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Article ; Online: Cardiomyopathies: An Overview.

Ciarambino, Tiziana / Menna, Giovanni / Sansone, Gennaro / Giordano, Mauro

International journal of molecular sciences

2021 Volume 22, Issue 14

Abstract: Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by structural and functional alterations of the heart.: Aims: The purpose of this narrative review is to focus on the most important cardiomyopathies and their ... ...

Abstract	Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by structural and functional alterations of the heart. Aims: The purpose of this narrative review is to focus on the most important cardiomyopathies and their epidemiology, diagnosis, and management. Methods: Clinical trials were identified by Pubmed until 30 March 2021. The search keywords were "cardiomyopathies, sudden cardiac arrest, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy, arrhythmogenic cardiomyopathy (ARCV), takotsubo syndrome". Results: Hypertrophic cardiomyopathy (HCM) is the most common primary cardiomyopathy, with a prevalence of 1:500 persons. Dilated cardiomyopathy (DCM) has a prevalence of 1:2500 and is the leading indication for heart transplantation. Restrictive cardiomyopathy (RCM) is the least common of the major cardiomyopathies, representing 2% to 5% of cases. Arrhythmogenic cardiomyopathy (ARCV) is a pathology characterized by the substitution of the myocardium by fibrofatty tissue. Takotsubo cardiomyopathy is defined as an abrupt onset of left ventricular dysfunction in response to severe emotional or physiologic stress. Conclusion: In particular, it has been reported that HCM is the most important cause of sudden death on the athletic field in the United States. It is needless to say how important it is to know which changes in the heart due to physical activity are normal, and when they are pathological.
MeSH term(s)	Cardiomyopathies/diagnosis ; Cardiomyopathies/epidemiology ; Cardiomyopathies/pathology ; Cardiomyopathy, Dilated/pathology ; Cardiomyopathy, Hypertrophic/pathology ; Death, Sudden, Cardiac/pathology ; Humans ; Myocardium/pathology
Language	English
Publishing date	2021-07-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22147722
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Article ; Online: Simple detecting of elevated ICP through liquor flow after lumbar puncture.

Barbato, Francesco / Troise, Augusta / Allocca, Roberto / Sansone, Gennaro / Bosso, Giorgio / Numis, Fabio Giuliano

The American journal of emergency medicine

2023 Volume 75, Page(s) 128–130

Abstract: Elevated intracranial pressure (ICP) is defined as a cerebrospinal fluid (CSF) opening pressure (OP) greater than 25 cmH2O. When a diagnostic lumbar puncture is performed it is useful to estimate also intracranial pressure. To do this it is required a ... ...

Abstract	Elevated intracranial pressure (ICP) is defined as a cerebrospinal fluid (CSF) opening pressure (OP) greater than 25 cmH2O. When a diagnostic lumbar puncture is performed it is useful to estimate also intracranial pressure. To do this it is required a presence of pressure gauges, which are currently the gold standard, not available in most resource-constrained contexts. We decided to evaluate whether it is possible to estimate it simply by counting the drops of cerebrospinal liquor, which are collected after lumbar puncture, according to Poiseuille's law. Was examined a sample of 52 patients, aged between 18 and 85 years, belonging to the emergency room of "Santa Maria delle Grazie" Hospital in Pozzuoli (Naples) who needed a diagnostic lumbar puncture (LP). The ICP was initially measured using a standard narrow-gauge manometer by attaching it to the spinal needle. After removing the pressure gauge, the number of drops of cerebrospinal fluid flowing from the spinal needle in 30 seconds was counted. A statistical analysis was made with linear regression and ROC analysis. OP as measured by standard manometry was raised on 17 occasions with CSF drop rate median of 47 drops/30 seconds and range 30-74 drops/30 seconds. OP was normal on 35 occasions with CSF drop rate median of 23 drops/30 seconds with range of 14-34 drops/30 seconds. A linear regression analysis was performed which resulted in a Pearson correlation of 0.936 an adjusted R square of 0.874 (see Fig. 1). Analysis through ANOVA documented an F of 355.301 with p < 0.01 and Dubin Watson of 1.642. The analysis through ROC showed an AUC of 0.980, with a sensitivity of 100% and a specificity of 91% if chosen as a limit, 29 drops in 30 seconds (Youden Index of 0.9140). Therefore, we have concluded, that although there are several precautions, like patient's position, it is technically feasible to indirectly estimate cerebrospinal fluid pressure with good accuracy by counting the drops of cerebrospinal fluid flowing from a 22 G spinal needle.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Spinal Puncture/methods ; Intracranial Pressure ; Intracranial Hypertension/diagnosis ; ROC Curve ; Manometry/methods
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2023.10.029
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Article: Oxygen Therapy in Headache Disorders: A Systematic Review.

Ciarambino, Tiziana / Sansone, Gennaro / Menna, Giovanni / Para, Ombretta / Signoriello, Giuseppe / Leoncini, Laura / Giordano, Mauro

Brain sciences

2021 Volume 11, Issue 3

Abstract: Background: The global active prevalence of migraines is approximately 14.7%. Oxygen therapy may reduce the use of non-steroidal anti-inflammatory drugs (NSAIDs) which often have various negative side effects. The purpose of this systematic review is to ...

