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  1. Article: Traditional Agriculture and Food Sovereignty: Quilombola Knowledge and Management of Food Crops

    Gonçalves, Maiara Cristina / da Silva, Fernanda Ribeiro / Cantelli, Daniele / dos Santos, Maria Rita / Aguiar, Paulo Volnei / Pereira, Eliseu Santos / Hanazaki, Natalia

    Journal of ethnobiology. 2022 July 19, v. 42, no. 2

    2022  

    Abstract: In several parts of the world, forests have been safeguarded by Indigenous and traditional people, whose plant food production is mostly for self-consumption and for sale based on the promotion of forest biological processes and crop diversification. In ... ...

    Abstract In several parts of the world, forests have been safeguarded by Indigenous and traditional people, whose plant food production is mostly for self-consumption and for sale based on the promotion of forest biological processes and crop diversification. In the Brazilian Atlantic Forest, Quilombola groups are black communities that have protected and managed agrobiodiversity since the fifteenth century. Although the dynamics of use, production, and donations of Quilombola food plants are still poorly understood, these processes can help us to understand the vulnerability to food insecurity. We analyzed the food security related to food availability in a Quilombola community in southern Brazil (São Roque Pedra Branca), focusing on their dependence on locally produced food plants. Today, São Roque families depend on agriculture, government benefits, and urban low-paid civil construction and general helper jobs. We evaluated the interactions between Quilombola farmers and the cultivated species and varieties and the role of farmer families within the community. The hypothesis is that farmers who produce, manage, and conserve more local species and varieties of plants also contribute to less food vulnerability within the community. The small-scale agriculture carried out by the Quilombolas implies the management of high inter- and intraspecific diversity. During the 2019 agricultural year, 42 species were cultivated in plots and gardens, comprising 83 varieties. Most farmers cultivate a subset of major species and varieties for self-consumption and donations. The farmers who grow the most varieties are the ones who donate the most. Some vulnerability to food insecurity was observed in 53% of the family units. Exchanges and donations between families contribute to the community's food security, but there are still families in a situation of food insecurity. Local agrobiodiversity and established exchange networks strengthen Quilombola food sovereignty.
    Keywords agrobiodiversity ; crop diversification ; ethnobiology ; farmers ; food availability ; food production ; food security ; food sovereignty ; forests ; small-scale farming ; traditional farming ; Brazil
    Language English
    Dates of publication 2022-0719
    Size p. 241-260.
    Publishing place Society of Ethnobiology
    Document type Article
    ISSN 2162-4496
    DOI 10.2993/0278-0771-42.2.241
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Paternal age and risk for selected birth defects in a large South American sample.

    Gili, Juan A / Rittler, Monica / Heisecke, Silvina / Campaña, Hebe / Giménez, Lucas / Santos, María Rita / Ratowiecki, Julia / Cosentino, Viviana / López Camelo, Jorge / Poletta, Fernando A

    Birth defects research

    2023  Volume 115, Issue 19, Page(s) 1866–1875

    Abstract: Background: The relationship between maternal age (MA) and birth defects (BD) has been extensively studied while much less research, mostly with discordant results, has focused on the risk of paternal age (PA) for BD. Furthermore, no consensus has been ... ...

