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  1. Book: Biomaterials in regenerative medicine and the immune system

    Santambrogio, Laura

    2015  

    Author's details Laura Santambrogio ed
    Keywords Biomaterials ; Regenerative medicine ; Macrophages ; Inflammation ; immunology
    Language English
    Size IX, 280 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018761741
    ISBN 978-3-319-18044-1 ; 978-3-319-18045-8 ; 3-319-18044-4 ; 3-319-18045-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3306 available for loan (reading room) Lesesaal EG

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  2. Book: Immunology of the lymphatic system

    Santambrogio, Laura

    2013  

    Author's details Laura Santambrogio ed
    Language English
    Size V, 177 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017670872
    ISBN 978-1-4614-3234-0 ; 1-4614-3234-0 ; 9781461432357 ; 1461432359
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1276 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Autoimmunity to the modified self.

    Santambrogio, Laura

    Science (New York, N.Y.)

    2023  Volume 379, Issue 6637, Page(s) 1092–1093

    Abstract: Protein posttranslational modifications can break tolerance to the self-proteome. ...

    Abstract Protein posttranslational modifications can break tolerance to the self-proteome.
    MeSH term(s) Humans ; Autoimmunity ; Protein Processing, Post-Translational/immunology ; Proteome/immunology ; Autoimmune Diseases/immunology ; Spondylitis, Ankylosing/immunology ; Self Tolerance
    Chemical Substances Proteome
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg3925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  4. Article ; Online: Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome.

    Santambrogio, Laura

    Frontiers in immunology

    2022  Volume 13, Page(s) 878271

    Abstract: In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented ... ...

    Abstract In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition of different conformers, functional differences in endosomal processing along the endocytic tract, and the interplay between the MHC class II chaperones DM and DO. The sum of all these variables contributes, qualitatively and quantitatively, to the composition of the MHC II ligandome, altogether ensuring that the immunopeptidome landscape is highly sensitive to any changes in the composition of the intra- and extracellular proteome for a comprehensive survey of the microenvironment for MHC II presentation to CD4 T cells.
    MeSH term(s) Animals ; Antigen Presentation/physiology ; CD4-Positive T-Lymphocytes ; Genes, MHC Class II ; Histocompatibility Antigens Class II/physiology ; Humans ; Proteome
    Chemical Substances Histocompatibility Antigens Class II ; Proteome
    Language English
    Publishing date 2022-05-16
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.878271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Lymphatic Fluid.

    Santambrogio, Laura

    International review of cell and molecular biology

    2018  Volume 337, Page(s) 111–133

    Abstract: This review will highlight our current understanding of the formation, circulation, and immunological role of lymphatic fluid. The formation of the extracellular fluid depends on the net balance between the hydrostatic and osmotic pressure gradients ... ...

    Abstract This review will highlight our current understanding of the formation, circulation, and immunological role of lymphatic fluid. The formation of the extracellular fluid depends on the net balance between the hydrostatic and osmotic pressure gradients effective in the capillary beds. Lymph originates from the extracellular fluid and its composition combines the ultrafiltrated plasma proteins with the proteome generated by the metabolic activities of each parenchymal tissue. Several analyses have indicated how the lymph composition reflects the organs' physiological and pathological states. The collected lymphatic fluid moves from the capillaries into progressively larger collectors toward the draining lymph node aided by the lymphangion contractility and unidirectional valves, which prevent backflow. The proteomic composition of the lymphatic fluid is reflected in the MHC II peptidome presented by nodal antigen-presenting cells. Taken together, the past few years have generated new interest in the formation, transport, and immunological role of the lymphatic fluid.
    MeSH term(s) Animals ; Extracellular Fluid/immunology ; Humans ; Lymph/immunology ; Proteome ; Proteomics
    Chemical Substances Proteome
    Language English
    Publishing date 2018-02-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2017.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Uc I Zs.317: Show issues Location:
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  6. Article ; Online: The yin/yang balance of the MHC-self

    Santambrogio, Laura / Franco, Alessandra

    Frontiers in immunology

    2022  Volume 13, Page(s) 1035363

    Abstract: The MHC- ...