Abstract	Background: The global active prevalence of migraines is approximately 14.7%. Oxygen therapy may reduce the use of non-steroidal anti-inflammatory drugs (NSAIDs) which often have various negative side effects. The purpose of this systematic review is to analyze the literature on the efficacy of high flow oxygen for the management of headache disorders, compared to placebo treatment. Methods: Studies were identified by PubMed, Web of Science and Scopus database from 1980 to the 30 October 2020. The search included the following terms: "oxygen therapy" and "headache" and "migraine". Studies were included if high flow oxygen was used in the treatment of headache disorders. All selected studies were qualitatively analyzed. Results: Our literature search identified 71 studies, of which 65 were discarded and 6 were included in the meta-analysis. The random effect model did not show a pooled significant resolution of headache disorders (OR 2.08 (95% CI 0.92-4.70), Conclusion: In our systematic review of six studies, there were no significant differences between high flow oxygen and placebo treatment groups.
Language	English
Publishing date	2021-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11030379
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Article ; Online: Lung ultrasound-guided PEEP titration in COVID-19 patients treated with CPAP.

Bosso, Giorgio / Sansone, Gennaro / Papillo, Martina / Giaquinto, Alessandro / Orefice, Silvia / Allegorico, Enrico / Serra, Claudia / Minerva, Valentina / Mercurio, Valentina / Cannavacciuolo, Francesca / Dello Vicario, Ferdinando / Porta, Giovanni / Pagano, Antonio / Numis, Fabio Giuliano

Journal of basic and clinical physiology and pharmacology

2023 Volume 34, Issue 5, Page(s) 677–682

Abstract: Objectives: An increasing number of COVID-19 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 ... ...

Abstract	Objectives: An increasing number of COVID-19 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 patients requiring CPAP. Methods: This is a single center, prospective, randomized clinical study. Sixty-three COVID-19 patients with hypoxemic respiratory failure and bilateral pneumonia were randomized in two Groups: Group A received CPAP with fixed PEEP of 10 cm H Results: Thirty-two patients were enrolled in Conclusions: Lung ultrasound-guided PEEP trial is associated with lower mortality in COVID-19 patients treated with CPAP. Identifying the best PEEP is useful to increase oxygenation and reduce the incidence of complications.
MeSH term(s)	Humans ; Pneumothorax ; Prospective Studies ; COVID-19/therapy ; Lung/diagnostic imaging ; Ultrasonography, Interventional
Language	English
Publishing date	2023-07-20
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2023-0165
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Article ; Online: The impact of a non-restrictive Antimicrobial Stewardship Program in the emergency department of a secondary-level Italian hospital.

Monari, Caterina / Onorato, Lorenzo / Allegorico, Enrico / Minerva, Valentina / Macera, Margherita / Bosso, Giorgio / Calò, Federica / Pagano, Antonio / Russo, Teresa / Sansone, Gennaro / D'Isanto, Marina / Casciotta, Antonio / Vanni, Monica / Numis, Fabio Giuliano / Coppola, Nicola

Internal and emergency medicine

2023 Volume 19, Issue 2, Page(s) 493–500

Abstract: Evidence supporting the effectiveness of Antimicrobial Stewardship (AMS) Programs in the emergency department (ED) setting is limited. We conducted a prospective cohort study to assess the efficacy of an AMS program in an ED and a short-stay observation ... ...

Abstract	Evidence supporting the effectiveness of Antimicrobial Stewardship (AMS) Programs in the emergency department (ED) setting is limited. We conducted a prospective cohort study to assess the efficacy of an AMS program in an ED and a short-stay observation unit. The intervention included periodic prospective audits (twice a week), conducted by four infectious disease consultants. Primary outcomes included the difference in the hospital mortality rate, antibiotic consumption, and the incidence of bloodstream infections (BSI) caused by multidrug resistant (MDR) bacteria, before March 2020-February 2021 and after March 2021-February 2022 when the program was implemented. Interrupted time-series analysis was performed to assess the effect of our program. During the 12-month program, we performed 152 audits and evaluated 366 antibiotic therapies out of a total of 853 patients admitted. In the intervention period, we observed a non-statistically significant decrease in total antibiotic consumption, with a change in level of - 31.2 defined daily dose/100 patient-days (PD) (p = 0.71). Likewise, we found no significant variations in the rate of BSI due to MDR Gram-positive (CT - 0.02 events/PD, p = 0.84), MDR Gram-negative bacteria (CT 0.08, p = 0.71), or Candida spp. (CT 0.008, p = 0.86). Conversely, we found a significant decrease in the mortality rate between the pre- and post-intervention periods (- 1.98 deaths/100 PD, CI - 3.9 to - 0.007, p = 0.049). The Antibiotic Stewardship Program in the ED was associated with a significant decrease in the mortality rate. More high-quality studies are needed to determine the most effective ASP strategies in this unique setting.
MeSH term(s)	Humans ; Antimicrobial Stewardship ; Prospective Studies ; Anti-Bacterial Agents/therapeutic use ; Hospitals ; Emergency Service, Hospital ; Italy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-09-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03418-1
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Article ; Online: Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review.