    Abstract Background: The relationship between maternal age (MA) and birth defects (BD) has been extensively studied while much less research, mostly with discordant results, has focused on the risk of paternal age (PA) for BD. Furthermore, no consensus has been reached on the best way to control the association of PA with MA.
    Objectives: The aim of the study was to evaluate the risk of PA increase, at 1-year intervals, for selected BD, especially controlling for the confounding effect of MA.
    Methods: The sample comprised of 27,944 liveborns presenting 1 of 18 selected isolated BD. Conditional logistic regressions were applied to evaluate the risk of advanced PA and its yearly increase, adjusting by MA and other variables.
    Results: Of the 18 analyzed BD, only the risk for preaxial polydactyly (PreP) showed a significant association with increasing PA, while advanced MA was of low risk. For esophageal and anal atresia, associations with both PA and MA increases were observed.
    Conclusions: Results support the hypothesis of advanced PA as a risk factor for PreP and helps clarify the so far unexplained nonrandom association between this defect and Down syndrome.
    MeSH term(s) Humans ; Male ; Anus, Imperforate/epidemiology ; Paternal Age ; Risk Factors ; South America/epidemiology ; Polydactyly/epidemiology
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2104792-3
    ISSN 2472-1727
    ISSN (online) 2472-1727
    DOI 10.1002/bdr2.2252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diseases during pregnancy in a large unselected South American sample.

    Santos, María Rita / Campaña, Hebe / Heisecke, Silvina / Ratowiecki, Julia / Elías, Darío / Giménez, Lucas / Poletta, Fernando Adrián / Gili, Juan / Uranga, Rocío / Cosentino, Viviana / Krupitzki, Hugo / Rittler, Mónica / Camelo, Jorge López

    Revista brasileira de epidemiologia = Brazilian journal of epidemiology

    2022  Volume 25, Page(s) e220043

    Abstract: Objective: Our aim was to describe the prevalence of diseases during pregnancy and the association between fetal exposure to the most frequent maternal diseases and the risk of preterm (PTB) and/or small for gestational age (SGA) newborns in an ... ...

    Abstract Objective: Our aim was to describe the prevalence of diseases during pregnancy and the association between fetal exposure to the most frequent maternal diseases and the risk of preterm (PTB) and/or small for gestational age (SGA) newborns in an unselected sample of women who gave birth in South American countries.
    Methods: We conducted a descriptive, cross-sectional study including 56,232 mothers of non-malformed infants born between 2002 and 2016, using data from the Latin American Collaborative Study of Congenital Malformations (ECLAMC). Diseases with higher- than-expected PTB/SGA frequencies were identified. Odds ratios of confounding variables for diseases and birth outcomes were calculated with a multivariable logistic regression.
    Results: Of the 14 most reported diseases, hypertension, genitourinary infection, epilepsy, hypothyroidism, diabetes, and HIV/AIDS showed higher PTB and/or SGA frequencies. Advanced and low maternal age, previous fetal loss, low socioeconomic level, and African-American ancestry were associated with PTB, while advanced maternal age, primigravidity, previous fetal loss, low socioeconomic level, and African-American ancestry were associated with SGA. After adjusting for the associated variables, the identified illnesses maintained their association with PTB and all, except epilepsy, with SGA.
    Conclusion: The description of an unselected population of mothers allowed identifying the most frequent diseases occurring during gestation and their impact on pregnancy outcomes. Six diseases were associated with PTB and two with SGA newborns. To the best of our knowledge, there are no similar reports about women not intentionally selected by specific diseases during pregnancy in South American populations.
    MeSH term(s) Infant, Newborn ; Female ; Humans ; Pregnancy ; Cross-Sectional Studies ; Brazil
    Language English
    Publishing date 2022-12-05
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2183366-7
    ISSN 1980-5497 ; 1980-5497
    ISSN (online) 1980-5497
    ISSN 1980-5497
    DOI 10.1590/1980-549720220043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Human Y chromosome sequences from Q Haplogroup reveal a South American settlement pre-18,000 years ago and a profound genomic impact during the Younger Dryas.

    Paz Sepúlveda, Paula B / Mayordomo, Andrea Constanza / Sala, Camila / Sosa, Ezequiel Jorge / Zaiat, Jonathan Javier / Cuello, Mariela / Schwab, Marisol / Rodríguez Golpe, Daniela / Aquilano, Eliana / Santos, María Rita / Dipierri, José Edgardo / Alfaro Gómez, Emma L / Bravi, Claudio M / Muzzio, Marina / Bailliet, Graciela

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0271971

    Abstract: The settlement of the Americas has been the focus of incessant debate for more than 100 years, and open questions regarding the timing and spatial patterns of colonization still remain today. Phylogenetic studies with complete human Y chromosome ... ...

