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Article: Plant-Produced Viral Nanoparticles as a Functionalized Catalytic Support for Metabolic Engineering.

Sator, Christian / Lico, Chiara / Pannucci, Elisa / Marchetti, Luca / Baschieri, Selene / Warzecha, Heribert / Santi, Luca

Plants (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: Substrate channeling could be very useful for plant metabolic engineering; hence, we propose that functionalized supramolecular self-assembly scaffolds can act as enzymatic hubs able to perform reactions in close contiguity. Virus nanoparticles (VNPs) ... ...

Abstract	Substrate channeling could be very useful for plant metabolic engineering; hence, we propose that functionalized supramolecular self-assembly scaffolds can act as enzymatic hubs able to perform reactions in close contiguity. Virus nanoparticles (VNPs) offer an opportunity in this context, and we present a functionalization strategy to display different enzymes on the outer surface of three different VNPs produced in plants. Tomato bushy stunt virus (TBSV) and Potato virus X (PVX) plant viruses were functionalized by the genetic fusion of the E-coil peptide coding sequence to their respective coat proteins genes, while the enzyme lichenase was tagged with the K-coil peptide. Immobilized E-coil VNPs were able to interact
Language	English
Publishing date	2024-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13040503
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Plant derived veterinary vaccines.

Santi, L

Veterinary research communications

2009 Volume 33 Suppl 1, Page(s) 61–66

Abstract: Infectious diseases remain one of the main causes of death and economic losses in animals despite the fact that prophylactic vaccination has been extremely successful in disease prevention. New effective viral, bacterial and parasitic vaccines are needed, ...

Abstract	Infectious diseases remain one of the main causes of death and economic losses in animals despite the fact that prophylactic vaccination has been extremely successful in disease prevention. New effective viral, bacterial and parasitic vaccines are needed, but unfortunately production costs still remain prohibitive. In this respect plants can offer a valid alternative. Production of antigenic proteins in plants relies on a well developed and proven technology, several expression platforms are available and many different plant species can be utilized. Plant based veterinary vaccine studies have addressed protection issues in model animals and, more interestingly, some of them have examined the relevant challenge model in the specific species of interest. A general overview of the topic will be outlined together with a few selected promising examples.
MeSH term(s)	Animal Diseases/prevention & control ; Animals ; Bacterial Infections/prevention & control ; Bacterial Infections/veterinary ; Gene Expression Regulation, Plant/physiology ; Plant Proteins/immunology ; Plants, Genetically Modified ; Recombinant Proteins/immunology ; Recombinant Proteins/metabolism ; Vaccination/veterinary ; Vaccines/immunology ; Virus Diseases/prevention & control ; Virus Diseases/veterinary
Chemical Substances	Plant Proteins ; Recombinant Proteins ; Vaccines
Language	English
Publishing date	2009-07-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	406735-6
ISSN	1573-7446 ; 0165-7380
ISSN (online)	1573-7446
ISSN	0165-7380
DOI	10.1007/s11259-009-9246-z
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Article ; Online: Phenolic Compounds as Preventive and Therapeutic Agents in Diabetes-Related Oxidative Stress, Inflammation, Advanced Glycation End-Products Production and Insulin Sensitivity.

Pannucci, Elisa / Spagnuolo, Ludovica / De Gara, Laura / Santi, Luca / Dugo, Laura

Discovery medicine

2023 Volume 35, Issue 178, Page(s) 715–732

Abstract: Diabetes mellitus and its complications represent an extremely concerning health problem across the world. The extraordinary worldwide increase of the disease incidence highlights a challenging need for the development of new, safe, effective, and ... ...

