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  1. Article ; Online: Surgical management of skull base meningiomas and vestibular schwannomas.

    Gambacciani, Carlo / Grimod, Gianluca / Sameshima, Tetsuro / Santonocito, Orazio S

    Current opinion in oncology

    2022  Volume 34, Issue 6, Page(s) 713–722

    Abstract: Purpose of review: The aim of this study is to discuss surgical management of meningiomas and schwannomas of skull base.: Recent findings: Meningiomas and schwannomas are typically benign neoplasm with a good prognosis after surgery. Patients should ... ...

    Abstract Purpose of review: The aim of this study is to discuss surgical management of meningiomas and schwannomas of skull base.
    Recent findings: Meningiomas and schwannomas are typically benign neoplasm with a good prognosis after surgery. Patients should be treated individually related to several features: size and localization of tumor and its proximity with deep critical neurovascular structures, neurological status, age and comorbidity. Also, the widespread use of neuroimaging and the progressive and constant aging of the populations inevitably result in the increase of detection rate of incidental (asymptomatic) neoplasm.Nowadays, there are still controversies about the correct management strategy.
    Summary: Surgery represents the gold standard treatment, with the objective of gross total resection; however, it is not always feasible due to localization, encasement of neuro-vascular structure, invasion of cranial nerve and brain parenchyma. Stereotactic radiosurgery and radiation therapy are important to achieve a satisfactory functional outcome and tumor control in case of residue or recurrence. A multidisciplinary approach is pivotal.
    MeSH term(s) Humans ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/surgery ; Meningioma/diagnostic imaging ; Meningioma/surgery ; Neuroma, Acoustic/surgery ; Radiosurgery/methods ; Retrospective Studies ; Skull Base/pathology ; Skull Base Neoplasms/diagnostic imaging ; Skull Base Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) PET as a potential selection tool for second surgery in glioblastoma patients.

    Santonocito, Orazio S / Grimod, Gianluca / DI Stefano, Anna L / Pieri, Francesco / Nizzola, Mariagrazia / Mazzuca, Nicola / Pasqualetti, Francesco / Morganti, Riccardo / Zucchi, Vanna / Gambacciani, Carlo

    Journal of neurosurgical sciences

    2023  

    Abstract: Background: Treatment-related changes still represent a diagnostic challenge in the management of patients with suspect of recurrent glioblastoma. The specificity of conventional MRI in detecting recurrence remains limited. Brain PET imaging provides ... ...

    Abstract Background: Treatment-related changes still represent a diagnostic challenge in the management of patients with suspect of recurrent glioblastoma. The specificity of conventional MRI in detecting recurrence remains limited. Brain PET imaging provides information on tumor metabolism and can contribute to improving the diagnostic accuracy of cerebral neoplasms. We performed a retrospective analysis to evaluate the clinical value of O-(2-
    Methods: A retrospective analysis on patients considered suitable for salvage surgery for recurrence glioblastoma was performed.
    Results: Forty-two of the 51 patients who underwent
    Conclusions: 18
    Language English
    Publishing date 2023-12-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.23.06019-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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