LIVIVO - Search results -

Search results

Result 1 - 10 of total 31

Search options

Article ; Online: Uncovering Surface Penetration by Enterococci From Urinary Tract Infection Patients.

Sansone, Stephanie / Ramos, Yusibeska / Segal, Saya / Asfaw, Tirsit S / Morales, Diana K

Urogynecology (Philadelphia, Pa.)

2024 Volume 30, Issue 3, Page(s) 320–329

Abstract: Importance: The relationship between Enterococcus faecalis vaginal colonization and urinary tract infections (UTIs) remains uncertain.: Objective: We aimed to evaluate the surface invasion capability of E faecalis isolates from patients with and ... ...

Abstract	Importance: The relationship between Enterococcus faecalis vaginal colonization and urinary tract infections (UTIs) remains uncertain. Objective: We aimed to evaluate the surface invasion capability of E faecalis isolates from patients with and without UTIs as a potential readout of pathogenicity. Study design: Participants were females from urogynecology clinics, comprising symptomatic UTI and asymptomatic non-UTI patients, categorized by the presence or absence of E faecalis-positive cultures identified via standard urine culture techniques. Vaginal and urine samples from patients were plated on enterococci selective medium, and E faecalis isolates detected in both cohorts were species specific identified using 16S rRNA sequencing. Clinical isolates were inoculated on semisolid media, and both external colonies and underneath colony prints formed by agar-penetrating enterococci were imaged. External growth and invasiveness were quantified by determining colony-forming units of the noninvading and agar-penetrating cells and compared with the E faecalis OG1RF. Results: We selected E faecalis isolates from urine and vaginal samples of 4 patients with and 4 patients without UTIs. Assays demonstrated that most isolates formed similarly sized external colonies with comparable colony-forming unit. Surface invasion differed across patients and isolation sites compared with OG1RF. The vaginal isolate from UTI patient 1, who had the most recurrences, exhibited significantly greater agar-invading capacity compared with OG1RF. Conclusions: Our pilot study indicates that ex vivo invasion assays may unveil virulence traits in E faecalis from UTI patients. Enhanced enterococcal surface penetration could increase urogenital invasion risk. Further research is needed to correlate penetration with disease severity in a larger patient group.
MeSH term(s)	Female ; Humans ; Male ; Enterococcus/genetics ; Agar ; Pilot Projects ; RNA, Ribosomal, 16S ; Urinary Tract Infections
Chemical Substances	Agar (9002-18-0) ; RNA, Ribosomal, 16S
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ISSN	2771-1897
ISSN (online)	2771-1897
DOI	10.1097/SPV.0000000000001476
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Therapeutic components of digital counseling for chronic heart failure.

Fezza, Gabriel C / Sansone, Stephanie / Nolan, Robert P

Frontiers in psychiatry

2022 Volume 13, Page(s) 888524

Abstract: Background: Task force statements support the use of cognitive behavioral therapy (CBT) and motivational interviewing (MI) to promote self-care in chronic heart failure (CHF) patients. Digital counseling interventions have the potential to complement ... ...

Abstract	Background: Task force statements support the use of cognitive behavioral therapy (CBT) and motivational interviewing (MI) to promote self-care in chronic heart failure (CHF) patients. Digital counseling interventions have the potential to complement conventional programs. However, therapeutic components of digital programs associated with improved outcomes are not clearly established. Objective: Identify therapeutic components of the Canadian e-Platform to Promote Behavioral Self-Management in Chronic Heart Failure (CHF-CePPORT) protocol that were associated with improved health-related quality of life (HRQL). Materials and methods: Ordinal logistic regression was used to identify therapeutic components of the CHF-CePPORT protocol. The primary outcome was the 12-month Kansas City Cardiomyopathy Questionnaire Overall Summary (KCCQ-OS) tertile. Logistic regressions determined the association between 12-month KCCQ-OS tertile, using logon hours for key segments of the protocol, modality of content delivery, and clinical themes. Results: A total of 117 patients were enrolled in the e-Counseling arm of the CHF-CePPORT trial. Median age was 60 years (IQR 52-69). Total logon hours in the initial 4-month segment of CHF-CePPORT (Sessions 1-16) was associated with increased 12-month KCCQ-OS tertile (Odds Ratio, OR = 1.31, 95% CI, 1.1-1.5, Conclusion: This study highlights the importance of using evidence-based guidelines from CBT and MI as core components of digital counseling, delivered through videos and interactive tools/trackers, to improve HRQL with CHF.
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.888524
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Rare complications of pessary use: A systematic review of case reports.

