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  1. Conference proceedings: Radiosurgery for ventricular meningiomas

    Santacroce, Antonio

    2021  , Page(s) P171

    Title translation Radiochirurgie bei ventrikulären Meningiomen
    Event/congress 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-06-04
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dgnc452
    Database German Medical Science

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  2. Conference proceedings: Radiosurgery for skull base meningiomas – outcomes from over 3500 cases – update a comparative analysis with anatomical nuances

    Santacroce, Antonio

    2021  , Page(s) V080

    Title translation Radiochirurgie bei Schädelbasismeningiomen
    Event/congress 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; sine loco [digital]; Deutsche Gesellschaft für Neurochirurgie; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-06-04
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dgnc081
    Database German Medical Science

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  3. Article: Self-Shielding Gyroscopic Radiosurgery: A Prospective Experience and Analysis of the First 100 Patients.

    Ehret, Felix / Kohlhase, Nadja / Eftimova, Dochka / Hofmann, Theresa / Fürweger, Christoph / Haidenberger, Alfred / Kufeld, Markus / Muacevic, Alexander / Santacroce, Antonio

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56035

    Abstract: Background Stereotactic radiosurgery is a well-established treatment option for the management of various benign and malignant brain tumors. It can be delivered with several treatment platforms, usually requiring shielded radiation vaults to meet ... ...

    Abstract Background Stereotactic radiosurgery is a well-established treatment option for the management of various benign and malignant brain tumors. It can be delivered with several treatment platforms, usually requiring shielded radiation vaults to meet regulatory safety requirements. Recent technical advances have led to the first self-shielding platform enabling the delivery of gyroscopic radiosurgery (GRS). Given the limited number of GRS treatment platforms, the novelty of its characteristics, and the lack of available data, we report our prospective experience with the first 100 patients treated with GRS. Materials and methods Patients undergoing GRS for the treatment of intracranial tumors were enrolled in this prospective study. Patient and treatment characteristics, including patient satisfaction, were collected and analyzed. Results A total of 100 patients with 155 tumors were treated. The most commonly treated tumors comprised brain metastases (BM) (49%), vestibular schwannomas (31%), and meningiomas (14%). The median prescription dose for malignant and benign tumors was 20 and 13 Gy, respectively. The median prescription isodose line was 56%. Gross tumor volumes were small, with a median of 0.37 cc for BM and 0.92 cc for the other entities. The median total treatment time was 40 minutes. Dosimetric performance indices showed median values of 1.20 (conformity index), 1.24 (new conformity index), 1.74 (homogeneity index), and 3.13 (gradient index). Volumetric assessment of the treated tumors showed an overall decrease in size at the first available follow-up. Most patients were satisfied with the treatment experience. Conclusion Our first prospective experience of the use of GRS is favorable. Analyses of the dosimetric performance, treatment times, volumetric assessment, and patient satisfaction demonstrate its suitability for stereotactic treatments of intracranial tumors. Further prospective clinical and dosimetric analyses for GRS are pending.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56035
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  4. Conference proceedings: Radiosurgery for skull base meningiomas – outcomes from over 3500 cases – update a comparative analysis with anatomical nuances

    Santacroce, Antonio / Nakamura, Makoto / Fortmann, Thomas / Ewelt, Christian

    2022  , Page(s) V011

    Title translation Radiochirurgie bei Scnädelbasis Meningiomen – Ergebnisse aus über 3500 Fällen – Aktualisierung einer vergleichenden Analyse mit anatomischen Nuancen
    Event/congress 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-05-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dgnc012
    Database German Medical Science

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  5. Article ; Online: Revitalizing neurosurgical frontiers: The EANS frontiers in neurosurgery committee's strategic framework.

    Lawson McLean, Aaron / Vetrano, Ignazio G / Lawson McLean, Anna C / Conti, Alfredo / Mertens, Patrick / Müther, Michael / Nemir, Jakob / Peschillo, Simone / Santacroce, Antonio / Sarica, Can / Tuleasca, Constantin / Zoia, Cesare / Régis, Jean

    Brain & spine

    2024  Volume 4, Page(s) 102794

    Abstract: Introduction: The field of neurosurgery faces challenges with the increasing involvement of other medical specialties in areas traditionally led by neurosurgeons. This paper examines the implications of this development for neurosurgical practice and ... ...

