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  1. Book ; Online: A Characterization Theorem for Equivariant Networks with Point-wise Activations

    Pacini, Marco / Dong, Xiaowen / Lepri, Bruno / Santin, Gabriele

    2024  

    Abstract: Equivariant neural networks have shown improved performance, expressiveness and sample complexity on symmetrical domains. But for some specific symmetries, representations, and choice of coordinates, the most common point-wise activations, such as ReLU, ... ...

    Abstract Equivariant neural networks have shown improved performance, expressiveness and sample complexity on symmetrical domains. But for some specific symmetries, representations, and choice of coordinates, the most common point-wise activations, such as ReLU, are not equivariant, hence they cannot be employed in the design of equivariant neural networks. The theorem we present in this paper describes all possible combinations of finite-dimensional representations, choice of coordinates and point-wise activations to obtain an exactly equivariant layer, generalizing and strengthening existing characterizations. Notable cases of practical relevance are discussed as corollaries. Indeed, we prove that rotation-equivariant networks can only be invariant, as it happens for any network which is equivariant with respect to connected compact groups. Then, we discuss implications of our findings when applied to important instances of exactly equivariant networks. First, we completely characterize permutation equivariant networks such as Invariant Graph Networks with point-wise nonlinearities and their geometric counterparts, highlighting a plethora of models whose expressive power and performance are still unknown. Second, we show that feature spaces of disentangled steerable convolutional neural networks are trivial representations.

    Comment: Accepted at the 12th International Conference on Learning Representations (ICLR 2024)
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence
    Subject code 514
    Publishing date 2024-01-17
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Temporal clustering of social interactions trades-off disease spreading and knowledge diffusion.

    Cencetti, Giulia / Lucchini, Lorenzo / Santin, Gabriele / Battiston, Federico / Moro, Esteban / Pentland, Alex / Lepri, Bruno

    Journal of the Royal Society, Interface

    2024  Volume 21, Issue 210, Page(s) 20230471

    Abstract: Non-pharmaceutical measures such as preventive quarantines, remote working, school and workplace closures, lockdowns, etc. have shown effectiveness from an epidemic control perspective; however, they have also significant negative consequences on social ... ...

    Abstract Non-pharmaceutical measures such as preventive quarantines, remote working, school and workplace closures, lockdowns, etc. have shown effectiveness from an epidemic control perspective; however, they have also significant negative consequences on social life and relationships, work routines and community engagement. In particular, complex ideas, work and school collaborations, innovative discoveries and resilient norms formation and maintenance, which often require face-to-face interactions of two or more parties to be developed and synergically coordinated, are particularly affected. In this study, we propose an alternative hybrid solution that balances the slowdown of epidemic diffusion with the preservation of face-to-face interactions, that we test simulating a disease and a knowledge spreading simultaneously on a network of contacts. Our approach involves a two-step partitioning of the population. First, we tune the level of node clustering, creating 'social bubbles' with increased contacts within each bubble and fewer outside, while maintaining the average number of contacts in each network. Second, we tune the level of temporal clustering by pairing, for a certain time interval, nodes from specific social bubbles. Our results demonstrate that a hybrid approach can achieve better trade-offs between epidemic control and complex knowledge diffusion. The versatility of our model enables tuning and refining clustering levels to optimally achieve the desired trade-off, based on the potentially changing characteristics of a disease or knowledge diffusion process.
    MeSH term(s) Social Interaction ; Epidemics ; Diffusion ; Cluster Analysis ; Quarantine
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2023.0471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A new method to design energy-conserving surrogate models for the coupled, nonlinear responses of intervertebral discs.

    Hammer, Maria / Wenzel, Tizian / Santin, Gabriele / Meszaros-Beller, Laura / Little, Judith Paige / Haasdonk, Bernard / Schmitt, Syn

    Biomechanics and modeling in mechanobiology

    2024  Volume 23, Issue 3, Page(s) 757–780

    Abstract: The aim of this study was to design physics-preserving and precise surrogate models of the nonlinear elastic behaviour of an intervertebral disc (IVD). Based on artificial force-displacement data sets from detailed finite element (FE) disc models, we ... ...