    Abstract The settlement of the Americas has been the focus of incessant debate for more than 100 years, and open questions regarding the timing and spatial patterns of colonization still remain today. Phylogenetic studies with complete human Y chromosome sequences are used as a highly informative tool to investigate the history of human populations in a given time frame. To study the phylogenetic relationships of Native American lineages and infer the settlement history of the Americas, we analyzed Y chromosome Q Haplogroup, which is a Pan-American haplogroup and represents practically all Native American lineages in Mesoamerica and South America. We built a phylogenetic tree for Q Haplogroup based on 102 whole Y chromosome sequences, of which 13 new Argentine sequences were provided by our group. Moreover, 1,072 new single nucleotide polymorphisms (SNPs) that contribute to its resolution and diversity were identified. Q-M848 is known to be the most frequent autochthonous sub-haplogroup of the Americas. The present is the first genomic study of Q Haplogroup in which current knowledge on Q-M848 sub-lineages is contrasted with the historical, archaeological and linguistic data available. The divergence times, spatial structure and the SNPs found here as novel for Q-Z780, a less frequent sub-haplogroup autochthonous of the Americas, provide genetic support for a South American settlement before 18,000 years ago. We analyzed how environmental events that occurred during the Younger Dryas period may have affected Native American lineages, and found that this event may have caused a substantial loss of lineages. This could explain the current low frequency of Q-Z780 (also perhaps of Q-F4674, a third possible sub-haplogroup autochthonous of the Americas). These environmental events could have acted as a driving force for expansion and diversification of the Q-M848 sub-lineages, which show a spatial structure that developed during the Younger Dryas period.
    MeSH term(s) Chromosomes, Human, Y/genetics ; Genetics, Population ; Genomics ; Haplotypes ; Humans ; Phylogeny
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0271971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lethality of Birth Defects in Live Born Infants Categorized by Gestational Age and Birth Weight.

    Rittler, Monica / Campaña, Hebe / Heisecke, Silvina / Ratowiecki, Julia / Elias, Dario / Gimenez, Lucas / Poletta, Fernando A / Gili, Juan / Pawluk, Mariela / Santos, Maria Rita / Uranga, Rocio / Cosentino, Viviana / Camelo, Jorge Lopez

    American journal of perinatology

    2021  Volume 40, Issue 13, Page(s) 1406–1412

    Abstract: Objective: This study aimed to describe lethality of birth defects (BDs) in newborns categorized by gestational age and birth weight and to identify BDs associated with prematurity.: Study design: Live born infants (: Results: Overall fewer ... ...

    Abstract Objective: This study aimed to describe lethality of birth defects (BDs) in newborns categorized by gestational age and birth weight and to identify BDs associated with prematurity.
    Study design: Live born infants (
    Results: Overall fewer malformed than nonmalformed infants were of adequate growth, while the opposite occurred in the preterm and SGA categories where gastroschisis and esophageal atresia were among the most outstanding defects. For most severe BDs, the early neonatal death rate was higher than control values in all categories; for mild defects, except cleft lip in the preterm category, they did not differ. Diaphragmatic hernia showed the highest lethality values, while those of spina bifida were among the lowest. Talipes, hypospadias, and septal heart defects were mild defects significantly associated with prematurity.
    Conclusion: Although reasons, such as induced preterm delivery of fetuses with certain anomalies, could partially account for their high prematurity rates, susceptibility to preterm birth might exist through underlying mechanisms related with the defects. The identification of BDs associated with prematurity should serve to improve measures that prevent preterm birth especially of fetuses at risk.
    Key points: · Some BDs predispose to prematurity.. · Prematurity is an additional risk factor for mortality in infants with mild defects.. · Lethality values should be adjusted by gestational age and birth weight..
    MeSH term(s) Male ; Female ; Infant, Newborn ; Infant ; Humans ; Pregnancy ; Birth Weight ; Gestational Age ; Premature Birth ; Infant, Premature ; Infant, Small for Gestational Age ; Fetal Growth Retardation
    Language English
    Publishing date 2021-10-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0041-1735867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inequidades sociales en madres adolescentes y la relación con resultados perinatales adversos en poblaciones sudamericanas.