    Abstract The MHC-
    MeSH term(s) Receptors, Antigen, T-Cell ; Thymus Gland ; T-Lymphocytes, Regulatory ; Antigen-Presenting Cells ; Peptides
    Chemical Substances Receptors, Antigen, T-Cell ; Peptides
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1035363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The broad spectrum of pathogenic autoreactivity.

    Santambrogio, Laura / Marrack, Philippa

    Nature reviews. Immunology

    2022  Volume 23, Issue 2, Page(s) 69–70

    MeSH term(s) Humans ; Autoimmunity ; Autoantibodies
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-022-00812-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

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  8. Article ; Online: Non-mutational neoantigens in disease.

    Stern, Lawrence J / Clement, Cristina / Galluzzi, Lorenzo / Santambrogio, Laura

    Nature immunology

    2024  Volume 25, Issue 1, Page(s) 29–40

    Abstract: The ability of mammals to mount adaptive immune responses culminating with the establishment of immunological memory is predicated on the ability of the mature T cell repertoire to recognize antigenic peptides presented by syngeneic MHC class I and II ... ...

    Abstract The ability of mammals to mount adaptive immune responses culminating with the establishment of immunological memory is predicated on the ability of the mature T cell repertoire to recognize antigenic peptides presented by syngeneic MHC class I and II molecules. Although it is widely believed that mature T cells are highly skewed towards the recognition of antigenic peptides originating from genetically diverse (for example, foreign or mutated) protein-coding regions, preclinical and clinical data rather demonstrate that novel antigenic determinants efficiently recognized by mature T cells can emerge from a variety of non-mutational mechanisms. In this Review, we describe various mechanisms that underlie the formation of bona fide non-mutational neoantigens, such as epitope mimicry, upregulation of cryptic epitopes, usage of non-canonical initiation codons, alternative RNA splicing, and defective ribosomal RNA processing, as well as both enzymatic and non-enzymatic post-translational protein modifications. Moreover, we discuss the implications of the immune recognition of non-mutational neoantigens for human disease.
    MeSH term(s) Animals ; Humans ; Antigens ; T-Lymphocytes ; Epitopes ; Peptides ; Mammals/metabolism
    Chemical Substances Antigens ; Epitopes ; Peptides
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01664-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 42: Show issues

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  9. Book ; Online: Biomaterials in regenerative medicine and the immune system

    Santambrogio, Laura

    2015  

    Author's details Laura Santambrogio, editor
    Keywords Biomedical materials ; Immunology ; Regenerative medicine
    Language English
    Size Online-Ressource (ix, 280 pages), illustrations (some color)
    Publisher Springer
    Publishing place Cham
    Document type Book ; Online
    Note Includes index
    ISBN 3319180452 ; 9783319180441 ; 9783319180458 ; 3319180444
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Advances in understanding and examining lymphatic function: relevance for understanding autoimmunity.

    Ambler, William / Santambrogio, Laura / Lu, Theresa T

    Current opinion in rheumatology

    2021  Volume 34, Issue 2, Page(s) 133–138

    Abstract: Purpose of review: The aim of this review is to give insights into how novel lymphatics functions may influence autoimmunity.: Recent findings: The lymphatic system connects peripheral tissues to draining lymph nodes to regulate adaptive immunity and ...

    Abstract Purpose of review: The aim of this review is to give insights into how novel lymphatics functions may influence autoimmunity.
    Recent findings: The lymphatic system connects peripheral tissues to draining lymph nodes to regulate adaptive immunity and directly interfaces with leukocytes in lymph vessels and in the lymph node. Here, we discuss recent findings showing evidence of dysfunctional lymphatics in autoimmune disease, new understanding of how afferent lymphatic regulation can modulate immunity, lymph node lymphatic heterogeneity and how these lymphatics can directly modulate lymphocyte function, how this understanding can be harnessed for new therapeutics, and new tools for the investigation of lymphatic and immune biology.
    Summary: Lymphatics have an active role in the regulation of inflammation and the adaptive immune response. Here, we review recent findings in lymphatics biology in peripheral tissues and lymph nodes and emphasize the relevance for better understanding autoimmune diseases.
    MeSH term(s) Autoimmune Diseases ; Autoimmunity ; Humans ; Lymph Nodes ; Lymphatic System ; Lymphatic Vessels
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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