    Abstract The aim of this study was to design physics-preserving and precise surrogate models of the nonlinear elastic behaviour of an intervertebral disc (IVD). Based on artificial force-displacement data sets from detailed finite element (FE) disc models, we used greedy kernel and polynomial approximations of second, third and fourth order to train surrogate models for the scalar force-torque -potential. Doing so, the resulting models of the elastic IVD responses ensured the conservation of mechanical energy through their structure. At the same time, they were capable of predicting disc forces in a physiological range of motion and for the coupling of all six degrees of freedom of an intervertebral joint. The performance of all surrogate models for a subject-specific L4
    MeSH term(s) Intervertebral Disc/physiology ; Humans ; Nonlinear Dynamics ; Models, Biological ; Finite Element Analysis ; Biomechanical Phenomena ; Elasticity ; Computer Simulation ; Range of Motion, Articular/physiology
    Language English
    Publishing date 2024-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093052-5
    ISSN 1617-7940 ; 1617-7959
    ISSN (online) 1617-7940
    ISSN 1617-7959
    DOI 10.1007/s10237-023-01804-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: A Framework for Verifiable and Auditable Federated Anomaly Detection

    Santin, Gabriele / Skarbovsky, Inna / Fournier, Fabiana / Lepri, Bruno

    2022  

    Abstract: Federated Leaning is an emerging approach to manage cooperation between a group of agents for the solution of Machine Learning tasks, with the goal of improving each agent's performance without disclosing any data. In this paper we present a novel ... ...

    Abstract Federated Leaning is an emerging approach to manage cooperation between a group of agents for the solution of Machine Learning tasks, with the goal of improving each agent's performance without disclosing any data. In this paper we present a novel algorithmic architecture that tackle this problem in the particular case of Anomaly Detection (or classification or rare events), a setting where typical applications often comprise data with sensible information, but where the scarcity of anomalous examples encourages collaboration. We show how Random Forests can be used as a tool for the development of accurate classifiers with an effective insight-sharing mechanism that does not break the data integrity. Moreover, we explain how the new architecture can be readily integrated in a blockchain infrastructure to ensure the verifiable and auditable execution of the algorithm. Furthermore, we discuss how this work may set the basis for a more general approach for the design of federated ensemble-learning methods beyond the specific task and architecture discussed in this paper.
    Keywords Computer Science - Machine Learning ; Computer Science - Cryptography and Security
    Subject code 006
    Publishing date 2022-03-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Reprogramming FairGANs with Variational Auto-Encoders

    Nobile, Beatrice / Santin, Gabriele / Lepri, Bruno / Brutti, Pierpaolo

    A New Transfer Learning Model

    2022  

    Abstract: Fairness-aware GANs (FairGANs) exploit the mechanisms of Generative Adversarial Networks (GANs) to impose fairness on the generated data, freeing them from both disparate impact and disparate treatment. Given the model's advantages and performance, we ... ...

    Abstract Fairness-aware GANs (FairGANs) exploit the mechanisms of Generative Adversarial Networks (GANs) to impose fairness on the generated data, freeing them from both disparate impact and disparate treatment. Given the model's advantages and performance, we introduce a novel learning framework to transfer a pre-trained FairGAN to other tasks. This reprogramming process has the goal of maintaining the FairGAN's main targets of data utility, classification utility, and data fairness, while widening its applicability and ease of use. In this paper we present the technical extensions required to adapt the original architecture to this new framework (and in particular the use of Variational Auto-Encoders), and discuss the benefits, trade-offs, and limitations of the new model.
    Keywords Computer Science - Machine Learning
    Publishing date 2022-03-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Simultaneous determination of 16 organophosphorus flame retardants and plasticizers in fish by liquid chromatography-tandem mass spectrometry

    Santín, G / D. Barceló / E. Eljarrat

    Journal of chromatography. 2016 Apr. 08, v. 1441

    2016  

    Abstract: In this work a method to analyze simultaneously sixteen organophosphorus flame retardants (OPFRs) by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT-MS) in fish samples was successfully developed. Sample preparation ... ...

