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Article ; Online: Criteria for a good research topic. Starting point: The research question.

Santarrufina Martínez, Sandra / Millán Scheiding, Mónica

Cirugia espanola

2022 Volume 100, Issue 5, Page(s) 309–311

Language	English
Publishing date	2022-04-25
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2021.10.014
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Article ; Online: Laparoscopic strictureplasty as a treatment for stenosing Crohn's disease - a video vignette.

Santarrufina Martínez, S / Caiña Ruiz, R / Gómez Ruiz, M / Cristobal Poch, L / Cagigas Fernández, C / Del Castillo Diego, J

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2020 Volume 22, Issue 11, Page(s) 1787–1788

MeSH term(s)	Constriction, Pathologic/etiology ; Constriction, Pathologic/surgery ; Crohn Disease/complications ; Crohn Disease/surgery ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Laparoscopy ; Recurrence ; Reoperation ; Treatment Outcome
Language	English
Publishing date	2020-07-12
Publishing country	England
Document type	Letter ; Video-Audio Media
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15201
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Article ; Online: Extension of lymphadenectomy of the peri-ileal lymph nodes during right colectomy for caecal cancer - a video vignette.

Santarrufina Martinez, Sandra / Gómez Ruiz, Marcos / García Cardo, Juan / Cagigas Fernández, Carmen / Cristobal Poch, Lidia / José Del Castillo Diego, Julio

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 5, Page(s) 1274

MeSH term(s)	Cecal Neoplasms/surgery ; Colectomy ; Humans ; Lymph Node Excision ; Lymph Nodes/surgery
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Letter ; Video-Audio Media
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15556
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Article ; Online: Conversion to open surgery during laparoscopic common bile duct exploration: predictive factors and impact on the perioperative outcomes.

Payá-Llorente, Carmen / Domingo-Del Pozo, Carlos / Gonzálvez-Guardiola, Paula / Santarrufina-Martínez, Sandra / Pareja-Ibars, Eugenia / Martínez-Pérez, Aleix

HPB : the official journal of the International Hepato Pancreato Biliary Association

2021 Volume 24, Issue 1, Page(s) 87–93

Abstract: Background: Laparoscopic common bile duct exploration (LCBDE) is an effective treatment for choledocholithiasis. The aim of this study was to determine the predictive factors associated with conversion during LCBDE and to assess the implications of ... ...

Abstract	Background: Laparoscopic common bile duct exploration (LCBDE) is an effective treatment for choledocholithiasis. The aim of this study was to determine the predictive factors associated with conversion during LCBDE and to assess the implications of conversion on the patients' postoperative course. Methods: A retrospective cohort study based on patients undergoing LCBDE between 2000 and 2018 was conducted. Uni- and multivariate regression analyses were performed. Results: A total of 357 patients underwent LCBDE, and the conversion rate was 14.2%. The main reasons for conversion were lithiasis extraction (21; 41%) and difficult dissection (13; 26%). Independent predictors for conversion were increasing levels of serum bilirubin prior to surgery (OR=4.745, 95% CI: 1.390-16.198; p=0.013), and emergency setting (OR=4.144, 95% CI: 1.449-11.846; p=0.008). Age was independently associated with lower odds of conversion (OR=0.979, 95% CI: 0.960-0.999; p=0.036). Conversion had a negative impact on the patients' postoperative course, including severe complication (21.6% vs. 5.2% p<0.001) and surgical reintervention (11.8% vs. 2.6% p=0.002) rates. Conclusion: Conversion to open surgery during LCBDE was associated with increased postoperative morbidity. Emergency surgery and increasing levels of serum bilirubin previous to surgery independently increase the probability of conversion; however age was independently associated with lower odds of conversion.
MeSH term(s)	Cholecystectomy, Laparoscopic/adverse effects ; Choledocholithiasis/diagnostic imaging ; Choledocholithiasis/surgery ; Common Bile Duct/surgery ; Conversion to Open Surgery ; Humans ; Laparoscopy/adverse effects ; Retrospective Studies
Language	English
Publishing date	2021-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2021.05.009
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Zs.A 6326: Show issues

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Article ; Online: Pilonidal disease. Three flap procedures every colorectal surgeon should know-a video vignette.

