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  1. Article ; Online: Severe gastrintestinal bleeding as an unusual presentation of pediatric tuberculosis: a situation for injectable antituberculous drugs use?

    Santos, Ana Carolina Etrusco Zaroni / Sztajnbok, Jaques / Duarte-Neto, Amaro Nunes / Sousa, Amanda Freire Tamburini / Lopes, Alessandra Geisler Daud / Barrientos, Anna Carlota Mott

    Revista do Instituto de Medicina Tropical de Sao Paulo

    2020  Volume 62, Page(s) e78

    Abstract: Disseminated tuberculosis is a severe disease with high-mortality that requires early diagnosis and treatment. Intestinal tuberculosis accounts for only 2% of tuberculosis cases worldwide and is extremely rare in children. We report a case of a 4-year- ... ...

    Abstract Disseminated tuberculosis is a severe disease with high-mortality that requires early diagnosis and treatment. Intestinal tuberculosis accounts for only 2% of tuberculosis cases worldwide and is extremely rare in children. We report a case of a 4-year-old girl admitted due to disseminated tuberculosis with extensive intestinal involvement characterized by massive intestinal bleeding and hemorrhagic shock. The severity of the intestinal involvement precluded the exclusive use of oral anti-tuberculosis drugs and the patient was successfully treated with a combination of injectable and oral anti-tuberculosis agents. We discuss the importance of a regimen with injectable drugs for treating severe forms of tuberculosis in which the intestinal involvement impaired the use of oral drugs.
    MeSH term(s) Antitubercular Agents/therapeutic use ; Child, Preschool ; Female ; Humans ; Pharmaceutical Preparations ; Tuberculosis/drug therapy
    Chemical Substances Antitubercular Agents ; Pharmaceutical Preparations
    Language English
    Publishing date 2020-10-30
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 128928-7
    ISSN 1678-9946 ; 0036-4665
    ISSN (online) 1678-9946
    ISSN 0036-4665
    DOI 10.1590/S1678-9946202062078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acute petrified myocardium associated with meningococcal sepsis in childhood-onset systemic lupus erythematous: a fatal case.

    Santos, Ana Carolina Etrusco Zaroni / Luglio, Michele / Delgado, Artur Figueiredo / Schuwartz, Constance Dell Santo Vieira / Marques, Heloísa Helena Sousa / Valões, Clarissa Carvalho de Miranda / Dominguez, Maria Andreina Cabrera / Carvalho, Werther Brunow de / Silva, Clovis Artur / Duarte-Neto, Amaro Nunes

    Revista do Instituto de Medicina Tropical de Sao Paulo

    2019  Volume 61, Page(s) e39

    Abstract: Acute petrified myocardium associated with septic shock, diagnosed by autopsy has rarely been described. A 15-year-old adolescent male was diagnosed with childhood-onset systemic lupus erythematosus. One year later, he was hospitalized with fever, ... ...

    Abstract Acute petrified myocardium associated with septic shock, diagnosed by autopsy has rarely been described. A 15-year-old adolescent male was diagnosed with childhood-onset systemic lupus erythematosus. One year later, he was hospitalized with fever, myalgia, headache, arthritis, vomiting, dyspnea and was diagnosed with sepsis secondary to bronchopneumonia and meningitis. Blood culture identified Neisseria meningitidis serogroup Y. Despite antibiotics and intensive therapeutic measures, he died after 29 days of hospitalization. The autopsy revealed necrotic cardiomyocytes with dystrophic calcification and interstitial fibrosis.
    MeSH term(s) Adolescent ; Calcinosis/diagnostic imaging ; Calcinosis/etiology ; Calcinosis/pathology ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/etiology ; Cardiomyopathies/pathology ; Fatal Outcome ; Humans ; Lupus Erythematosus, Systemic/complications ; Male ; Meningococcal Infections/complications ; Sepsis/complications
    Language English
    Publishing date 2019-08-08
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 128928-7
    ISSN 1678-9946 ; 0036-4665
    ISSN (online) 1678-9946
    ISSN 0036-4665
    DOI 10.1590/S1678-9946201961039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

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