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  1. Article ; Online: The management of osteoarthritis symptomatology through nanotechnology: a patent review.

    Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny De Araujo / Rajkumar, Gomathi / Frank, Luiza Abrahão / Serafini, Mairim Russo

    Journal of microencapsulation

    2023  Volume 40, Issue 7, Page(s) 475–490

    Abstract: Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for ... ...

    Abstract Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.
    MeSH term(s) Humans ; Drug Delivery Systems ; Nanotechnology ; Osteoarthritis/drug therapy
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 843632-0
    ISSN 1464-5246 ; 0265-2048
    ISSN (online) 1464-5246
    ISSN 0265-2048
    DOI 10.1080/02652048.2023.2258955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2267: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Devices for osteoarthritis symptoms treatment: a patent review.

    Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Carvalho Nascimento, José Adão / Santana, Cláudio Carvalho / Oliveira, Ana Maria Santos / Cezar, Silvia Vitoria Silva / Santos, Alcimary Bispo / Frank, Luiza Abrahão / Serafini, Mairim Russo

    Expert review of medical devices

    2024  Volume 21, Issue 1-2, Page(s) 91–107

    Abstract: Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, ... ...

    Abstract Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, joint pain, stiffness, crepitus, limited movement, and local inflammation.
    Areas covered: The selected patents were deposited from 2010 to April 2022 involving 57 documents that were in line with the study objective in the final selection. The patents were classified in years, country, and applicants. Also, the therapeutic fields that presented the most documents were electrical stimulation, phototherapy, and ultrasound, followed by magnetic, electromagnetic, and thermotherapy. Therefore, the most current therapies used in the documents are already on the market.
    Expert opinion: Although the OA is cureless, non-surgical treatments are classified as the primary management approach for this disease. The pharmacological and non-pharmacological therapies are employed to reduce its prevalence and ensure the effectiveness of treatments. A strategy for relieving OA symptoms is non-pharmacological treatment, which can be based on exercise and patient education, combined with other alternative therapies. These therapies are used as supplements to the main OA treatments, enhancing the effectiveness of treatment outcomes.
    MeSH term(s) Humans ; Quality of Life ; Osteoarthritis/therapy ; Hyperthermia, Induced ; Inflammation ; Exercise
    Language English
    Publishing date 2024-02-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2023.2298729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6424: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Mapping of New Pharmacological Alternatives in the Face of the Emergence of Antibiotic Resistance in COVID-19 Patents Treated for Opportunistic Respiratory Bacterial Pathogens.

    Santos, Anamaria Mendonça / Santos, Mariana Mendonça / Nascimento Júnior, José Adão Carvalho / Brito, João Rafael Lisboa Rêgo / de Araújo Andrade, Tatianny / Frank, Luiza Abrahão / Serafini, Mairim Russo

    Recent advances in anti-infective drug discovery

    2022  Volume 17, Issue 1, Page(s) 34–53

    Abstract: Background: The increase in bacterial resistance against antibiotics is thought to be another type of pandemic after COVID-19. Emergency treatment based on antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella ... ...

    Abstract Background: The increase in bacterial resistance against antibiotics is thought to be another type of pandemic after COVID-19. Emergency treatment based on antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella pneumoniae, are the most affected by the indiscriminate use of antibiotics, since they are resistant to most antibiotics currently available on the market.
    Objective: This review aimed to evaluate patents of new drugs and formulations, for the treatment of infections caused by Klebsiella pneumoniae.
    Methods: The present patent review was carried out through a specialized search database Espacenet. The selection was based on the criteria of patents published from 2010 to May 2021, in any language, and containing the keywords in title or abstract. Also, a research was performed on the PubMed database, using the inclusion criteria.
    Results: Twenty-two patents were selected for the analysis according to the aim of the study. The advance of new patents has been mostly observed in the World Intellectual Property Organization, China, and United States. The results showed that the main approach was the drug association, followed by drug carriers, new isolated products, and vaccines.
    Conclusion: It has been observed that few studies use new drug alternatives for the treatment, probably due to the higher cost of the development and lack of investments. The effectiveness and safety of these therapies depend on the acceptance, the correct prescription, and rational use of medicines. Therefore, this review can further develop new treatments as alternatives against Klebsiella pneumoniae and pneumonia caused by it.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria ; COVID-19/drug therapy ; Drug Carriers ; Drug Resistance, Microbial ; Humans ; Klebsiella pneumoniae
    Chemical Substances Anti-Bacterial Agents ; Drug Carriers
    Language English
    Publishing date 2022-05-20
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 2772-4352
    ISSN (online) 2772-4352
    DOI 10.2174/1574891X16666220518142347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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