Dabic, Stefan / Sze, Christina / Sansone, Stephanie / Chughtai, Bilal

BJUI compass

2022 Volume 3, Issue 6, Page(s) 415–423

Abstract: Introduction: Pessaries are desirable for its overall safety profiles. Serious complications have been reported; however, there is little summative evidence. This systematic review aimed to consolidate all reported serious outcomes from pessaries usage ... ...

Abstract	Introduction: Pessaries are desirable for its overall safety profiles. Serious complications have been reported; however, there is little summative evidence. This systematic review aimed to consolidate all reported serious outcomes from pessaries usage to better identify and counsel patients who might be at higher risk of developing these adverse events. Methods: We performed a systematic literature review using search terms such as 'prolapse', 'stress urinary incontinence' and 'pessary or pessaries or pessarium' on PubMed, Embase and CINAHL. A total of 36 articles were identified. Patient-level data were extracted from case reports to further describe complications on an individual level. Results: Overall median age of the patients was 82 years (range 62-98). The most frequent complications were vesicovaginal fistula (25%, Conclusion: Pessaries are a reasonable and durable treatment for POP with exceedingly rare reports of severe adverse complications. The ideal candidate for pessary should have a good self-care index. Studies to determine causative factors of the more serious adverse events are needed; however, this may be difficult given the long follow-up that is required.
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2688-4526
ISSN (online)	2688-4526
DOI	10.1002/bco2.174
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Can Women Accurately Predict Their Voided Volumes?

Drangsholt, Siri / Sansone, Stephanie / Donnelly, Megan / Chughtai, Bilal

Female pelvic medicine & reconstructive surgery

2022 Volume 28, Issue 3, Page(s) 160–164

Abstract: Importance: Voiding diaries can be onerous, we sought to investigate if some women can predict their voided volumes.: Objectives: The objective of this study is to determine the accuracy of estimated voided volumes and characteristics most predictive ...

Abstract	Importance: Voiding diaries can be onerous, we sought to investigate if some women can predict their voided volumes. Objectives: The objective of this study is to determine the accuracy of estimated voided volumes and characteristics most predictive of accuracy. Study design: We prospectively collected data on 101 women undergoing urodynamics for lower urinary tract symptoms and/or prolapse at a tertiary care facility. Data collection included postvoid residual volume, urodynamic diagnosis, flow time and rate, and a 1-time measurement of voided volume into a blinded uroflow. Linear and logistic regression analyses were performed to examine predictors of estimated voided volume (mL). Results: Mean age was 58.2 years (standard deviation, 12.8 years). The median estimated voided volume and actual voided volume were 240 and 215 mL, respectively. The average percent error was 15% (63% of patients being within a 30% margin of error and 32.7% being within a 20% margin of error). On linear regression analysis, smaller voids of 101 to 200 mL were associated with greater accuracy (R2 = 0.37 P = 0.001) and diagnosis of anxiety was associated with a higher voided volume percent error (P = 0.028). Logistic regression analysis revealed that for every 1 year increase in age, there was a 3% decrease in odds of predicting voiding volume within 30% (odds ratios, 0.97; P = 0.041). Conclusions: Nearly two-thirds of women estimated their voided volume within 30% of the actual void and one-third of women could predict within 20%. This should be taken into consideration when obtaining patient history, particularly with age and diagnosis of anxiety, and may substantiate use of voiding diaries for accurate measurement in specific populations.
MeSH term(s)	Female ; Humans ; Lower Urinary Tract Symptoms ; Male ; Middle Aged ; Urination ; Urination Disorders/diagnosis ; Urodynamics
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2542707-6
ISSN	2154-4212 ; 2151-8378
ISSN (online)	2154-4212
ISSN	2151-8378
DOI	10.1097/SPV.0000000000001148
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Sugarcoating it: Enterococcal polysaccharides as key modulators of host-pathogen interactions.

Ramos, Yusibeska / Sansone, Stephanie / Morales, Diana K

PLoS pathogens

2021 Volume 17, Issue 9, Page(s) e1009822

MeSH term(s)	Enterococcus faecalis/metabolism ; Enterococcus faecium/metabolism ; Gastrointestinal Microbiome ; Gram-Positive Bacterial Infections/metabolism ; Host-Pathogen Interactions/physiology ; Humans ; Polysaccharides/metabolism
Chemical Substances	Polysaccharides
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1009822
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Incarcerated ventral wall hernia after robotic urogynecologic surgery: A case report.