Abstract	Diabetes mellitus and its complications represent an extremely concerning health problem across the world. The extraordinary worldwide increase of the disease incidence highlights a challenging need for the development of new, safe, effective, and affordable therapeutic approaches. This complex disease, characterized by high blood sugar levels, involves numerous pathogenic processes in its etiology. Even though the molecular mechanisms behind are not clear, it is broadly recognized that oxidative stress, the accumulation of advanced glycation end-products (AGEs) and inflammation are implicated in the development, the progression and the related complications of the disease. In this regard, phenolic compounds represent a valuable therapeutic perspective. Thus, this review is focused on the role of phenolic compounds in diabetes-related oxidative stress, AGEs production and inflammation. In particular, we summarized recent results of
MeSH term(s)	Humans ; Insulin Resistance ; Maillard Reaction ; Glycation End Products, Advanced/metabolism ; Diabetes Mellitus/drug therapy ; Oxidative Stress ; Phenols/therapeutic use ; Inflammation/drug therapy ; Inflammation/metabolism
Chemical Substances	Glycation End Products, Advanced ; Phenols
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2415544-5
ISSN	1944-7930 ; 1944-7930
ISSN (online)	1944-7930
ISSN	1944-7930
DOI	10.24976/Discov.Med.202335178.68
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Article ; Online: Ketocarotenoids adonirubin and adonixanthin: Properties, health benefits, current technologies, and emerging challenges.

Mussagy, Cassamo U / Farias, Fabiane O / Tropea, Alessia / Santi, Luca / Mondello, Luigi / Giuffrida, Daniele / Meléndez-Martínez, Antonio J / Dufossé, Laurent

Food chemistry

2024 Volume 443, Page(s) 138610

Abstract: Given their multifaceted roles, carotenoids have garnered significant scientific interest, resulting in a comprehensive and intricate body of literature that occasionally presents conflicting findings concerning the proper characterization, ... ...

Abstract	Given their multifaceted roles, carotenoids have garnered significant scientific interest, resulting in a comprehensive and intricate body of literature that occasionally presents conflicting findings concerning the proper characterization, quantification, and bioavailability of these compounds. Nevertheless, it is undeniable that the pursuit of novel carotenoids remains a crucial endeavor, as their diverse properties, functionalities and potential health benefits make them invaluable natural resources in agri-food and health promotion through the diet. In this framework, particular attention is given to ketocarotenoids, viz., astaxanthin (one of them) stands out for its possible multifunctional role as an antioxidant, anticancer, and antimicrobial agent. It has been widely explored in the market and utilized in different applications such as nutraceuticals, food additives, among others. Adonirubin and adonixanthin can be naturally found in plants and microorganisms. Due to the increasing significance of natural-based products and the remarkable opportunity to introduce these ketocarotenoids to the market, this review aims to provide an expert overview of the pros and cons associated with adonirubin and adonixanthin.
MeSH term(s)	Carotenoids ; Canthaxanthin/analogs & derivatives ; Antioxidants
Chemical Substances	adonixanthin (PSZ3Q7662U) ; adonirubin (HFX9MQ934U) ; Carotenoids (36-88-4) ; Canthaxanthin (4C3C6403MU) ; Antioxidants
Language	English
Publishing date	2024-01-28
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138610
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Article: Plant derived veterinary vaccines

Santi, L

Veterinary research communications. 2009 Sept., v. 33, suppl. 1

2009

Abstract	Infectious diseases remain one of the main causes of death and economic losses in animals despite the fact that prophylactic vaccination has been extremely successful in disease prevention. New effective viral, bacterial and parasitic vaccines are needed, but unfortunately production costs still remain prohibitive. In this respect plants can offer a valid alternative. Production of antigenic proteins in plants relies on a well developed and proven technology, several expression platforms are available and many different plant species can be utilized. Plant based veterinary vaccine studies have addressed protection issues in model animals and, more interestingly, some of them have examined the relevant challenge model in the specific species of interest. A general overview of the topic will be outlined together with a few selected promising examples.
Keywords	animal diseases ; bacterial infections ; viral diseases of animals and humans ; parasitoses ; disease control ; vaccination ; vaccines ; vaccine development ; new methods ; new technology ; biobased products ; antigens ; plant proteins ; biological production ; biopharmaceuticals ; biotechnology ; molecular farming ; pharmacology
Language	English
Dates of publication	2009-09
Size	p. 61-66.
Publisher	Springer Netherlands
Publishing place	Dordrecht
Document type	Article
Note	In the special issue: LXII annual meeting of the Italian Society for Veterinary Sciences, San Benedetto del Tronto, 2008 / edited by Antonio Pugliese and Gabriele Bono.
ZDB-ID	406735-6
ISSN	1573-7446 ; 0165-7380
ISSN (online)	1573-7446
ISSN	0165-7380
DOI	10.1007/s11259-009-9246-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Polyphenols Extracts from Oil Production Waste Products (OPWPs) Reduce Cell Viability and Exert Anti-Inflammatory Activity via PPARγ Induction in Colorectal Cancer Cells.

