We observed an upward trend in risk of lymphoma (all subtypes combined) and B-cell lymphoma with frequency of intake of well done grilled/roasted chicken (p for trend=0.01), and pizza (p for trend=0.047), Neither adherence to Mediterranean diet nor a frequent intake of its individual components conveyed protection. We detected heterogeneity in risk associated with several food items and groups thereof by lymphoma subtypes although we could not rule out chance as responsible for the observed direct or inverse associations.
    Conclusions: Adherence to a Mediterranean diet does not seem to convey protection against the development of lymphoma. The association with specific food items might vary by lymphoma subtype.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Diet ; Female ; Humans ; Italy ; Lymphoma/epidemiology ; Male ; Middle Aged ; Risk Factors ; Surveys and Questionnaires
    Language English
    Publishing date 2015-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2508729-0
    ISSN 1877-783X ; 1877-7821
    ISSN (online) 1877-783X
    ISSN 1877-7821
    DOI 10.1016/j.canep.2015.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1427: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: The burden of multiple sclerosis variants in continental Italians and Sardinians.

    Barizzone, Nadia / Zara, Ilenia / Sorosina, Melissa / Lupoli, Sara / Porcu, Eleonora / Pitzalis, Maristella / Zoledziewska, Magdalena / Esposito, Federica / Leone, Maurizio / Mulas, Antonella / Cocco, Eleonora / Ferrigno, Paola / Guerini, Franca R / Brambilla, Paola / Farina, Gabriele / Murru, Raffaele / Deidda, Francesca / Sanna, Sonia / Loi, Alessia /
    Barlassina, Cristina / Vecchio, Domizia / Zauli, Andrea / Clarelli, Ferdinando / Braga, Daniele / Poddie, Fausto / Cantello, Roberto / Martinelli, Vittorio / Comi, Giancarlo / Frau, Jessica / Lorefice, Lorena / Pugliatti, Maura / Rosati, Giulio / Melis, Maurizio / Marrosu, Maria G / Cusi, Daniele / Cucca, Francesco / Martinelli Boneschi, Filippo / Sanna, Serena / D'Alfonso, Sandra

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2015  Volume 21, Issue 11, Page(s) 1385–1395

    Abstract: Background: Recent studies identified > 100 non-HLA (human leukocyte antigen) multiple sclerosis (MS) susceptibility variants in Northern European populations, but their role in Southern Europeans is largely unexplored.: Objective: We aimed to ... ...

    Abstract Background: Recent studies identified > 100 non-HLA (human leukocyte antigen) multiple sclerosis (MS) susceptibility variants in Northern European populations, but their role in Southern Europeans is largely unexplored.
    Objective: We aimed to investigate the cumulative impact of those variants in two Mediterranean populations: Continental Italians and Sardinians.
    Methods: We calculated four weighted Genetic Risk Scores (wGRS), using up to 102 non-HLA MS risk variants and 5 HLA MS susceptibility markers in 1691 patients and 2194 controls from continental Italy; and 2861 patients and 3034 controls from Sardinia. We then assessed the differences between populations using Nagelkerke's R(2) and the area under the Receiver Operating Characteristic (ROC) curves.
    Results: As expected, the genetic burden (mean wGRS value) was significantly higher in MS patients than in controls, in both populations. Of note, the burden was significantly higher in Sardinians. Conversely, the proportion of variability explained and the predictive power were significantly higher in continental Italians. Notably, within the Sardinian patients, we also observed a significantly higher burden of non-HLA variants in individuals who do not carry HLA risk alleles.
    Conclusions: The observed differences in MS genetic burden between the two Mediterranean populations highlight the need for more genetic studies in South Europeans, to further expand the knowledge of MS genetics.
    MeSH term(s) Biomarkers ; Genetic Predisposition to Disease ; Genotype ; HLA Antigens/genetics ; Humans ; Italy/ethnology ; Multiple Sclerosis/ethnology ; Multiple Sclerosis/genetics ; Polymorphism, Single Nucleotide ; Risk
    Chemical Substances Biomarkers ; HLA Antigens
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458515596599
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top