    Ratowiecki, Julia / Santos, María Rita / Poletta, Fernando / Heisecke, Silvina / Elias, Dario / Gili, Juan / Gimenez, Lucas / Pawluk, Mariela / Uranga, Rocio / Cosentino, Viviana / Campaña, Hebe / Rittler, Mónica / Camelo, Jorge S López

    Cadernos de saude publica

    2021  Volume 36, Issue 12, Page(s) e00247719

    Abstract: The aim was to explain differences in the rates of adverse perinatal events in teenage mothers with low and high schooling. The sample was collected from the Latin American Colaborative Study of Congenital Malformations (ECLAMC) database. From a total of ...

    Title translation Social inequities in teenage mothers and the relationship to adverse perinatal outcomes in South American populations.
    Abstract The aim was to explain differences in the rates of adverse perinatal events in teenage mothers with low and high schooling. The sample was collected from the Latin American Colaborative Study of Congenital Malformations (ECLAMC) database. From a total of 2,443,747 births in 93 hospitals, 66,755 live newborns without congenital malformations were recruited from 2000 to 2017. Teenage mothers were classified according to low, medium, and high schooling. A multivariate model was used that included reproductive history, access to health services, demographic and socioeconomic variables, and ethnic group. The Fairlie decomposition model was applied to quantify the contribution of explanatory variables to the adverse perinatal event rates. Of the 66,755 newborns analyzed, 21.1% (n = 14,078) were born to teenage mothers. Distribution of maternal schooling was 24.2%, 59.8%, and 16% for low, medium, and high schooling, respectively. The highest rates of adverse perinatal events were seen in teenage mothers with low schooling. The variable "access to health services" explained 35%, 37%, and 23% of the disparities in low birthweight, prematurity, and intrauterine growth restriction, respectively, among teenage mother with low and high schooling. Low number of prenatal visits was the only risk factor for the two levels of schooling and the variable that best explained the differences between the rates of adverse perinatal events. From the public health perspective, prenatal care represents a low-cost intervention with the possibility of increased implementation through adequate information for the population and systematic measures in primary care.
    MeSH term(s) Adolescent ; Brazil/epidemiology ; Female ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Mothers ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy in Adolescence ; Prenatal Care
    Language Spanish
    Publishing date 2021-01-11
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1115730-6
    ISSN 1678-4464 ; 0102-311X
    ISSN (online) 1678-4464
    ISSN 0102-311X
    DOI 10.1590/0102-311X00247719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A graph theory approach to analyze birth defect associations.

    Elias, Dario / Campaña, Hebe / Poletta, Fernando / Heisecke, Silvina / Gili, Juan / Ratowiecki, Julia / Gimenez, Lucas / Pawluk, Mariela / Santos, Maria Rita / Cosentino, Viviana / Uranga, Rocio / Rittler, Monica / Lopez Camelo, Jorge

    PloS one

    2020  Volume 15, Issue 5, Page(s) e0233529

    Abstract: Birth defects are prenatal morphological or functional anomalies. Associations among them are studied to identify their etiopathogenesis. The graph theory methods allow analyzing relationships among a complete set of anomalies. A graph consists of nodes ... ...