Leo, Manuela / Muccillo, Livio / Dugo, Laura / Bernini, Roberta / Santi, Luca / Sabatino, Lina

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: Olive oil production is associated with the generation of oil production waste products (OPWPs) rich in water-soluble polyphenols that represent serious environmental problems. Yet OPWPs can offer new opportunities by exploiting their bioactive ... ...

Abstract	Olive oil production is associated with the generation of oil production waste products (OPWPs) rich in water-soluble polyphenols that represent serious environmental problems. Yet OPWPs can offer new opportunities by exploiting their bioactive properties. In this study, we chemically characterized OPWPs polyphenolic extracts and investigated their biological activities in normal and colorectal cancer cells. Hydroxytyrosol (HTyr), the major constituent of these extracts, was used as the control. We show that both HTyr and the extracts affect cell viability by inducing apoptosis and cell cycle arrest. They downregulate inflammation by impairing NF-κB phosphorylation and expression of responsive cytokine genes, as
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11040624
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Article ; Online: In vitro

Basiricò, Loredana / Mastrogiovanni, Fabio / Lacetera, Nicola / Santi, Luca / Bernini, Roberta / Bernabucci, Umberto

Natural product research

2022 Volume 37, Issue 10, Page(s) 1725–1729

Abstract: ... In ... ...

Abstract	In this
MeSH term(s)	Cattle ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Olea ; Cell Line ; Reactive Oxygen Species/metabolism ; Epithelial Cells ; Anti-Inflammatory Agents/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/metabolism
Chemical Substances	Antioxidants ; oleuropein (2O4553545L) ; Reactive Oxygen Species ; Anti-Inflammatory Agents ; Plant Extracts
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2106485
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Article: Targeting of Tomato Bushy Stunt Virus with a Genetically Fused C-End Rule Peptide.

Marchetti, Luca / Simon-Gracia, Lorena / Lico, Chiara / Mancuso, Mariateresa / Baschieri, Selene / Santi, Luca / Teesalu, Tambet

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 8

Abstract: Homing peptides are widely used to improve the delivery of drugs, imaging agents, and nanoparticles (NPs) to their target sites. Plant virus-based particles represent an emerging class of structurally diverse nanocarriers that are biocompatible, ... ...

Abstract	Homing peptides are widely used to improve the delivery of drugs, imaging agents, and nanoparticles (NPs) to their target sites. Plant virus-based particles represent an emerging class of structurally diverse nanocarriers that are biocompatible, biodegradable, safe, and cost-effective. Similar to synthetic NPs, these particles can be loaded with imaging agents and/or drugs and functionalized with affinity ligands for targeted delivery. Here we report the development of a peptide-guided Tomato Bushy Stunt Virus (TBSV)-based nanocarrier platform for affinity targeting with the C-terminal C-end rule (CendR) peptide, RPARPAR (RPAR). Flow cytometry and confocal microscopy demonstrated that the TBSV-RPAR NPs bind specifically to and internalize in cells positive for the peptide receptor neuropilin-1 (NRP-1). TBSV-RPAR particles loaded with a widely used anticancer anthracycline, doxorubicin, showed selective cytotoxicity on NRP-1-expressing cells. Following systemic administration in mice, RPAR functionalization conferred TBSV particles the ability to accumulate in the lung tissue. Collectively, these studies show the feasibility of the CendR-targeted TBSV platform for the precision delivery of payloads.
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13081428
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Article ; Online: Proteomic profile of Cryptococcus gattii biofilm: Metabolic shift and the potential activation of electron chain transport.