Ciarambino, Tiziana / Giannico, Orazio V / Menna, Giovanni / Sansone, Gennaro / Para, Ombretta / Giordano, Mauro / Corrente, Antonio / Adinolfi, Luigi E

Minerva gastroenterologica e dietologica

2020

Abstract: Introduction: The American Society for Gastrointestinal Endoscopy (ASGE) has produced numerous algorithms for the management of gastrointestinal bleeding (GIB) in which endoscopy plays a major role. The aim of this Systematic Review was to evaluate the ... ...

Abstract	Introduction: The American Society for Gastrointestinal Endoscopy (ASGE) has produced numerous algorithms for the management of gastrointestinal bleeding (GIB) in which endoscopy plays a major role. The aim of this Systematic Review was to evaluate the diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB). Methods: Studies were identified on PubMed, Web of Science and Scopus databases from 2009 to 2019. The search performed included the following terms: "digestive" and "bleeding" as well as "acute bleeding gastrointestinal" or "acute bleeding digestive". Studies were included if enrolled adult patients and included measures of diagnostic accuracy (sensibility and specificity) of CT angiography in detecting GIB. Studies on variceal bleeding were excluded. First, a bivariate diagnostic randomeffects meta-analysis was fitted through REML (Restricted maximum likelihood approach) method, with the estimation of pooled sensitivity, specificity and SROC curve. Then, an univariate model was fitted for the 11 studies, with the estimation of pooled Diagnostic Odds Ratio and Cochrane's Q for heterogeneity. Results: Eleven studies were eligible for inclusion criteria and so included in the analysis. The pooled sensitivity is 85% [75%, 92%], the pooled specificity 93% [89%, 96%]. The pooled DOR is 94.35 [37.91, 234.82]. Q for heterogeneity is not significant (p=0.377). Conclusions: CT angiography showed a good sensibility and specificity in detecting NVGIB. Therefore, it would be useful to consider CT angiography use also in the suspicion of NVGIB, especially when endoscopy is not immediately available and there are signs and symptoms of bleeding in progress.
Language	English
Publishing date	2020-10-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1077354-x
ISSN	1827-1642 ; 1121-421X ; 0026-4776
ISSN (online)	1827-1642
ISSN	1121-421X ; 0026-4776
DOI	10.23736/S1121-421X.20.02762-2
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Article: Un dolore al fianco apparentemente banale.

Sansone, Gennaro / Torraca, Serena / Delfino, Francesco / Schettini, Rito

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2010 Volume 27, Issue 1, Page(s) 82–84

Abstract: We describe the case of an 80-year-old man who came to our observation with pain in his left side and iliac region. Ultrasonography showed an incidentaloma with a largest diameter of 10 cm in the left suprarenal fossa. It extended downward and anteriorly ...

Title translation	A case of apparently trivial flank pain.
Abstract	We describe the case of an 80-year-old man who came to our observation with pain in his left side and iliac region. Ultrasonography showed an incidentaloma with a largest diameter of 10 cm in the left suprarenal fossa. It extended downward and anteriorly from the apex of the left kidney; the picture was suggestive of a saccate hematoma. Further examination resulted in a diagnosis of an adrenally located extranodal non-Hodgkin's lymphoma and the patient was treated accordingly.
MeSH term(s)	Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/surgery ; Adrenalectomy ; Aged, 80 and over ; Diagnosis, Differential ; Flank Pain/etiology ; Hematoma/diagnosis ; Humans ; Incidental Findings ; Lymphoma, Non-Hodgkin/complications ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/surgery ; Male ; Treatment Outcome
Language	Italian
Publishing date	2010-01
Publishing country	Italy
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1237110-5
ISSN	0393-5590
ISSN	0393-5590
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Book: Genetica umana

Sansone, Gennaro

(Trattato di pediatria e puericultura)

1969

Series title	Trattato di pediatria e puericultura
MeSH term(s)	Genetics, Medical
Language	Italian
Size	xiii, 346 p., illus.
Publisher	Minerva medica
Publishing place	Torino
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Il favismo

Sansone, Gennaro

1958

Author's details	[di] G. Sansone, A. M. Piga [e] G. Segni
MeSH term(s)	Favism
Language	Italian
Size	xiv, 225 p., ill.
Publisher	Minerva medica
Publishing place	Torino
Document type	Book
Note	Summary in Italian, French, and English.
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Le malattie del feto e del neonato da incompatibilità di sangue,

Sansone, Gennaro

con particolare riguardo al fattore Rh

1950

Keywords	Erythroblastosis / Fetal ; Rh factor
Language	Italian
Size	269 p., ill.
Publisher	Edizioni Minerva médica
Publishing place	Genova
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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