    Abstract Birth defects are prenatal morphological or functional anomalies. Associations among them are studied to identify their etiopathogenesis. The graph theory methods allow analyzing relationships among a complete set of anomalies. A graph consists of nodes which represent the entities (birth defects in the present work), and edges that join nodes indicating the relationships among them. The aim of the present study was to validate the graph theory methods to study birth defect associations. All birth defects monitoring records from the Estudio Colaborativo Latino Americano de Malformaciones Congénitas gathered between 1967 and 2017 were used. From around 5 million live and stillborn infants, 170,430 had one or more birth defects. Volume-adjusted Chi-Square was used to determine the association strength between two birth defects and to weight the graph edges. The complete birth defect graph showed a Log-Normal degree distribution and its characteristics differed from random, scale-free and small-world graphs. The graph comprised 118 nodes and 550 edges. Birth defects with the highest centrality values were nonspecific codes such as Other upper limb anomalies. After partition, the graph yielded 12 groups; most of them were recognizable and included conditions such as VATER and OEIS associations, and Patau syndrome. Our findings validate the graph theory methods to study birth defect associations. This method may contribute to identify underlying etiopathogeneses as well as to improve coding systems.
    MeSH term(s) Congenital Abnormalities/epidemiology ; Data Science/methods ; Databases, Factual ; Humans ; Infant, Newborn ; Statistical Distributions
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0233529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Continental Origin for Q Haplogroup Patrilineages in Argentina and Paraguay.

    Jurado Medina, Laura S / Paz Sepúlveda, Paula B / Ramallo, Virginia / Sala, Camila / Beltramo, Julieta / Schwab, Marisol / Motti, Josefina M B / Santos, María Rita / Cuello, Mariela V / Salceda, Susana / Dipierri, José E / Alfaro Gómez, Emma L / Muzzio, Marina / Bravi, Claudio M / Bailliet, Graciela

    Human biology

    2021  Volume 92, Issue 2, Page(s) 63–80

    Abstract: Haplogroup Q originated in Eurasia around 30,000 years ago. It is present in Y-chromosomes from Asia and Europe at rather low frequencies. Since America is undoubtedly one of the continents where this haplogroup is highly represented, it has been defined ...

    Abstract Haplogroup Q originated in Eurasia around 30,000 years ago. It is present in Y-chromosomes from Asia and Europe at rather low frequencies. Since America is undoubtedly one of the continents where this haplogroup is highly represented, it has been defined as one of the founding haplogroups. Its M3 clade has been early described as the most frequent, with pan-American representation. However, it was also possible to find several other haplogroup Q clades at low frequencies. Numerous mutations have been described for haplogroup Q, allowing analysis of its variability and assignment of its geographic origin. We have analyzed 442 samples of unrelated men from Argentina and Paraguay belonging to haplogroup Q; here we report specifically on 27 Q (xM3) lineages. We tested 3 single-nucleotide polymorphisms (SNPs) by amplified product-length polymorphism (APLP) analysis, 3 SNPs for restriction fragment length polymorphism (RFLP) analysis, 15 SNPs by Sanger sequencing, and 17 short tandem repeats (STRs). Our approach allowed us to identify five subhaplogroups. Q-M3 and Q-CTS2730/Z780 are undoubtedly autochthonous lineages and represent the most frequent subhaplogroups, with significant representation in self-defined aboriginal populations, and their autochthonous status has been previously described. The aim of present work was to identify the continental origin of the remaining Q lineages. Thus, we analyzed the STR haplotypes for the samples and compared them with haplotypes described by other authors for the rest of the world. Even when haplogroup Q lineages have been extensively studied in America, some of them could have their origin in post-Columbian human migration from Europe and Middle East.
    MeSH term(s) Americas ; Argentina ; Asia ; Chromosomes, Human, Y/genetics ; Europe ; Genetics, Population ; Haplotypes/genetics ; Humans ; Male ; Microsatellite Repeats ; Middle East ; Paraguay ; Phylogeny ; Polymorphism, Single Nucleotide/genetics
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1116-2
    ISSN 1534-6617 ; 0018-7143
    ISSN (online) 1534-6617
    ISSN 0018-7143
    DOI 10.13110/humanbiology.92.2.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina.