Badiner, Nora / Sansone, Stephanie / Fenster, Tamatha / Segal, Saya

Case reports in women's health

2021 Volume 32, Page(s) e00350

Abstract: Trocar site hernia is a rare complication of minimally invasive surgery, with incidence estimates varying widely. Studies have demonstrated rates of up to 1.2% in patients undergoing gynecologic surgery. Yet, little is known about hernia risk in the ... ...

Abstract	Trocar site hernia is a rare complication of minimally invasive surgery, with incidence estimates varying widely. Studies have demonstrated rates of up to 1.2% in patients undergoing gynecologic surgery. Yet, little is known about hernia risk in the urogynecologic patient population who undergo robotic reconstructive surgery. Risk factors for the development of trocar site hernia include both incisional risk factors (trocar placement location, trocar diameter, intraoperative trocar manipulation) and patient risk factors (obesity, pelvic organ prolapse or other hernia). This report presents a case of large incarcerated small bowel hernia at a trocar site following robotic urogynecologic surgery and the resulting interventions, including repeat surgery, to reduce the hernia. This case should prompt urogynecologic surgeons to check port sites after extensive dissections to assess if large peritoneal or fascial defects need additional closure.
Language	English
Publishing date	2021-08-08
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2800286-6
ISSN	2214-9112 ; 2214-9112
ISSN (online)	2214-9112
ISSN	2214-9112
DOI	10.1016/j.crwh.2021.e00350
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: No pelvic exam, no problem: patient satisfaction following the integration of comprehensive urogynecology telemedicine.

Sansone, Stephanie / Lu, Jessica / Drangsholt, Siri / Asfaw, Tirsit S / Segal, Saya

International urogynecology journal

2022 Volume 33, Issue 9, Page(s) 2401–2407

Abstract: Introduction and hypothesis: The COVID-19 pandemic revolutionized the practice of medicine, requiring rapid adoption of telemedicine. However, patient satisfaction has not been well characterized for telemedicine visits for a broad range of ... ...

Abstract	Introduction and hypothesis: The COVID-19 pandemic revolutionized the practice of medicine, requiring rapid adoption of telemedicine. However, patient satisfaction has not been well characterized for telemedicine visits for a broad range of urogynecologic conditions. Methods: We performed a cross-sectional survey study following a retrospective review of all urogynecologic telemedicine visits from March 1, 2020, to March 31, 2021, at a tertiary care center. The survey queried patient satisfaction using the Likert scale. Descriptive statistics and Fisher's exact analyses were performed. Results: There were 256 telemedicine visits at our institution during the study period, and 88 patients (34% unadjusted response rate) completed the survey. The average age of study participants was 55 (SD 17; 24, 84) years old. The majority of patients were white (69%), lived within the five boroughs of NYC (81%), and had higher levels of education (72% with a bachelor's or professional degree). Most visits were for urinary complaints (68%), with those patients reporting greater fulfillment of urogynecologic needs compared to patients presenting with pelvic complaints (p = 0.02). There were no significant differences in satisfaction among other demographics (p > 0.05). Altogether, high satisfaction rates were noted for scheduling (99%), technology (90%), provider interaction (96%), fulfillment of personal needs (91%), and overall satisfaction (94%). Conclusions: We demonstrate high patient satisfaction for telemedicine visits in a tertiary urogynecology clinic for a variety of indications, with greater fulfillment of urogynecologic needs observed for those visits which may not necessitate an in-person exam (e.g., urinary complaint).
MeSH term(s)	COVID-19/epidemiology ; Cross-Sectional Studies ; Humans ; Pandemics ; Patient Satisfaction ; Telemedicine
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-022-05104-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3070: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Implementation of international guidelines for polycystic ovary syndrome: barriers and facilitators among gynecologists and primary care providers.

Lee, Iris Tien-Lynn / Sansone, Stephanie / Irfan, Maryam / Copp, Tessa / Beidas, Rinad / Dokras, Anuja

F&S reports

2022 Volume 3, Issue 2, Page(s) 94–101

Abstract: Objective: To identify barriers and facilitators to the implementation of evidence-based guidelines among gynecologists and primary care physicians (PCPs) caring for women with polycystic ovary syndrome (PCOS).: Design: Qualitative semi-structured ... ...