Santi, Lucélia / Berger, Markus / Guimarães, Jorge A / Calegari-Alves, Yohana Porto / Vainstein, Marilene H / Yates, John R / Beys-da-Silva, Walter O

Journal of proteomics

2023 Volume 290, Page(s) 105022

Abstract: Cryptococcus gattii is a primary pathogenic fungus that causes pneumonia. This species is also responsible for an outbreak in Vancouver, Canada, and spreading to the mainland and United States. The use of medical devices is often complicated by ... ...

Abstract	Cryptococcus gattii is a primary pathogenic fungus that causes pneumonia. This species is also responsible for an outbreak in Vancouver, Canada, and spreading to the mainland and United States. The use of medical devices is often complicated by infections with biofilm-forming microbes with increased resistance to antimicrobial agents and host defense mechanisms. This study investigated the comparative proteome of C. gattii R265 (VGIIa) grown under planktonic and biofilm conditions. A brief comparison with C. neoformans H99 biofilm and the use of different culture medium and surface were also evaluated. Using Multidimensional Protein Identification Technology (MudPIT), 1819 proteins were identified for both conditions, where 150 (8.2%) were considered differentially regulated (up- or down-regulated and unique in biofilm cells). Overall, the proteomic approach suggests that C. gattii R265 biofilm cells are maintained by the induction of electron transport chain for reoxidation, and by alternative energy metabolites, such as succinate and acetate. SIGNIFICANCE: Since C. gattii is considered a primary pathogen and is one of the most virulent and less susceptible to antifungals, understanding how biofilms are maintained is fundamental to search for new targets to control this important mode of growth that is difficult to eradicate.
MeSH term(s)	Cryptococcus gattii/metabolism ; Electron Transport ; Proteomics ; Electrons ; Cryptococcus neoformans ; Biofilms
Language	English
Publishing date	2023-10-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2400835-7
ISSN	1876-7737 ; 1874-3919
ISSN (online)	1876-7737
ISSN	1874-3919
DOI	10.1016/j.jprot.2023.105022
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Article ; Online: Simulation-Optimization Approach for Siting Injection Wells in Urban Area with Complex Hydrogeology.

Mok, Chin Man / Carrera, Barbara / Hort, Hiroko / Santi, Lauren / Daus, Anthony / Panday, Sorab / Jones, David / Partington, Brian / Ferguson, Everett

Ground water

2023 Volume 62, Issue 2, Page(s) 236–249

Abstract: Managed aquifer recharge has become a standard water resources management practice to promote the development of locally sustainable water supplies and combat water scarcity. However, installation of injection wells for replenishment purposes in urban ... ...

Abstract	Managed aquifer recharge has become a standard water resources management practice to promote the development of locally sustainable water supplies and combat water scarcity. However, installation of injection wells for replenishment purposes in urban areas with complex hydrogeology faces many challenges, such as limited land availability, potential impacts on municipal production wells and known subsurface contamination plumes, and complex spatially variable hydraulic connections between aquifer units. To assess the feasibility and cost-effectiveness of injecting advanced treated water (ATW) into a complex urban aquifer system, a Simulation-Optimization (SO) model was developed to automate a systematic search for the most cost-effective locations to install new wells for injecting various quantities of ATW, if feasible. The generalized workflow presented here uses an existing MODFLOW groundwater model-along with advanced optimization routines that are publicly available-to flexibly accommodate a multiobjective function, complex constraints, and specific project requirements. The model successfully placed wells for injection of 1 to 4 MGD of ATW in aquifers underlying the study area. The injection well placement was primarily constrained by avoiding excessive impact on environmental sites with underlying groundwater plumes. The largest costs were for well installation and piping to the wells from the existing ATW pipes. This workflow is readily adaptable to other sites with different complexities, decision variables, or constraints.
MeSH term(s)	Groundwater ; Water Supply ; Water Wells ; Water Resources
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	246212-6
ISSN	1745-6584 ; 0017-467X
ISSN (online)	1745-6584
ISSN	0017-467X
DOI	10.1111/gwat.13317
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