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  1. Article: Assessing Intervention Effects in Sentence Processing: Object Relatives vs. Subject Control.

    Delgado, João / Raposo, Ana / Santos, Ana Lúcia

    Frontiers in psychology

    2021  Volume 12, Page(s) 610909

    Abstract: Object relative clauses are harder to process than subject relative clauses. Under Grillo's (2009) Generalized Minimality framework, complexity effects of object relatives are construed as intervention effects, which result from an interaction between ... ...

    Abstract Object relative clauses are harder to process than subject relative clauses. Under Grillo's (2009) Generalized Minimality framework, complexity effects of object relatives are construed as intervention effects, which result from an interaction between locality constraints on movement (Relativized Minimality) and the sentence processing system. Specifically, intervention of the subject DP in the movement dependency is expected to generate a minimality violation whenever processing limitations render the moved object underspecified, resulting in compromised comprehension. In the present study, assuming Generalized Minimality, we compared the processing of object relatives with the processing of subject control in ditransitives, which, like object relatives, instantiates a syntactic dependency across an intervening DP. This comparison is justified by the current debate on whether Control should be analyzed as movement: if control involves movement of the controller DP, as proposed by Hornstein (1999), a parallel between the processing of object relatives and subject control in ditransitives may be anticipated on the basis of intervention. In addition, we explored whether general cognitive factors contribute to complexity effects ascribed to movement across a DP. Sixty-nine adult speakers of European Portuguese read sentences and answered comprehension probes in a self-paced reading task with moving-window display, comprising four experimental conditions:
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.610909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Parental Reports of Preschoolers' Lexical and Syntactic Development: Validation of the CDI-III for European Portuguese.

    Cadime, Irene / Santos, Ana Lúcia / Ribeiro, Iolanda / Viana, Fernanda Leopoldina

    Frontiers in psychology

    2021  Volume 12, Page(s) 677575

    Abstract: This study presents the validation analysis of the European Portuguese version of the MacArthur-Bates Communicative Development Inventory III (CDI-III-PT). The CDI-III-PT is a parental report measure allowing researchers to assess expressive vocabulary ... ...

    Abstract This study presents the validation analysis of the European Portuguese version of the MacArthur-Bates Communicative Development Inventory III (CDI-III-PT). The CDI-III-PT is a parental report measure allowing researchers to assess expressive vocabulary and the syntactic abilities of children aged 2;6-4;0. In this study, we present a version comprising a lexical subscale which follows the Swedish adaptation and an original syntactic subscale allowing us to include language-specific structures. The reports of 739 children were collected; in addition, a standardized measure of language was also administered to a sub-sample of these children and the reports of preschool teachers were collected for another sub-sample. The results indicate a high internal consistency of the lexical and syntactic subscales. As for sociodemographic variables often found to be predictors of language development, as measured by this type of instrument, the results indicate that age and maternal education are significant predictors of the scores, and that first-born children attain higher scores in vocabulary than later born children, but no significant gender differences were found. The scores of the CDI-III-PT are positively correlated with the ones obtained in the standardized language measure, thus supporting their validity. A high agreement between the reports of parents and teachers was also found. These findings indicate that the CDI-III-PT has adequate psychometric properties and that it can be a useful tool for research and clinical practice. The age-based norms that are now provided can be used to evaluate whether a child is performing poorly compared to their peers.
    Language English
    Publishing date 2021-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.677575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: RESPONSIVENESS OF UPPER LIMB SCALES AND TRUNK CONTROL FOR THE EVOLUTION OF PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY.

    Maciel, Flaviana Kelly de Lima / Santos, Ana Lúcia Yaeko da Silva / Sá, Cristina Dos Santos Cardoso de

    Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo

    2021  Volume 39, Page(s) e2020045

    Abstract: Objective: To verify the interval of responsiveness to the scales Segmental Assessment of Trunk Control (SATCo-BR), Performance of Upper Limbs (PUL), and Jebsen Taylor Test (JTT) in patients with Duchenne Muscular Dystrophy (DMD).: Methods: We ... ...