Abstract	Objective: To identify barriers and facilitators to the implementation of evidence-based guidelines among gynecologists and primary care physicians (PCPs) caring for women with polycystic ovary syndrome (PCOS). Design: Qualitative semi-structured interview study. Setting: Academic medical center. Patients: None. Interventions: None. Main outcome measures: Barriers and facilitators in the diagnosis and management of PCOS. Results: We interviewed 10 gynecologists and 8 PCPs to reach thematic saturation using a thematic analysis approach. Four themes were identified: diagnostic considerations, treatment of symptoms of PCOS, screening for long-term complications of PCOS, and counseling on long-term complications. Many gynecologists did not perform the recommended metabolic screening and were uncomfortable managing metabolic complications of PCOS. They uniformly counseled patients on the risk of endometrial hyperplasia and infertility. PCPs expressed the lack of familiarity with diagnostic criteria and often did not complete a comprehensive workup before making a diagnosis of PCOS. However, they routinely counseled patients on cardiometabolic risk and were familiar with managing the related long-term complications. Common barriers to comprehensive care delivery included the lack of knowledge and inadequate time and resources. Important facilitators included the overlap between the management of PCOS and other conditions such as obesity and abnormal uterine bleeding. Conclusions: Our study highlights the need for interventions that target the barriers identified among gynecologists and PCPs in implementing guidelines for diagnosing and managing PCOS. In conjunction with prior studies, our findings support a multidisciplinary care model for women with PCOS. Future studies should focus on implementation strategies to facilitate evidence-based care.
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article
ISSN	2666-3341
ISSN (online)	2666-3341
DOI	10.1016/j.xfre.2022.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The Role of Pessaries in the Treatment of Women With Stress Urinary Incontinence: A Systematic Review and Meta-Analysis.

Klein, Julia / Stoddard, Michelina / Rardin, Charles / Menefee, Shawn / Sedrakyan, Art / Sansone, Stephanie / Chughtai, Bilal

Female pelvic medicine & reconstructive surgery

2022 Volume 28, Issue 6, Page(s) e171–e178

Abstract: Importance: Pessaries are an important conservative therapy for stress urinary incontinence (SUI), but few studies have comprehensively evaluated their utility.: Objective: The objective of this study is to evaluate the existing evidence on the ... ...

Abstract	Importance: Pessaries are an important conservative therapy for stress urinary incontinence (SUI), but few studies have comprehensively evaluated their utility. Objective: The objective of this study is to evaluate the existing evidence on the efficacy and safety of pessaries for the treatment of SUI. Study design: We searched for the terms "stress urinary incontinence" and "pessar/y/ies/ium" in PubMed, Embase, and Cinhal on June 10, 2020. Studies that characterized subjective and/or objective data were included. Studies performed in pediatric populations, pregnancy, and use of pessaries not for SUI were excluded. Two reviewers independently screened and assessed data quality and risk of bias according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Ten studies, including 376 patients, were included. In terms of subjective outcomes, 76% of 72 patients reported feeling continent after pessary treatment compared with 0% of 86 patients surveyed before pessary use (P < 0.0001). Both Urinary Distress Inventory and Incontinence Impact Questionnaire scores decreased significantly by 46.7% (n = 155 baseline, n = 139 follow-up; P < 0.0001) and 67.8% (n = 139 baseline, n = 107 follow-up; P < 0.0001), respectively. Significant objective measures associated with pessary use included increased urethral closure pressure (n = 122; g = 0.56; 95% confidence interval [CI], -0.66 to 1.77; P < 0.049) and decreased pad weight (n = 129 baseline; n = 118 follow-up; g = -0.89; 95% CI, -1.986 to 0.19; P = 0.009). Adverse events significantly decreased at greater than 6 months follow-up compared with less than 6 months follow-up, including pain (31.5%, n = 29/92 vs 14.3%, n = 5/35; P = 0.0513) and discomfort (50%, n = 46/92 vs 29.3%, n = 12/41; P = 0.0268). Conclusions: Based on both subjective and objective measures, pessaries are an effective conservative treatment option for SUI. This supports pessary use, though larger studies with longer-term follow-up are warranted.
MeSH term(s)	Child ; Female ; Humans ; Pessaries/adverse effects ; Surveys and Questionnaires ; Urethra ; Urinary Incontinence/therapy ; Urinary Incontinence, Stress/therapy
Language	English
Publishing date	2022-04-05
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2542707-6
ISSN	2154-4212 ; 2151-8378
ISSN (online)	2154-4212
ISSN	2151-8378
DOI	10.1097/SPV.0000000000001180
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Thesis ; Online: The FMR1 Gene and Differential Susceptibility to HPA-axis and Immune Dysfunction

Sansone, Stephanie Marie

Examination of a Gene-Environment Interaction with Stress

2015

Abstract: There is strong evidence linking psychological stress, HPA-axis activity, and the immune system dysregulation with negative health outcomes. For example, chronic stress, HPA-axis and immune system dysfunction are all associated with greater risk of ... ...