    Abstract Introduction: The field of neurosurgery faces challenges with the increasing involvement of other medical specialties in areas traditionally led by neurosurgeons. This paper examines the implications of this development for neurosurgical practice and patient care, with a focus on specialized areas like pain management, peripheral nerve surgery, and stereotactic radiosurgery.
    Research question: To assess the implications of the expanded scope of other specialties for neurosurgical practice and to consider the response of the EANS Frontiers in Neurosurgery Committee to these challenges.
    Materials and methods: Analysis of recent trends in neurosurgery, including the shift in various procedures to other specialties, demographic challenges, and the emergence of minimally invasive techniques. This analysis draws on relevant literature and the initiatives of the Frontiers in Neurosurgery Committee.
    Results: We explore a possible decrease in neurosurgical involvement in certain areas, which may have implications for patient care and access to specialized neurosurgical interventions. The Frontiers in Neurosurgery Committee's role in addressing these concerns is highlighted, particularly in terms of training, education, research, and networking for neurosurgeons, especially those early in their careers.
    Discussion and conclusion: The potential decrease in neurosurgical involvement in certain specialties warrants attention. This paper emphasizes the importance of carefully considered responses by neurosurgical societies, such as the EANS, to ensure neurosurgeons continue to play a vital role in managing neurological diseases. Emphasis on ongoing education, integration of minimally invasive techniques, and multidisciplinary collaboration is essential for maintaining the field's competence and quality in patient care.
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2024.102794
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  6. Conference proceedings: Radiosurgery for parasagittal meningiomas

    Santacroce, Antonio / Nakamura, Makoto / Regis, Jean / Fortmann, Thomas / Ewelt, Christian

    2022  , Page(s) V041

    Title translation Radiochirurgie bei parasagittalen Meningiomen
    Event/congress 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; Köln; Deutsche Gesellschaft für Neurochirurgie; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-05-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dgnc049
    Database German Medical Science

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  7. Article ; Online: Transition of a vestibular schwannoma to a malignant peripheral nerve sheath tumor with loss of H3K27 trimethylation after radiosurgery-a case report and review of the literature.

    Behling, Felix / Bersali, Imane / Santacroce, Antonio / Hempel, Johann / Kandilaris, Kosmas / Schittenhelm, Jens / Tatagiba, Marcos

    Neurosurgical review

    2021  Volume 45, Issue 1, Page(s) 915–922

    MeSH term(s) Cell Transformation, Neoplastic/pathology ; Humans ; Nerve Sheath Neoplasms/surgery ; Neurofibrosarcoma ; Neuroma, Acoustic/diagnostic imaging ; Neuroma, Acoustic/pathology ; Neuroma, Acoustic/surgery ; Radiosurgery
    Language English
    Publishing date 2021-08-15
    Publishing country Germany
    Document type Case Reports ; Letter ; Review
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-021-01620-3
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    Zs.A 1445: Show issues Location:
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  8. Article: Rescuing Infected Deep Brain Stimulation Therapies in Severely Affected Patients.

    Fortmann, Thomas / Zawy Alsofy, Samer / Lewitz, Marc / Santacroce, Antonio / Welzel Saravia, Heinz / Sakellaropoulou, Ioanna / Wilbers, Eike / Grabowski, Steffen / Stroop, Ralf / Cinibulak, Zafer / Nakamura, Makoto / Lehrke, Ralph

    Brain sciences

    2023  Volume 13, Issue 12

    Abstract: 1) Background: Infections in deep brain stimulation (DBS) hardware, while an undesired complication of DBS surgeries, can be effectively addressed. Minor infections are typically treated with wound revision and IV antibiotics. However, when visible ... ...

    Abstract (1) Background: Infections in deep brain stimulation (DBS) hardware, while an undesired complication of DBS surgeries, can be effectively addressed. Minor infections are typically treated with wound revision and IV antibiotics. However, when visible hardware infection occurs, most centers opt for complete removal, leaving the patient in a preoperative state and necessitating post-removal care. To avoid the need for such care, a novel technique was developed. (2) Methods: The electrodes are placed at the exact same spot and then led to the contralateral side. new extensions and a new generator contralateral to the infection as well. Subsequently, the infected system is removed. This case series includes six patients. (3) Results: The average duration of DBS system implantation before the second surgery was 272 days. Only one system had to be removed after 18 months due to reoccurring infection; the others remained unaffected. Laboratory alterations and pathogens were identified in only half of the patients. (4) Conclusions: The described surgical technique proves to be safe, well tolerated, and serves as a viable alternative to complete system removal. Importantly, it effectively prevents the need of post-removal care for patients.
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13121650
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  9. Article ; Online: Proton beam radiation therapy for vestibular schwannomas-tumor control and hearing preservation rates: a systematic review and meta-analysis.

    Santacroce, Antonio / Trandafirescu, Mioara- Florentina / Levivier, Marc / Peters, David / Fürweger, Christoph / Toma-Dasu, Iuliana / George, Mercy / Daniel, Roy Thomas / Maire, Raphael / Nakamura, Makoto / Faouzi, Mohamed / Schiappacasse, Luis / Dasu, Alexandru / Tuleasca, Constantin

    Neurosurgical review

    2023  Volume 46, Issue 1, Page(s) 163

    Abstract: Objective: Proton beam therapy is considered, by some authors, as having the advantage of delivering dose distributions more conformal to target compared with stereotactic radiosurgery (SRS). Here, we performed a systematic review and meta-analysis of ... ...