    Abstract Objective: To verify the interval of responsiveness to the scales Segmental Assessment of Trunk Control (SATCo-BR), Performance of Upper Limbs (PUL), and Jebsen Taylor Test (JTT) in patients with Duchenne Muscular Dystrophy (DMD).
    Methods: We assessed patients with DMD aged 6 to 19 years old and with mini-mental (MMSE) score above 10 points. The assessments were performed individually, in a single session. The upper limb function was performed by PUL and JTT, and trunk control by SATCo-BR. Assessments were repeated six and 12 months after the initial assessment. The repeated-measures analysis of variance model and Bonferroni's multiple comparison method were employed as post hoc analysis; when the ANOVA assumptions were not met, the Friedman test was applied.
    Results: The sample consisted of 28 patients evaluated in three moments (initial, and six and 12 months after the beginning). There was a time effect for the Upper Limb function performance in the total JTT, and for the subtests, except for subtests 1 and 6, which did not show a difference between the different moments. There was also a time effect for the score of total PUL, proximal PUL, intermediate PUL, and distal PUL. In the SATCo-BR, this effect was observed between the initial and 6 months, and between the initial and 12 months.
    Conclusions: The JTT, PUL, and SATCo-BR scales can detect changes over time, and they showed responsiveness to detect the evolution of the disease in the 6-month interval.
    Language Portuguese
    Publishing date 2021-02-24
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2560228-7
    ISSN 1984-0462 ; 1984-0462
    ISSN (online) 1984-0462
    ISSN 1984-0462
    DOI 10.1590/1984-0462/2021/39/2020045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Motor Compensation Strategies for Reduced Upper Limb Function Among Individuals With Duchenne Muscular Dystrophy.

    Maciel, Flaviana Kelly de Lima / Santos, Ana Lúcia Yaeko da Silva / Artilheiro, Mariana Cunha / Sá, Cristina Dos Santos Cardoso de

    Perceptual and motor skills

    2021  Volume 128, Issue 3, Page(s) 1059–1077

    Abstract: The purpose of this longitudinal study was to identify and verify the compensatory motor strategies for upper limb functioning of individuals with Duchenne Muscular Dystrophy (DMD). We evaluated 32 patients diagnosed with DMD (aged 6-19 years) for ... ...

    Abstract The purpose of this longitudinal study was to identify and verify the compensatory motor strategies for upper limb functioning of individuals with Duchenne Muscular Dystrophy (DMD). We evaluated 32 patients diagnosed with DMD (aged 6-19 years) for cognitive and motor functioning using the Mini Mental State Examination (MMSE), Vignos Scale Jebsen Taylor Test (JTT) and Functional Skill Scale (FSS) at baseline testing and over retest intervals of six and 12 months. We used the MMSE to screen participants for capacity to engage in the research, and we analyzed absolute and percentile changes in the frequency distribution of motor strategies participants used on each JTT subtest. We also used analysis of variance with repeated measures and Bonferroni post-hoc testing of multiple comparisons to identify disease progression through FSS scores. We observed an increased frequency of compensatory motor strategies over six months. We recommend the associated use of the JTT and FSS to assess patients with DMD, since we observed worsened movement quality over a time interval of six months even while essential motor competence was maintained.
    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Longitudinal Studies ; Muscular Dystrophy, Duchenne ; Upper Extremity ; Young Adult
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204507-2
    ISSN 1558-688X ; 0031-5125
    ISSN (online) 1558-688X
    ISSN 0031-5125
    DOI 10.1177/0031512521998278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Innate Immune Cells in the Tumor Microenvironment of Liver Metastasis from Colorectal Cancer: Contribution to a Comprehensive Therapy.