Cristóbal Poch, Lidia / Santarrufina Martínez, Sandra / Laínez Escribano, Mario / Anderson, Edward Joseph / Castillo Diego, Julio / Sanz Gimenez-Rico, Juan Ramon

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 5, Page(s) 1286–1287

MeSH term(s)	Colorectal Neoplasms ; Humans ; Neoplasm Recurrence, Local ; Pilonidal Sinus/surgery ; Recurrence ; Surgeons ; Surgical Flaps ; Treatment Outcome
Language	English
Publishing date	2021-03-15
Publishing country	England
Document type	Letter ; Video-Audio Media
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15575
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Article ; Online: The impact of age and comorbidity on the postoperative outcomes after emergency surgical management of complicated intra-abdominal infections.

Payá-Llorente, Carmen / Martínez-López, Elías / Sebastián-Tomás, Juan Carlos / Santarrufina-Martínez, Sandra / de'Angelis, Nicola / Martínez-Pérez, Aleix

Scientific reports

2020 Volume 10, Issue 1, Page(s) 1631

Abstract: Age-adjusted Charlson Comorbidity Index (a-CCI) score has been used to weight comorbid conditions in predicting adverse outcomes. A retrospective cohort study on adult patients diagnosed with complicated intra-abdominal infections (cIAI) requiring ... ...

Abstract	Age-adjusted Charlson Comorbidity Index (a-CCI) score has been used to weight comorbid conditions in predicting adverse outcomes. A retrospective cohort study on adult patients diagnosed with complicated intra-abdominal infections (cIAI) requiring emergency surgery was conducted in order to elucidate the role of age and comorbidity in this scenario. Two main outcomes were evaluated: 90-day severe postoperative complications (grade ≥ 3 of Dindo-Clavien Classification), and 90-day all-cause mortality. 358 patients were analyzed. a-CCI score for each patient was calculated and then divided in two comorbid categories whether they were ≤ or > to percentile 75 ( = 4): Grade-A (0-4) and Grade-B ( ≥ 5). Univariate and multivariate regression analyses were performed, and the predictive validity of the models was evaluated by the area under the receiver operating characteristics (AUROC) curve. Independent predictors of 90-day severe postoperative complications were Charlson Grade-B (Odds Ratio [OR] = 3.49, 95% confidence interval [95%CI]: 1.86-6.52; p < 0.0001), healthcare-related infections (OR = 7.84, 95%CI: 3.99-15.39; p < 0.0001), diffuse peritonitis (OR = 2.64, 95%CI: 1.45-4.80; p < 0.01), and delay of surgery > 24 hours (OR = 2.28, 95%CI: 1.18-4.68; p < 0.02). The AUROC was 0.815 (95%CI: 0.758-0.872). Independent predictors of 90-day mortality were Charlson Grade-B (OR = 8.30, 95%CI: 3.58-19.21; p < 0.0001), healthcare-related infections (OR = 6.38, 95%CI: 2.72-14.95; p < 0.0001), sepsis status (OR = 3.98, 95%CI: 1.04-15.21; p < 0.04) and diffuse peritonitis (OR = 3.06, 95%CI: 1.29-7.27; p < 0.01). The AUROC for mortality was 0.887 (95%CI: 0.83-0.93). Post-hoc sensitivity analyses confirmed that the degree of comorbidity, estimated by using an age-adjusted score, has a critical impact on the postoperative course following emergency surgery for cIAI. Early assessment and management of patient's comorbidity is mandatory at emergency setting.
MeSH term(s)	Comorbidity ; Emergency Service, Hospital ; Female ; Humans ; Intraabdominal Infections/complications ; Intraabdominal Infections/surgery ; Male ; Middle Aged ; Odds Ratio ; Postoperative Complications/etiology ; Postoperative Period ; ROC Curve ; Retrospective Studies ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2020-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-58453-1
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Article ; Online: Predictors for prolonged length of stay after laparoscopic appendectomy for complicated acute appendicitis in adults.