    Abstract Objective: Proton beam therapy is considered, by some authors, as having the advantage of delivering dose distributions more conformal to target compared with stereotactic radiosurgery (SRS). Here, we performed a systematic review and meta-analysis of proton beam for VSs, evaluating tumor control and cranial nerve preservation rates, particularly with regard to facial and hearing preservation.
    Methods: We reviewed, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) articles published between 1968 and September 30, 2022. We retained 8 studies reporting 587 patients.
    Results: Overall rate of tumor control (both stability and decrease in volume) was 95.4% (range 93.5-97.2%, p heterogeneity= 0.77, p<0.001). Overall rate of tumor progression was 4.6% (range 2.8-6.5%, p heterogeneity < 0.77, p<0.001). Overall rate of trigeminal nerve preservation (absence of numbness) was 95.6% (range 93.5-97.7%, I
    Conclusion: Proton beam therapy for VSs achieves high tumor control rates, as high as 95.4%. Facial rate preservation overall rates are 93%, which is lower compared to the most SRS series. Compared with most currently reported SRS techniques, proton beam radiation therapy for VSs does not offer an advantage for facial and hearing preservation compared to most of the currently reported SRS series.
    MeSH term(s) Humans ; Neuroma, Acoustic/radiotherapy ; Neuroma, Acoustic/surgery ; Neuroma, Acoustic/pathology ; Proton Therapy ; Hearing ; Cranial Nerves ; Facial Nerve/pathology ; Radiosurgery/methods ; Treatment Outcome ; Follow-Up Studies ; Retrospective Studies
    Language English
    Publishing date 2023-07-04
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02060-x
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    Zs.A 1445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Retrospective Comparison of Minimally Invasive and Open Monosegmental Lumbar Fusion, and Impact of Virtual Reality on Surgical Planning and Strategy.

    Zawy Alsofy, Samer / Nakamura, Makoto / Ewelt, Christian / Kafchitsas, Konstantinos / Lewitz, Marc / Schipmann, Stephanie / Suero Molina, Eric / Santacroce, Antonio / Stroop, Ralf

    Journal of neurological surgery. Part A, Central European neurosurgery

    2021  Volume 82, Issue 5, Page(s) 399–409

    Abstract: Background and study aims:  Spinal fusion for symptomatic lumbar spondylolisthesis can be accomplished using an open or minimally invasive surgical (MIS) technique. Evaluation of segmental spondylolisthesis and instabilities and review of their ... ...

    Abstract Background and study aims:  Spinal fusion for symptomatic lumbar spondylolisthesis can be accomplished using an open or minimally invasive surgical (MIS) technique. Evaluation of segmental spondylolisthesis and instabilities and review of their therapies are inseparably connected with lumbar tomographic imaging. We analyzed a cohort of patients who underwent MIS or open monosegmental dorsal fusion and compared surgical outcomes along with complication rates. We furthermore evaluated the influence of virtual reality (VR) visualization on surgical planning in lumbar fusion.
    Material and methods:  Patient files were retrospectively analyzed regarding patient- and disease-related data, operative performance, surgical outcomes, and perioperative surgical complications. Preoperative computed tomography (CT) and magnetic resonance imaging (MRI) scans were retrospectively visualized via VR software. A questionnaire evaluated the influence of three-dimensional (3D) VR images versus two-dimensional CT and MRI scans on therapy planning, fusion method, and surgical technique and procedure.
    Results:  Overall, 171 patients were included (MIS/open: 90/81). MIS was associated with less blood loss, shorter surgery time and hospital stay, lower complication rates, equivalent long-term patient-reported outcomes, but lower fusion rates and higher late reoperation rates than open surgery. Image presentation using VR significantly influenced the recommended surgical therapies (decompression only/decompression and fusion;
    Conclusion:  In patients with monosegmental degenerative or isthmic spondylolisthesis, MIS fusion was advantageous concerning perioperative complication rates and perioperative surgical outcomes, but disadvantageous regarding fusion and reoperation rates compared to open fusion. 3D-VR-based analysis of sectional images significantly influenced the recommended surgical planning.
    MeSH term(s) Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Lumbosacral Region ; Minimally Invasive Surgical Procedures ; Retrospective Studies ; Spinal Fusion ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/surgery ; Treatment Outcome ; Virtual Reality
    Language English
    Publishing date 2021-02-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2651663-9
    ISSN 2193-6323 ; 2193-6315
    ISSN (online) 2193-6323
    ISSN 2193-6315
    DOI 10.1055/s-0040-1719099
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