    Santos, María Rita / Ramallo, Virginia / Muzzio, Marina / Camelo, Jorge S López / Bailliet, Graciela

    Revista medica de Chile

    2015  Volume 143, Issue 4, Page(s) 444–450

    Abstract: Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, ...

    Title translation Association between NAT2 polymorphisms with non-syndromic cleft lip with or without cleft palate in Argentina.
    Abstract Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment.
    Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP.
    Material and methods: We analyzed *5 (481C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and *4 (wild type) allele by polymerase chain reaction/restriction fragment length polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT).
    Results: TDT showed a positive association between allele *5 and NSCLP (odds ratio = 1,6; p = 0,03).
    Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP.
    MeSH term(s) Alleles ; Amplified Fragment Length Polymorphism Analysis ; Analysis of Variance ; Argentina ; Arylamine N-Acetyltransferase/genetics ; Cleft Lip/genetics ; Cleft Palate/genetics ; Fathers ; Female ; Genetic Carrier Screening ; Genetic Predisposition to Disease ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Mothers ; Polymorphism, Restriction Fragment Length/genetics
    Chemical Substances Arylamine N-Acetyltransferase (EC 2.3.1.5) ; NAT2 protein, human (EC 2.3.1.5)
    Language Spanish
    Publishing date 2015-04
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872015000400005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Lethality of Birth Defects in Live Born Infants Categorized by Gestational Age and Birth Weight

    Rittler, Monica / Campaña, Hebe / Heisecke, Silvina / Ratowiecki, Julia / Elias, Dario / Gimenez, Lucas / Poletta, Fernando A. / Gili, Juan / Pawluk, Mariela / Santos, Maria Rita / Uranga, Rocio / Cosentino, Viviana / Camelo, Jorge Lopez

    American Journal of Perinatology

    2021  Volume 40, Issue 13, Page(s) 1406–1412

    Abstract: Objective: This study aimed to describe lethality of birth defects (BDs) in newborns categorized by gestational age and birth weight and to identify BDs associated with prematurity.: Study Design: Live born infants ( n  = 16,452) with isolated BDs ... ...

    Abstract Objective: This study aimed to describe lethality of birth defects (BDs) in newborns categorized by gestational age and birth weight and to identify BDs associated with prematurity.
    Study Design: Live born infants ( n  = 16,452) with isolated BDs classified by severity, and 42,511 healthy controls were assigned to categories: adequate growth, preterm, or small for gestational age (SGA). Proportion of cases and BDs' lethality rates were obtained by category and compared with controls.
    Results: Overall fewer malformed than nonmalformed infants were of adequate growth, while the opposite occurred in the preterm and SGA categories where gastroschisis and esophageal atresia were among the most outstanding defects. For most severe BDs, the early neonatal death rate was higher than control values in all categories; for mild defects, except cleft lip in the preterm category, they did not differ. Diaphragmatic hernia showed the highest lethality values, while those of spina bifida were among the lowest. Talipes, hypospadias, and septal heart defects were mild defects significantly associated with prematurity.
    Conclusion: Although reasons, such as induced preterm delivery of fetuses with certain anomalies, could partially account for their high prematurity rates, susceptibility to preterm birth might exist through underlying mechanisms related with the defects. The identification of BDs associated with prematurity should serve to improve measures that prevent preterm birth especially of fetuses at risk.
    Key Points: Some BDs predispose to prematurity. Prematurity is an additional risk factor for mortality in infants with mild defects. Lethality values should be adjusted by gestational age and birth weight.
    Keywords Lethality ; birth defects ; prematurity ; birth weight ; risk ; ECLAMC
    Language English
    Publishing date 2021-10-11
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0041-1735867
    Database Thieme publisher's database

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