Martínez-Pérez, Aleix / Payá-Llorente, Carmen / Santarrufina-Martínez, Sandra / Sebastián-Tomás, Juan Carlos / Martínez-López, Elías / de'Angelis, Nicola

Surgical endoscopy

2020 Volume 35, Issue 7, Page(s) 3628–3635

Abstract: Background: Appendicitis-related hospitalizations linked with peritonitis or postoperative complications result in longer lengths of stay and higher costs. The aim of the present study was to assess the independent association between potential ... ...

Abstract	Background: Appendicitis-related hospitalizations linked with peritonitis or postoperative complications result in longer lengths of stay and higher costs. The aim of the present study was to assess the independent association between potential predictors and prolonged hospitalization after laparoscopic appendectomy (LA) for complicated acute appendicitis (CAA). Methods: A retrospective cohort study was conducted on adult patients diagnosed with CAA in which LA was attempted. The primary outcome was a prolonged length of stay (LOS) after surgery, defined as hospitalizations longer than or equal to the 75th percentile for LOS, including the day of discharge. Hierarchical regression models were run to elucidate the independent predictors for the variable of interest. Results: The present study involved 160 patients with a mean age of 50.71 years. The conversion rate was 1.9%, and the overall postoperative morbidity rate was 23.8%. The median length of stay (LOS) was 5 days (75th percentile: 7 days). Multivariate analyses included nine variables that are statistically and/or clinically relevant to assess its relationship with a prolonged LOS: three preoperative (age, sex, and comorbidity), four intraoperative (appendix gangrene, perforation, degree of peritonitis, and drain placement), and two postoperative (immediate ICU admission and complications). The development of postoperative complications (OR 6.162, 95% CI 2.451-15.493; p = 0.000) and the placement of an abdominal drain (OR 3.438, 95% CI 1.107-10.683; p = 0.033) were found to be independent predictors for prolonged LOS. For patients not presenting postoperative complications, drain placement was the only independent predictor for the outcome (OR 7.853, 95% CI 1.520-40.558; p = 0.014). Sensitivity analyses showed confirmatory results. Conclusion: The intraoperative process of care has a clear impact on LOS after LA for CAA in adults; therefore, the decision of whether to drain in these situations should be made more restrictively yet with judicious caution.
MeSH term(s)	Adult ; Appendectomy/adverse effects ; Appendicitis/surgery ; Humans ; Infant, Newborn ; Laparoscopy ; Length of Stay ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-020-07841-9
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Article ; Online: Robotic surgery for colorectal cancer.

Gómez Ruiz, Marcos / Lainez Escribano, Mario / Cagigas Fernández, Carmen / Cristobal Poch, Lidia / Santarrufina Martínez, Sandra

Annals of gastroenterological surgery

2020 Volume 4, Issue 6, Page(s) 646–651

Abstract: Minimally invasive surgery has demonstrated many benefits in general surgery, particularly in colon and rectal procedures. On the other hand, it has some limitations that must be taken into account, especially technical drawback. Robotic surgery has ... ...

Abstract	Minimally invasive surgery has demonstrated many benefits in general surgery, particularly in colon and rectal procedures. On the other hand, it has some limitations that must be taken into account, especially technical drawback. Robotic surgery has incorporated many improvements to overcome this disadvantage, such as 3D visualization, articulating instruments assisting complex and precise movements. As a result, robotic colorectal surgery shows less intraoperative blood loss, shorter time to oral tolerance and initial flatus (particularly associated with "Enhanced Recovery After Surgery" protocol), less conversion rate to open surgery, shortened hospital stay, and longer distal margins compared to laparoscopic and open surgery. This approach also shows a shorter learning curve. Some studies suggest that it could decrease perioperatively or 30 days after the intervention's mortality, raise overall survival, reduce wound infection, and improve functional results, while others show no significant difference. However, it lengthens surgical time. Otherwise, the studies included do not show statistically significant changes in the number of resected lymph nodes and anastomotic leaks. Economic costs remain one of the major concerns, although to date there are no large-scale studies that have evaluated this aspect from a global point of view. Robotic surgery represents a qualitative leap in surgical instruments and, although there is no strong evidence in favor of the use of robotic surgery over laparoscopic or open surgery, there is enough evidence to support its use in colorectal surgery, with potential advantages for patients.
Language	English
Publishing date	2020-12-10
Publishing country	Japan
Document type	Journal Article ; Review
ISSN	2475-0328
ISSN (online)	2475-0328
DOI	10.1002/ags3.12401
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Article: Massive gastrointestinal pneumatosis in a patient with celiac disease and superior mesenteric artery syndrome.