    Abstract In this work a method to analyze simultaneously sixteen organophosphorus flame retardants (OPFRs) by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT-MS) in fish samples was successfully developed. Sample preparation strategies, including different extraction techniques and clean-ups were tested. The chosen methodology is based on the extraction of 0.25g of dried fish by ultrasound and clean-up by solid phase extraction (SPE) with a tandem of C18 and basic alumina cartridges. Recoveries were between 45 to 115%, with RSDs lower than 25%. mLODs and mLOQs were between 0.34–11.6ng/g lw and 1.12–38.8ng/g lw, respectively, with the exception of Tris(tribromoneopentyl)phosphate (TBNPP) (37.4 and 125ng/g lw, respectively) and Tris(isopropyl-phenyl)phosphate (IPPP) (51.6 and 172ng/g lw, respectively) which had higher limits. The developed method was applied to twelve river fish samples. Thirteen out of sixteen analyzed compounds were detected. At least, one of the sixteen studied OPFRs was detected in all the analyzed samples, with ΣOPFR levels up to 2423ng/g lw. This is the first study reporting IPPP and Isodecyldiphenyl phosphate (IDPP) levels in biota samples. Moreover, levels found for IPPP are quite high (up to 601ng/g lw) and thus it is important to consider in the future development of analytical methodologies for OPFR analysis.
    Keywords aluminum oxide ; dried fish ; fish ; flame retardants ; liquid chromatography ; phosphates ; plasticizers ; solid phase extraction ; tandem mass spectrometry
    Language English
    Dates of publication 2016-0408
    Size p. 34-43.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 218139-3
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    DOI 10.1016/j.chroma.2016.02.058
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Cesáreas por desproporción céfalo-pélvica: realización sin prueba. Tiene lugar la céfalo-pelvimetría radiológica en la obstetricia actual?

    Santín, Guillermo

    Ginecologia y obstetricia de Mexico

    2011  Volume 79, Issue 6, Page(s) 368–372

    Title translation Caesarean section for cephalo-pelvic disproportion performed without evidence. Does the radiological pelvimetry has a place in obstetrics today?.
    MeSH term(s) Algorithms ; Cephalopelvic Disproportion/diagnostic imaging ; Cephalopelvic Disproportion/epidemiology ; Cephalopelvic Disproportion/surgery ; Cesarean Section/statistics & numerical data ; Female ; Humans ; Infant, Newborn ; Pelvimetry/methods ; Pregnancy ; Radiography ; Unnecessary Procedures
    Language Spanish
    Publishing date 2011-06
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 731087-0
    ISSN 0300-9041 ; 0072-453X
    ISSN 0300-9041 ; 0072-453X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Digital proximity tracing on empirical contact networks for pandemic control.

    Cencetti, G / Santin, G / Longa, A / Pigani, E / Barrat, A / Cattuto, C / Lehmann, S / Salathé, M / Lepri, B

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 1655

    Abstract: Digital contact tracing is a relevant tool to control infectious disease outbreaks, including the COVID-19 epidemic. Early work evaluating digital contact tracing omitted important features and heterogeneities of real-world contact patterns influencing ... ...

    Abstract Digital contact tracing is a relevant tool to control infectious disease outbreaks, including the COVID-19 epidemic. Early work evaluating digital contact tracing omitted important features and heterogeneities of real-world contact patterns influencing contagion dynamics. We fill this gap with a modeling framework informed by empirical high-resolution contact data to analyze the impact of digital contact tracing in the COVID-19 pandemic. We investigate how well contact tracing apps, coupled with the quarantine of identified contacts, can mitigate the spread in real environments. We find that restrictive policies are more effective in containing the epidemic but come at the cost of unnecessary large-scale quarantines. Policy evaluation through their efficiency and cost results in optimized solutions which only consider contacts longer than 15-20 minutes and closer than 2-3 meters to be at risk. Our results show that isolation and tracing can help control re-emerging outbreaks when some conditions are met: (i) a reduction of the reproductive number through masks and physical distance; (ii) a low-delay isolation of infected individuals; (iii) a high compliance. Finally, we observe the inefficacy of a less privacy-preserving tracing involving second order contacts. Our results may inform digital contact tracing efforts currently being implemented across several countries worldwide.
    MeSH term(s) Basic Reproduction Number/prevention & control ; Basic Reproduction Number/statistics & numerical data ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Computer Simulation ; Contact Tracing/methods ; Contact Tracing/statistics & numerical data ; Humans ; Models, Statistical ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Privacy ; Quarantine/methods ; Quarantine/statistics & numerical data ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-21809-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Simultaneous determination of 16 organophosphorus flame retardants and plasticizers in fish by liquid chromatography-tandem mass spectrometry.