    Sampaio-Ribeiro, Gabriela / Ruivo, Ana / Silva, Ana / Santos, Ana Lúcia / Oliveira, Rui Caetano / Gama, João / Cipriano, Maria Augusta / Tralhão, José Guilherme / Paiva, Artur

    Cancers

    2023  Volume 15, Issue 12

    Abstract: Colorectal cancer (CRC) is the third most prevalent type of cancer, and liver metastasis is the most common site of metastatic development. In the tumor microenvironment (TME), various innate immune cells are known to influence cancer progression and ... ...

    Abstract Colorectal cancer (CRC) is the third most prevalent type of cancer, and liver metastasis is the most common site of metastatic development. In the tumor microenvironment (TME), various innate immune cells are known to influence cancer progression and metastasis occurrence. CD274 (PD-L1) and CD206 (MRC1) are proteins that have been associated with poor prognosis and disease progression. We conducted a study on tumoral and non-tumoral biopsies from 47 patients with CRC liver metastasis, using flow cytometry to phenotypically characterize innate immune cells. Our findings showed an increase in the expression of CD274 on classical, intermediate, and non-classical monocytes when comparing tumor with non-tumor samples. Furthermore, tumor samples with a desmoplastic growth pattern exhibited a significantly decreased percentage of CD274- and CD206-positive cells in all monocyte populations compared to non-desmoplastic samples. We found a correlation between a lower expression of CD206 or CD274 on classical, intermediate, and non-classical monocytes and increased disease-free survival, which points to a better prognosis for these patients. In conclusion, our study has identified potential new targets and biomarkers that could be incorporated into a personalized medicine approach to enhance the outcome for colorectal cancer patients.
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15123222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Trunk Control and Upper Limb Function of Walking and Non-walking Duchenne Muscular Dystrophy Individuals.

    Santos, Ana Lucia Yaeko da Silva / Maciel, Flaviana Kelly de Lima / Fávero, Francis Meire / Grossklauss, Luis Fernando / de Sá, Cristina Dos Santos Cardoso

    Developmental neurorehabilitation

    2021  Volume 24, Issue 7, Page(s) 435–441

    Abstract: ... ...

    Abstract Aim
    MeSH term(s) Child ; Cross-Sectional Studies ; Humans ; Muscular Dystrophy, Duchenne ; Upper Extremity ; Walking
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280007-4
    ISSN 1751-8431 ; 1751-8423
    ISSN (online) 1751-8431
    ISSN 1751-8423
    DOI 10.1080/17518423.2020.1869337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The development of vocabulary and grammar: a longitudinal study of European Portuguese-speaking toddlers.

    Cadime, Irene / Moreira, Célia S / Santos, Ana Lúcia / Silva, Carla / Ribeiro, Iolanda / Viana, Fernanda Leopoldina

    Journal of child language

    2019  Volume 46, Issue 4, Page(s) 653–681

    Abstract: The goals of this study were to analyze the growth and stability of vocabulary, mean length of the three longest utterances (MLLUw), and sentence complexity in European Portuguese-speaking children aged 1;4-2;6, to explore differences in growth as a ... ...

    Abstract The goals of this study were to analyze the growth and stability of vocabulary, mean length of the three longest utterances (MLLUw), and sentence complexity in European Portuguese-speaking children aged 1;4-2;6, to explore differences in growth as a function of personal and family-related variables, and to investigate the inter-relationships among the three language dimensions. Fifty-one European Portuguese-speaking toddlers were longitudinally assessed at 1;4, 1;9, 2;1, and 2;6, through parent reports. Exponential growth models best described acquisition patterns during this period, but the vocabulary growth accelerated across the full age-range, whereas the growth of grammar dimensions accelerated mainly after 1;9. High variability was observed in the scores, but the toddlers' relative positions were mostly stable over time. Gender approached significance as a predictor of vocabulary growth. Maternal educational level did not predict the growth of any of the three language dimensions. Both vocabulary and MLLUw predicted sentence complexity.
    MeSH term(s) Child ; Child Language ; Child, Preschool ; Female ; Humans ; Infant ; Language Development ; Linguistics ; Longitudinal Studies ; Male ; Portugal ; Vocabulary
    Language English
    Publishing date 2019-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1466489-6
    ISSN 1469-7602 ; 0305-0009
    ISSN (online) 1469-7602
    ISSN 0305-0009
    DOI 10.1017/S0305000919000060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Age and input effects in the acquisition of mood in Heritage Portuguese.