Abstract	There is strong evidence linking psychological stress, HPA-axis activity, and the immune system dysregulation with negative health outcomes. For example, chronic stress, HPA-axis and immune system dysfunction are all associated with greater risk of infection and diagnosis of chronic inflammatory disease, autoimmune disease, depression, and anxiety. Yet, some individuals do not develop significant health issues and instead demonstrate great resilience under these same stressful environments. The factors or mechanisms that contribute to this variability remain to be determined. Understanding these influences and how they relate to both psychological and physiological changes are especially important for current and forthcoming research on intervention, prevention and clinical application. The following dissertation contains two related studies that together are guided by a gene x environment interaction approach aimed at understanding important unanswered questions regarding the relative and collective contributions of fragile X mental retardation 1 (FMR1) genotype and psychological stress on two important physiological systems, the HPA-axis and immune system. In the first study (Chapter 2), we examined how the relationship between FMR1 genotype and immunological functioning is moderated by self-reported psychological stress. Much of the research and theory thus far has focused on FMR1 gene expression-related pathogenic mechanism (i.e. mRNA toxicity) as the cause of various negative health outcomes associated with FMR1 alleles in the premutation range. Moreover, previous work has disproportionately focused on mothers caring for a son/daughter with FXS who are known to be greatly affected by caregiving-associated chronic stress. Therefore, an important goal of this first study was to determine the extent to which the effect of self-reported stress differentially affects the association between FMR1 genotype and immune functioning by oversampling women with the premutation who are not caregivers of affected children. Another important feature of the first study was the focus on underlying biologically-based endophenotypes instead of diagnostic categories. Women with activation ratio-corrected CGG (AR-CGG) repeat lengths in the mid-premutation range (around 60-80 AR-CGG repeats) were more sensitive to the effects of psychological stress, such that women in this range with higher levels of stress display higher levels of IL-10 and lower levels of Th1-associated cytokines. In part, these findings differ from previous research demonstrating more broad suppression of cytokine production among women with FMR1 alleles in the premutation range. However, our results are consistent with previous findings of a Th1/Th2 shift in the immune system reported to be associated with stress. Specifically, higher levels of cortisol are thought to shift the balance toward more Th2-associated cytokines. This type of immunological imbalance is observed in fibromyalgia, atopic dermatitis, asthma, anxiety and depression. This may in part explain why women with the premutation are also more likely to experience some of these health issues. Our second study (Chapter 3) focuses on how psychological stress and FMR1 genotype interact and affect HPA-axis activity. This study was a natural extension of the first, namely by determining whether HPA-axis activity, which has been shown to be dysregulated in women with certain FMR1 alleles, mediates the association between FMR1 genotype and immune system dysregulation. We found that among women with AR-CGG lengths greater than 80 repeats, higher levels of self-reported stress were associated with elevated waking cortisol levels and flatter diurnal slopes. Additionally, we observed a curvilinear association between AR-CGG repeat size and waking cortisol which was moderated by stress. Women with FMR1 alleles in the 60-80 AR-CGG repeat range were more sensitive to the effect of negative life events displaying elevated waking cortisol. Our moderated-mediation analysis found no mediating effect of HPA-axis activity between stress and FMR1 genotype with immune system functioning. In sum, women with FMR1 alleles in the mid-premutation range were found to be more sensitive to the effects of stress on diurnal cortisol. These findings have implications for understanding the association between the FMR1 gene and the increased risk of developing depression, anxiety, and various inflammatory/autoimmune disorders among women with the premutation. In total, the goal of these two studies was to implement a gene-environment interaction approach in order to; (a) determine the extent to which the susceptibility of developing immune system dysregulation among certain FMR1 alleles is regulated at least in part by psychological stress and (b) determine whether diurnal HPA-axis dysregulation is a possible biological mechanism underlying this relationship. The results of these studies have the potential to impact society in a variety of ways. First, the findings from these two studies can advance our general understanding of basic biological processes underlying why and how the environment in which we live and develop gets “under the skin” affecting two important physiological systems and overall health. Second, these findings have the capacity to inform a substantial portion of the population (1 in 113-152 women are FMR1 premutation carriers), indicating that the FMR1 gene may be an important contributor to immune dysregulation in the general population. Finally, counseling and preventative research will benefit from a better understanding of when and how stress can affect individuals who might be more genetically vulnerable.
Keywords	Physiological psychology
Subject code	150
Language	ENG
Publishing date	2015-01-01 00:00:01.0
Publisher	University of California, Davis
Publishing country	us
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED