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Article ; Online: Optimising Radioligand Therapy for Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumours: Expert Opinion from an Italian Multidisciplinary Group.

Fazio, Nicola / Falconi, Massimo / Foglia, Emanuela / Bartolomei, Mirco / Berruti, Alfredo / D'Onofrio, Mirko / Ferone, Diego / Giordano, Alessandro / Grimaldi, Franco / Milione, Massimo / Panzuto, Francesco / Santimaria, Monica / Schillaci, Orazio / Seregni, Ettore / Stasi, Michele / Volante, Marco / Lastoria, Secondo

Advances in therapy

2023 Volume 41, Issue 1, Page(s) 113–129

Abstract: Radioligand therapy (RLT) with lutetium ( ...

Abstract	Radioligand therapy (RLT) with lutetium (
MeSH term(s)	Humans ; Pancreatic Neoplasms/radiotherapy ; Pancreatic Neoplasms/drug therapy ; Neuroendocrine Tumors/radiotherapy ; Expert Testimony ; Somatostatin/therapeutic use ; Liver Neoplasms/drug therapy
Chemical Substances	Somatostatin (51110-01-1)
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-023-02714-8
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Zs.A 2101: Show issues

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Article ; Online: Quantification of Internal Filtration in Hollow Fiber Hemodialyzers with Medium Cut-Off Membrane.

Lorenzin, Anna / Neri, Mauro / Lupi, Andrea / Todesco, Martina / Santimaria, Monica / Alghisi, Alberta / Brendolan, Alessandra / Ronco, Claudio

Blood purification

2018 Volume 46, Issue 3, Page(s) 196–204

Abstract: Background: Inadequate removal of molecules between 5 and 50 KDa may cause long-term complication in chronic hemodialysis. Medium cut-off (MCO) is a new class of membranes with enhanced sieving properties and negligible albumin loss. MCO membrane makes ... ...

Abstract	Background: Inadequate removal of molecules between 5 and 50 KDa may cause long-term complication in chronic hemodialysis. Medium cut-off (MCO) is a new class of membranes with enhanced sieving properties and negligible albumin loss. MCO membrane makes it possible to perform expanded hemodialysis (HDx), a technique based on high internal filtration (IF).The present study is designed to quantify IF in 2 MCO dialyzers (Theranova 400 and 500, Baxter, Deerfield, USA) using a nuclear imaging technique previously validated. Methods: Blood and dialysate compartment pressure drop along with transmembrane pressure; they were measured in a closed in vitro circuit with human blood (blood flow [QB] = 300 and 400 mL/min; dialysate flow 500 mL/min; net ultrafiltration rate 0 mL/min). A non-diffusible marker molecule (albumin macro-aggregates labeled with 99Tc metastable) was injected in the blood compartment and nuclear emission was recorded by a gamma camera. Relative variations in the concentration of the marker molecule along the length of the filter were used to calculate local cross filtration. Results: Based on marker concentration profiles, IF was estimated. For Theranova 400, IF were 29.7 and 41.6 mL/min for QB of 300 and 400 mL/min. For Theranova 500, IF were 31.6 and 53.1 mL/min for QB of 300 and 400 mL/min respectively. Conclusions: MCO membrane provides significant amounts of IF due to the particular combination between hydraulic permeability of the membrane and reduced inner diameter of the fibers. High IF combined with enhanced sieving profile of MCO membrane leads to improved removal of a wider spectrum of uremia retention molecules in HDx, without requiring complex equipment.
MeSH term(s)	Filtration ; Humans ; Membranes, Artificial ; Renal Dialysis/instrumentation ; Renal Dialysis/methods
Chemical Substances	Membranes, Artificial
Language	English
Publishing date	2018-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000489993
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Article ; Online: Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice.

Astori, Giuseppe / Bernardi, Martina / Bozza, Angela / Catanzaro, Daniela / Chieregato, Katia / Merlo, Anna / Santimaria, Monica / Barbazza, Roberto / Amodeo, Giuseppe / Ciccocioppo, Rachele / Elice, Francesca / Ruggeri, Marco

Journal of translational medicine

2020 Volume 18, Issue 1, Page(s) 451

Abstract: Background: During the coronavirus disease-2019 (COVID-19) pandemic, Italian hospitals faced the most daunting challenges of their recent history, and only essential therapeutic interventions were feasible. From March to April 2020, the Laboratory of ... ...

Abstract	Background: During the coronavirus disease-2019 (COVID-19) pandemic, Italian hospitals faced the most daunting challenges of their recent history, and only essential therapeutic interventions were feasible. From March to April 2020, the Laboratory of Advanced Cellular Therapies (Vicenza, Italy) received requests to treat a patient with severe COVID-19 and a patient with acute graft-versus-host disease with umbilical cord-derived mesenchymal stromal cells (UC-MSCs). Access to clinics was restricted due to the risk of contagion. Transport of UC-MSCs in liquid nitrogen was unmanageable, leaving shipment in dry ice as the only option. Methods: We assessed effects of the transition from liquid nitrogen to dry ice on cell viability; apoptosis; phenotype; proliferation; immunomodulation; and clonogenesis; and validated dry ice-based transport of UC-MSCs to clinics. Results: Our results showed no differences in cell functionality related to the two storage conditions, and demonstrated the preservation of immunomodulatory and clonogenic potentials in dry ice. UC-MSCs were successfully delivered to points-of-care, enabling favourable clinical outcomes. Conclusions: This experience underscores the flexibility of a public cell factory in its adaptation of the logistics of an advanced therapy medicinal product during a public health crisis. Alternative supply chains should be evaluated for other cell products to guarantee delivery during catastrophes.
MeSH term(s)	Acute Disease ; COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/therapy ; Cell Proliferation ; Cell Survival ; Cells, Cultured ; Cord Blood Stem Cell Transplantation/adverse effects ; Delivery of Health Care/organization & administration ; Delivery of Health Care/standards ; Dry Ice ; Equipment and Supplies, Hospital/standards ; Equipment and Supplies, Hospital/supply & distribution ; Graft vs Host Disease/etiology ; Graft vs Host Disease/pathology ; Graft vs Host Disease/therapy ; Humans ; Italy/epidemiology ; Materials Management, Hospital/organization & administration ; Materials Management, Hospital/standards ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cell Transplantation/standards ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/physiology ; Organization and Administration/standards ; Pandemics ; Phenotype ; Point-of-Care Systems/organization & administration ; Point-of-Care Systems/standards ; SARS-CoV-2/physiology ; Severity of Illness Index ; Transportation/methods ; Transportation/standards
Chemical Substances	Dry Ice
Language	English
Publishing date	2020-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-020-02625-0
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Article ; Online: The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumonia.

Stem cell research & therapy

2021 Volume 12, Issue 1, Page(s) 316

Abstract: Coronavirus disease 2019 (COVID-19) may result in a life-threatening condition due to a hyperactive immune reaction to severe acute respiratory syndrome-coronavirus-2 infection, for which no effective treatment is available. Based on the potent ... ...

Abstract	Coronavirus disease 2019 (COVID-19) may result in a life-threatening condition due to a hyperactive immune reaction to severe acute respiratory syndrome-coronavirus-2 infection, for which no effective treatment is available. Based on the potent immunomodulatory properties of mesenchymal stromal cells (MSCs), a growing number of trials are ongoing. This prompted us to carry out a thorough immunological study in a patient treated with umbilical cord-derived MSCs and admitted to the Intensive Care Unit for COVID-19-related pneumonia. The exploratory analyses were assessed on both peripheral blood and bronchoalveolar fluid lavage samples at baseline and after cellular infusion by means of single-cell RNA sequencing, flow cytometry, ELISA, and functional assays. Remarkably, a normalization of circulating T lymphocytes count paralleled by a reduction of inflammatory myeloid cells, and a decrease in serum levels of pro-inflammatory cytokines, mostly of interleukin-6 and tumor necrosis factor-α, were observed. In addition, a drop of plasma levels of those chemokines essential for neutrophil recruitment became evident that paralleled the decrease of lung-infiltrating inflammatory neutrophils. Finally, circulating monocytes and low-density gradient neutrophils acquired immunosuppressive function. This scenario was accompanied by an amelioration of respiratory, renal, inflammatory, and pro-thrombotic indexes. Our results provide the first immunological data possibly related to the use of umbilical cord-derived MSCs in severe COVID-19 context.
MeSH term(s)	COVID-19 ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; SARS-CoV-2 ; Umbilical Cord
Language	English
Publishing date	2021-06-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-021-02376-9
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Article ; Online: Influence of blood pressure profile on frailty phenotype in community-dwelling elders in Brazil - FIBRA study.

Fattori, A / Santimaria, M R / Alves, R M A / Guariento, M E / Neri, A L

Archives of gerontology and geriatrics

2013 Volume 56, Issue 2, Page(s) 343–349

Abstract: Frailty is a clinical condition associated with pathological aging and biological vulnerability. In the spectrum of events related to frailty, aging of the cardiocirculatory system and abnormalities in arterial blood pressure (BP) partly explain the ... ...

Abstract	Frailty is a clinical condition associated with pathological aging and biological vulnerability. In the spectrum of events related to frailty, aging of the cardiocirculatory system and abnormalities in arterial blood pressure (BP) partly explain the changes in tissue perfusion and, potentially, the decrease in physiological reserves. This study investigated the relationship between BP levels, systemic arterial hypertension (SAH) and the frailty phenotype by analyzing frailty criteria in a cross-sectional model into the FIBRA network, a populational sample of community-dwelling elders in Southeastern Brazil. Study participants with ≥65 years were selected by probabilistic sampling of residents in the urban area of the municipality of Campinas (n=900). Considering frailty as a whole and the difference between genders, there was a greater proportion of frail or pre-frail individuals among women than men. Analysis of individual frailty criteria showed that weight loss and fatigue were more common among women (18.3% vs. 12.5%, p=0.034 and 22.5% vs. 11.9%, p<0.001, respectively). Comparison of individuals with or without SAH failed to reveal any differences related to frailty criteria. Nevertheless, averages of diastolic blood pressure (DBP) and mean arterial blood pressure values were lower among elderly individuals with reduced grip strength, physical activity and the frailty classification as a whole (OR 0.986, IC 0.975-0.997) (for every 1 mmHg reduction in MBP values, the likelihood of being frail increased 1.4%). Our findings corroborate the relationship between BP values and frailty in the elderly and contribute to an understanding of the pathophysiological mechanisms of the syndrome.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Blood Pressure/physiology ; Brazil/epidemiology ; Cross-Sectional Studies ; Female ; Frail Elderly ; Geriatric Assessment/methods ; Humans ; Hypertension/epidemiology ; Hypertension/physiopathology ; Male ; Phenotype ; Prevalence ; Retrospective Studies
Language	English
Publishing date	2013-03
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2012.08.004
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Zs.A 1729: Show issues

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Article: Quantification of Internal Filtration in Hollow Fiber Hemodialyzers with Medium Cut-Off Membrane

Lorenzin, Anna / Neri, Mauro / Lupi, Andrea / Todesco, Martina / Santimaria, Monica / Alghisi, Alberta / Brendolan, Alessandra / Ronco, Claudio

Blood Purification

2018 Volume 46, Issue 3, Page(s) 196–204

Institution	International Renal Research Institute of Vicenza, Vicenza, Italy Department of Nuclear medicine, San Bortolo Hospital, aULSS8 Berica, Vicenza, Italy Department of Transfusion Medicine, San Bortolo Hospital, aULSS8 Berica, Vicenza, Italy Department of Nephrology Dialysis and Transplantation, St. Bortolo Hospital, aULSS8 Berica, Vicenza, Italy
Abstract	Background: Inadequate removal of molecules between 5 and 50 KDa may cause long-term complication in chronic hemodialysis. Medium cut-off (MCO) is a new class of membranes with enhanced sieving properties and negligible albumin loss. MCO membrane makes it possible to perform expanded hemodialysis (HDx), a technique based on high internal filtration (IF).The present study is designed to quantify IF in 2 MCO dialyzers (Theranova 400 and 500, Baxter, Deerfield, USA) using a nuclear imaging technique previously validated. Methods: Blood and dialysate compartment pressure drop along with transmembrane pressure; they were measured in a closed in vitro circuit with human blood (blood flow [QB] = 300 and 400 mL/min; dialysate flow 500 mL/min; net ultrafiltration rate 0 mL/min). A non-diffusible marker molecule (albumin macro-aggregates labeled with 99Tc metastable) was injected in the blood compartment and nuclear emission was recorded by a gamma camera. Relative variations in the concentration of the marker molecule along the length of the filter were used to calculate local cross filtration. Results: Based on marker concentration profiles, IF was estimated. For Theranova 400, IF were 29.7 and 41.6 mL/min for QB of 300 and 400 mL/min. For Theranova 500, IF were 31.6 and 53.1 mL/min for QB of 300 and 400 mL/min respectively. Conclusions: MCO membrane provides significant amounts of IF due to the particular combination between hydraulic permeability of the membrane and reduced inner diameter of the fibers. High IF combined with enhanced sieving profile of MCO membrane leads to improved removal of a wider spectrum of uremia retention molecules in HDx, without requiring complex equipment.
Keywords	Expanded hemodialysis ; Medium cut-off ; Dialysis membrane ; Internal filtration ; Nuclear imaging
Language	English
Publishing date	2018-06-08
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Paper
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000489993
Database	Karger publisher's database

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Article ; Online: Loss of cardiac Wnt/β-catenin signalling in desmoplakin-deficient AC8 zebrafish models is rescuable by genetic and pharmacological intervention.

Giuliodori, Alice / Beffagna, Giorgia / Marchetto, Giulia / Fornetto, Chiara / Vanzi, Francesco / Toppo, Stefano / Facchinello, Nicola / Santimaria, Mattia / Vettori, Andrea / Rizzo, Stefania / Della Barbera, Mila / Pilichou, Kalliopi / Argenton, Francesco / Thiene, Gaetano / Tiso, Natascia / Basso, Cristina

Cardiovascular research

2018 Volume 114, Issue 8, Page(s) 1082–1097

Abstract: Aims: Arrhythmogenic cardiomyopathy (AC) is an inherited heart disease characterized by life-threatening ventricular arrhythmias and fibro-fatty replacement of the myocardium. More than 60% of AC patients show pathogenic mutations in genes encoding for ... ...

Abstract	Aims: Arrhythmogenic cardiomyopathy (AC) is an inherited heart disease characterized by life-threatening ventricular arrhythmias and fibro-fatty replacement of the myocardium. More than 60% of AC patients show pathogenic mutations in genes encoding for desmosomal proteins. By focusing our attention on the AC8 form, linked to the junctional protein desmoplakin (DSP), we present here a zebrafish model of DSP deficiency, exploited to identify early changes of cell signalling in the cardiac region. Methods and results: To obtain an embryonic model of Dsp deficiency, we first confirmed the orthologous correspondence of zebrafish Dsp genes (dspa and dspb) to the human DSP counterpart. Then, we verified their cardiac expression, at embryonic and adult stages, and subsequently we targeted them by antisense morpholino strategy, confirming specific and disruptive effects on desmosomes, like those identified in AC patients. Finally, we exploited our Dsp-deficient models for an in vivo cell signalling screen, using pathway-specific reporter transgenes. Out of nine considered, three pathways (Wnt/β-catenin, TGFβ/Smad3, and Hippo/YAP-TAZ) were significantly altered, with Wnt as the most dramatically affected. Interestingly, under persistent Dsp deficiency, Wnt signalling is rescuable both by a genetic and a pharmacological approach. Conclusion: Our data point to Wnt/β-catenin as the final common pathway underlying different desmosomal AC forms and support the zebrafish as a suitable model for detecting early signalling pathways involved in the pathogenesis of DSP-associated diseases, possibly responsive to pharmacological or genetic rescue.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Arrhythmogenic Right Ventricular Dysplasia/genetics ; Arrhythmogenic Right Ventricular Dysplasia/metabolism ; Arrhythmogenic Right Ventricular Dysplasia/pathology ; Desmoplakins/deficiency ; Desmoplakins/genetics ; Desmoplakins/metabolism ; Disease Models, Animal ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Indoles/pharmacology ; Maleimides/pharmacology ; Morphogenesis ; Myocardium/metabolism ; Myocardium/ultrastructure ; Oligonucleotides, Antisense/genetics ; Oligonucleotides, Antisense/metabolism ; Wnt Signaling Pathway/drug effects ; Wnt Signaling Pathway/genetics ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/deficiency ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Chemical Substances	Desmoplakins ; Indoles ; Maleimides ; Oligonucleotides, Antisense ; SB 216763 ; Zebrafish Proteins
Language	English
Publishing date	2018-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvy057
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Zs.A 565: Show issues

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Article: Role of nuclear medicine in the treatment of malignant gliomas: the locoregional radioimmunotherapy approach.

Riva, P / Franceschi, G / Riva, N / Casi, M / Santimaria, M / Adamo, M

European journal of nuclear medicine

2000 Volume 27, Issue 5, Page(s) 601–609

Abstract: The high-grade malignant gliomas (anaplastic astrocytomas and glioblastoma) have a very bad prognosis since the available methods of treatment (surgery, radiotherapy and chemotherapy) are unable to control the progression of the disease for long. The use ...

Abstract	The high-grade malignant gliomas (anaplastic astrocytomas and glioblastoma) have a very bad prognosis since the available methods of treatment (surgery, radiotherapy and chemotherapy) are unable to control the progression of the disease for long. The use of specific monoclonal antibodies labelled with a suitable isotope (iodine-131 or yttrium-90) represents an effective approach to hamper tumour regrowth. Some authors have injected the antibodies intravenously, or have tried to increase the tumour/background ratio with the avidin/biotin system. In many cases the labelled monoclonal antibodies were injected directly into the tumoral bed after the operation. The authors' experiences concern a quite large locoregional radioimmunotherapy study which was performed by using antitenascin antibodies labelled initially with 131I and more recently with 90Y. The clinical results demonstrate the ability of this technique to control, for a long time, the growth of these tumours. The glioblastoma median survival was prolonged to 25 months (131I group) or 31 months (90Y group). The response rate (which comprises PR, CR and NED) was 47.1% (glioblastoma 131I group) or 40% ( glioblastoma 90Y group). In many cases a significant tumour shrinking effect was radiologically demonstrated. The use of 90Y proved more favourable in bulky lesions, and reduced the radioprotection problems.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/therapy ; Glioma/radiotherapy ; Glioma/therapy ; Humans ; Nuclear Medicine ; Radioimmunotherapy
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2000-05
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s002590050549
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Zs.A 1227: Show issues

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Article: Experiments on a new phosphine-peptide chelator for labelling of peptides with Tc-99m.

Santimaria, M / Blok, D / Feitsma, R I / Mazzi, U / Pauwels, E K

Nuclear medicine and biology

1999 Volume 26, Issue 3, Page(s) 251–258

Abstract: A phosphine-containing ligand providing a N-[N-[3-(diphenylphosphino)propionyl]glycyl]-L-S-benzyl-cystein (PNNS) donor atomset for the chelation of 99mTc was studied in labelling experiments with a model peptide (tetragastrin, cholecystokinin-fragment). ... ...

Abstract	A phosphine-containing ligand providing a N-[N-[3-(diphenylphosphino)propionyl]glycyl]-L-S-benzyl-cystein (PNNS) donor atomset for the chelation of 99mTc was studied in labelling experiments with a model peptide (tetragastrin, cholecystokinin-fragment). The peptide was conjugated to the ligand chelator by active ester chemistry either before or after radiolabelling. Both the chelator-conjugate and the preformed chelate approaches resulted in the same radiolabelled isomers of the ligand peptide. Sequence and reaction conditions influence yield and purity.
MeSH term(s)	Chelating Agents/chemistry ; Chromatography, High Pressure Liquid ; Isotope Labeling/methods ; Organotechnetium Compounds/chemical synthesis ; Organotechnetium Compounds/chemistry ; Peptides/chemistry ; Phosphines/chemistry ; Radiopharmaceuticals/chemical synthesis ; Technetium/chemistry ; Tetragastrin/chemistry
Chemical Substances	Chelating Agents ; Organotechnetium Compounds ; Peptides ; Phosphines ; Radiopharmaceuticals ; Tetragastrin (0OL293AV80) ; Technetium (7440-26-8) ; phosphine (FW6947296I)
Language	English
Publishing date	1999-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1138098-6
ISSN	1872-9614 ; 0969-8051 ; 0883-2897
ISSN (online)	1872-9614
ISSN	0969-8051 ; 0883-2897
DOI	10.1016/s0969-8051(98)00106-1
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Zs.A 1090: Show issues

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Article ; Online: Comparison of 18F-DOPA, 18F-FDG and 68Ga-somatostatin analogue PET/CT in patients with recurrent medullary thyroid carcinoma.

Treglia, Giorgio / Castaldi, Paola / Villani, Maria Felicia / Perotti, Germano / de Waure, Chiara / Filice, Angelina / Ambrosini, Valentina / Cremonini, Nadia / Santimaria, Monica / Versari, Annibale / Fanti, Stefano / Giordano, Alessandro / Rufini, Vittoria

European journal of nuclear medicine and molecular imaging

2012 Volume 39, Issue 4, Page(s) 569–580

Abstract: Purpose: To retrospectively evaluate and compare (18)F-FDG, (18)F-DOPA and (68)Ga-somatostatin analogues for PET/CT in patients with residual/recurrent medullary thyroid carcinoma (MTC) suspected on the basis of elevated serum calcitonin levels.: ... ...

Abstract	Purpose: To retrospectively evaluate and compare (18)F-FDG, (18)F-DOPA and (68)Ga-somatostatin analogues for PET/CT in patients with residual/recurrent medullary thyroid carcinoma (MTC) suspected on the basis of elevated serum calcitonin levels. Methods: Included in the study were 18 patients with recurrent MTC in whom functional imaging with the three tracers was performed. The PET/CT results were compared on a per-patient basis and on a per-lesion-basis. Results: At least one focus of abnormal uptake was observed on PET/CT in 13 patients with (18)F-DOPA (72.2% sensitivity), in 6 patients with (68)Ga-somatostatin analogues (33.3%) and in 3 patients with (18)F-FDG (16.7%) (p < 0.01). There was a statistically significant difference in sensitivity between (18)F-DOPA and (18)F-FDG PET/CT (p < 0.01) and between (18)F-DOPA and (68)Ga-somatostatin analogue PET/CT (p = 0.04). Overall, 72 lesions were identified on PET/CT with the three tracers. (18)F-DOPA PET/CT detected 85% of lesions (61 of 72), (68)Ga-somatostatin analogue PET/CT 20% (14 of 72) and (18)F-FDG PET/CT 28% (20 of 72). There was a statistically significant difference in the number of lymph node, liver and bone lesions detected with the three tracers (p < 0.01). In particular, post-hoc tests showed a significant difference in the number of lymph node, liver and bone lesions detected by (18)F-DOPA PET/CT and (18)F-FDG PET/CT (p < 0.01 for all the analyses) and by (18)F-DOPA PET/CT and (68)Ga-somatostatin analogue PET/CT (p < 0.01 for all the analyses). The PET/CT results led to a change in management of eight patients (44%). Conclusion: (18)F-DOPA PET/CT seems to be the most useful imaging method for detecting recurrent MTC lesions in patients with elevated serum calcitonin levels, performing better than (18)F-FDG and (68)Ga-somatostatin analogue PET/CT. (18)F-FDG may complement (18)F-DOPA in patients with an aggressive tumour.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Calcitonin/blood ; Carcinoma, Neuroendocrine ; Dihydroxyphenylalanine/analogs & derivatives ; Female ; Fluorodeoxyglucose F18 ; Gallium Radioisotopes ; Humans ; Male ; Middle Aged ; Multimodal Imaging/methods ; Positron-Emission Tomography ; Precision Medicine ; Recurrence ; Retrospective Studies ; Somatostatin/analogs & derivatives ; Thyroid Neoplasms/blood ; Thyroid Neoplasms/diagnostic imaging ; Tomography, X-Ray Computed
Chemical Substances	Gallium Radioisotopes ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; fluorodopa F 18 (2C598205QX) ; Somatostatin (51110-01-1) ; Dihydroxyphenylalanine (63-84-3) ; Calcitonin (9007-12-9)
Language	English
Publishing date	2012-01-06
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-011-2031-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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