Martínez-Pérez, Aleix / Trullenque-Juan, Ramón / Santarrufina-Martínez, Sandra / Armañanzas-Villena, Ernesto

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2015 Volume 107, Issue 11, Page(s) 709–710

Abstract: Pneumatosis intestinalis (PI) is a radiological finding representing the presence of gas in the bowell, independently of the cause or location. We present the case of a 55-year-old man who was admitted presenting two-week history of intense vomiting. The ...

Abstract	Pneumatosis intestinalis (PI) is a radiological finding representing the presence of gas in the bowell, independently of the cause or location. We present the case of a 55-year-old man who was admitted presenting two-week history of intense vomiting. The patient was previously diagnosed with superior mesenteric artery syndrome and celiac disease. Plain x-ray and TC showed gastric and intestinal pneumatosis with important retropneumoperitoneum. Due to clinical stability the patient was managed conservatively, with a favorable outcome.
MeSH term(s)	Celiac Disease/complications ; Humans ; Intubation, Gastrointestinal ; Male ; Middle Aged ; Pneumatosis Cystoides Intestinalis/complications ; Retropneumoperitoneum/diagnostic imaging ; Superior Mesenteric Artery Syndrome/complications ; Tomography, X-Ray Computed
Language	English
Publishing date	2015-11
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2015.3858/2015
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Article: Mirizzi syndrome: a new insight provided by a novel classification.

Payá-Llorente, Carmen / Vázquez-Tarragón, Antonio / Alberola-Soler, Antonio / Martínez-Pérez, Aleix / Martínez-López, Elías / Santarrufina-Martínez, Sandra / Ortiz-Tarín, Inmaculada / Armañanzas-Villena, Ernesto

Annals of hepato-biliary-pancreatic surgery

2017 Volume 21, Issue 2, Page(s) 67–75

Abstract: Backgrounds/aims: Mirizzi syndrome (MS) is an uncommon complication of cholelithiasis. The aim of this study is to evaluate our 15-year experience in this challenging entity and to propose a new classification for this disease.: Methods: A ... ...

Abstract	Backgrounds/aims: Mirizzi syndrome (MS) is an uncommon complication of cholelithiasis. The aim of this study is to evaluate our 15-year experience in this challenging entity and to propose a new classification for this disease. Methods: A retrospective study including patients diagnosed with Mirizzi syndrome and undergoing surgical procedures for Mirizzi syndrome between January 2000 and October 2015 was conducted. Data collected included clinical, surgical procedure, postoperative morbidity. Patients were evaluated according to the Csendes classification and the proposed system, in which patients were divided into three types and three subtypes. Results: 28 patients were included for analysis. They accounted as the 0.5% of a total of 4853 cholecystectomies performed in the study period. There were 21 women and 7 men. Initial laparotomic approach was performed in 12 patients and in 16 patients laparoscopic procedures were attempted. The procedure was completed in only 6 patients, 5 presenting type I and 1 type II Mirizzi syndrome. Mean postoperative stay was 15±9 days. Postoperative morbidity rate was 28%. Postoperative mortality was none. Conclusions: Laparoscopic surgery for Mirizzi syndrome has been shown succesful only in early stages. A novel classification is proposed, based on the types of common bile duct injuries and in the presence cholecystoenteric fistula.
Language	English
Publishing date	2017-05-23
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3012179-6
ISSN	2508-5859 ; 2508-5778
ISSN (online)	2508-5859
ISSN	2508-5778
DOI	10.14701/ahbps.2017.21.2.67
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