    Flores, Cristina / Santos, Ana Lúcia / Jesus, Alice / Marques, Rui

    Journal of child language

    2017  Volume 44, Issue 4, Page(s) 795–828

    Abstract: The present study analyzes the effect of age and amount of input in the acquisition of European Portuguese as a heritage language. An elicited production task centred on mood choice in complement clauses was applied to a group of fifty bilingual children ...

    Abstract The present study analyzes the effect of age and amount of input in the acquisition of European Portuguese as a heritage language. An elicited production task centred on mood choice in complement clauses was applied to a group of fifty bilingual children (six- to sixteen-year-olds) who are acquiring Portuguese as a minority language in a German dominant environment. The results show a significant effect of the age at testing and the amount of input in the acquisition of the subjunctive. In general, acquisition is delayed with respect to monolinguals, even though higher convergence with the monolingual grammar is observed after twelve years of age. Results also reveal that children with more exposure to the heritage language at home show faster acquisition than children from mixed households: the eight- to nine-year-old age boundary seems relevant for those speakers with more exposure, and the twelve- to thirteen-year-old age boundary for those with less exposure.
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1466489-6
    ISSN 1469-7602 ; 0305-0009
    ISSN (online) 1469-7602
    ISSN 0305-0009
    DOI 10.1017/S0305000916000222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Minimal Answers

    Santos, Ana Lúcia

    Ellipsis, syntax and discourse in the acquisition of European Portuguese

    2009  

    Abstract: This book offers a new contribution to the debate concerning the acquisition of the syntax-discourse interface. It provides evidence that children acquiring European Portuguese have a very early ability to spontaneously produce VP ellipsis as answers to ... ...

    Abstract This book offers a new contribution to the debate concerning the acquisition of the syntax-discourse interface. It provides evidence that children acquiring European Portuguese have a very early ability to spontaneously produce VP ellipsis as answers to yes-no questions. It is also argued that the distribution of VP ellipsis in European Portuguese (including its co-existence with Null Complement Anaphora) supports the hypothesis that the identification condition on ellipsis is derivable from some innate knowledge of the syntax-discourse interface. Answers to yes-no questions also provide evide
    Language English
    Size Online-Ressource (314 p.)
    Publisher John Benjamins Publishing Company
    Publishing place Amsterdam/Philadelphia
    Document type Book ; Online
    Note Description based upon print version of record
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article: Extensive Phenotypic Characterization of T Cells Infiltrating Liver Metastasis from Colorectal Cancer: A Potential Role in Precision Medicine.

    Sampaio-Ribeiro, Gabriela / Ruivo, Ana / Silva, Ana / Santos, Ana Lúcia / Oliveira, Rui Caetano / Laranjeira, Paula / Gama, João / Cipriano, Maria Augusta / Tralhão, José Guilherme / Paiva, Artur

    Cancers

    2022  Volume 14, Issue 24

    Abstract: Colorectal cancer (CRC) is one of the most common cancers worldwide, with liver metastasis being its main cause of death. This study harvested fresh biological material from non-tumor and tumor tissue from 47 patients with CRC liver metastasis after ... ...

    Abstract Colorectal cancer (CRC) is one of the most common cancers worldwide, with liver metastasis being its main cause of death. This study harvested fresh biological material from non-tumor and tumor tissue from 47 patients with CRC liver metastasis after surgery, followed by mechanical cellular extraction and stain-lyse-wash direct immunofluorescence technique. Here, 60 different T-cell populations were characterized by flow cytometry. Tumor samples were also subdivided according to their growth pattern into desmoplastic and non-desmoplastic. When we compared tumor versus non-tumor samples, we observed a significantly lower percentage of T-lymphocyte infiltration in the tumor in which the CD4
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14246069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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