    Santín, G / Eljarrat, E / Barceló, D

    Journal of chromatography. A

    2016  Volume 1441, Page(s) 34–43

    Abstract: In this work a method to analyze simultaneously sixteen organophosphorus flame retardants (OPFRs) by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT-MS) in fish samples was successfully developed. Sample preparation ... ...

    Abstract In this work a method to analyze simultaneously sixteen organophosphorus flame retardants (OPFRs) by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT-MS) in fish samples was successfully developed. Sample preparation strategies, including different extraction techniques and clean-ups were tested. The chosen methodology is based on the extraction of 0.25 g of dried fish by ultrasound and clean-up by solid phase extraction (SPE) with a tandem of C18 and basic alumina cartridges. Recoveries were between 45 to 115%, with RSDs lower than 25%. mLODs and mLOQs were between 0.34-11.6 ng/g lw and 1.12-38.8 ng/g lw, respectively, with the exception of Tris(tribromoneopentyl)phosphate (TBNPP) (37.4 and 125 ng/g lw, respectively) and Tris(isopropyl-phenyl)phosphate (IPPP) (51.6 and 172 ng/g lw, respectively) which had higher limits. The developed method was applied to twelve river fish samples. Thirteen out of sixteen analyzed compounds were detected. At least, one of the sixteen studied OPFRs was detected in all the analyzed samples, with ΣOPFR levels up to 2423 ng/g lw. This is the first study reporting IPPP and Isodecyldiphenyl phosphate (IDPP) levels in biota samples. Moreover, levels found for IPPP are quite high (up to 601 ng/g lw) and thus it is important to consider in the future development of analytical methodologies for OPFR analysis.
    MeSH term(s) Animals ; Chromatography, Liquid ; Fishes ; Flame Retardants/analysis ; Plasticizers/analysis ; Rivers ; Solid Phase Extraction ; Tandem Mass Spectrometry/methods ; Water Pollutants, Chemical/analysis
    Chemical Substances Flame Retardants ; Plasticizers ; Water Pollutants, Chemical
    Language English
    Publishing date 2016-04-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2016.02.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Space radiation quality factor for Galactic Cosmic Rays and typical space mission scenarios using a microdosimetric approach.

    Papadopoulos, Alexis / Kyriakou, Ioanna / Incerti, Sébastien / Santin, Giovanni / Nieminen, Petteri / Daglis, Ioannis A / Li, Weibo / Emfietzoglou, Dimitris

    Radiation and environmental biophysics

    2023  Volume 62, Issue 2, Page(s) 221–234

    Abstract: Space radiation exposure from omnipresent Galactic Cosmic Rays (GCRs) in interplanetary space poses a serious carcinogenic risk to astronauts due to the-limited or absent-protective effect of the Earth's magnetosphere and, in particular, the terrestrial ... ...

    Abstract Space radiation exposure from omnipresent Galactic Cosmic Rays (GCRs) in interplanetary space poses a serious carcinogenic risk to astronauts due to the-limited or absent-protective effect of the Earth's magnetosphere and, in particular, the terrestrial atmosphere. The radiation risk is directly influenced by the quality of the radiation, i.e., its pattern of energy deposition at the micron/DNA scale. For stochastic biological effects, radiation quality is described by the quality factor, [Formula: see text], which can be defined as a function of Linear Energy Transfer (LET) or the microdosimetric lineal energy ([Formula: see text]). In the present work, the average [Formula: see text] of GCR for different mission scenarios was calculated using a modified version of the microdosimetric Theory of Dual Radiation Action (TDRA). NASA's OLTARIS platform was utilized to generate the radiation environment behind different aluminum shielding (0-30 g/cm
    MeSH term(s) Humans ; Astronauts ; Cosmic Radiation ; Relative Biological Effectiveness ; Ions ; Radiation Exposure ; Space Flight
    Chemical Substances Ions
    Language English
    Publishing date 2023-04-16
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124987-3
    ISSN 1432-2099 ; 0301-634X
    ISSN (online) 1432-2099
    ISSN 0301-634X
    DOI 10.1007/s00411-023-01023-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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